Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

BCAA 5000 Unflavored Ingredients & Drug Interactions

by MET-Rx

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

BCAA 5000 Unflavored is a dietary supplement by MET-Rx with 4 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of BCAA 5000 Unflavored by MET-Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 4 active ingredients: three branched-chain amino acids (L-leucine, L-isoleucine, and L-valine—often called BCAAs) and vitamin B6. BCAAs are amino acids your body uses to build and repair muscle, and they're popular among athletes.

Vitamin B6 is a B vitamin involved in protein metabolism and nervous system function. The product also contains pyridoxine hydrochloride as an inactive ingredient—that's the chemical form of vitamin B6.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Post-workout muscle recovery and protein synthesis.
  • We looked for evidence on: Muscle protein synthesis, Amino acid metabolism, Exercise recovery.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

In our data, vitamin B6 is rated effective for sideroblastic anemia (a blood disorder) and vitamin B6 deficiency itself, and likely effective for high homocysteine levels (a heart-risk marker). It's possibly effective for pregnancy-related nausea and vomiting.

We don't hold effectiveness data for the branched-chain amino acids in this product.

The evidence, ingredient by ingredient Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated in doses under 100 mg daily. At higher doses or over long periods, the main concern is nerve damage (sensory neuropathy), especially with daily doses over 1,000 mg or cumulative doses of 1,000 grams or more, though it can occur at lower amounts too.

Common side effects at standard doses include headache, nausea, heartburn, and loss of appetite. For pregnancy, vitamin B6 is rated likely safe overall, though one rating notes possibly unsafe—talk with your doctor if you're pregnant or planning to be.

It's rated likely safe during breastfeeding. We don't have safety data on file for the three branched-chain amino acids.

Side effects, ingredient by ingredient Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 210 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this if you use phenytoin (Dilantin) or phenobarbital for seizures—vitamin B6 may lower their levels (Moderate). Also double-check if you take antihypertensive drugs, amiodarone (Cordarone), or levodopa alone.

High doses of vitamin B6 in this product could affect how those work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

BCAA 5000 is straightforward as a muscle-support supplement, but its vitamin B6 content means you'll want to check your medications first—especially if you take seizure drugs, blood pressure medication, amiodarone, or levodopa. If you're pregnant, discuss it with your doctor.

Otherwise, chat with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BCAA 5000 Unflavored, straight from the product label.

Brand MET-Rx
Barcode (UPC) 786560312011
Net contents 0.66 lb; 10.58 oz.; 300 Gram(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 66278
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BCAA 5000 Unflavored by MET-Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
60
UPC/BARCODE
786560312011
IngredientAmount% DV
Calories20 Calorie(s)--
Vitamin B616 mg800%
L-Leucine2250 mg--
L-Isoleucine1250 mg--
L-Valine1500 mg--

Other ingredients: Pyridoxine Hydrochloride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

New look

BRANCHED CHAIN AMINO ACIDS MAY BE THE MOST IMPORTANT AMINOS FOR EXERCISE AND RECOVERY AS THEY WORK DIRECTLY WITHIN MUSCLE TO REGULATE PROTEIN SYNTHESIS AT THE GENETIC LEVEL.* BCAAS CAN ALSO INCREASE NITROGEN RETENTION AND CAN BE USED AS AN ENERGY SOURCE TO FUEL EXERCISE.*

Contents are sold by weight. Some settling may occur.

Accelerates Post-Workout Recovery*

Suggested/Recommended/Usage/Directions

POST-WORKOUT FOR MAXIMUM RESULTS, MIX ONE (1) SCOOP OF POWDER TO 6-8 OUNCES OF COLD WATER OR MILK AND CONSUME IMMEDIATELY AFTER EXERCISE.

Use in conjunction with an intense daily exercise program and a balanced diet including an adequate caloric intake.

Directions: Add one (1) scoop of powder to 6-8 ounces of cold water or milk and consume immediately after exercise. Take 2 servings per day.

Formula

MET-Rx BCAA 5000 SUPPLIES A PRECISE, CLINICALLY STUDIED RATIO OF LEUCINE, VALINE AND ISOLEUCINE (45/30/25).

5g BCAAs Clinically Studied BCAA Ratio

Brand IP Statement(s)

Massive MET-Rx BCAA 5000 Benefits: - Provides dual benefits since BCAAs can be used to build protein or broken down in muscle to supply a direct source of energy.* - BCAAs provide muscle nitrogen support for a variety of metabolic functions, which can be especially important during heavy training.* Taken before and after exercise or competition, MET-Rx BCAA 5000 will give you a jump-start on recovery so you can unleash your genetic potential and come back better than ever.*

MET-Rx Sports Nutrition

2016

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

No Artificial Sweeteners, Flavors or Colors

FDA Statement of Identity

DIETARY SUPPLEMENT POWDER

Precautions

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

General

31201 04D B31201 Part No. 30-41046

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

See for yourself

BCAA 5000 Unflavored by MET-Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in BCAA 5000 Unflavored by MET-Rx

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
16 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

L-Leucine

2250 mg per serving

L-Isoleucine

1250 mg per serving

L-Valine

1500 mg per serving

Other (inactive) ingredients: Pyridoxine Hydrochloride. These complete the product’s ingredient list but are not active constituents.

Interaction report

BCAA 5000 Unflavored by MET-Rx Drug Interactions

Want to check YOUR meds against BCAA 5000 Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
210Drugs
205 Moderate 5 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in BCAA 5000 Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for BCAA 5000 Unflavored, from the product label.

MET-Rx

See all MET-Rx products
Name
MET-Rx Nutrition, Inc.
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-800-556-3879
Web Address
www.MET-Rx.com
Pharmacist Counseling Corner

BCAA 5000 Unflavored by MET-Rx: Common Questions

Does BCAA 5000 Unflavored by MET-Rx interact with any medications?
Yes. Based on its ingredients, BCAA 5000 Unflavored has a known interaction with 210 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BCAA 5000 Unflavored contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Vitamin B6 is rated likely safe in pregnancy overall, though one rating notes possibly unsafe. If you're pregnant or planning to be, talk with your doctor or pharmacist about whether this product is right for you—don't start it on your own.
Will vitamin B6 in this supplement hurt my nerves?
Vitamin B6 is well tolerated at doses under 100 mg daily. Nerve damage is mainly a risk with very high doses—over 1,000 mg daily or 1,000 grams total—though it can happen at lower amounts with long use. If you're taking this long-term, mention it to your pharmacist.
What are BCAAs actually for?
Branched-chain amino acids (leucine, isoleucine, and valine) are building blocks your body uses to build and repair muscle. They're popular with athletes and people doing resistance training. We don't have effectiveness data on file for them in this product.
Can I breastfeed while taking this?
Vitamin B6 is rated likely safe during breastfeeding. We don't have safety data on the other ingredients. If you have concerns, check with your pharmacist or doctor.
What are the most common side effects?
At standard doses, vitamin B6 can cause headache, nausea, heartburn, and loss of appetite. Most people tolerate it without trouble at doses under 100 mg daily.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BCAA 5000 Unflavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BCAA 5000 Unflavored label
Go deeper

The Full Monographs Behind BCAA 5000 Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

BCAA 5000 Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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