8 Billion Acidophilus & Bifidus Ingredients & Drug Interactions
What is this page for?
First and foremost: checking 8 Billion Acidophilus & Bifidus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
8 Billion Acidophilus & Bifidus is a dietary supplement by Douglas Cooper Co. with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus LA-14, Bifidobacterium longum BI-05. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against 8 Billion Acidophilus & Bifidus by Douglas Cooper Co.
Ask about any prescription or over-the-counter medication and we check it for interactions with 8 Billion Acidophilus & Bifidus by Douglas Cooper Co. — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of 8 Billion Acidophilus & Bifidus by Douglas Cooper Co.
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 3 active ingredients: Lactobacillus acidophilus LA-14 and Bifidobacterium longum BI-05, two well-known probiotic bacteria, plus Bifidobacterium lactis BI-04. The inactive ingredients are microcrystalline cellulose, hypromellose, stearic acid, and silicon dioxide — these are the capsule, binder, and filler materials.
Does it work?
Moderate evidence
The evidence for Lactobacillus acidophilus in this product is strongest for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis — all rated possibly effective. For Bifidobacterium longum, the data we hold don't establish effectiveness for the conditions studied; most are rated insufficient evidence to rate.
We have no effectiveness data on file for Bifidobacterium lactis BI-04.
How safe is it?
Well-documented data
Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Uncommon side effects can include stomach discomfort, bloating, gas, diarrhea, or nausea.
In rare cases, the live bacteria have caused serious bloodstream or organ infections in people with compromised immune systems — this is thought to happen when bacteria from the gut cross into the bloodstream. Bifidobacterium longum is also generally well tolerated, but caution is advised for people who are seriously ill or immune-compromised; rare gastrointestinal side effects (abdominal pain, bloating, flatulence) and one case of dry cough have been reported.
Both ingredients are rated possibly safe in pregnancy; data on breastfeeding are limited, so check with your doctor.
Meds to double-check
Moderate interaction found
Antibiotic drugs are the main concern — they can kill the live organisms in this product and reduce its effect. Separate your antibiotic dose from this supplement by several hours, and confirm the exact timing with your pharmacist.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This is a straightforward two-strain probiotic for people interested in supporting gut health — especially those dealing with irritable bowel syndrome or diarrhea after antibiotics. If you take antibiotics, space them out from this product and confirm the timing with your pharmacist.
Anyone who is seriously ill or has a weakened immune system should talk to their doctor first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about 8 Billion Acidophilus & Bifidus, straight from the product label.
| Brand | Douglas Cooper Co. |
|---|---|
| Net contents | 60 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2022 |
| DSLD ID | 275190 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for 8 Billion Acidophilus & Bifidus by Douglas Cooper Co., sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bifidobacterium lactis BI-04 | 0 NP | -- |
| Lactobacillus acidophilus LA-14 | 0 NP | -- |
| Blend of Probiotic Bacteria | 0 NP | -- |
| Bifidobacterium longum BI-05 | 0 NP | -- |
Other ingredients: Microcrystalline Cellulose, Hypromellose, Stearic Acid, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 capsule 1 to 2 times daily between meals or on an empty stomach.
Storage
Refrigerate to maintain potency.
Formula
This product has a balanced blend of the two prominent species of resident intestinal bacteria. Regular intake of probiotics can aid in maintaining healthy intestinal flora.
The probiotic strains in this product have been identity-verified using DNA-fingerprinting technology.
This product is formulated to deliver a potency of 8 billion CFU through the best by date.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: Consult physician if pregnant/nursing, taking medication (especially immune-suppressing drugs), or have a medical condition (especially if immune system is compromised).
Keep out of reach of children.
To report a serious adverse event, or for product information, contact 1-800-234-8686
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Brand IP Statement(s)
Douglas Cooper Co. "Trace minerals make the difference" since 1950
Formulation
Promotes positive probiotic balance
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens. Non-GMO
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
8 Billion Acidophilus & Bifidus by Douglas Cooper Co. label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in 8 Billion Acidophilus & Bifidus by Douglas Cooper Co.
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Blend of Probiotic Bacteria
- › Bifidobacterium lactis BI-04
- › Lactobacillus acidophilus LA-14
- › Bifidobacterium longum BI-05
Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Stearic Acid, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
8 Billion Acidophilus & Bifidus by Douglas Cooper Co. Drug Interactions
HelloPharmacist Interaction Report
Douglas Cooper Co.'s 8 Billion Acidophilus & Bifidus is a probiotic blend that does interact with one major medication type: antibiotic drugs.
Both Lactobacillus acidophilus and Bifidobacterium longum in this product contain live organisms that antibiotics can kill. Taking them at the same time may reduce how well the probiotic works, so separate your doses — ask your pharmacist or doctor for timing guidance.
Read the full breakdown — every affected drug type, severity by severity
Additionally, we couldn't check Bifidobacterium lactis BI-04 — we hold no data on it. Altogether, these interactions span 182 individual medications.
That count includes all the antibiotics in our database; your specific antibiotic may or may not be one of them, and either way the advice is the same: space them out.
Use the medication checker below to verify your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against 8 Billion Acidophilus & Bifidus?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in 8 Billion Acidophilus & Bifidus interact with 182 drugs. Click any drug to see the details.
2 of the 3 ingredients in 8 Billion Acidophilus & Bifidus interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus LA-14 Bifidobacterium longum BI-05
AmikacinAmikin, Arikayce
How Amikacin interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Amikacin interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Amikacin interactionAmoxicillinAmix, Amoram, Amoxident, Amoxil Capsules, Amoxil Injection, Galenamox +3 more
How Amoxicillin interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Amoxicillin interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Amoxicillin interactionAmoxicillin VeterinaryBiomox
How Amoxicillin Veterinary interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Amoxicillin Veterinary interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Amoxicillin Veterinary interactionAmoxicillin, Clavulanate PotassiumAugmentin, Augmentin '125/31 SF', Augmentin '250/62 SF', Augmentin XR, Augmentin-Duo 400/57, Clavulin
How Amoxicillin, Clavulanate Potassium interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Amoxicillin, Clavulanate Potassium interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Amoxicillin, Clavulanate Potassium interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Amphotericin, Tetracycline interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Amphotericin, Tetracycline interactionAmpicillinOmnipen, Omnipen-N, Penbritin, Principen, Rimacillin
How Ampicillin interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Ampicillin interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Ampicillin interactionAmpicillin, SulbactamUnasyn
How Ampicillin, Sulbactam interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Ampicillin, Sulbactam interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Ampicillin, Sulbactam interactionAvibactam Sodium, CeftazidimeAvycaz
How Avibactam Sodium, Ceftazidime interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Avibactam Sodium, Ceftazidime interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Avibactam Sodium, Ceftazidime interactionAzithromycinAzasite, Zithromax, Zmax
How Azithromycin interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Azithromycin interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Azithromycin interactionAztreonamAzactam
How Aztreonam interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Aztreonam interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Aztreonam interactionBacampicillinPenglobe
How Bacampicillin interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Bacampicillin interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Bacampicillin interactionBacitracinBaci-IM, Baciguent, Bacitracin Ointment
How Bacitracin interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Bacitracin interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Bacitracin interactionBenznidazoleBenznidazole
How Benznidazole interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Benznidazole interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Benznidazole interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionCapreomycinCapastat
How Capreomycin interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Capreomycin interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Capreomycin interactionCarbenicillin Indanyl SodiumGeocillin
How Carbenicillin Indanyl Sodium interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Carbenicillin Indanyl Sodium interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Carbenicillin Indanyl Sodium interactionCefaclorCeclor, Ceclor CD
How Cefaclor interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefaclor interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefaclor interactionCefadroxilCef-Tab, Duricef, Ultracef
How Cefadroxil interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefadroxil interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefadroxil interactionCefamandoleMandol
How Cefamandole interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefamandole interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefamandole interactionCefazolinAncef
How Cefazolin interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefazolin interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefazolin interactionCefdinirOmnicef
How Cefdinir interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefdinir interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefdinir interactionCefditoren PivoxilSpectracef
How Cefditoren Pivoxil interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefditoren Pivoxil interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefditoren Pivoxil interactionCefepimeMaxipime
How Cefepime interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefepime interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefepime interactionCefiderocol Sulfate TosylateFetroja
How Cefiderocol Sulfate Tosylate interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefiderocol Sulfate Tosylate interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefiderocol Sulfate Tosylate interactionCefiximeSuprax
How Cefixime interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefixime interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefixime interactionCefmetazoleZefazone
How Cefmetazole interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefmetazole interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefmetazole interactionCefonicidMonocid
How Cefonicid interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefonicid interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefonicid interactionCefoperazoneCefobid
How Cefoperazone interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Lactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefoperazone interactionBifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefoperazone interactionCefotaximeClaforan
How Cefotaxime interacts with 8 Billion Acidophilus & Bifidus — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bi-05Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bi-05 + Cefotaxime interactionLactobacillus Acidophilus La-14Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Lactobacillus Acidophilus La-14 + Cefotaxime interactionEach ingredient & the kinds of drugs it affects
For each ingredient in 8 Billion Acidophilus & Bifidus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Lactobacillus acidophilus LA-14
Antibiotic Drugs
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.
Bifidobacterium longum BI-05
Antibiotic Drugs
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.
Brand information
Manufacturer and brand details for 8 Billion Acidophilus & Bifidus, from the product label.
Douglas Cooper Co.
See all Douglas Cooper Co. products- Name
- Douglas Cooper Co.
- City
- Carmel
- State
- IN
- ZipCode
- 46032
- Phone Number
- 1-800-234-8686
8 Billion Acidophilus & Bifidus by Douglas Cooper Co.: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind 8 Billion Acidophilus & Bifidus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lactobacillus Acidophilus
Interacts with 182 drugsLactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...
Read the full Lactobacillus Acidophilus monograph → Herb & supplement monographBifidobacterium Longum
Interacts with 182 drugsBifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...
Read the full Bifidobacterium Longum monograph →Sources & How We Checked
8 Billion Acidophilus & Bifidus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lactobacillus Acidophilus 15 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
- Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
- Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
- Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
- Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
- Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
- Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
- Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
- Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
- Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.
See these in context on the Lactobacillus Acidophilus monograph →
Bifidobacterium Longum 21 references
- Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
- Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
- Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
- Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
- Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
- Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
- US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
- Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
- Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
- Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
- Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
- Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
- Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
- Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
- Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
- Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
- Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed
See these in context on the Bifidobacterium Longum monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC