Amp Up Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Amp Up against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Amp Up is a dietary supplement by Greens First Lean with 2 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 67 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Adenosine Monophosphate, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Amp Up by Greens First Lean
Ask about any prescription or over-the-counter medication and we check it for interactions with Amp Up by Greens First Lean — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Amp Up by Greens First Lean
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This liquid contains 2 active ingredients. Vitamin B12 is a B vitamin your body needs to make red blood cells, support your nerves, and keep your energy up.
Adenosine monophosphate is a compound related to adenosine, which plays roles in heart rhythm and blood vessel function. The rest of the product is made up of inactive ingredients — water, vegetable glycerin, citric acid, natural flavors, rebaudioside A, potassium sorbate, sodium hexametaphosphate, and monk fruit extract — that help with taste, texture, and shelf life.
Does it work?
Strong evidence
Vitamin B12 is effective for B12 deficiency and a rare inherited condition called Imerslund-Grasbeck disease, and it's likely effective for cyanide poisoning. It's also possibly effective for canker sores and a type of nerve pain called postherpetic neuralgia.
Adenosine monophosphate is effective for a heart rhythm problem called paroxysmal supraventricular tachycardia and for diagnostic cardiac stress tests. However, the evidence we have on adenosine monophosphate comes mainly from the prescription injectable form; information about how well the oral supplement form works is limited.
How safe is it?
Well-documented data
Vitamin B12 is generally very well tolerated. It's safe during pregnancy and breastfeeding at recommended amounts — in fact, you need it during both.
Any excess B12 is removed through your urine, so there's no established upper limit. For adenosine monophosphate, the situation is different: safety information for the oral supplement form is limited, and the facts we have suggest caution.
The prescription injectable form is powerful and carries real risks like chest pain, dizziness, low blood pressure, and irregular heartbeats — but that doesn't tell us much about the supplement. There isn't enough safety data to recommend the supplement form during pregnancy, and it should be avoided while breastfeeding.
Meds to double-check
Major interaction found
Check your medications against these drug types before taking Amp Up: dipyridamole (a heart medication — this is the most serious interaction), carbamazepine (an anti-seizure drug), methylxanthines (like caffeine, theophylline, or aminophylline), and metformin (a diabetes medication).
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
If you take dipyridamole, carbamazepine, methylxanthines (including caffeine pills or theophylline), or metformin, run this product through the medication checker below before you start. The adenosine monophosphate ingredient carries some uncertainty because safety data on the oral supplement form is thin.
Talk with your pharmacist about whether this product makes sense for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Amp Up, straight from the product label.
| Brand | Greens First Lean |
|---|---|
| Barcode (UPC) | 853367008093 |
| Net contents | 1 fl. Oz. |
| Market status | On market |
| Date entered into DSLD | Nov 21, 2019 |
| DSLD ID | 208995 |
| Product type | Other Combinations |
| Supplement form | Liquid |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Amp Up by Greens First Lean, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin B12 | 1000 mcg/mL | 16667% |
| Adenosine Monophosphate | 25 mg/mL | -- |
Other ingredients: Water, Vegetable Glycerin, Citric Acid, Natural flavors, Rebaudioside A, Potassium Sorbate, Sodium Hexametaphosphate, Monk Fruit extract
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Recommended use: 2 sprays under tongue, 3 times daily. Do not swallow for 30 seconds.
Precautions
Do not swallow for 30 seconds.
Keep out of reach of children.
Do not use if safety seal is open or broken.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Made in USA
Supports Weight Loss
Formula
Plus B-12
FDA Statement of Identity
Dietary Supplement
Storage
Storage: Store in a cool dry place.
Formulation
Suitable for Vegans and Vegetarians
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Amp Up by Greens First Lean label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Amp Up by Greens First Lean
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.33 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin B12
Interacts with20 drugs
Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...
Vitamin B12 monograph & interactionsAdenosine Monophosphate
Interacts with47 drugs
Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat...
Adenosine Monophosphate monograph & interactionsOther (inactive) ingredients: Water, Vegetable Glycerin, Citric Acid, Natural flavors, Rebaudioside A, Potassium Sorbate, Sodium Hexametaphosphate, Monk Fruit extract. These complete the product’s ingredient list but are not active constituents.
Amp Up by Greens First Lean Drug Interactions
HelloPharmacist Interaction Report
Amp Up by Greens First Lean contains two active ingredients, and one of them — adenosine monophosphate — has documented interactions with several medications.
The most serious is with dipyridamole (Persantine), a heart medication: dipyridamole can increase both the therapeutic and toxic effects of adenosine, potentially causing dizziness, a slow heart rate (bradycardia), and fainting (syncope). If you take dipyridamole, you should stop it several days before any cardiac stress test using adenosine, and you'll want to check with your doctor or pharmacist before adding this product.
Read the full breakdown — every affected drug type, severity by severity
Adenosine monophosphate also interacts with carbamazepine (Tegretol), an anti-seizure medication: both can cause heart block, and using them together may add up to a higher risk. It also interacts with methylxanthines — including caffeine, theophylline, and aminophylline — which block adenosine's effects by competing for the same cell receptors.
Vitamin B12, the other active ingredient, has a minor interaction with metformin (Glucophage), a diabetes medication: metformin can lower B12 levels over time by interfering with how your digestive system absorbs it.
Additionally, we hold no interaction data for several of the inactive ingredients in this product. Altogether, these interactions span 66 individual medications.
Use the medication checker on this page to see if any of your prescriptions are on that list.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Amp Up?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Amp Up interact with 67 drugs. Click any drug to see the details.
2 of the 2 ingredients in Amp Up interact with drugs. Each result below shows which ingredient is responsible. Adenosine Monophosphate Vitamin B12
Aspirin, DipyridamoleAggrenox, Asasantin Retard
How Aspirin, Dipyridamole interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateDipyridamole (persantine) Major
Interaction Summary
Dipyridamole can increase the therapeutic and toxic effects of adenosine.
Read the full Adenosine Monophosphate + Aspirin, Dipyridamole interactionDipyridamoleDipyridamole, Persantin, Persantin Injection, Persantin Retard, Persantine
How Dipyridamole interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateDipyridamole (persantine) Major
Interaction Summary
Dipyridamole can increase the therapeutic and toxic effects of adenosine.
Read the full Adenosine Monophosphate + Dipyridamole interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateCarbamazepine (tegretol) Moderate
Interaction Summary
Carbamazepine might increase the risk of heart block when used concomitantly with adenosine.
Read the full Adenosine Monophosphate + Carbamazepine interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Acetaminophen, Caffeine, Pyrilamine interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Alogliptin, Metformin interactionAminophyllineAminophylline
How Aminophylline interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aminophylline interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aminophylline, Amobarbital, Ephedrine interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionCaffeine (otc Drug)Molie, Overtime, Vivarin
How Caffeine (otc Drug) interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Caffeine (otc Drug) interactionCaffeine (prescription Drug)Caffeine, Dextrophin
How Caffeine (prescription Drug) interacts with Amp Up — through 1 ingredient. Tap an ingredient for the detail:
Adenosine MonophosphateMethylxanthines Minor
Interaction Summary
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
Read the full Adenosine Monophosphate + Caffeine (prescription Drug) interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Amp Up with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Adenosine Monophosphate
Dipyridamole (Persantine)
Dipyridamole can increase the therapeutic and toxic effects of adenosine.
Dipyridamole decreases the metabolism of adenosine. Intravenous infusion of adenosine in patients who are taking dipyridamole can cause dizziness, bradycardia, and syncope. Dipyridamole should be discontinued for several days prior to a cardiac stress test using adenosine.
Carbamazepine (Tegretol)
Carbamazepine might increase the risk of heart block when used concomitantly with adenosine.
Carbamazepine and adenosine can both cause heart block. Giving them concurrently might produce an additive effect.
Methylxanthines
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
The methylxanthines, aminophylline, caffeine, and theophylline, can block the effects of adenosine by acting as competitive antagonists at adenosine cell surface receptors. It is recommended that methylxanthines be avoided for 24 hours prior to cardiac stress tests.
Vitamin B12
Metformin (Glucophage)
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.
Brand information
Manufacturer and brand details for Amp Up, from the product label.
Greens First Lean
See all Greens First Lean products- Name
- Ceautamed Worldwide, LLC
- Street Address
- 1289 Clint Moore Road
- City
- Boca Raton
- State
- FL
- ZipCode
- 33487
- Phone Number
- 866-409-6262
- Web Address
- GreensFirst.com
Amp Up by Greens First Lean: Common Questions
Does Amp Up by Greens First Lean interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this have a lot of caffeine in it?
Can I take this if I'm pregnant?
Is B12 in here enough if I'm taking metformin?
What does adenosine monophosphate actually do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Amp Up is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Amp Up’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin B12
Interacts with 20 drugsVitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...
Read the full Vitamin B12 monograph → Herb & supplement monographAdenosine
Interacts with 47 drugsAdenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat certain fast heart rhythms. As an over-t...
Read the full Adenosine monograph →Sources & How We Checked
Amp Up's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 40 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin B12 30 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
- Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
- Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
- Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
- Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
- Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
- Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
- Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
- Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
- Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
- Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
- Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
- Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
- Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
- Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
- Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
- Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
- Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
- Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
- Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
- Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
- Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
- Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
- Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
- Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
- Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
- Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
- Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed
Adenosine 10 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
- Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
- Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
- Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
- Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42.. PubMed
- Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
- Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
- Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed
- Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC