Interactions on record — worth a quick check against your medications. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

AminH2O Watermelon Ingredients & Drug Interactions

by Advanced Nutrition Systems

AminH2O Watermelon label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking AminH2O Watermelon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

AminH2O Watermelon is a dietary supplement by Advanced Nutrition Systems with 9 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 331 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline DL Malate, Taurine, Coconut (Cocos nucifera) Water powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against AminH2O Watermelon by Advanced Nutrition Systems

Ask about any prescription or over-the-counter medication and we check it for interactions with AminH2O Watermelon by Advanced Nutrition Systems — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of AminH2O Watermelon by Advanced Nutrition Systems

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 9 active ingredients.
  • “Branched-Chain Amino Acids” is listed as a grouped ingredient — the label gives one combined amount (4 Gram(s)) without saying how much of each component you get.
  • “Recover and Hydrate Blend” is a proprietary blend — the label gives one combined amount (4 Gram(s)) without saying how much of each component you get.

AminH2O Watermelon contains 9 active ingredients designed to support hydration and muscle recovery. The main amino acids are L-Glutamine, L-Leucine, L-Isoleucine, and L-Valine — building blocks your muscles use, especially after exercise or injury.

Taurine is an amino acid that supports heart and muscle function. Betaine Anhydrous helps your body use these amino acids more efficiently.

Potassium replenishes electrolytes lost through sweat. L-Citrulline DL Malate supports blood flow and oxygen delivery to muscles.

Coconut water powder adds natural electrolytes and hydration support.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Glutamine) (Natural Medicines).
  • On file: Homocystinuria — rated "Effective" (Betaine Anhydrous) (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Glutamine) (Natural Medicines).
  • On file: Critical illness (trauma) — rated "Possibly Effective" (Glutamine) (Natural Medicines).
  • On file: Postoperative recovery — rated "Possibly Effective" (Glutamine) (Natural Medicines).

The evidence for these ingredients is mixed and condition-specific. L-Glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

Taurine is possibly effective for hepatitis and congestive heart failure (CHF), though possibly ineffective for weight loss. Betaine Anhydrous is effective for homocystinuria (a rare metabolic condition) and possibly effective for high homocysteine levels, but evidence is insufficient for fatty liver disease, depression, and GERD.

L-Citrulline is possibly effective for athletic performance but possibly ineffective for sarcopenia (muscle loss); evidence is insufficient for cardiovascular disease, heart failure, and diabetes. Coconut water powder has insufficient evidence for any of the conditions studied.

For a general hydration and recovery drink, effectiveness depends on your specific goal — ask your pharmacist which ingredients match what you're after.

The evidence, ingredient by ingredient Potassium Glutamine Taurine Betaine Anhydrous L-citrulline Coconut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is generally well tolerated in healthy adults but requires medical supervision if you have kidney or liver disease; supplement doses aren't recommended during pregnancy or breastfeeding unless your doctor advises. Orally, common side effects include belching, bloating, constipation, flatulence, nausea, vomiting, diarrhea, headache, and stomach pain.

High doses (10–30 grams daily) used in trials for sickle cell disease caused more GI upset. Rare cases of dizziness and mood changes (mania or hypomania) have been reported in people with bipolar disorder.

Taurine is generally well tolerated short-term but long-term safety is less established. Common side effects are constipation, diarrhea, and indigestion.

Rare allergic reactions (hives, severe hypersensitivity) can occur, especially in people sensitive to sulfonamides or sulfites. Potassium is generally well tolerated at normal dietary levels; supplement side effects include abdominal pain, belching, diarrhea, nausea, and vomiting, with rare serious effects like heart rhythm problems and low blood pressure at dangerously high levels.

L-Citrulline is generally well tolerated; common side effects are stomach discomfort and heartburn. Avoid supplements during pregnancy and breastfeeding — safety is not well studied.

Betaine Anhydrous is generally well tolerated; side effects include body odor, diarrhea, nausea, vomiting, and GI distress. Coconut water powder is likely safe in food amounts but can cause allergic reactions (hives to anaphylaxis) in sensitive people; most reactions occur with oral exposure.

Side effects, ingredient by ingredient Potassium Glutamine Taurine Betaine Anhydrous L-citrulline Coconut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Potassium, Glutamine, Taurine, L-citrulline, Coconut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; diabetes medications; lithium.
  • For scale: 331 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use: anticonvulsant/seizure medications (Moderate risk from glutamine), blood pressure drugs or blood thinners (Moderate risk from taurine and L-citrulline), potassium-sparing diuretics, ACE inhibitors, or ARBs (Moderate risk from potassium), lithium (Moderate risk from taurine), or diabetes medications (Minor risk from coconut water powder). Your pharmacist can help match your exact medications against this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This is a hydration and amino acid recovery drink aimed at active people and those recovering from illness or surgery. If you take blood pressure medications, potassium-sparing diuretics, lithium, diabetes drugs, or erectile dysfunction medications, check with your pharmacist before using it — several ingredients interact with these.

People with kidney or liver disease, bipolar disorder, or a history of coconut allergy should talk to their doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 31, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AminH2O Watermelon, straight from the product label.

Brand Advanced Nutrition Systems
Barcode (UPC) 814995020185
Net contents 10.5 oz.; 297 Gram(s)
Market status On market
Date entered into DSLD Aug 31, 2018
DSLD ID 180522
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AminH2O Watermelon by Advanced Nutrition Systems, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
9.9 Gram(s)
Maximum serving Sizes:
9.9 Gram(s)
Servings per container
30
UPC/BARCODE
814995020185
IngredientAmount% DV
L-Glutamine0 NP--
L-Leucine0 NP--
L-Isoleucine0 NP--
Taurine0 NP--
L-Valine0 NP--
Betaine Anhydrous0 NP--
Branched-Chain Amino Acids4 Gram(s)--
Potassium90 mg3%
Recover and Hydrate Blend4 Gram(s)--
L-Citrulline DL Malate0 NP--
Coconut (Cocos nucifera) Water powder0 NP--

Other ingredients: Malic Acid, Natural and Artificial flavors, Calcium Silicate, Sucralose, Citric Acid, Silicon Dioxide, Acesulfame Potassium, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Do not use if pregnant, nursing, or plan on becoming pregnant.

This product is intended for use by healthy adults over the age of 18. Do not use this product continuously for more than 8 weeks. Do not combine with alcohol. Not intended for use by those with a medical condition. Use only as directed. Do not exceed recommended daily intake.

Consult a physician or licensed qualified health care professional prior to use if you are pregnant, or nursing, or if you are taking medication, or if you have a medical condition, including, but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, enlarged prostate, or glaucoma.

Discontinue 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache or shortness of breath. Do not use if safety seal under cap is broken.

Keep out of the reach of children.

Contains: Tree Nut (Coconut)

Storage

Store in a cool, dry place.

General Statements

Please recycle.

Made in the USA Proudly made in the USA with carefully selected ingredients of international and domestic origin.

30 Servings

Strength Hydration Recovery

Naturally and Artificially Flavored

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

Item ANS-121 1.1

Formula

3:1:1 Ratio BCAA + Hydration

AminH2O contains 4g of BCAAs designed to fuel recovery, replenish electrolytes and support muscle growth.

3:1:1 Ratio BCAA + Hydration

Contains: Tree Nut (Coconut)

Suggested/Recommended/Usage/Directions

This product can be taken before, during or after your workout to provide your body with the nutrients it needs to stay hydrated, promote endurance and build strength.

Suggested Use: As a dietary supplement, adults mix each serving (1 scoop) with 8 oz of water 20-30 minutes before, during, or immediately after your workout. Please read the entire label before use.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

AminH2O Watermelon by Advanced Nutrition Systems label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

AminH2O Watermelon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in AminH2O Watermelon by Advanced Nutrition Systems

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size9.9 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Branched-Chain Amino Acids

4 Gram(s) per serving
  • › L-Leucine
  • › L-Isoleucine
  • › L-Valine

Potassium

Interacts with
62 drugs
90 mg per serving Form: Potassium Phosphate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Recover and Hydrate Blend

4 Gram(s) per serving

Other (inactive) ingredients: Malic Acid, Natural and Artificial flavors, Calcium Silicate, Sucralose, Citric Acid, Silicon Dioxide, Acesulfame Potassium, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

AminH2O Watermelon by Advanced Nutrition Systems Drug Interactions

Want to check YOUR meds against AminH2O Watermelon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
331Drugs
245 Moderate 86 Minor

Ingredients driving the most interactions

L-Citrulline DL Malate 178
Taurine 173
Coconut (Cocos nucifera) Water powder 86
Potassium 62
L-Glutamine 50

Individual Drug Interactions

The ingredients in AminH2O Watermelon interact with 331 drugs. Click any drug to see the details.

5 of the 9 ingredients in AminH2O Watermelon interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline DL Malate Taurine Coconut (Cocos nucifera) Water powder Potassium L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in AminH2O Watermelon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline DL Malate2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline DL Malate full monograph & interactions

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
Taurine full monograph & interactions

Coconut (Cocos nucifera) Water powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D
Coconut (Cocos nucifera) Water powder full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for AminH2O Watermelon, from the product label.

Advanced Nutrition Systems

See all Advanced Nutrition Systems products
Name
Advanced Nutrition LLC
Street Address
221 S. Cherokee St.
City
Denver
State
CO
ZipCode
80223
Web Address
www.advanced247.com
Pharmacist Counseling Corner

AminH2O Watermelon by Advanced Nutrition Systems: Common Questions

Does AminH2O Watermelon by Advanced Nutrition Systems interact with any medications?
Yes. Based on its ingredients, AminH2O Watermelon has a known interaction with 331 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AminH2O Watermelon contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with muscle recovery after my workouts?
L-Citrulline is possibly effective for athletic performance, and the amino acids (glutamine, leucine, isoleucine, and valine) support muscle repair — that's the basic idea behind the formula. But evidence for general recovery in healthy athletes isn't as strong as for some medical conditions like sickle cell disease or critical illness. It's designed to hydrate and replenish electrolytes too, which matters after exercise.
Is this safe if I'm pregnant or breastfeeding?
L-Glutamine and Taurine are likely safe in pregnancy and lactation based on the data we hold, and Potassium is also likely safe. L-Citrulline and Coconut water powder, however, have insufficient safety data — the facts advise against supplements during pregnancy and breastfeeding. Because this product mixes ingredients with different safety profiles, talk to your doctor or pharmacist before using it.
What are the side effects I should watch for?
Most common are GI side effects: bloating, gas, constipation, diarrhea, nausea, and stomach discomfort. Headache and body odor are also reported. If you have a tree nut or coconut allergy, allergic reactions ranging from hives to anaphylaxis are possible. Rare mood changes (mania) have been reported in people with bipolar disorder taking high-dose glutamine. Stop and call your doctor if you notice heart palpitations, severe weakness, or trouble breathing.
Can I take this if I have kidney disease?
No — not without talking to your doctor first. L-Glutamine requires medical supervision in kidney disease, and Potassium is especially risky because your kidneys control how much your body keeps. Kidney disease plus a potassium supplement can lead to dangerously high blood potassium.
Does this product have any fillers or artificial ingredients?
Yes. The inactive ingredients include malic acid, artificial flavors, calcium silicate, sucralose (artificial sweetener), citric acid, silicon dioxide, acesulfame potassium (another artificial sweetener), and FD&C Red #40 (food coloring). If you're avoiding any of these, check the label.
Will this help me lose weight?
The data we hold shows taurine is possibly ineffective for weight loss, and coconut water powder has insufficient evidence. This product is designed for hydration and muscle recovery, not weight loss — talk to your pharmacist or doctor about what might actually help with your weight goals.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if AminH2O Watermelon is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AminH2O Watermelon label
Go deeper

The Full Monographs Behind AminH2O Watermelon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Coconut

Interacts with 86 drugs

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...

Read the full Coconut monograph →
Sources

Sources & How We Checked

AminH2O Watermelon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 73 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Taurine 21 references
  1. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990;38:912-8. PubMed
  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  3. Obermann M, Schorn CF, Mummel P, et al. Taurine induced toxic encephalopathy? Clin Neurol Neurosurg 2006;108:812-3. PubMed
  4. Bichler, A., Swenson, A., and Harris, M. A. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 2006;31(4):471-476. PubMed
  5. Iyadurai, S. J. and Chung, S. S. New-onset seizures in adults: possible association with consumption of popular energy drinks. Epilepsy Behav 2007;10(3):504-508. PubMed
  6. Berger, A. J. and Alford, K. Cardiac arrest in a young man following excess consumption of caffeinated "energy drinks". Med J Aust. 1-5-2009;190(1):41-43. PubMed
  7. Worthley, M. I., Prabhu, A., De, Sciscio P., Schultz, C., Sanders, P., and Willoughby, S. R. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med 2010;123(2):184-187. PubMed
  8. Morchon, Simon D. and Perez Castrillon, J. L. [Hypoglycemia by intake of taurine]. Rev.Clin Esp. 2010;210(1):49.
  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
  10. Schoffl, I., Kothmann, J. F., Schoffl, V., Rupprecht, H. D., and Rupprecht, T. "Vodka energy": too much for the adolescent nephron? Pediatrics 2011;128(1):e227-e231. PubMed
  11. Calabro, R. S., Italiano, D., Gervasi, G., and Bramanti, P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav 2012;23(3):384-385. PubMed
  12. Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3):525-532. PubMed
  13. Darling, P. B., Lepage, G., Leroy, C., Masson, P., and Roy, C. C. Effect of taurine supplements on fat absorption in cystic fibrosis. Pediatr Res 1985;19(6):578-582. PubMed
  14. Fukuyama, Y. and Ochiai, Y. Therapeutic trial by taurine for intractable childhood epilepsies. Brain Dev. 1982;4(1):63-69. PubMed
  15. Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
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Betaine Anhydrous 11 references
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Potassium 12 references
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  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
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  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
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  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

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L-citrulline 8 references
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  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
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  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

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Coconut 10 references
  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
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  5. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
  6. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
  8. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

See these in context on the Coconut monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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