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Dietary supplement

100% Pure L-Citrulline 500 Milligrams Ingredients & Drug Interactions

by NutraBio

100% Pure L-Citrulline 500 Milligrams label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 100% Pure L-Citrulline 500 Milligrams against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

100% Pure L-Citrulline 500 Milligrams is a dietary supplement by NutraBio with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against 100% Pure L-Citrulline 500 Milligrams by NutraBio

Ask about any prescription or over-the-counter medication and we check it for interactions with 100% Pure L-Citrulline 500 Milligrams by NutraBio — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 100% Pure L-Citrulline 500 Milligrams by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-Citrulline, an amino acid your body uses to support blood vessel function and blood flow. The capsule itself is made from vegetable material (an inactive ingredient).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded L-citrulline's overall clinical evidence instead.

Moderate

Some clinical evidence supports L-citrulline for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Athletic performance — rated "Possibly Effective" (Natural Medicines).

L-Citrulline is possibly effective for athletic performance — the evidence suggests it may help with exercise outcomes. For sarcopenia (age-related muscle loss), the data we hold rates it possibly ineffective.

For cardiovascular disease, heart failure, Reye syndrome, and diabetes, the evidence available isn't strong enough to rate it either way.

The evidence, ingredient by ingredient L-citrulline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal discomfort and heartburn.

A small number of people have reported cough when taking the supplement. There isn't enough safety data during pregnancy, so it's best to avoid this supplement if you're pregnant.

Safety while breastfeeding is also unknown, so avoid supplemental use if you're nursing. Talk with your doctor or pharmacist about whether this product is right for your individual situation.

Side effects, ingredient by ingredient L-citrulline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood pressure medications (antihypertensive drugs) and erectile dysfunction medications (phosphodiesterase-5 inhibitors like sildenafil or tadalafil) before taking this product — both have Moderate severity interactions with L-Citrulline.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

L-Citrulline may interest you if you're looking to support athletic performance, but it's not established for heart health conditions in our data. If you take blood pressure medication or erectile dysfunction medication, you'll need to check with your pharmacist first — the interaction risk is real.

Pregnant and nursing people should skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 100% Pure L-Citrulline 500 Milligrams, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908236076
Net contents 500 V-Cap(s)
Market status On market
Date entered into DSLD Sep 25, 2015
DSLD ID 50979
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 100% Pure L-Citrulline 500 Milligrams by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 V-Cap(s)
Maximum serving Sizes:
4 V-Cap(s)
Servings per container
125
UPC/BARCODE
649908236076
IngredientAmount% DV
L-Citrulline2000 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

NUTRABIO Since 1996

Made in a GMP & FDA inspected facility

True Label Full label disclosure

OU

KQ Kyowa Quality

Suggested/Recommended/Usage/Directions

4 capsules 1-2x daily Suggested Use: As a dietary supplement, take 4 capsules (2000 mg) 1 to 2 times daily or as directed by your physician.

Formulation

VEGETARIAN

~ NON-GMO GLUTEN FREE ~ BSE/TSE FREE

This product is Kosher, Vegetarian, Hypoallergenic, Non-GMO, Gluten Free, & BSE/TSE Free.

This product is Kosher, Vegetarian, Hypoallergenic, Non-GMO, Gluten Free, & BSE/TSE Free. No added sugars, salt, preservatives, salicylates, or artificial color, flavor or fragrance. ZERO Fillers or Excipients Inferior ingredients Banned substances Added sugars Proprietary Blends Hidden ingredients

No Fillers No Excipients No Additives

Free of harmful impurities

Formula

ALLERGEN FREE

This product is Kosher, Vegetarian, Hypoallergenic, Non-GMO, Gluten Free, & BSE/TSE Free.

This product is Kosher, Vegetarian, Hypoallergenic, Non-GMO, Gluten Free, & BSE/TSE Free.

Precautions

Warning: NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN.

If you are pregnant, breast feeding, have known medical conditions (including kidney or liver disease) or are taking prescription or OTC medication(s) consult with your health care practitioner before using this product.

General Statements

Manufactured in a GMP & FDA inspected facility FDA Registration: 16906175560

Free Form Amino Acid

Pharmaceutical Grade HPLC Lab Tested for Potency

125 servings

500 milligrams

Vegetable Capsule

Quality and purity since 1996. NutraBio manufactures in our own FDA registered & inspected GMP facility complying with FDA 21 CFR Part 111 regulations.

Made in USA

Brand IP Statement(s)

AMINO THERAPY

Kyowa Quality and/or the KQ logo are trademarks of Kyowa Hakko Bio Co., Ltd.

FDA Statement of Identity

Dietary Supplement

Storage

STORE IN A COOL DRY PLACE.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure or prevent any disease.

General

23607-007 B20078-002

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

100% Pure L-Citrulline 500 Milligrams by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

100% Pure L-Citrulline 500 Milligrams label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 100% Pure L-Citrulline 500 Milligrams by NutraBio

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 V-Cap(s) Dosage formCapsule Servings per container125 Amounts shown are per serving.

L-Citrulline

Interacts with
178 drugs
2000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

100% Pure L-Citrulline 500 Milligrams by NutraBio Drug Interactions

Want to check YOUR meds against 100% Pure L-Citrulline 500 Milligrams?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
178Drugs
178 Moderate

Ingredients driving the most interactions

L-Citrulline 178

Individual Drug Interactions

The ingredients in 100% Pure L-Citrulline 500 Milligrams interact with 178 drugs. Click any drug to see the details.

1 of the 1 ingredient in 100% Pure L-Citrulline 500 Milligrams interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline

Each ingredient & the kinds of drugs it affects

For each ingredient in 100% Pure L-Citrulline 500 Milligrams with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 100% Pure L-Citrulline 500 Milligrams, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

100% Pure L-Citrulline 500 Milligrams by NutraBio: Common Questions

Does 100% Pure L-Citrulline 500 Milligrams by NutraBio interact with any medications?
Yes. Based on its ingredients, 100% Pure L-Citrulline 500 Milligrams has a known interaction with 178 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
100% Pure L-Citrulline 500 Milligrams contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does L-Citrulline do in the body?
L-Citrulline is an amino acid that your body converts to L-arginine. This increases nitric oxide, which relaxes blood vessel walls and improves blood flow.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data for pregnancy, so it's best to avoid it. Safety while breastfeeding is also unknown, so avoid supplemental use if you're nursing. Talk with your doctor.
What are the most common side effects?
Gastrointestinal discomfort and heartburn are the most common. A small number of people have reported cough.
Does it really help with workout performance?
The evidence rates it possibly effective for athletic performance, which means there's some research support but it's not proven across all studies.
Is this good for heart health?
For cardiovascular disease and heart failure, we don't have enough reliable evidence to say whether it works or not.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 100% Pure L-Citrulline 500 Milligrams is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

100% Pure L-Citrulline 500 Milligrams label
Go deeper

The Full Monographs Behind 100% Pure L-Citrulline 500 Milligrams’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph →
Sources

Sources & How We Checked

100% Pure L-Citrulline 500 Milligrams's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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