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Dietary supplement

Agmatine Sulfate 600 mg Unflavored Ingredients & Drug Interactions

by Muscle Empire

Agmatine Sulfate 600 mg Unflavored label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agmatine Sulfate 600 mg Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agmatine Sulfate 600 mg Unflavored is a dietary supplement by Muscle Empire with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agmatine Sulfate 600 mg Unflavored by Muscle Empire

Ask about any prescription or over-the-counter medication and we check it for interactions with Agmatine Sulfate 600 mg Unflavored by Muscle Empire — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Agmatine Sulfate 600 mg Unflavored by Muscle Empire

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: agmatine sulfate powder at 600 mg per serving. Agmatine is a compound naturally made in the body from the amino acid arginine.

There are no other inactive ingredients listed.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: pre-workout support and muscle performance.
  • We looked for evidence on: Athletic performance, Muscle strength, Exercise endurance, Workout recovery, Nitric oxide production.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for agmatine isn't established yet. Our data shows insufficient reliable evidence to rate it for alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder.

If you're considering this supplement for any of those purposes, the science isn't there yet to support a clear benefit.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated. However, long-term safety in humans hasn't been well studied, so caution is warranted if you're thinking about using it long-term.

The most common side effects reported in small studies were diarrhea, indigestion (dyspepsia), and nausea—typically mild to moderate and appearing within 2 to 3 days of starting. These effects resolved when people stopped taking it.

During pregnancy and breastfeeding, there isn't enough safety data, so it's best to avoid use. If you're pregnant, planning pregnancy, or breastfeeding, talk with your pharmacist or doctor before taking this supplement.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check any blood-pressure medications (antihypertensives) you're on—agmatine could theoretically make them work too well and drop your blood pressure too low. Also check diabetes medications (antidiabetes drugs)—the same logic applies to blood sugar.

Use the search tool on this page with your exact medication names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Agmatine Sulfate may be of interest to people looking for athletic or cognitive support, but the evidence for those uses is still developing. If you take blood-pressure or diabetes medications, you need to check with your pharmacist first—this supplement could theoretically lower blood pressure or blood sugar further.

Start with your pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agmatine Sulfate 600 mg Unflavored, straight from the product label.

Brand Muscle Empire
Barcode (UPC) 798711493074
Net contents 250 Gram(s); 0.55 lbs
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71453
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agmatine Sulfate 600 mg Unflavored by Muscle Empire, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.6 Gram(s)
Maximum serving Sizes:
0.6 Gram(s)
Servings per container
416
UPC/BARCODE
798711493074
IngredientAmount% DV
Agmatine Sulfate powder600 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC mediciation(s).

Do not exceed 4 servings in one day.

Always consult with a qualified health physician before taking any new dietary supplement.

Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC mediciation(s).

Do not use or consume if inner seal is broken.

General Statements

416 Servings

Agmatine is a byproduct of arginine that is produced through a process called decarboxylation. Agmatine is thought to act as a neurotransmitter, a chemical that modulates the activity of cells in your brain, and is also an intermediate product in the synthesis of polyamines, an important chemical for cell growth. Agmatine can also help regulate the production of NO from arginine by inhibiting enzyme synthetase in the body. The uptake of agmatine effects arginine in NO synthesis and blood vessel dilation which is usually limited naturally by your body.

Q Premium quality Dietary Supplement

100% Pure powder

Promotes muscle cell growth Improves nitric oxide synthesis and balance Increases pump intensity and duration

Scoop inside Serving Scoop included (may settle during shipping)

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one serving (1 scoop) mixed with 8-16 ounces of water or suitable beverage. Taken 1-2 times daily, once in the morning and again as a pre-workout (optional). Cycling on and off with training and resting days may provide optimal results when used. Do not exceed 4 servings in one day.

Morning Pre During Post Night

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab tested for purity and quality

Packed in USA

Formula

Agmatine Sulfate 600 mg per serving

Formulation

Allergens: This product contains no soy, dairy & dairy byproducts, eggs, fish, shellfish, wheat, gluten, tree nuts, or sesame seeds.

General

Part # 66665-55TT VER 2 0 REV 07 30 2015

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agmatine Sulfate 600 mg Unflavored by Muscle Empire label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agmatine Sulfate 600 mg Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agmatine Sulfate 600 mg Unflavored by Muscle Empire

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.6 Gram(s) Dosage formPowder Servings per container416 Amounts shown are per serving.

Agmatine Sulfate powder

Interacts with
258 drugs
600 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate powder monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agmatine Sulfate 600 mg Unflavored by Muscle Empire Drug Interactions

Want to check YOUR meds against Agmatine Sulfate 600 mg Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine Sulfate powder 258

Individual Drug Interactions

The ingredients in Agmatine Sulfate 600 mg Unflavored interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agmatine Sulfate 600 mg Unflavored interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Agmatine Sulfate 600 mg Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate powder2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agmatine Sulfate 600 mg Unflavored, from the product label.

Muscle Empire

See all Muscle Empire products
Name
Supplement Partners, LLC.
Street Address
3820 W Happy Valley Rd Ste 141 - #420
City
Glendale
State
AZ
ZipCode
85310
Web Address
MUSCLEEMPIRE.COM
Pharmacist Counseling Corner

Agmatine Sulfate 600 mg Unflavored by Muscle Empire: Common Questions

Does Agmatine Sulfate 600 mg Unflavored by Muscle Empire interact with any medications?
Yes. Based on its ingredients, Agmatine Sulfate 600 mg Unflavored has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agmatine Sulfate 600 mg Unflavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is agmatine and what is it supposed to do?
Agmatine is a compound your body naturally makes from the amino acid arginine. It's been studied for various uses including athletic performance, anxiety, and neurological conditions, but we don't yet have strong reliable evidence that it works for those purposes.
What are the most common side effects?
In small studies, the most frequently reported side effects were diarrhea, indigestion, and nausea. These were usually mild to moderate, appeared within a few days of starting, and went away when people stopped taking it.
Is it safe to use long-term?
Short-term use appears generally well tolerated, but we don't have good data on long-term safety in humans. If you're thinking of using it regularly over months or years, talk with your pharmacist about what we do and don't know.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data during pregnancy or breastfeeding, so it's best to avoid use in both situations. Talk with your pharmacist or doctor if you're pregnant, planning to become pregnant, or nursing.
Why do I need to check my blood-pressure and diabetes medications?
Animal research suggests agmatine can lower blood pressure and blood sugar. If you're already on medications for those, adding agmatine could theoretically make them work too well, putting you at risk of blood pressure or blood sugar dropping too low.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agmatine Sulfate 600 mg Unflavored is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agmatine Sulfate 600 mg Unflavored label
Go deeper

The Full Monographs Behind Agmatine Sulfate 600 mg Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Agmatine Sulfate 600 mg Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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