Major interaction on record — check this product against your medications before combining. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Complete PCT Ingredients & Drug Interactions

by Nutra Innovations

Complete PCT label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Complete PCT against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Complete PCT is a dietary supplement by Nutra Innovations with 7 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,211 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are BioPerine, Tribulus terrestris, Mucuna Seed Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Complete PCT by Nutra Innovations

Ask about any prescription or over-the-counter medication and we check it for interactions with Complete PCT by Nutra Innovations — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Complete PCT by Nutra Innovations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Complete PCT contains seven active ingredients. The most pharmacologically significant are Mucuna Seed Extract, which supplies levodopa (a compound related to dopamine medications), BioPerine (the piperine from black pepper), Tribulus terrestris (a plant used traditionally for sexual function), Nettle Root Extract, and Fadogia agrestis.

The product also includes D-Aspartic Acid and Abieta-8,11,13-Trien-18-Oic Acid. The capsules are filled with inactive ingredients including gelatin, dicalcium phosphate, magnesium stearate, silicon dioxide, titanium dioxide, and colorants (FD&C Blue #1 and FD&C Red #40).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: hormone support and sexual function post-cycle.
  • We looked for evidence on: Erectile dysfunction (ED), Sexual desire, Sexual dysfunction, Male infertility, Premature ejaculation, Athletic performance — and 4 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Premature ejaculation, Male infertility, Exercise-induced muscle damage.

The evidence picture is mixed and mostly uncertain. Tribulus terrestris is rated Possibly Effective for sexual dysfunction based on clinical research, though it's rated Possibly Ineffective for athletic performance.

Nettle Root Extract is rated Possibly Effective for diabetes. For the other ingredients and conditions listed—Mucuna for anxiety, Parkinson disease, or rheumatoid arthritis; BioPerine for allergic rhinitis, asthma, athletic performance, headache, depression, or diarrhea; and Fadogia for athletic performance, erectile dysfunction, or malaria—the evidence in our data is rated Insufficient, meaning we don't have enough reliable data to know whether they work.

The evidence, ingredient by ingredient Black Pepper Tribulus Cowhage Fadogia Agrestis Stinging Nettle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

BioPerine (black pepper) is generally well tolerated in food amounts, though concentrated supplements warrant caution. Common side effects from oral use include a burning aftertaste, indigestion, and reduced taste perception; inhaled powder can cause cough.

Allergic reactions are rare but possible. Tribulus is often well tolerated short-term in healthy adults, but long-term safety data are limited; rare serious effects (liver and kidney injury, seizures, painful erection) have been reported.

Mucuna Seed Extract, which contains levodopa, carries a caution due to its drug-like potency—diarrhea, flatulence, nausea, and insomnia have been reported. Nettle Root Extract is generally well tolerated, with constipation and diarrhea as the most common oral side effects; a rare case of liver injury has been reported.

Fadogia agrestis has limited human safety data, and animal studies raise concern about potential harm to the testicles, liver, and kidneys.

Side effects, ingredient by ingredient Black Pepper Tribulus Cowhage Fadogia Agrestis Stinging Nettle

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Tribulus, Stinging Nettle, Black Pepper, Cowhage.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,212 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Complete PCT, check with your pharmacist if you use non-selective MAOIs, methyldopa, levodopa, guanethidine, propranolol, theophylline, blood thinners (especially warfarin), seizure drugs, antidiabetes medications, blood pressure drugs, lithium, or diuretics. Mucuna's levodopa poses Major risks with certain blood pressure and MAOI drugs; black pepper's piperine raises levels of eight medication types.

Your exact prescriptions need to be checked against this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product pairs several botanical extracts with a levodopa-containing ingredient and black pepper, making it a high-interaction-risk supplement—especially if you take blood pressure, diabetes, seizure, heart, or psychiatric medications. Tribulus may help with sexual function, but Nettle and Mucuna evidence is weak or absent for most uses.

Talk to your pharmacist before you start, particularly if you take any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Complete PCT, straight from the product label.

Brand Nutra Innovations
Barcode (UPC) 850027848105
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 321696
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Complete PCT by Nutra Innovations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
850027848105
IngredientAmount% DV
D-Aspartic Acid3000 mg--
BioPerine5 mg--
Abieta-8,11,13-Trien-18-Oic Acid50 mg--
Tribulus terrestris300 mg--
Mucuna Seed Extract150 mg--
Fadogia agrestis, Powder150 mg--
Nettle Root Extract75 mg--

Other ingredients: Gelatin, Dicalcium Phosphate, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, FD&C Blue #1, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Cycle Support Complete PCT is a comprehensive hormone support formula designed to support natural testosterone production, minimize estrogen, promote lean muscle mass and improve a healthy libido. Balance hormones Improved libido Manage estrogen

Cycle Support Premium post-cycle therapy

General Statements

Did you love it? We hope you did & we'd love to hear your feedback. 1. Open your camera app & scan the QR code 2. Give us a follow & DM us what you think!

Instagram, Twitter, Facebook @Nutrainnovation // www.nutrainnovations.com

Precautions

Warning: Keep out of reach of children. For adult use only.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Do not exceed recommended dosage. Do not take longer than 4 weeks without a 4 week off period.

Seals/Symbols

FDA Registered FAcility GMP Good Manufacturing Practice Made in USA

FDA Statement of Identity

Dietary Supplement

Formula

BioPerine

Brand IP Statement(s)

BioPerine is a trademark of Sabinsa Corp.

Suggested/Recommended/Usage/Directions

Suggested Use: Take (3) Capsules twice daily with food. Do not take longer than 4 weeks without a 4 week off period.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Complete PCT by Nutra Innovations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Complete PCT label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Complete PCT by Nutra Innovations

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

D-Aspartic Acid

3000 mg per serving

BioPerine

Interacts with
1,019 drugs
5 mg per serving Form: Piper nigrum

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

BioPerine monograph & interactions

Abieta-8,11,13-Trien-18-Oic Acid

50 mg per serving

Tribulus terrestris

Interacts with
259 drugs
300 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris monograph & interactions

Mucuna Seed Extract

Interacts with
193 drugs
150 mg per serving Form: L-Dopa

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Mucuna Seed Extract monograph & interactions

Fadogia agrestis, Powder

No known
interactions
150 mg per serving

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes most...

Fadogia agrestis, Powder monograph & interactions

Nettle Root Extract

Interacts with
164 drugs
75 mg per serving

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Nettle Root Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Dicalcium Phosphate, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, FD&C Blue #1, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Complete PCT by Nutra Innovations Drug Interactions

Want to check YOUR meds against Complete PCT?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,211Drugs
17 Major 1,155 Moderate 39 Minor

Ingredients driving the most interactions

BioPerine 1,019
Tribulus terrestris 259
Mucuna Seed Extract 193
Nettle Root Extract 164

Individual Drug Interactions

The ingredients in Complete PCT interact with 1,211 drugs. Click any drug to see the details.

4 of the 7 ingredients in Complete PCT interact with drugs. Each result below shows which ingredient is responsible. BioPerine Tribulus terrestris Mucuna Seed Extract Nettle Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Complete PCT with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

BioPerine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
BioPerine full monograph & interactions

Tribulus terrestris3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris full monograph & interactions

Mucuna Seed Extract8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Mucuna Seed Extract full monograph & interactions

Nettle Root Extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Nettle Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Complete PCT, from the product label.

Nutra Innovations

See all Nutra Innovations products
Name
Nutra Innovations
Street Address
6290 McDonough Dr Suite E
City
Norcross
State
GA
ZipCode
30093
Web Address
www.NutraInnovations.com
Pharmacist Counseling Corner

Complete PCT by Nutra Innovations: Common Questions

Does Complete PCT by Nutra Innovations interact with any medications?
Yes. Based on its ingredients, Complete PCT has a known interaction with 1,211 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Complete PCT contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
No. Tribulus should be avoided during pregnancy because it may affect hormones, and safety is not established. Mucuna should also be avoided in pregnancy due to its dopamine effects and lack of safety data. Nettle Root should be avoided in pregnancy based on traditional concerns. Mucuna additionally should be avoided while breastfeeding because its levodopa can lower prolactin levels and reduce milk supply. For the others, safety data during pregnancy or breastfeeding are either absent or not on file—talk with your doctor or pharmacist for personalized advice.
What does Tribulus do in this formula?
Tribulus terrestris is included for sexual function—the evidence rates it Possibly Effective for sexual dysfunction. It may also have blood pressure-lowering and blood sugar-lowering effects, which is why it interacts with certain medications.
Why is there black pepper (BioPerine) in a PCT product?
BioPerine is piperine from black pepper, added to supplements as an absorption enhancer—it increases how the body takes in and retains other compounds. However, because it slows the elimination of several medications, it also increases their blood levels, which is why it carries interaction warnings with heart, infection, and other drugs.
What are the most common side effects I might experience?
From BioPerine, you might notice a burning aftertaste, indigestion, or reduced taste perception. Mucuna Seed Extract can cause diarrhea, flatulence, nausea, or (in about 3% of users) insomnia. Nettle Root typically causes constipation or diarrhea. Tribulus is usually well tolerated short-term. If side effects persist or worsen, stop and talk to your pharmacist.
Does Mucuna Seed Extract contain a prescription-type ingredient?
Yes. Mucuna Seed Extract contains levodopa, a compound closely related to the prescription medication used for Parkinson disease. This is why it must be handled carefully and why it has serious interactions with certain blood pressure and psychiatric medications.
Can I use this for athletic performance?
The evidence doesn't support it. Tribulus is rated Possibly Ineffective for athletic performance, and BioPerine's rating for athletic performance is Insufficient—meaning we don't have enough reliable data to say whether it works. Fadogia is also rated Insufficient for this use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Complete PCT label
Go deeper

The Full Monographs Behind Complete PCT’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph → Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph → Herb & supplement monograph

Fadogia Agrestis

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal...

Read the full Fadogia Agrestis monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph →
Sources

Sources & How We Checked

Complete PCT's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 76 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  4. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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