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Dietary supplement

Agmatine Ingredients & Drug Interactions

by NutraKey

Agmatine label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agmatine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agmatine is a dietary supplement by NutraKey with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agmatine by NutraKey

Ask about any prescription or over-the-counter medication and we check it for interactions with Agmatine by NutraKey — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Agmatine by NutraKey

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

NutraKey Agmatine contains one active ingredient: agmatine sulfate. Agmatine is a compound naturally found in the body that research suggests may play a role in nerve function and blood vessel health.

The capsule itself is made with gelatin.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: athletic performance and nitric oxide levels.
  • We looked for evidence on: Athletic performance, Muscle strength, Endurance, Blood flow, Exercise recovery.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for agmatine isn't established yet. Trials have examined it for alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder, but the data we hold rates all of these as insufficient — meaning there isn't enough reliable evidence to say whether it works for any of them.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated in the amounts studied. The most common side effects reported in small trials were diarrhea, indigestion, and nausea — mild to moderate, appearing within a few days and resolving when people stopped taking it.

However, we don't have good long-term safety data in humans. Agmatine shouldn't be used during pregnancy or while breastfeeding because there isn't enough safety information.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood pressure medications and diabetes medications before taking this supplement. Agmatine may lower blood pressure and blood sugar further, increasing your risk of excessively low readings with either drug type.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Agmatine is a single-ingredient supplement with limited evidence of effectiveness for the conditions studied so far. If you take blood pressure or diabetes medications, you'll need to check with your pharmacist before starting — it may amplify their effects.

Short-term side effects are usually mild, but long-term safety isn't well understood.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agmatine, straight from the product label.

Brand NutraKey
Barcode (UPC) 456352932672
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 287381
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agmatine by NutraKey, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
456352932672
IngredientAmount% DV
Agmatine Sulfate1000 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Improve athletic performance & nitric oxide levels Agmatine is derived from the amino acid L-Arginine. Agmatine acts as a neurotransmitter to induce the production of growth hormone, nitric oxide, creatine and protein. It helps decrease blood glucose levels and aid in the removal of nitrogen waste products from the body. Agmatine is noted for its ability to extend nitric oxide (NO) levels in muscles during training. Extending NO levels results in more efficient delivery of oxygen and performance sustaining nutrients to working muscles. Thus increasing endurance and reducing recovery times. Enhance muscular pumps Noted Agmatine benefits include promoting muscular pumps, nutrient transport, nutrient partitioning (greater number of calories utilized by muscle tissue and less stored in fat cells), increased blood flow, as well as playing a role supporting the production of luteinizing hormone (LH) and growth hormone (GH) secretion.

Suggested/Recommended/Usage/Directions

Take with Arginine Alpha-Ketoglutarate and Citrulline Malate for sustained and intense NO performance. Stacking these key amino acids together has proven to significantly enhance athletic performance.

Recommended use: Take 1 serving (2 capsules) with water or your favorite beverage twice daily on an empty stomach. Take first dose in the morning and second dose one hour prior to workout. If workout is in the morning, take second dose a half hour prior to lunch. To maximize results, drink at least 64 ounces of water daily while taking this product.

General Statements

Nutrakeyhealth.com Follow us free giveaways Facebook Pinterest Instagram Twitter #makelifebetter

Pure nutrition Go green

Formulation

High-Performance Liquid Chromatography (HPLC) verified

Muscle performance Ultra pure ingredients Ultra micronized Max bioavailability Nitric oxide performance Enhance blood flow to muscles Reduce recovery time Increase nitric oxide (NO) HPLC verified Pharmaceutical grade

Improve nitric oxide (NO) levels Boost nutrient transport to muscle Enhance kidney function Assist in stress reduction

Brand IP Statement(s)

Nutrakey Health Performance Inc

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking dietary supplements.

Do not use if seal is broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agmatine by NutraKey label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agmatine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agmatine by NutraKey

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Agmatine Sulfate

Interacts with
258 drugs
1000 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agmatine by NutraKey Drug Interactions

Want to check YOUR meds against Agmatine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine Sulfate 258

Individual Drug Interactions

The ingredients in Agmatine interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agmatine interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Agmatine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agmatine, from the product label.

NutraKey

See all NutraKey products
Name
Nutrakey
Street Address
975 Bennett Drive
City
Longwood
State
FL
ZipCode
32750
Web Address
Nutrakeyhealth.com
Pharmacist Counseling Corner

Agmatine by NutraKey: Common Questions

Does Agmatine by NutraKey interact with any medications?
Yes. Based on its ingredients, Agmatine has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agmatine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is agmatine, and what is it supposed to do?
Agmatine is a compound your body naturally produces. Research suggests it may support nerve function and blood vessel health, but we don't have reliable evidence yet that it works for any specific condition — including alcohol use disorder, anxiety, Alzheimer disease, or autism spectrum disorder.
Will this give me side effects?
Short-term use seems well tolerated, but some people in trials reported diarrhea, indigestion, and nausea within a few days — usually mild to moderate and stopping once they quit taking it. We don't have good data on long-term side effects.
Is it safe to take while pregnant or breastfeeding?
No. There isn't enough safety data, so you should avoid this supplement during pregnancy and while breastfeeding. Talk to your doctor or pharmacist if you're considering it during these times.
What's in the capsule besides agmatine?
The capsule itself is made from gelatin. Agmatine sulfate is the only active ingredient.
How long should I take this?
The data we have covers short-term use only — we don't know much about what happens with long-term use. Talk to your pharmacist about how long is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agmatine is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agmatine label
Go deeper

The Full Monographs Behind Agmatine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Agmatine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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