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Dietary supplement

Apple Cider Vinegar 1600 mg Ingredients & Drug Interactions

by NutriFlair

Apple Cider Vinegar 1600 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apple Cider Vinegar 1600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apple Cider Vinegar 1600 mg is a dietary supplement by NutriFlair with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, weight management, digestive upset.Based on those ingredients, 162 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Apple Cider Vinegar. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Apple Cider Vinegar 1600 mg by NutriFlair

Ask about any prescription or over-the-counter medication and we check it for interactions with Apple Cider Vinegar 1600 mg by NutriFlair — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Apple Cider Vinegar 1600 mg by NutriFlair

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: apple cider vinegar, a fermented apple juice that's been used traditionally in cooking and home remedies. At 1600 mg per capsule, you're getting a concentrated form of the vinegar.

The capsule itself is made with cellulose, an inactive ingredient that serves as a filler and helps form the capsule shell.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Apple Cider Vinegar's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy weight management and digestion.
  • We looked for evidence on: Obesity, Dyspepsia, Gastroparesis, metabolic health, glucose control.
  • The closest evidence on file: Apple Cider Vinegar is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Apple Cider Vinegar is rated "Insufficient Reliable Evidence To Rate" for Obesity, Gastroparesis.

The evidence for apple cider vinegar doesn't yet support its use for the conditions we have data on—acne, athletic performance, cognitive function, dental plaque, depression, and atopic dermatitis (eczema) all fall into insufficient reliable evidence to rate. That means the research so far hasn't shown a clear benefit, though it doesn't rule out that one might exist.

If you're considering this product for one of those reasons, the science isn't there yet to back it.

The evidence, ingredient by ingredient Apple Cider Vinegar

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

In the amounts you'd eat in food, apple cider vinegar is generally well tolerated. However, this is a supplement dose—much larger than food amounts—and the safety data on long-term use at this level is limited.

Large doses, especially over years, have been tied to serious but rare problems: dangerously low potassium, elevated renin levels (affecting blood pressure and kidney function), and bone loss (osteoporosis). One documented case involved daily use of 250 mL (over 8 ounces) for 6 years.

Short-term use at medicinal doses appears tolerated, but there isn't enough safety data on long-term supplement use to say it's completely safe. If you're pregnant or breastfeeding, there isn't enough data on file to know whether supplement doses are safe—talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Apple Cider Vinegar

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Apple Cider Vinegar.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 162 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check it with your doctor or pharmacist if you're on digoxin (Lanoxin) for your heart, diuretics (water pills) for blood pressure or fluid, insulin, or other diabetes medications. All of these carry documented interaction risk—Moderate for digoxin, diuretics, and insulin, and Minor for other blood sugar drugs.

No other medication interactions are documented for this ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Apple cider vinegar supplement may appeal to you if you're drawn to traditional remedies, but the evidence for the conditions it's marketed for isn't established yet. The bigger concern is if you take heart, kidney, diabetes, or blood pressure medication—this product can interfere with how those drugs work and potentially cause serious problems.

Check your exact medications with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apple Cider Vinegar 1600 mg, straight from the product label.

Brand NutriFlair
Barcode (UPC) X001OT61XR
Net contents 120 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 268749
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apple Cider Vinegar 1600 mg by NutriFlair, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X001OT61XR
IngredientAmount% DV
Apple Cider Vinegar1600 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, take two (2) veggie capsules once daily, preferably with a meal and water, or as directed by your healthcare professional. For best results, take daily for at least 30 days.

Formulation

Supports healthy weight management Natural cleanser for overall health Helps to support digestion & circulation Supports cartilage & joint health

Raw, Unfiltered Detox, digestion, weight management

Vegan & Vegetarian

Made with Non-GMO Ingredients

Non-GMO, Gluten & Dairy free Ingredients Zero fillers, binders, preservatives, artificial ingredients, milk, soy, eggs, gelatin, dioxides, peanuts, fish, shellfish.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition, should consult a healthcare professional before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition, should consult a healthcare professional before using this or any dietary supplement. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

1600 mg per serving

With the mother

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA Lab Tested Premium Quality Purity & Potency GMP Good Manufacturing Practice

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apple Cider Vinegar 1600 mg by NutriFlair label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apple Cider Vinegar 1600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apple Cider Vinegar 1600 mg by NutriFlair

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Apple Cider Vinegar

Interacts with
162 drugs
1600 mg per serving

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apple Cider Vinegar 1600 mg by NutriFlair Drug Interactions

Want to check YOUR meds against Apple Cider Vinegar 1600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
162Drugs
89 Moderate 73 Minor

Ingredients driving the most interactions

Apple Cider Vinegar 162

Individual Drug Interactions

The ingredients in Apple Cider Vinegar 1600 mg interact with 162 drugs. Click any drug to see the details.

1 of the 1 ingredient in Apple Cider Vinegar 1600 mg interact with drugs. Each result below shows which ingredient is responsible. Apple Cider Vinegar

Each ingredient & the kinds of drugs it affects

For each ingredient in Apple Cider Vinegar 1600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Apple Cider Vinegar4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apple Cider Vinegar 1600 mg, from the product label.

NutriFlair

See all NutriFlair products
Name
NutriFlair
City
Seattle
State
WA
ZipCode
98116
Phone Number
+1 (800) 432-2031
Web Address
www.nutriflair.com
Pharmacist Counseling Corner

Apple Cider Vinegar 1600 mg by NutriFlair: Common Questions

Does Apple Cider Vinegar 1600 mg by NutriFlair interact with any medications?
Yes. Based on its ingredients, Apple Cider Vinegar 1600 mg has a known interaction with 162 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apple Cider Vinegar 1600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does apple cider vinegar actually work for acne, eczema, or the other things it's marketed for?
The evidence we have doesn't support it yet. Acne, eczema, dental plaque, athletic performance, mood, and brain function all fall into insufficient evidence to rate—meaning the research so far hasn't shown a clear benefit. That doesn't mean it won't work for you, just that we don't have solid proof.
Is it safe to take long-term?
Food amounts of apple cider vinegar are generally well tolerated, but supplement doses are a different story. Long-term use at high doses has been linked to dangerously low potassium, bone loss, and kidney changes. We don't have enough safety data on long-term supplement use to say it's completely safe—talk with your doctor before taking it consistently.
What's the hypokalemia risk I keep reading about?
Hypokalemia is low blood potassium. Apple cider vinegar can lower your potassium levels, and if you're already taking a diuretic (water pill), that risk goes up. Low potassium can cause muscle weakness, heart problems, and be especially dangerous if you take digoxin or insulin. It's why checking with your doctor matters.
Can I take this if I'm on a diuretic for my blood pressure?
You shouldn't without clearing it with your doctor or pharmacist first. Both diuretics and apple cider vinegar lower potassium, and combining them raises the risk of dangerously low levels. Your doctor can assess whether it's safe for your specific situation.
What's in the capsule besides the vinegar?
The only inactive ingredient is cellulose, which is a plant fiber used to form the capsule and hold the product together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Apple Cider Vinegar 1600 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apple Cider Vinegar 1600 mg label
Go deeper

The Full Monographs Behind Apple Cider Vinegar 1600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph →
Sources

Sources & How We Checked

Apple Cider Vinegar 1600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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