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Dietary supplement

Apple Cider Vinegar Chewables 500 mg Ingredients & Drug Interactions

by KAL

Apple Cider Vinegar Chewables 500 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apple Cider Vinegar Chewables 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apple Cider Vinegar Chewables 500 mg is a dietary supplement by KAL with 2 active ingredients. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 267 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia Leaf Extract, Apple Cider Vinegar, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Apple Cider Vinegar Chewables 500 mg by KAL

Ask about any prescription or over-the-counter medication and we check it for interactions with Apple Cider Vinegar Chewables 500 mg by KAL — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Apple Cider Vinegar Chewables 500 mg by KAL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: stevia leaf extract and apple cider vinegar powder. Stevia is a natural sweetener derived from the stevia plant leaf, while apple cider vinegar powder is a dehydrated form of fermented apple juice.

The product also includes several inactive ingredients—sorbitol, maltodextrin, xylitol, natural flavors, stearic acid, and silica—which are fillers and binders that make up the tablet.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This product is marketed for general wellness, not a specific health condition, so there's no single claim to grade against clinical evidence.

Why this rating?
  • The label markets general wellness (“General wellbeing support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The facts we hold show insufficient evidence to establish how well either ingredient works for any of the conditions mentioned—stevia's effects on diabetes, hypertension, and obesity, and apple cider vinegar's effects on acne, athletic performance, cognitive function, dental plaque, depression, and eczema. That means the evidence isn't strong enough yet to make a reliable claim about what this chewable will or won't do for you.

The evidence, ingredient by ingredient Stevia Apple Cider Vinegar

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

In food amounts, both stevia and apple cider vinegar are generally well tolerated. However, stevia in high-dose supplements hasn't been well studied, so caution is advised.

Apple cider vinegar in large or long-term doses carries more concern—rare serious effects from chronic overuse include low potassium, high renin levels, and bone loss (osteoporosis). Common minor side effects from stevia may include bloating, dizziness, headache, muscle pain, nausea, or numbness, though most resolve within the first week.

The facts don't contain pregnancy or breastfeeding safety data for either ingredient, so talk with your pharmacist or doctor before using this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Stevia Apple Cider Vinegar

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Stevia, Apple Cider Vinegar.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; lithium.
  • For scale: 267 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use diuretic drugs (water pills), digoxin or other heart medications, insulin, any diabetes or blood pressure medication, or lithium. Apple cider vinegar's low-potassium risk is Moderate with diuretics, digoxin, and insulin, and stevia's interaction with lithium is also Moderate.

Both ingredients carry Minor risks with diabetes and blood pressure drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This chewable is generally well tolerated in normal amounts, but it carries real interaction risks if you take water pills, heart medications like digoxin, insulin, diabetes drugs, blood pressure medications, or lithium. Before you start, check your exact medications against the tool on this page or talk with your pharmacist.

The effectiveness evidence for the claims around blood sugar, blood pressure, or weight isn't yet established in our data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apple Cider Vinegar Chewables 500 mg, straight from the product label.

Brand KAL
Barcode (UPC) 021245518655
Net contents 60 Chewable (s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 322889
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apple Cider Vinegar Chewables 500 mg by KAL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
1 Chewable Tablet(s)
Servings per container
60
UPC/BARCODE
021245518655
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Stevia Leaf Extract6 mg--
Apple Cider Vinegar, Powder500 mg--

Other ingredients: Sorbitol, Maltodextrin, Xylitol, natural Green Apple flavor, other Natural flavors, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

KAL Trust Quality Since 1932

Suggested/Recommended/Usage/Directions

1 Daily

Directions: Take 1 chewable tablet up to two times daily. For a more mild sour apple flavor, treat tablet as a lozenge, allowing it to dissolve gradually. Use only as directed.

Formulation

General wellbeing support

Non GMO Gluten free

Vegan

Seals/Symbols

Vegan

General Statements

PCR Bottle

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formula

Discussion: This great tasting, natural green apple flavored chewable is concentrated with a minimum 35% acidity as acetic acid.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apple Cider Vinegar Chewables 500 mg by KAL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apple Cider Vinegar Chewables 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apple Cider Vinegar Chewables 500 mg by KAL

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Stevia Leaf Extract

Interacts with
259 drugs
6 mg per serving Form: Stevia rebaudiana leaf extract

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia Leaf Extract monograph & interactions

Apple Cider Vinegar, Powder

Interacts with
162 drugs
500 mg per serving Form: Acetic Acid

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar, Powder monograph & interactions

Other (inactive) ingredients: Sorbitol, Maltodextrin, Xylitol, Natural Green Apple flavor, Other Natural flavors, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apple Cider Vinegar Chewables 500 mg by KAL Drug Interactions

Want to check YOUR meds against Apple Cider Vinegar Chewables 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
267Drugs
90 Moderate 177 Minor

Ingredients driving the most interactions

Stevia Leaf Extract 259
Apple Cider Vinegar, Powder 162

Individual Drug Interactions

The ingredients in Apple Cider Vinegar Chewables 500 mg interact with 267 drugs. Click any drug to see the details.

2 of the 2 ingredients in Apple Cider Vinegar Chewables 500 mg interact with drugs. Each result below shows which ingredient is responsible. Stevia Leaf Extract Apple Cider Vinegar, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Apple Cider Vinegar Chewables 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia Leaf Extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia Leaf Extract full monograph & interactions

Apple Cider Vinegar, Powder4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apple Cider Vinegar Chewables 500 mg, from the product label.

KAL

See all KAL products
Name
KAL
City
Salt Lake City
State
UT
ZipCode
84101
Phone Number
800-538-5888
Web Address
www.kalvitamins.com
Pharmacist Counseling Corner

Apple Cider Vinegar Chewables 500 mg by KAL: Common Questions

Does Apple Cider Vinegar Chewables 500 mg by KAL interact with any medications?
Yes. Based on its ingredients, Apple Cider Vinegar Chewables 500 mg has a known interaction with 267 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apple Cider Vinegar Chewables 500 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a water pill for high blood pressure?
Not without checking first. Apple cider vinegar in this product may increase your risk of low potassium if you take diuretics, which is a Moderate concern. Talk with your pharmacist—they can check your specific medication and help you decide.
What side effects might I notice?
Stevia may cause bloating, dizziness, headache, muscle pain, nausea, or numbness, though most people who experience these see them fade within the first week. Serious allergic reactions are rare. Apple cider vinegar in food amounts is usually well tolerated, but large doses over time carry a risk of low potassium.
Is this safe to use if I'm pregnant or breastfeeding?
We don't have safety data on file for either ingredient in pregnancy or breastfeeding. Talk with your doctor or pharmacist to get personalized advice for your situation.
Does this actually help with blood sugar or weight?
The evidence we hold is insufficient to establish whether stevia or apple cider vinegar reliably help with diabetes, weight, or other health claims. The science isn't there yet to back those uses.
What are the inactive ingredients?
The chewable contains sorbitol, maltodextrin, xylitol, natural green apple and other natural flavors, stearic acid, and silica—all fillers or binders that help form the tablet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Apple Cider Vinegar Chewables 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apple Cider Vinegar Chewables 500 mg label
Go deeper

The Full Monographs Behind Apple Cider Vinegar Chewables 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph →
Sources

Sources & How We Checked

Apple Cider Vinegar Chewables 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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