Bai Zhu Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Bai Zhu against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bai Zhu is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for digestive upset and poor appetite, bloating and fluid retention, general fatigue or 'weakness'.Based on those ingredients, 801 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bai Zhu (Atractylodes macrocephala) dried rhizome extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bai Zhu by Herbal Terra
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HelloPharmacist Scorecard of Bai Zhu by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Bai Zhu contains one active ingredient: Atractylodes macrocephala dried rhizome extract, a traditional Chinese botanical. The liquid form also includes menstruum as an inactive ingredient (a solvent used to concentrate the plant material).
Does it work?
Couldn't assess
The evidence we have doesn't establish whether Bai Zhu works for any condition. It has been used traditionally for anorexia nervosa, cachexia, lung cancer, common cold, and diarrhea, but the research to back those uses is insufficient.
You'd want to talk with your healthcare provider if you're considering it for a specific health goal.
How safe is it?
Well-documented data
Safety data on atractylodes in humans is limited, so caution and professional guidance are advised. The most common side effects reported with oral use are allergic reaction, dry mouth, and nausea.
Because we don't have enough reliable safety information, it's best avoided during pregnancy; safety while breastfeeding is unknown, so it should be avoided then as well. If you're pregnant or nursing, talk with your doctor or pharmacist before taking this.
Meds to double-check
Moderate interaction found
Double-check this supplement if you take blood thinners or antiplatelet drugs (like warfarin or clopidogrel), aromatase inhibitors for hormone-related cancer, or hexobarbital. Also review any medication your liver breaks down using CYP1A2 or CYP3A4 pathways—atractylodes may alter their levels.
Run your exact prescriptions through the checker on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Bai Zhu is a traditional single-herb extract with limited human safety data and no established effectiveness in our records for the conditions it's traditionally used for. If you take blood thinners, aromatase inhibitors, or other prescription drugs—especially those your liver metabolizes—check with your pharmacist first.
Pregnant or breastfeeding? Skip it unless your provider advises otherwise.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bai Zhu, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 617503484581 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2020 |
| DSLD ID | 234641 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bai Zhu by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bai Zhu (Atractylodes macrocephala) dried rhizome extract | 970 mg | -- |
Other ingredients: Menstruum
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Origin of plant material: India.
Manufactured in the USA in an FDA registered facility
Alcohol free
Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Alcohol-free liquid herbal extract
Non GMO
No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free
Suggested/Recommended/Usage/Directions
Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.
FDA Disclaimer Statement
Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Caution May have contraindications.
Do not use if you are allergic to any ingredients.
Consult a physician before using during pregnancy, if nursing, or if you are on any medications.
Keep out of the reach of children.
Storage
Store in a cool, dry, dark place.
Formula
Atractylodes macrocephala
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA Made in an FDA registered facility Natural Gluten Free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bai Zhu by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bai Zhu by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Bai Zhu (Atractylodes macrocephala) dried rhizome extract
Interacts with801 drugs
Atractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue, often as p...
Bai Zhu (Atractylodes macrocephala) dried rhizome extract monograph & interactionsOther (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.
Bai Zhu by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Bai Zhu by Herbal Terra contains a single active ingredient—Atractylodes macrocephala—that interacts with several medication types.
The most serious concern is with blood thinners and antiplatelet drugs (Moderate severity): lab research shows that compounds in atractylodes may reduce how platelets clump, which could add to the bleeding risk of these medications, though this hasn't been proven in people yet.
Read the full breakdown — every affected drug type, severity by severity
Atractylodes also has Moderate interactions with aromatase inhibitors (hormone-related cancer drugs) through a potential additive effect, and with hexobarbital, a sedating medication where animal studies suggest atractylodes could prolong its effects—again, unconfirmed in humans. Additionally, it may affect how your body processes certain medications: Minor interactions exist with drugs metabolized by CYP1A2 enzymes (where atractylodes might lower their levels) and CYP3A4 substrates (where it might raise them), based on animal data at high doses.
Altogether, these interactions span 791 individual medications. Use the medication checker on this page to look up your exact prescriptions before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bai Zhu?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bai Zhu interact with 801 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bai Zhu interact with drugs. Each result below shows which ingredient is responsible. Bai Zhu (Atractylodes macrocephala) dried rhizome extract
Diclofenac SodiumAcoflam, Acoflam 75 SR, Acoflam Retard, Defenac, Defenac Retard, Defenac SR +40 more
How Diclofenac Sodium interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Diclofenac Sodium interactionDiclofenac Sodium, MisoprostolArthrotec 50, Arthrotec 75
How Diclofenac Sodium, Misoprostol interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Diclofenac Sodium, Misoprostol interactionDiclofenac EpolamineFlector, Licart
How Diclofenac Epolamine interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Diclofenac Epolamine interactionDicumarolDicumarol
How Dicumarol interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Dicumarol interactionDiphenhydramine Hydrochloride, Naproxen SodiumAleve PM
How Diphenhydramine Hydrochloride, Naproxen Sodium interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Diphenhydramine Hydrochloride, Naproxen Sodium interactionDipyridamoleDipyridamole, Persantin, Persantin Injection, Persantin Retard, Persantine
How Dipyridamole interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Dipyridamole interactionEdoxabanSavaysa
How Edoxaban interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Edoxaban interactionEffientPrasugrel
How Effient interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Effient interactionEnoxaparinLovenox
How Enoxaparin interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Enoxaparin interactionEptifibatideIntegrilin
How Eptifibatide interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Eptifibatide interactionEsomeprazole, NaproxenVimovo
How Esomeprazole, Naproxen interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Esomeprazole, Naproxen interactionExemestaneAromasin
How Exemestane interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Aromatase Inhibitors Moderate
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Exemestane interactionFamotidine, IbuprofenDuexis
How Famotidine, Ibuprofen interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Famotidine, Ibuprofen interactionFish Oil TriglyceridesOmegaven
How Fish Oil Triglycerides interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Fish Oil Triglycerides interactionFondaparinuxArixtra
How Fondaparinux interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Fondaparinux interactionHeparinHeparin
How Heparin interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Heparin interactionHexobarbitalHexobarbital, Sombulex
How Hexobarbital interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractHexobarbital Moderate
Interaction Summary
Theoretically, taking atractylodes may prolong the therapeutic and adverse effects of hexobarbital.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Hexobarbital interactionHydrocodone, IbuprofenVicoprofen
How Hydrocodone, Ibuprofen interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Hydrocodone, Ibuprofen interactionIbrutinibImbruvica
How Ibrutinib interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Ibrutinib interactionIbuprofenAdvil, Arthrofen, Brufen, Brufen Retard, Calodor, Calprofen +14 more
How Ibuprofen interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Ibuprofen interactionIbuprofen LysineNeoProfen
How Ibuprofen Lysine interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Ibuprofen Lysine interactionIbuprofen, AcetaminophenAdvil Dual Action
How Ibuprofen, Acetaminophen interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Ibuprofen, Acetaminophen interactionIbuprofen, HydrocodoneIbucodone
How Ibuprofen, Hydrocodone interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Ibuprofen, Hydrocodone interactionIbuprofen, OxycodoneCombunox
How Ibuprofen, Oxycodone interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Ibuprofen, Oxycodone interactionIbuprofen, PseudoephedrineDristan
How Ibuprofen, Pseudoephedrine interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Ibuprofen, Pseudoephedrine interactionIcosapent Ethyl (prescription Drug)Vascepa
How Icosapent Ethyl (prescription Drug) interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Icosapent Ethyl (prescription Drug) interactionIloprostAurlumyn, Ventavis
How Iloprost interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Iloprost interactionInotersenTegsedi
How Inotersen interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Inotersen interactionKetoprofenOrudis, Oruvail Gel, Oruvail Injection, Powergel
How Ketoprofen interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Ketoprofen interactionLepirudinRefludan
How Lepirudin interacts with Bai Zhu — through 1 ingredient. Tap an ingredient for the detail:
Bai Zhu (atractylodes Macrocephala) Dried Rhizome ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Bai Zhu (atractylodes Macrocephala) Dried Rhizome Extract + Lepirudin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bai Zhu with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bai Zhu (Atractylodes macrocephala) dried rhizome extract
Anticoagulant/Antiplatelet Drugs
Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Laboratory research suggests that atractylenolides II and III, constituents of atractylodes, reduce platelet activation. So far, this has not been shown in humans.
Aromatase Inhibitors
Theoretically, atractylodes may have an additive effect when used with other aromatase inhibitors.
Laboratory research suggests that atractylodes and its constituents exhibit aromatase inhibitor effects.
Hexobarbital
Theoretically, taking atractylodes may prolong the therapeutic and adverse effects of hexobarbital.
In animals, atractylodes has been shown to prolong the effects of hexobarbital. These effects have not been shown in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.
In animals, atractylodes administered at high doses has been shown to induce CYP1A2 activity. This effect has not been shown in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
In animals, atractylodes administered at high doses has been shown to inhibit CYP3A1 activity, which is a homolog to the human CYP3A4 enzyme. This effect has not been shown in humans.
Brand information
Manufacturer and brand details for Bai Zhu, from the product label.
Bai Zhu by Herbal Terra: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bai Zhu is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bai Zhu’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bai Zhu's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Atractylodes 6 references
- Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44. PubMed
- Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202. PubMed
- Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules. 2011 Apr 14;16(4):3146-51. PubMed
- Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014 Jun;7(6):421-8. PubMed
- Li L, Tang LY, Man GC, Yeung BH, Lau CB, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011 Dec;26(12):3280-8. PubMed
- Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLoS One 2022;17(11):e0277614. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC