Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Adults 50+ Ultimate Flora Probiotic 25 Billion Ingredients & Drug Interactions

by Renew Life

Adults 50+ Ultimate Flora Probiotic 25 Billion label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Adults 50+ Ultimate Flora Probiotic 25 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Adults 50+ Ultimate Flora Probiotic 25 Billion is a dietary supplement by Renew Life with 5 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Adults 50+ Ultimate Flora Probiotic 25 Billion by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Adults 50+ Ultimate Flora Probiotic 25 Billion by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Adults 50+ Ultimate Flora Probiotic 25 Billion by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Adults 50+ 25 Billion Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 5 active ingredients, all of them Bifidobacterium strains — a type of beneficial bacterium (probiotic) that lives naturally in your gut. The three we can verify are B. bifidum, B. breve, and B. longum; the product also includes B. infantis and B. lactis, plus a proprietary blend labeled "Adults 50+ 25 Billion" that delivers 25 billion live organisms per capsule.

The inactive ingredients are a vegetable capsule and cellulose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health for adults 50+.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Constipation, Diarrhea, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Constipation, Rotaviral diarrhea, Irritable bowel syndrome (IBS), and more.

The evidence is mixed and often limited. B. bifidum shows possible effectiveness for irritable bowel syndrome (IBS) and respiratory tract infections, but data on the other strains for most conditions is insufficient — meaning we don't yet have enough reliable evidence to rate them.

For conditions like allergic rhinitis, anxiety, asthma, and cognitive decline, the facts in our database don't support effectiveness claims. If you're considering this for a specific health goal, talk with your doctor or pharmacist about whether the evidence supports using it for that condition.

The evidence, ingredient by ingredient Bifidobacterium Bifidum Bifidobacterium Breve Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All three Bifidobacterium strains we checked are generally well tolerated in healthy people. That said, if you have a weakened immune system or are critically ill, exercise caution and check with your doctor first — there are rare reports of these bacteria causing infection in such patients.

Bloating and flatulence are reported with probiotics in general, though not specifically tied to these strains in the data. One case of vomiting and fever was reported in a child taking two probiotic species together, but it's unclear if probiotics caused it.

For pregnancy, B. bifidum and B. longum are rated possibly safe, though data are limited; we have no pregnancy or breastfeeding data on file for B. breve.

Side effects, ingredient by ingredient Bifidobacterium Bifidum Bifidobacterium Breve Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Bifidobacterium Breve, Bifidobacterium Bifidum, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main thing to flag. All three Bifidobacterium strains in this product can be killed by antibiotics if you take them together, which defeats the purpose of the probiotic.

Separate your antibiotic and probiotic doses by a few hours. We couldn't check two of the five ingredients in this product for interactions, so use the medication search tool on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a 50+ formulation worth considering if you have IBS or recurrent respiratory infections and want to try probiotics — B. bifidum shows possible benefit for both. If you take antibiotics, don't take them at the same time as this supplement; space them apart so the antibiotics don't kill the live bacteria.

Anyone with a weakened immune system or serious illness should check with their doctor first. Ask your pharmacist to confirm your medications are clear before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Adults 50+ Ultimate Flora Probiotic 25 Billion, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257154194
Net contents 40 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2018
DSLD ID 178594
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Seniors/Mature (>50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Adults 50+ Ultimate Flora Probiotic 25 Billion by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
40
UPC/BARCODE
631257154194
IngredientAmount% DV
Bifidobacterium bifidum0 NP--
Bifidobacterium breve0 NP--
Bifidobacterium longum0 NP--
Bifidobacterium infantis0 NP--
Adults 50+ 25 Billion Blend0 NP--
Bifidobacterium lactis0 NP--

Other ingredients: Vegetable Capsule, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Digestive wellness, naturally

For nearly two decades, we have pioneered superior-quality digestive care supplements to help people achieve optimal health from the inside out.

Ultimate Flora 25 Billion Adults 50+ Everyday Probiotic contains 6 specially selected strains for adults over the age of 50 who want to support digestive and immune health.

Good for you gut! Your gut is your engine, your digestive core.

When taken regularly, bifidobacteria and lactobacilli help promote digestive and immune balance so you feel better, lighter, and more energized.

Powerful & effective Did you know there are 100 trillion bacteria inside your digestive tract? To keep that complex system thriving, our high-potency formulas work hard to provide more of the good-for-you bacteria that occur in a naturally healthy gut.

Multi-strain benefits Having a good balance among all the diverse microbes in your gut is key to well-being. But stress, aging, diet, and other issues can upset this delicate equilibrium. Ultimate Flora Probiotics are made with multiple, scientifically studied strains to support digestive balance and harmony.

Targeted delivery Our once daily delayed-release capsules help ensure more friendly probiotics reach your intestinal tract.

25 billion live cultures guaranteed

Bonus! 33% more free

6 probiotic strains Promotes regularity Supports digestive & immune health

Quality, purity, and potency guaranteed through expiration.

Manufactured in USA in a GMP facility.

Actual size capsule

Brand IP Statement(s)

At Renew Life, we believe a healthy gut is a happy gut.

Our Ultimate Flora Everyday Probiotics support daily well-being so you can feel good every day.

Keep it running smoothly with Ultimate Flora Probiotics.

Formula

Everyday probiotic for adults 50+

It contains more cultures to promote regularity while also replenishing bifidobacteria that decline with age.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Tamper Evident: Do not use if safety seal on bottle is broken or missing.

Keep out of reach of children.

Consult your healthcare professional before using this or any product if you are pregnant, nursing, or under medical supervision.

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Directions: For best results, take one (1) capsule daily, with or without food.

Formulation

Gluten free Dairy free Soy free No artificial ingredients

Storage

Store at 77(0)F (25(0)C) or below. Best if refrigerated.

General

#15419 20117 65501B

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Adults 50+ Ultimate Flora Probiotic 25 Billion by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Adults 50+ Ultimate Flora Probiotic 25 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Adults 50+ Ultimate Flora Probiotic 25 Billion by Renew Life

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Adults 50+ 25 Billion Blend

0 NP per serving

Other (inactive) ingredients: Vegetable Capsule, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Adults 50+ Ultimate Flora Probiotic 25 Billion by Renew Life Drug Interactions

Want to check YOUR meds against Adults 50+ Ultimate Flora Probiotic 25 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium bifidum 182
Bifidobacterium breve 182
Bifidobacterium longum 182

Individual Drug Interactions

The ingredients in Adults 50+ Ultimate Flora Probiotic 25 Billion interact with 182 drugs. Click any drug to see the details.

3 of the 5 ingredients in Adults 50+ Ultimate Flora Probiotic 25 Billion interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium bifidum Bifidobacterium breve Bifidobacterium longum

Each ingredient & the kinds of drugs it affects

For each ingredient in Adults 50+ Ultimate Flora Probiotic 25 Billion with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Bifidobacterium breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Adults 50+ Ultimate Flora Probiotic 25 Billion, from the product label.

Renew Life

Name
Renew Life Formulas
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.ultimateflora.com
Pharmacist Counseling Corner

Adults 50+ Ultimate Flora Probiotic 25 Billion by Renew Life: Common Questions

Does Adults 50+ Ultimate Flora Probiotic 25 Billion by Renew Life interact with any medications?
Yes. Based on its ingredients, Adults 50+ Ultimate Flora Probiotic 25 Billion has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Adults 50+ Ultimate Flora Probiotic 25 Billion contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
Not at the same time. Antibiotics can kill the live bacteria in this supplement, making it less effective. Space your antibiotic and probiotic doses a few hours apart — your doctor or pharmacist can help you figure out the best timing.
Is this safe if I have a weak immune system?
You should check with your doctor first. While these bacteria are generally well tolerated in healthy people, there are rare cases of infection reported in critically ill or immunocompromised patients. Your doctor knows your health situation best.
What is this probiotic supposed to help with?
The evidence is strongest for irritable bowel syndrome (IBS) and respiratory tract infections — B. bifidum shows possible effectiveness for both. For other conditions like anxiety or allergies, the data isn't established enough yet to say whether it will help.
Will this cause bloating?
Bloating and flatulence have been reported with probiotics in general, though not specifically proven to come from these Bifidobacterium strains. If you're sensitive to digestive changes, start with a lower dose and see how you feel.
Is it safe to take this while pregnant or breastfeeding?
B. bifidum and B. longum are rated possibly safe in pregnancy, though data are limited. For B. breve, we have no pregnancy or breastfeeding data on file. Talk with your doctor or pharmacist — they can give you personalized advice for your situation.
How many live bacteria does each capsule contain?
This product delivers 25 billion live organisms per capsule across all five Bifidobacterium strains combined.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Adults 50+ Ultimate Flora Probiotic 25 Billion is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Adults 50+ Ultimate Flora Probiotic 25 Billion label
Go deeper

The Full Monographs Behind Adults 50+ Ultimate Flora Probiotic 25 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Adults 50+ Ultimate Flora Probiotic 25 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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