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Dietary supplement

ActivFulvic Ingredients & Drug Interactions

by Zemvelo

ActivFulvic label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ActivFulvic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ActivFulvic is a dietary supplement by Zemvelo with 1 active ingredient. Its ingredients are commonly taken for general wellness and energy, gut health, antioxidant support.Based on those ingredients, 257 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ActivFulvic. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ActivFulvic by Zemvelo

Ask about any prescription or over-the-counter medication and we check it for interactions with ActivFulvic by Zemvelo — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ActivFulvic by Zemvelo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

ActivFulvic is a liquid supplement containing one active ingredient: fulvic acid, a compound formed from the breakdown and combination of organic matter in soil. The product also contains sorbic acid as a preservative.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Fulvic Acid's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: enhances nutrient absorption and supports immunity.
  • We looked for evidence on: Fatigue, Lead toxicity, Respiratory tract infections, Antioxidant support, Detoxification, Mineral bioavailability.
  • The closest evidence on file: Fulvic Acid is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).
  • Also on file: Fulvic Acid is rated "Insufficient Reliable Evidence To Rate" for Fatigue, Lead toxicity.

The evidence we hold doesn't establish how well fulvic acid works. We have insufficient reliable evidence to rate it for respiratory tract infections, lead toxicity, eczema (atopic dermatitis), fatigue, or allergic rhinitis (hay fever).

That means there isn't enough quality research yet to say whether it's effective for these uses.

The evidence, ingredient by ingredient Fulvic Acid

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of fulvic acid appears generally well tolerated when taken by mouth, though high-quality safety data in humans is limited. The most common side effects reported in trials were diarrhea, headache, and sore throat; a small number of trial participants experienced these.

Rarely, a serious bone condition called Kashin-Beck disease has been reported with oral use, though this is uncommon. Do not use this product during pregnancy or while breastfeeding.

There isn't enough safety information to know either way, and the facts advise against it.

Side effects, ingredient by ingredient Fulvic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Fulvic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 257 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), thyroid hormone therapy, or immunosuppressant medications. These are Moderate severity interactions documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

ActivFulvic might interest you if you're exploring fulvic acid for general wellness, but the evidence for its effectiveness isn't established yet. If you take any blood thinners, thyroid medication, or immunosuppressants, talk to your pharmacist before starting — the interactions here are real enough to matter.

Pregnant or breastfeeding? Skip it and ask your doctor or pharmacist for guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ActivFulvic, straight from the product label.

Brand Zemvelo
Barcode (UPC) 891663002179
Net contents 16.2 Fluid Ounce(s); 480 mL
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 333493
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ActivFulvic by Zemvelo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 mL
Maximum serving Sizes:
15 mL
Servings per container
32
UPC/BARCODE
891663002179
IngredientAmount% DV
ActivFulvic5 Gram(s)--

Other ingredients: Sorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Enhances vitamin, mineral & nutrient absorption Supports & boosts the immune system Cleanses, neutralizes & removes toxins & heavy metals Antioxidants reduce free radicals & inflammation

Vegan

Gluten-free Non-GMO

Third Party Tested

FDA Statement of Identity

Dietary Supplement

General Statements

"Love & Gratitude"

Seals/Symbols

Manufactured in the U.S.A.

Suggested/Recommended/Usage/Directions

Directions: Adults: Place 1 Tablespoon (15ml) into 6-8oz of water or juice as maintenance. Use more if needed or as recommended by your healthcare professional. For Detox: Take 2-3 Tablespoons (30-45ml) for 21 days. Take 1 hour before food or supplements when used as a detox. Children Under 4: Consult a physician. Shake well before use.

Precautions

Do not use if tamper evident seal is broken or missing.

Storage

For freshness, keep refrigerated after opening.

Formula

Clinically tested & multi-patented pure source of fulvic acid

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ActivFulvic by Zemvelo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ActivFulvic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ActivFulvic by Zemvelo

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size15 mL Dosage formLiquid Servings per container32 Amounts shown are per serving.

ActivFulvic

Interacts with
257 drugs
5 Gram(s) per serving Form: Fulvic Acid

Fulvic acid is a natural compound formed when plants and microbes break down in soil, and it is sold as a supplement for energy, gut, and overall well...

ActivFulvic monograph & interactions

Other (inactive) ingredients: Sorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

ActivFulvic by Zemvelo Drug Interactions

Want to check YOUR meds against ActivFulvic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
257Drugs
257 Moderate

Ingredients driving the most interactions

ActivFulvic 257

Individual Drug Interactions

The ingredients in ActivFulvic interact with 257 drugs. Click any drug to see the details.

1 of the 1 ingredient in ActivFulvic interact with drugs. Each result below shows which ingredient is responsible. ActivFulvic

Each ingredient & the kinds of drugs it affects

For each ingredient in ActivFulvic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ActivFulvic3 drug types · 257 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
In vitro evidence shows that fulvic acid, formed from the oxidation and polymerization of protocatechuic acid, can shorten prothrombin time in human plasma, increasing the risk of clot formation.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.
Animal research shows that fulvic acid stimulates immune function.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, taking fulvic acid with thyroid hormone therapy might interfere with the ability to normalize thyroid function.
Animal research shows that fulvic acid increases the plasma level of thyroid-stimulating hormone (TSH) and decreases the thyroxine (T4):triiodothyronine (T3) ratio.

Likelihood Possible Evidence D
ActivFulvic full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ActivFulvic, from the product label.

Zemvelo

See all Zemvelo products
Name
Zemvelo by Mineralife
Phone Number
800.303.1376
Web Address
zemvelo.com
Pharmacist Counseling Corner

ActivFulvic by Zemvelo: Common Questions

Does ActivFulvic by Zemvelo interact with any medications?
Yes. Based on its ingredients, ActivFulvic has a known interaction with 257 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ActivFulvic contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is fulvic acid?
Fulvic acid is a compound that forms when organic matter in soil breaks down and recombines. It's the active ingredient in ActivFulvic.
Can I take this while I'm on thyroid medication?
No — not without talking to your pharmacist first. Animal research shows fulvic acid can interfere with how your body processes thyroid hormones, which is a Moderate severity interaction. Check with your pharmacist about whether it's safe for you.
Does ActivFulvic actually work for what it claims?
We don't have enough reliable evidence yet to say whether fulvic acid is effective for respiratory infections, lead toxicity, eczema, fatigue, or hay fever. The data we hold rates it as insufficient evidence for all of these.
What side effects might I experience?
The most common side effects reported in trials were diarrhea, headache, and sore throat. Serious effects are rare, though bone disease called Kashin-Beck disease has been reported with oral use in very rare cases.
Is it safe if I'm pregnant or breastfeeding?
No — avoid it. There isn't enough safety information to know either way, and the facts advise against use in both pregnancy and breastfeeding. Talk to your doctor or pharmacist for alternatives.
Are there any fillers or other inactive ingredients?
Yes — sorbic acid is included as a preservative. Beyond that, you're getting fulvic acid.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ActivFulvic is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ActivFulvic label
Go deeper

The Full Monographs Behind ActivFulvic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fulvic Acid

Interacts with 257 drugs

Fulvic acid is a natural compound formed when plants and microbes break down in soil, and it is sold as a supplement for energy, gut, and overall wellness. Human research is very limited, so...

Read the full Fulvic Acid monograph →
Sources

Sources & How We Checked

ActivFulvic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fulvic Acid 3 references
  1. Lu, FJ. Arsenic as a promoter in the effect of humic substances on plasma prothrombin time in vitro. Thromb Res 6-15-1990;58(6):537-541. PubMed
  2. Vucskits, AV, Hullar, I, Bersenyi, A, Andrasofszky, E, Kulcsar, M, Szabo, J. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl) 2010;94(6):721-728. PubMed
  3. Gandy JJ, Meeding JP, Snyman JR, et al. Phase 1 clinical study of the acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid. Clin Pharmacol. 2012;4:7-11. PubMed

See these in context on the Fulvic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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