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Dietary supplement

Axxis Ingredients & Drug Interactions

by Vaxxen Labs

Axxis label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Axxis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Axxis is a dietary supplement by Vaxxen Labs with 1 active ingredient. Its ingredients are commonly taken for muscle building, strength and athletic performance, boosting testosterone.Based on those ingredients, 8 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 4-DHEA Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Axxis by Vaxxen Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Axxis by Vaxxen Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Axxis by Vaxxen Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “4-DHEA Blend” is a proprietary blend — the label gives one combined amount (75 mg) without saying how much of each component you get.

Axxis contains 3 active ingredients, all prohormones: 4-Androstene-3b-Ol, 17-One, 4 Androstene-3b-ol, 17-one Undecanoate, and 4 Androstene-3b-ol, 17-one Caprylate, which are designed to be converted in your body to androgens (male hormones). The product also contains several inactive ingredients including microcrystalline cellulose, phosphatidylcholine, hydroxypropyl-beta-cyclodextrin, phytosterol, stearic acid, magnesium stearate, starch, titanium dioxide, silica, and FD&C Blue #1.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient 4-androsterone product and its label doesn't state a use — see 4-androsterone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't have effectiveness data on file for the ingredients in Axxis. The product contains prohormones intended to support testosterone and related androgens, but the evidence for their efficacy hasn't been established in our data.

The evidence, ingredient by ingredient 4-androsterone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Prohormones carry real safety concerns. They can disrupt your hormone balance, put strain on your liver, and affect your cholesterol levels—and these effects aren't well studied in the long term.

The safety notes specifically advise against use during pregnancy because androgenic hormones can harm a developing baby, and breastfeeding mothers should also avoid it because the hormonal effects on a nursing infant are unknown and potentially harmful. Theoretically, 4-androsterone could cause serious steroid-like side effects including stroke, kidney failure, and liver injury, though we don't have robust data on how often these occur.

Side effects, ingredient by ingredient 4-androsterone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — 4-androsterone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 8 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Axxis, check with your doctor or pharmacist if you're on testosterone or testosterone-like products. The documented interaction is Moderate severity and involves additive hormone effects that may stress your cardiovascular system, kidneys, and liver.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Axxis is a prohormone product aimed at people seeking to support testosterone levels, but it carries significant caution flags: hormone disruption, liver strain, and effects we don't fully understand. If you take any testosterone or related hormonal medications, you need to talk with your doctor or pharmacist before starting this.

Pregnant or breastfeeding women should not use it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Axxis, straight from the product label.

Brand Vaxxen Labs
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 210055
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Axxis by Vaxxen Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
IngredientAmount% DV
4-DHEA Blend75 mg--
4 Androstene-3b-Ol, 17-One0 NP--
4 Androstene-3b-ol, 17-one Undecanoate0 NP--
4 Androstene-3b-ol, 17-one Caprylate0 NP--

Other ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Mass Agent 75 mg

Liposomal Delivery System Vaxxen Labs

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Axxis by Vaxxen Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Axxis label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Axxis by Vaxxen Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

4-DHEA Blend

Interacts with
8 drugs
75 mg per serving

4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human...

4-DHEA Blend monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Axxis by Vaxxen Labs Drug Interactions

Want to check YOUR meds against Axxis?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
8Drugs
8 Moderate

Ingredients driving the most interactions

4-DHEA Blend 8

Individual Drug Interactions

The ingredients in Axxis interact with 8 drugs. Click any drug to see the details.

1 of the 1 ingredient in Axxis interact with drugs. Each result below shows which ingredient is responsible. 4-DHEA Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Axxis with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

4-DHEA Blend1 drug type · 8 drugs

Testosterone

4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion. Theoretically, taking 4-androsterone with testosterone may increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.

Likelihood Possible Evidence D
4-DHEA Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Axxis, from the product label.

Vaxxen Labs

See all Vaxxen Labs products
Name
Vaxxen Labs
Pharmacist Counseling Corner

Axxis by Vaxxen Labs: Common Questions

Does Axxis by Vaxxen Labs interact with any medications?
Yes. Based on its ingredients, Axxis has a known interaction with 8 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Axxis contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are prohormones, and what do they do?
Prohormones are compounds your body theoretically converts into hormones like testosterone and other androgens. Axxis contains three different prohormone forms designed to support these hormonal pathways, though the effectiveness data isn't established in our files.
Can I take Axxis if I'm pregnant or breastfeeding?
No. Androgenic hormones can harm a developing baby, so you should not use Axxis during pregnancy. The hormonal effects on a nursing infant are unknown and potentially harmful, so breastfeeding mothers should also avoid it.
What side effects should I watch for?
There isn't robust information on how often side effects occur, but theoretically 4-androsterone could cause serious effects similar to anabolic steroids, including stroke, kidney failure, and liver injury. Prohormones can also disrupt your hormones, strain your liver, and affect your cholesterol.
Why is Axxis a concern for my liver and kidneys?
Prohormones in general can stress the liver as it works to metabolize them, and they may affect kidney function as well. The safety data notes caution around liver strain and potential kidney problems, though long-term effects aren't well studied.
Can I take Axxis with testosterone replacement?
Not without talking to your doctor first. Taking 4-androsterone (which Axxis contains) alongside testosterone may increase additive effects including mood changes and cardiovascular, kidney, or liver strain.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Axxis label
Go deeper

The Full Monographs Behind Axxis’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

4-androsterone

Interacts with 8 drugs

4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries...

Read the full 4-androsterone monograph →
Sources

Sources & How We Checked

Axxis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

4-androsterone 3 references
  1. Anabolic Steroids and Other Appearance and Performance Enhancing Drugs (APEDs) — NIH National Institute on Drug Abuse Source
  2. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  3. DHEA — MedlinePlus Source

See these in context on the 4-androsterone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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