Allergy-Ease Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Allergy-Ease against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Allergy-Ease is a dietary supplement by Earth Friend Herb Co. with 2 active ingredients. Its ingredients are commonly taken for fatigue and low energy, stress and coping (adaptogen), mental performance and focus.Based on those ingredients, 1,275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola, Nettles. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Allergy-Ease by Earth Friend Herb Co.
Ask about any prescription or over-the-counter medication and we check it for interactions with Allergy-Ease by Earth Friend Herb Co. — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Allergy-Ease by Earth Friend Herb Co.
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Allergy-Ease contains two active herbal ingredients: Rhodiola and Nettles. The product also includes two inactive ingredients — alcohol and glycerin — which serve as preservatives and carriers in this liquid formulation.
Does it work?
Insufficient evidence
The evidence for what these ingredients do is limited. For Rhodiola, the data we hold shows insufficient reliable evidence for altitude sickness, anxiety, heart rhythm problems, athletic performance, and bladder cancer.
Nettles show possibly effective evidence for diabetes, but insufficient evidence for hay fever, anemia, asthma, enlarged prostate, and gum disease. Neither ingredient has established effectiveness for allergies or allergy relief specifically in our data.
How safe is it?
Well-documented data
Rhodiola is generally well tolerated for short-term use, though long-term safety hasn't been well studied. The most common side effects are dizziness and changes in saliva production — either dry mouth or too much saliva.
During pregnancy and breastfeeding, there isn't enough safety data, so the safety data advises against use. Nettles are generally well tolerated for most adults when used as directed, though quality varies by product.
Common side effects are constipation or diarrhea. If you touch the fresh plant, you may get localized itching, rash, and stinging.
During pregnancy, traditional concerns about effects on the uterus mean the safety data advises against it. Breastfeeding safety hasn't been established, so talk with your doctor before using.
Meds to double-check
Moderate interaction found
Before taking this product, double-check these medication types with your pharmacist: blood pressure medications (risk of low blood pressure), blood thinners like warfarin (nettles may reduce their effect), diabetes drugs (risk of low blood sugar), diuretics or water pills (additive effect), lithium (nettles may raise levels), and any drug metabolized by liver enzymes CYP2C9, CYP1A2, or CYP3A4 (rhodiola may raise levels). Most serious is the warfarin interaction and the risk of low blood pressure with antihypertensives.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Allergy-Ease carries real interaction risks with blood pressure meds, diabetes drugs, blood thinners, and several liver-metabolized medications. If you take any prescription drugs — especially for blood pressure, diabetes, or blood thinning — check them against our interaction tool before you start.
The evidence for what the product actually does for allergies isn't established in our data. Talk to your pharmacist about whether this product makes sense for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Allergy-Ease, straight from the product label.
| Brand | Earth Friend Herb Co. |
|---|---|
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 323637 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Allergy-Ease by Earth Friend Herb Co., sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Rhodiola | 0 NP | -- |
| Nettles | 0 NP | -- |
Other ingredients: Alcohol, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Use 10-15 drops 3x daily. Take straight-then drink water.
Precautions
Keep away from children.
Not for use with pregnancy or nursing.
General Statements
An Elijah Free formula
Formulation
All certified organic or wild crafted herbs.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Allergy-Ease by Earth Friend Herb Co. label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Allergy-Ease by Earth Friend Herb Co.
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size10 Drop(s) Dosage formLiquid Servings per container160 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Rhodiola
Interacts with1,271 drugs
Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...
Rhodiola monograph & interactionsNettles
Interacts with164 drugs
Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...
Nettles monograph & interactionsOther (inactive) ingredients: Alcohol, Glycerin. These complete the product’s ingredient list but are not active constituents.
Allergy-Ease by Earth Friend Herb Co. Drug Interactions
HelloPharmacist Interaction Report
Allergy-Ease by Earth Friend Herb Co. does interact with several medication types, and you'll want to check your specific drugs before starting.
Rhodiola, one of its two active ingredients, may increase the risk of low blood pressure (hypotension) if you're taking blood pressure medications, and it can slow how your body clears certain drugs — most notably it's been shown in a study to reduce losartan metabolism by 21%, which could raise losartan levels and side effects.
Read the full breakdown — every affected drug type, severity by severity
Rhodiola also theoretically affects how your body processes drugs broken down by your liver's CYP2C9, CYP1A2, and CYP3A4 enzymes — a broad group that includes many common medications. You'll want to check those specifically.
Additionally, rhodiola may increase the risk of low blood sugar (hypoglycemia) if combined with diabetes drugs, interfere with immunosuppressant medications, and raise levels of drugs that use P-glycoprotein for transport.
Nettles, the other ingredient, poses a separate concern: it may interfere with warfarin (a blood thinner) because nettles contain significant vitamin K. Nettles can also add to the effects of diabetes drugs and diuretics (water pills), and it may increase lithium levels by reducing how your kidneys clear it.
Altogether, these interactions span 1,257 individual medications. Please use the medication checker below with your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Allergy-Ease?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Allergy-Ease interact with 1,275 drugs. Click any drug to see the details.
2 of the 2 ingredients in Allergy-Ease interact with drugs. Each result below shows which ingredient is responsible. Rhodiola Nettles
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Allergy-Ease — through 2 ingredients. Tap an ingredient for the detail:
RhodiolaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola + Acarbose interactionNettlesAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Nettles + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola + Acebutolol interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Allergy-Ease — through 2 ingredients. Tap an ingredient for the detail:
NettlesDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Nettles + Acetaminophen, Caffeine, Pyrilamine interactionRhodiolaCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen, Ibuprofen interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Allergy-Ease — through 2 ingredients. Tap an ingredient for the detail:
NettlesDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Nettles + Acetaminophen, Pamabrom, Pyrilamine interactionRhodiolaCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
Read the full Rhodiola + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Allergy-Ease — through 2 ingredients. Tap an ingredient for the detail:
RhodiolaCns Depressants, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
Read the full Rhodiola + Acetazolamide interactionNettlesDiuretic Drugs Moderate
Interaction Summary
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Nettles + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Allergy-Ease — through 2 ingredients. Tap an ingredient for the detail:
NettlesAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Nettles + Acetohexamide interactionRhodiolaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola + Acetohexamide interactionAdalimumabHumira
How Adalimumab interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Adalimumab-fkjp interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
Read the full Rhodiola + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAfatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola + Afatinib Dimaleate interactionAgomelatineValdoxan
How Agomelatine interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaAntidepressant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
Read the full Rhodiola + Agomelatine interactionAlbiglutideTanzeum
How Albiglutide interacts with Allergy-Ease — through 2 ingredients. Tap an ingredient for the detail:
NettlesAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Nettles + Albiglutide interactionRhodiolaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaImmunosuppressants Moderate
Interaction Summary
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
Read the full Rhodiola + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
Read the full Rhodiola + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Allergy-Ease — through 2 ingredients. Tap an ingredient for the detail:
RhodiolaAntidiabetes Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola + Alogliptin interactionNettlesAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Nettles + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Allergy-Ease — through 2 ingredients. Tap an ingredient for the detail:
NettlesAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Nettles + Alogliptin, Metformin interactionRhodiolaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Allergy-Ease — through 2 ingredients. Tap an ingredient for the detail:
RhodiolaAntidiabetes Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rhodiola + Alogliptin, Pioglitazone interactionNettlesAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Read the full Nettles + Alogliptin, Pioglitazone interactionAlvimopanEntereg
How Alvimopan interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
Read the full Rhodiola + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Allergy-Ease — through 1 ingredient. Tap an ingredient for the detail:
RhodiolaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola + Amiloride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Allergy-Ease with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Rhodiola
Antidiabetes Drugs
Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.
Antihypertensive Drugs
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
Immunosuppressants
Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.
Losartan (Cozaar)
Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.
P-Glycoprotein Substrates
Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.
Antidepressant Drugs
Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.
Cns Depressants
Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.
Nettles
Antidiabetes Drugs
Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.
Diuretic Drugs
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.
Lithium
Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.
Warfarin (Coumadin)
There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.
Brand information
Manufacturer and brand details for Allergy-Ease, from the product label.
Earth Friend Herb Co.
See all Earth Friend Herb Co. products- Name
- Exsula Foods Inc.
- Street Address
- PO Box 44459
- City
- Tacoma
- State
- WA
- ZipCode
- 98448
- Phone Number
- 253-874-9092
- Web Address
- www.exsula.com
Allergy-Ease by Earth Friend Herb Co.: Common Questions
Does Allergy-Ease by Earth Friend Herb Co. interact with any medications?
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What side effects might I get?
Does this product contain fillers?
Can I take this with my blood pressure or diabetes medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Allergy-Ease is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Allergy-Ease’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Rhodiola
Interacts with 1,271 drugsRhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...
Read the full Rhodiola monograph → Herb & supplement monographStinging Nettle
Interacts with 164 drugsStinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...
Read the full Stinging Nettle monograph →Sources & How We Checked
Allergy-Ease's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Rhodiola 13 references
- Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
- Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
- Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
- Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
- Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
- Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8.
- Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11.
- Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6.
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