Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Ionic Manganese Ingredients & Drug Interactions

by Good State

Ionic Manganese label
See full label image
Liquid Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ionic Manganese against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ionic Manganese is a dietary supplement by Good State with 1 active ingredient. Its ingredients are commonly taken for bone health support, antioxidant and enzyme support, filling dietary gaps.Based on those ingredients, 83 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ionic Manganese by Good State

Ask about any prescription or over-the-counter medication and we check it for interactions with Ionic Manganese by Good State — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Ionic Manganese by Good State

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Good State Ionic Manganese is a single-ingredient liquid supplement containing manganese in an ionic (dissolved, charged) form. Manganese is an essential mineral your body needs in small amounts for bone health, metabolism, and nervous system function.

The product also contains water and sorbic acid (a preservative) as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Manganese supplementation for metabolism and calcium absorption.
  • We looked for evidence on: Manganese deficiency, Metabolic syndrome, Osteoporosis, Wound healing, bone metabolism, enzyme function.
  • The strongest evidence on file: Manganese is rated "Effective" for Manganese deficiency (Natural Medicines).
  • Also on file: Manganese is rated "Insufficient Reliable Evidence To Rate" for Osteoporosis, Wound healing, Metabolic syndrome.

Manganese is effective for treating manganese deficiency — a genuine but rare condition. For other uses like hay fever, osteoporosis, COPD, weight loss, and osteoarthritis, there isn't enough reliable evidence in our data to say whether it works.

If you're considering this supplement for one of those conditions, talk it over with your doctor or pharmacist about what the research actually supports.

The evidence, ingredient by ingredient Manganese

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Manganese is generally well tolerated in normal dietary amounts — the kind you get from food and standard prenatal vitamins. High-dose supplements are a different story.

Taking very large doses can cause serious neurotoxicity, including Parkinson-like symptoms; one severe case involved daily doses of 100 mg over 2–4 years and resulted in irreversible Parkinson disease. High-dose manganese can also harm your liver, causing cirrhosis and fatty liver disease.

Because of this risk, avoid high-dose supplements unless a clinician advises you to take them.

Side effects, ingredient by ingredient Manganese

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Manganese.
  • The most serious interaction on file is rated Moderate.
  • For scale: 83 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Ionic Manganese, check with your doctor or pharmacist if you're on antipsychotic drugs (like haloperidol or phenothiazines), quinolone antibiotics (like levofloxacin or ciprofloxacin), or tetracycline antibiotics (like doxycycline). Manganese may increase toxicity risk with antipsychotics and may lower how much of those antibiotics your body absorbs, making them less effective.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is appropriate if you have a documented manganese deficiency and your doctor recommends it. If you take antipsychotics or quinolone or tetracycline antibiotics, check with your doctor or pharmacist before adding it — the risks may outweigh the benefit.

High-dose manganese carries a real risk of nerve and liver damage, so stick to normal dietary amounts unless a clinician tells you otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ionic Manganese, straight from the product label.

Brand Good State
Barcode (UPC) 857515003114
Net contents 8 Fluid Ounce(s); 240 mL
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276956
Product type Mineral
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Children (All), No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ionic Manganese by Good State, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.5 mL
Maximum serving Sizes:
2.5 mL
Servings per container
96
UPC/BARCODE
857515003114
IngredientAmount% DV
Manganese2 mg90%

Other ingredients: reverse osmosis Water, Ionic Manganese, Sorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Manganese plays a critical part in our daily lives, even if we are unaware of it. Holding integral roles in numerous bodily functions, such as metabolism and calcium absorption, it is important to make sure you're getting manganese in its ionic form from good state!

Good State Ionic Minerals are known for their high bioavailabity, while others can be extremely low. Our minerals' size can be described in picometers, nanometers, or angstroms.

Good state is proud to follow Good Manufacturing Practices (GMP)

High bioavailability

Contains no sugars, soy, GMO, dairy, gluten, starch, artifiical flavors, colors, or animal by-products, and is hypoallergenic.

Contains no sugars, soy, GMO, dairy, gluten, starch, artifiical flavors, colors, or animal by-products, and is hypoallergenic.

Suitable for vegans.

General Statements

Note: Manganese benefits and/or deficiency symptoms are generic for the mineral. No product claims are being made or implied. Research is ongoing.

100% satisfaction guaranteed

Professional grade

+44 20 3608 0078 Text Support: +1-215-608-1124 FBA UK MED

Seals/Symbols

Made in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Good State Health Solutions Give your body what it needs!

Good State Nano Ionic Supplements

Formula

Ionic minerals

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: 2.5 mL (1/2 tsp) daily in water or juice as maintenance.

Use more if needed or as recommended by your health care professional.

Shake well before using.

Precautions

Children: Please consult a physician.

Caution: Keep out of reach of children.

Always speak with your physician before using any dietary supplement. Do not use if tamper-evident seal is broken or missing.

Dietary supplements should not be used as a substitute for a balanced and varied diet. This bottle is made from PET plastic.

Storage

For freshness after opening, store in a cool, dark place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ionic Manganese by Good State label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ionic Manganese label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ionic Manganese by Good State

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2.5 mL Dosage formLiquid Servings per container96 Amounts shown are per serving.

Manganese

Interacts with
83 drugs
2 mg per serving Form: Manganese Chloride

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Other (inactive) ingredients: Reverse osmosis Water, Ionic Manganese, Sorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ionic Manganese by Good State Drug Interactions

Want to check YOUR meds against Ionic Manganese?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
83Drugs
83 Moderate

Ingredients driving the most interactions

Manganese 83

Individual Drug Interactions

The ingredients in Ionic Manganese interact with 83 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ionic Manganese interact with drugs. Each result below shows which ingredient is responsible. Manganese

Each ingredient & the kinds of drugs it affects

For each ingredient in Ionic Manganese with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ionic Manganese, from the product label.

Good State

Name
GoodState, Inc.
Street Address
83 Ducie Street, #37147
State
Manchester
ZipCode
M1 2JQ
Phone Number
866-227-6097
Web Address
www.GoodState.co.uk
Pharmacist Counseling Corner

Ionic Manganese by Good State: Common Questions

Does Ionic Manganese by Good State interact with any medications?
Yes. Based on its ingredients, Ionic Manganese has a known interaction with 83 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ionic Manganese contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is manganese, and what does it do in my body?
Manganese is an essential mineral your body needs in trace amounts for bone health, metabolism, and nervous system function. You get it naturally from foods like nuts, seeds, whole grains, and leafy greens. This supplement provides it in liquid form.
Is this safe for high doses?
No. High-dose supplements are not safe — they can cause serious nerve damage (Parkinson-like symptoms) and liver damage (cirrhosis and fatty liver). One person taking 100 mg daily developed irreversible Parkinson disease. Stick to normal dietary amounts unless a doctor advises otherwise.
Can this help with osteoporosis or hay fever?
There isn't enough reliable evidence in our data to say this works for those conditions. If you're interested in manganese for osteoporosis, hay fever, COPD, weight, or joint pain, ask your doctor whether the evidence supports it for your situation.
Is it safe to breastfeed while taking this?
The data we have is unclear — some sources rate it possibly safe, others possibly or likely unsafe. Talk with your doctor or pharmacist about your individual situation before taking it while breastfeeding.
Can I take this with antibiotics?
It depends on which antibiotic. If you're on quinolone antibiotics (like levofloxacin) or tetracycline antibiotics (like doxycycline), manganese may reduce how much your body absorbs, making the antibiotic less effective. Check with your doctor or pharmacist before combining them.
What's in the bottle besides manganese?
Water and sorbic acid, a preservative. Those are the inactive ingredients — there are no fillers beyond that.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ionic Manganese is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ionic Manganese label
Go deeper

The Full Monographs Behind Ionic Manganese’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph →
Sources

Sources & How We Checked

Ionic Manganese's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Manganese 21 references
  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  2. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
  3. Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  5. Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
  6. Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
  7. McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
  8. Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
  9. Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
  10. Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
  11. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
  12. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
  13. Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
  14. Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
  15. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
  16. Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. PubMed
  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
  21. Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed

See these in context on the Manganese monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team