Medication interaction hub

What Supplements Interact with Telaprevir?

Telaprevir brand name: Incivek. Every interaction below applies to the brands too.

149 Interactions 3 Major 108 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Telaprevir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Telaprevir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

149 supplements and herbal ingredients have interactions with Telaprevir on file in the HelloPharmacist interaction database — 3 rated major, 108 moderate, and 38 minor. The most serious involve Grapefruit, St. John's Wort and Activated Charcoal.

Our assessment: with 3 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Telaprevir.

Major 3 Moderate 108 Minor 38 No known interaction 1,303

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Telaprevir: Top Interactions at a Glance

The most significant Telaprevir supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 149 interacting ingredients — plus 1,303 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Telaprevir + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Telapreviri

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely St. John's Wort + Telapreviri

St.

Read the full interaction Major Likelihood Probable Activated Charcoal + Telapreviri

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Telaprevir

All 1,452 ingredients in our database, ranked by severity — 149 with a Telaprevir interaction on file and 1,303 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Telaprevir?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hibiscus Sabdariffa with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Full Hibiscus Sabdariffa + Telaprevir answer

Can you take Puravive with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains Panax ginseng.

Full Puravive + Telaprevir answer

Can you take Sesame with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, sesame might alter the transport of P-glycoprotein substrates.

Full Sesame + Telaprevir answer

Can you take Valerian with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Telaprevir answer

Can you take Vitamin D with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Telaprevir answer

Can you take Xanthan Gum with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Telaprevir answer

Can you take Yerba Mate with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yerba mate might increase the levels and clinical effects of CYP3A4 substrates.

Full Yerba Mate + Telaprevir answer

Can you take Gymnema with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Telaprevir answer

Can you take Humann Superbeets Heart Chews with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Telaprevir answer

Can you take Jequirity with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Telaprevir answer

Can you take Milk Thistle with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Telaprevir answer

Can you take Mommy's Bliss Gripe Water with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Telaprevir answer

Can you take Ostarine with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of ostarine with CYP3A4 inhibitors could increase the effects and adverse effects of ostarine, although this...

Full Ostarine + Telaprevir answer

Can you take Polypodium Leucotomos with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Telaprevir answer

Can you take Pomegranate with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Telaprevir answer

Can you take Red Clover with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.

Full Red Clover + Telaprevir answer

Can you take Tangerine with Telaprevir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Telaprevir answer

Can you take Grapefruit with Telaprevir?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Telaprevir answer

Can you take St. John's Wort with Telaprevir?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Telaprevir answer

Can you take Activated Charcoal with Telaprevir?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Telaprevir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Telaprevir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Telaprevir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Telaprevir sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Telaprevir through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Telaprevir through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Telaprevir through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Telaprevir through this category.

Protease Inhibitors (Pis) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Telaprevir through this category.

About Telaprevir

Telaprevir is a prescription medication also sold under the brand name Incivek. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Telaprevir  ·  Brand name: Incivek.

See the full Telaprevir drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Telaprevir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Telaprevir.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Telaprevir & Supplements: Common Questions

What supplements interact with Telaprevir?
In our interaction database, 149 supplement and herbal ingredients have an interaction with Telaprevir on file — 3 rated major, 108 moderate, and 38 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, St. John's Wort, Activated Charcoal.
Which Telaprevir supplement interactions are the most serious?
Focus on the major group: Grapefruit, St. John's Wort and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Telaprevir?
That depends entirely on which supplement. The honest answer for Telaprevir is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Incivek have the same supplement interactions as Telaprevir?
Yes — Incivek all contain Telaprevir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Telaprevir and my other medications?
This page covers Telaprevir against supplements and herbal ingredients. Checking Telaprevir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Telaprevir drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.