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Dietary supplement

Andrographis paniculata Extract Powder 5% Ingredients & Drug Interactions

by Materia Organica

Andrographis paniculata Extract Powder 5% label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Andrographis paniculata Extract Powder 5% against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Andrographis paniculata Extract Powder 5% is a dietary supplement by Materia Organica with 1 active ingredient. Its ingredients are commonly taken for common cold and flu symptoms, upper respiratory infections, sore throat.Based on those ingredients, 413 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Andrographis paniculata Leaf Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Andrographis paniculata Extract Powder 5% by Materia Organica

Ask about any prescription or over-the-counter medication and we check it for interactions with Andrographis paniculata Extract Powder 5% by Materia Organica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Andrographis paniculata Extract Powder 5% by Materia Organica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: andrographis paniculata leaf extract, standardized to 5% andrographolides. Andrographis is a plant used traditionally in Ayurvedic and Chinese medicine; andrographolides are its key active compounds.

There are no other inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Andrographis's overall clinical evidence instead.

Moderate

Some clinical evidence supports Andrographis for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Ulcerative colitis — rated "Possibly Effective" (Natural Medicines).
  • On file: Osteoarthritis — rated "Possibly Effective" (Natural Medicines).
  • On file: Tonsillopharyngitis — rated "Possibly Effective" (Natural Medicines).

The evidence supports andrographis as possibly effective for three conditions: ulcerative colitis, tonsillopharyngitis (sore throat and tonsil inflammation), and osteoarthritis. For familial Mediterranean fever, we don't have enough reliable evidence to rate it.

If you're considering this for any of those first three uses, talk with your doctor about whether it fits your situation.

The evidence, ingredient by ingredient Andrographis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Andrographis is generally well tolerated when you take it short-term and keep doses moderate. The most common side effects are belly discomfort, taste changes, diarrhea, dizziness, fatigue, headache, nausea, vomiting, itching, and rash.

Headache and fatigue are more likely at higher doses. Serious allergic reactions, including anaphylaxis, are rare but can happen.

Long-term safety isn't well established, and product quality varies. Avoid this during pregnancy because of theoretical concerns and animal-study findings about reproductive effects.

There isn't enough safety information for breastfeeding, so skip it if you're nursing. If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before use.

Side effects, ingredient by ingredient Andrographis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Andrographis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 413 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) — the Moderate-severity bleeding risk is real. Also check blood pressure medications and any immunosuppressants you might be on.

If you take etoricoxib, celecoxib, or glipizide, confirm those with your pharmacist too, though the risk is Minor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Andrographis may help with sore throat, ulcerative colitis, or osteoarthritis if the evidence resonates with you and your doctor. But it interacts with blood thinners, blood pressure drugs, and immune-suppressing medications — if you take any of those, check your exact drugs with our tool first.

It's not for pregnancy or breastfeeding. Talk to your pharmacist before starting, especially if you're on any prescriptions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Andrographis paniculata Extract Powder 5%, straight from the product label.

Brand Materia Organica
Barcode (UPC) AP40009-100g
Net contents 3.5 Ounce(s); 100 Gram(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 336961
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Andrographis paniculata Extract Powder 5% by Materia Organica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
200
UPC/BARCODE
AP40009-100g
IngredientAmount% DV
Andrographis paniculata Leaf Extract, Powder500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

(5% Andrographolide)

Our water extraction and low-heat vacuum drying (wind dried, not sprayed dried) process preserves the natural nutrients and beneficial qualities of Andrographis paniculata with improved potency & bioavailability. 100% Andrographis paniculata leaf extract 5% Andrographolide by HPLC

Certified Star-K Kosher

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Star-K (Kosher)

General Statements

Materia Organica primarily sells bulk ingredients to manufacturers and brand owners.

Formulation

Water extracted & water soluble Better bioavailability & potency Vegetarian/Vegan, non-GMO, non-irradiated

No additives, fillers, or other ingredients No petroleum solvents in the extraction No pesticides used growing the andrographis Vegetarian/Vegan, non-GMO, non-irradiated

Vegetarian/Vegan, non-GMO, non-irradiated

No other ingredients added

Product of India 3rd party lab tested in USA

Suggested/Recommended/Usage/Directions

Suggested use: 500 mg daily, mixed into your favorite smoothie or beverage.

Precautions

For best results consult your physician.

Not recommended for children.

Storage

Store in sealed container in a dry, cool area.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Andrographis paniculata Extract Powder 5% by Materia Organica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Andrographis paniculata Extract Powder 5% label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Andrographis paniculata Extract Powder 5% by Materia Organica

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container200 Amounts shown are per serving.

Andrographis paniculata Leaf Extract, Powder

Interacts with
413 drugs
500 mg per serving Form: Andrographolides

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...

Andrographis paniculata Leaf Extract, Powder monograph & interactions
Interaction report

Andrographis paniculata Extract Powder 5% by Materia Organica Drug Interactions

Want to check YOUR meds against Andrographis paniculata Extract Powder 5%?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
413Drugs
408 Moderate 5 Minor

Ingredients driving the most interactions

Andrographis paniculata Leaf Extract, Powder 413

Individual Drug Interactions

The ingredients in Andrographis paniculata Extract Powder 5% interact with 413 drugs. Click any drug to see the details.

1 of the 1 ingredient in Andrographis paniculata Extract Powder 5% interact with drugs. Each result below shows which ingredient is responsible. Andrographis paniculata Leaf Extract, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Andrographis paniculata Extract Powder 5% with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Andrographis paniculata Leaf Extract, Powder6 drug types · 413 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.

Likelihood Possible Evidence D
Celecoxib (Celebrex)

Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.

Likelihood Possible Evidence D
Etoricoxib (Arcoxia)

Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.

Likelihood Possible Evidence D
Glipizide (Glucotrol)

Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.

Likelihood Possible Evidence D
Andrographis paniculata Leaf Extract, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Andrographis paniculata Extract Powder 5%, from the product label.

Materia Organica

See all Materia Organica products
Name
Materia Organica
City
Quitman
State
TX
ZipCode
75783
Phone Number
800-613-6311
Web Address
www.MateriaOrganica.com
Pharmacist Counseling Corner

Andrographis paniculata Extract Powder 5% by Materia Organica: Common Questions

Does Andrographis paniculata Extract Powder 5% by Materia Organica interact with any medications?
Yes. Based on its ingredients, Andrographis paniculata Extract Powder 5% has a known interaction with 413 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Andrographis paniculata Extract Powder 5% contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin?
Not without checking with your pharmacist first. Andrographis may increase bleeding risk when combined with blood thinners or antiplatelet drugs — that's a documented Moderate-severity interaction. Your pharmacist can review your specific medication and help you decide.
What are the most common side effects?
Belly discomfort, taste changes, diarrhea, dizziness, fatigue, headache, nausea, vomiting, itching, and rash. Headache and fatigue happen more often at higher doses. Serious allergic reactions are rare.
Is it safe to take long-term?
Long-term safety isn't well established. Andrographis is generally well tolerated short-term, but higher doses (5–10 mg/kg of andrographolide) or treatment over 14 days increase the chance of side effects.
Can I take this while pregnant or breastfeeding?
No. Avoid it during pregnancy because of theoretical concerns and animal-study findings about reproductive effects. There isn't enough safety data for breastfeeding either, so skip it if you're nursing. Talk with your doctor if you're pregnant or planning to become pregnant.
What is andrographis used for?
Evidence supports it as possibly effective for ulcerative colitis, sore throat and tonsil inflammation, and osteoarthritis. For familial Mediterranean fever, we don't have enough reliable evidence to rate it yet.
How many active ingredients does this powder have?
One: andrographis paniculata leaf extract, standardized to 5% andrographolides. There are no inactive fillers or other ingredients in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Andrographis paniculata Extract Powder 5% label
Go deeper

The Full Monographs Behind Andrographis paniculata Extract Powder 5%’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Andrographis

Interacts with 413 drugs

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten how long they last. The evidence is limi...

Read the full Andrographis monograph →
Sources

Sources & How We Checked

Andrographis paniculata Extract Powder 5%'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Andrographis 26 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 1991;74:437-42.
  3. Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101. PubMed
  4. Zhao HY, Fang WY. Antithrombotic effects of Andrographis paniculata nees in preventing myocardial infarction. Chin Med J (Engl) 1991;104:770-5.
  5. Amroyan E, Gabrielian E, Panossian A, et al. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999;6:27-31. PubMed
  6. Zhang C, Kuroyangi M, Tan BK. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacol Res 1998;38:413-7. PubMed
  7. Puri A, Saxena R, Saxena RP, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993;56:995-9. PubMed
  8. Melchoir J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-respirator
  9. Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14:333-8. PubMed
  10. Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97 PubMed
  11. Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45. PubMed
  12. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70:293-8.
  13. Kligler, B., Ulbricht, C., Basch, E., Kirkwood, C. D., Abrams, T. R., Miranda, M., Singh Khalsa, K. P., Giles, M., Boon, H., and Woods, J. Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standa
  14. Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., and Caceres, D. D. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled tria
  15. Saxena, R. C., Singh, R., Kumar, P., Yadav, S. C., Negi, M. P., Saxena, V. S., Joshua, A. J., Vijayabalaji, V., Goudar, K. S., Venkateshwarlu, K., and Amit, A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis pa
  16. Tang, T., Targan, S. R., Li, Z. S., Xu, C., Byers, V. S., and Sandborn, W. J. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment.Pharmacol Ther 2011;33(2) PubMed
  17. Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., and Tang, T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98. PubMed
  18. Melchior, J., Palm, S., and Wikman, G. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine. 1997;3(4):315-318. PubMed
  19. Balap A, Atre B, Lohidasan S, et al. Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats. J Ethnopharmacol. 2016 May 13;183:9-17. PubMed
  20. Bertoglio JC, Baumgartner M, Palma R, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016; 16(1):77. PubMed
  21. Suwankesawong W, Saokaew S, Permsuwan U, et al. Characterization of hypersensitivity reactions reported among Andrographis paniculata users in Thailand using Health Product Vigilance Center (HPVC) database. BMC Complement Altern Med. 2014; 14:515. PubMed
  22. Ciampi E, Uribe-San-Martin R, Cárcamo C, et al. Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial. BMC Neurol 2020;20(1):173. PubMed
  23. Worakunphanich W, Thavorncharoensap M, Youngkong S, Thadanipon K, Thakkinstian A. Safety of Andrographis paniculata: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 2021;30(6):727-739.
  24. More SJ, Tandulwadkar SS, Balap AR, Lohidasan S, Sinnathambi A, Mahadik KR. Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats. Futur J Pharm Sci. 2023;9(1):1. PubMed
  25. Sundhani E, Nugroho AE, Nurrochmad A, Puspitasari I, Amalia Prihati D, Lukitaningsih E. Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method. M PubMed
  26. Shang YX, Shen C, Stub T, et al. Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies. Front Pharmacol 20 PubMed

See these in context on the Andrographis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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