Medication interaction hub

What Supplements Interact with Streptozocin?

Streptozocin brand name: Zanosar. Every interaction below applies to the brands too.

13 Interactions 2 Major 10 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Streptozocin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Streptozocin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Streptozocin (Zanosar) is a chemotherapy drug whose best-known serious side effect is kidney damage, which makes its list of 13 interacting supplements one to treat with genuine care. Six are herbs that can injure the kidneys on their own, including both major-rated entries, Siberian cocklebur and asarabacca, and layering those onto a drug already hard on the kidneys risks compounding the harm. The other seven are antioxidants, familiar products like vitamin C, that might blunt the chemotherapy itself.

Streptozocin kills cancer cells partly through oxidative stress, and the concern is that antioxidant supplements could shield those cells from that effect. The research is mixed, but during active treatment even that uncertainty matters. Ten of the 13 are rated moderate and one minor, and Siberian cocklebur is the only interaction backed by solid human evidence. Bring every supplement you take to your oncology team before the next cycle.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 10 Minor 1 No known interaction 1,439

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Streptozocin: Top Interactions at a Glance

The most significant Streptozocin supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 13 interacting ingredients — plus 1,439 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Streptozocin + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Streptozocini

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Possible Asarabacca + Streptozocini

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Streptozocin

All 1,452 ingredients in our database, ranked by severity — 13 with a Streptozocin interaction on file and 1,439 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Streptozocin?

One-line answers, one card per combination — scroll through today’s 16 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coenzyme Q10 with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coenzyme Q10 has antioxidant effects.

Full Coenzyme Q10 + Streptozocin answer

Can you take Vitamin C with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Full Vitamin C + Streptozocin answer

Can you take Vitamin E with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.

Full Vitamin E + Streptozocin answer

Can you take Asian Water Plantain with Streptozocin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Streptozocin answer

Can you take Siberian Cocklebur with Streptozocin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the kidney.

Full Siberian Cocklebur + Streptozocin answer

Can you take Asarabacca with Streptozocin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Full Asarabacca + Streptozocin answer

Can you take Acerola with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Full Acerola + Streptozocin answer

Can you take Alpha-lipoic Acid with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.

Full Alpha-lipoic Acid + Streptozocin answer

Can you take Aristolochia with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aristolochia is nephrotoxic.

Full Aristolochia + Streptozocin answer

Can you take Mountain Ash with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Streptozocin answer

Can you take Rhubarb with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Streptozocin answer

Can you take Rose Hip with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative d...

Full Rose Hip + Streptozocin answer

Can you take Turmeric with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric has antioxidant effects.

Full Turmeric + Streptozocin answer

Can you take Vitamin C with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Full Vitamin C + Streptozocin answer

Can you take Vitamin E with Streptozocin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.

Full Vitamin E + Streptozocin answer

Can you take Asian Water Plantain with Streptozocin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Streptozocin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Streptozocin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Streptozocin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Streptozocin sits in 2 interaction categories. Open any one to see what the group means:

Alkylating Agents 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Streptozocin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Streptozocin through this category.

About Streptozocin

Streptozocin is a prescription medication also sold under the brand name Zanosar. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Streptozocin  ·  Brand name: Zanosar.

See the full Streptozocin drug information

Related: does Streptozocin deplete any nutrients?

Streptozocin has 1 reported nutrient association in the research literature — see the Streptozocin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Streptozocin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Streptozocin.

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Pharmacist Counseling Corner

Streptozocin & Supplements: Common Questions

What supplements interact with Streptozocin?
More than you might expect — 13 in total, though they are far from equal: 2 are rated major, 10 moderate, and 1 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Asarabacca, Acerola.
Which Streptozocin supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Asarabacca. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Streptozocin?
Usually yes — most people on Streptozocin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Zanosar have the same supplement interactions as Streptozocin?
Yes — Zanosar all contain Streptozocin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Streptozocin deplete any vitamins or nutrients?
It might — Streptozocin has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Streptozocin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Streptozocin and my other medications?
This page covers Streptozocin against supplements and herbal ingredients. Checking Streptozocin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Streptozocin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.