Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Belly Off Ingredients & Drug Interactions

by BioGenetic Laboratories

Belly Off label
See full label image
Softgel Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Belly Off against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Belly Off is a dietary supplement by BioGenetic Laboratories with 4 active ingredients. Its ingredients are commonly taken for energy and alertness, reducing fatigue, weight loss support.Based on those ingredients, 1,102 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Yerba Mate (herb) (leaf) extract, Guarana (seed) extract, Damiana (leaf) 4:1 concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Belly Off by BioGenetic Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Belly Off by BioGenetic Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Belly Off by BioGenetic Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “YGD Weight-Loss Blend” is a proprietary blend — the label gives one combined amount (381 mg) without saying how much of each component you get.

Belly Off contains 4 active ingredients. The main ones are Conjugated Linoleic Acid (a fatty acid), guarana seed extract, yerba mate leaf extract, and damiana leaf in concentrated form.

The product also includes several inactive ingredients—soybean oil, gelatin, glycerin, beeswax, and others—that serve as capsule material and binders. Guarana and yerba mate are both plant sources of natural caffeine; damiana is a traditional herbal extract.

We don't hold interaction data for Conjugated Linoleic Acid.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: weight loss and reduced belly fat appearance.
  • We looked for evidence on: Obesity, Body composition, Visceral adiposity, Metabolic syndrome.
  • The closest evidence on file: Damiana is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Yerba Mate is rated "Insufficient Reliable Evidence To Rate" for Obesity.
  • Also on file: Guarana is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence we have doesn't establish that any ingredient in Belly Off works for weight loss or the conditions it may be marketed for. Guarana's effectiveness for athletic performance, anxiety, cancer-related fatigue, and cancer-related anorexia is rated insufficient.

Yerba mate shows insufficient evidence for athletic performance, chronic fatigue, headache, cognitive function, arrhythmia, and osteoporosis. Damiana's evidence is insufficient for sexual dysfunction, asthma, headache, depression, constipation, and cognitive function.

In short, we don't have reliable evidence that this product's ingredients work for their intended purposes.

The evidence, ingredient by ingredient Guarana Yerba Mate Damiana

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Guarana and yerba mate are generally well tolerated in small amounts, but both are high in caffeine, which carries real risks with overuse—stomach upset, nausea, dizziness, insomnia, nervousness, tremors, and in rare cases anaphylaxis in sensitive people. Damiana has limited human safety data, though animal research found that very high doses caused convulsions.

Because of their caffeine content, guarana is advised against during pregnancy and should be limited while breastfeeding; yerba mate is advised against in both pregnancy and lactation due to insufficient safety data. Damiana should also be avoided during pregnancy and breastfeeding due to lack of safety evidence.

Side effects, ingredient by ingredient Guarana Yerba Mate Damiana

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Damiana, Yerba Mate, Guarana.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,103 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Belly Off, double-check if you use ephedrine (Major severity risk of serious stimulant side effects). Also review use of seizure-control drugs (valproate, felbamate, carbamazepine), clozapine or other antipsychotics, fluvoxamine or other antidepressants, disulfiram, diabetes medications, dipyridamole, or quinolone antibiotics—all Moderate interactions.

If you take any of these, run it through the medication checker on this page or ask your pharmacist before adding this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Belly Off is a multi-ingredient product with significant caffeine content and several documented drug interactions—especially concerning with stimulants, seizure medications, and psychiatric drugs. If you take any prescription medication, check it against the interactions listed here before starting.

Talk with your pharmacist, especially if you're pregnant, breastfeeding, or take medications for seizures, mental health, or heart conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Belly Off, straight from the product label.

Brand BioGenetic Laboratories
Barcode (UPC) 883488002670
Net contents 90 Softgel Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 58262
Product type Botanical With Nutrients
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Belly Off by BioGenetic Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel Capsule(s)
Maximum serving Sizes:
2 Softgel Capsule(s)
Servings per container
90
UPC/BARCODE
883488002670
IngredientAmount% DV
Conjugated Linoleic Acid1000 mg--
Guarana (seed) extract0 NP--
Yerba Mate (herb) (leaf) extract0 NP--
Damiana (leaf) 4:1 concentrate0 NP--
YGD Weight-Loss Blend381 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Mono {Glycerides} & Di-Glycerides, yellow Beeswax, purified Water, Sorbitol, Soy Lecithin, Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

START TODAY, AND HERE’S WHAT YOU MAY EXPECT: ~ Reduced appearance of belly fat ~ Help curbing hunger and boosting energy ~Support losing more body weight than dieting alone, to feel lighter, healthier, and more confident

Individual results may and will differ. Always consult a physician prior to any diet or exercise program

‡SCIENTIFIC STUDIES ON INGREDIENTS IN BELLY OFF: 1) Med Sci Sports Exerc. 2004 May;36(5):814-20. 2) Eur J Clin Nutr. 2003 Apr;57(4):595-603. 3) Br J Nutr. 2002 Sep;88(3):243-51. 4) Lipids. 2001 Mar;36(3):221-7. 5) Am J Clin Nutr. 2004 Jun;79(6):1118-25. 6) J Int Med Res. 2001 Sep-Oct;29(5):392-6. 7) Int J Obes Relat Metab Disord. 2001 Aug;25(8):1129-35. 8) Lipids. 2001 Aug;36(8):773-81. 9) J Nutr. 2000 Dec;130(12):2943-8. 10) J Nutr. 2007 May;137(5):1188-93. 11) Br J Nutr. 2007 May;97(5):1001-11. 12) Br J Nutr. 2007 Mar;97(3):550-60. 13) Br J Nutr. 2007 Feb;97(2):273-80. 14) Int J Obes (Lond). 2007 Mar;31(3):481-7. 15) Am J Clin Nutr. 2007 May;85(5):1203-11. 16) J Pharm Pharmacol. 1992 Sep;44(9):769-71. For full scientific references, visit BioGeneticLabs.com

QUALITY SATISFACTION GUARANTEE: If, for whatever reason, you are not satisfied, return it to your original place of purchase for the appropriate refund.

NEW WEIGHT-LOSS BREAKTHROUGH

COMBINED WITH DIET PROTOCOL INCLUDED!

Made in the USA with ingredients of international and domestic origin.

Seek the advice of a healthcare professional before beginning any supplement or exercise program. If you or your doctor has any questions about this product, please call 1-888-752-6615. Improper use of this product will not improve results and is not advised. Only follow a reduced calorie diet under the supervision of a doctor.

COMBINED WITH DIET PROTOCOL INCLUDED!

NOTICE: FOR BEST RESULTS, FOLLOW THE SCIENTIFICALLY DESIGNED DIET PLAN INCLUDED.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

032613

Seals/Symbols

CLINICALLY RESEARCHED KEY INGREDIENTS

BioGenetic Laboratories

Made in the USA

Brand IP Statement(s)

CLA + YGD Weight-Loss Blend

2013 iSatori, Inc.

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

NOTICE: KEEP OUT OF REACH OF CHILDREN. Not intended for individuals under the age of 18, unless instructed by a doctor.

Consult your physician prior to use if you have high blood pressure or heart problems or are taking prescription drugs.

Do not exceed the recommended daily intake.

THIS PRODUCT CONTAINS SOY.

Consult with your primary physician prior to use if you have any pre-existing medical conditions, including high blood pressure, thyroid problems, nervous disorders, or if you are using MAO inhibitors or taking any prescription drugs.

Individuals who are sensitive to caffeine should begin use with one-half the recommended dosage and limit the use of other caffeine-containing foods and drinks while taking this product because too much caffeine may cause nervousness, irritablitly, and sleeplessness.

DO NOT USE IF SAFETY SEAL UNDER CAP IS BROKEN.

Suggested/Recommended/Usage/Directions

DIRECTIONS FOR USE: As a dietary supplement, adults take 1 to 2 servings with each morning, lunch and afternoon meal, or as recommended by a physician. Please read the entire label carefully before use, and follow the diet plan

Formula

THIS PRODUCT CONTAINS SOY.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Belly Off by BioGenetic Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Belly Off label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Belly Off by BioGenetic Laboratories

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Conjugated Linoleic Acid

1000 mg per serving Form: Safflower Oil

YGD Weight-Loss Blend

381 mg per serving

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Mono {Glycerides} & Di-Glycerides, Yellow Beeswax, Purified Water, Sorbitol, Soy Lecithin, Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Belly Off by BioGenetic Laboratories Drug Interactions

Want to check YOUR meds against Belly Off?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,102Drugs
8 Major 588 Moderate 506 Minor

Ingredients driving the most interactions

Yerba Mate (herb) (leaf) extract 1,086
Guarana (seed) extract 655
Damiana (leaf) 4:1 concentrate 86

Individual Drug Interactions

The ingredients in Belly Off interact with 1,102 drugs. Click any drug to see the details.

3 of the 4 ingredients in Belly Off interact with drugs. Each result below shows which ingredient is responsible. Yerba Mate (herb) (leaf) extract Guarana (seed) extract Damiana (leaf) 4:1 concentrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Belly Off with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Yerba Mate (herb) (leaf) extract43 drug types · 1,086 drugs

Ephedrine

Theoretically, the caffeine in yerba mate might increase the risk for stimulant adverse effects when used concomitantly with ephedrine.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, the caffeine in yerba mate might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Yerba mate contains caffeine. Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. Still, some researchers recommend that methylxanthines, such as caffeine, as well as methylxanthine-containing products, should be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, the caffeine in yerba mate may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Yerba mate contains caffeine. Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, the caffeine in yerba mate might reduce the efficacy of benzodiazepines.
Yerba mate contains caffeine. Caffeine can antagonize the anxiolytic effects of benzodiazepines.

Likelihood Probable Evidence D
Beta-Adrenergic Agonists

Theoretically, the caffeine in yerba mate might increase the cardiac inotropic effects of beta-agonists, especially if taken in large amounts.
Yerba mate contains caffeine. Caffeine can increase cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, the caffeine in yerba mate might reduce the effects of carbamazepine and increase the risk for convulsions.
Yerba mate contains caffeine. Animal research suggests that caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine two-fold in healthy individuals.

Likelihood Possible Evidence B
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of the caffeine contained in yerba mate.
Yerba mate contains caffeine. Cimetidine decreases caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Theoretically, the caffeine in yerba mate might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Yerba mate contains caffeine. Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, the caffeine in yerba mate might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Yerba mate contains caffeine. Caffeine inhibits dipyridamole-induced vasodilation. Still, some researchers recommend that methylxanthines, such as caffeine, as well as methylxanthine-containing products, should be stopped 24 hours prior to pharmacological stress. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram might increase the levels and adverse effects of the caffeine in yerba mate.
Yerba mate contains caffeine. Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, the caffeine in yerba mate might increase the risk of hypokalemia when used concomitantly with other diuretics.
Yerba mate contains caffeine. Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of the caffeine in yerba mate.
Yerba mate contains caffeine. Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, the caffeine in yerba mate might reduce the effects of ethosuximide and increase the risk for convulsion.
Yerba mate contains caffeine. Animal research shows that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, the caffeine in yerba mate might reduce the effects of felbamate and increase the risk for convulsion.
Yerba mate contains caffeine. Animal research shows that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, the caffeine in yerba mate might increase the levels and adverse effects of flutamide.
Yerba mate contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of the caffeine in yerba mate.
Yerba mate contains caffeine. Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Theoretically, abrupt withdrawal of the caffeine in yerba mate might increase serum lithium levels.
Yerba mate contains caffeine, which has diuretic activity. When abruptly discontinued, it might alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal.

Likelihood Probable Evidence D
Midazolam (Versed)

Theoretically, use of yerba mate with midazolam might increase midazolam metabolite levels and adverse effects.
In vitro research shows that yerba mate extract containing 6.75% chlorogenic acid significantly inhibits the metabolism of midazolam via inhibition of cytochrome P450 3A4 (CYP3A4).

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, the caffeine in yerba mate might increase risk of a hypertensive crisis when used concomitantly with MAOIs.
Yerba mate contains caffeine. Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, the caffeine in yerba mate might increase risk of hypertension when used concomitantly with nicotine.
Yerba mate contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence D
Pentobarbital (Nembutal)

Theoretically, the caffeine in yerba mate might decrease the effects of pentobarbital.
The caffeine in yerba mate might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, the caffeine in yerba mate might reduce the effects of phenobarbital and increase the risk for convulsions.
Yerba mate contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension as well as the levels and adverse effects of the caffeine in yerba mate.
Yerba mate contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, the caffeine in yerba mate might reduce the effects of phenytoin and increase the risk for convulsions.
Yerba mate contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence B
Pioglitazone (Actos)

Theoretically, the caffeine in yerba mate might increase the levels and clinical effects of pioglitazone.
Yerba mate contains caffeine. Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Yerba Mate (herb) (leaf) extract full monograph & all 43 interactions

Guarana (seed) extract41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Guarana contains caffeine. Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, guarana might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Guarana contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, guarana may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that guarana extract can inhibit platelet aggregation. This effect may be due to the caffeine in guarana, which is also reported to have antiplatelet activity. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, concomitant use might increase the clinical effects of beta-adrenergic agonists.
Guarana contains caffeine. Theoretically, concomitant use of large amounts of caffeine might increase cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, guarana might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when given to animals in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine two-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, concomitant use might increase the effects and adverse effects of caffeine in guarana.
Guarana contains caffeine. Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Theoretically, guarana might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Guarana contains caffeine. Caffeine can increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Researchers speculate that caffeine might inhibit CYP1A2. However, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to the interaction between clozapine and caffeine.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, guarana might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Guarana contains caffeine. Caffeine might inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram might increase the risk of adverse effects from caffeine.
In human research, disulfiram decreases the clearance and increases the half-life of caffeine.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, using guarana with diuretic drugs might increase the risk of hypokalemia.
Guarana contains caffeine. Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Guarana contains caffeine. Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, guarana might reduce the effects of ethosuximide and increase the risk for convulsions.
Guarana contains caffeine. Animal research shows that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. This effect has not been observed in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, guarana might reduce the effects of felbamate and increase the risk for convulsions.
Guarana contains caffeine. Animal research shows that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. This effect has not been observed in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, guarana might increase the levels and adverse effects of flutamide.
Guarana contains caffeine. In vitro evidence shows that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Guarana contains caffeine. Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Theoretically, abrupt guarana withdrawal might increase the levels and adverse effects of lithium.
Guarana contains caffeine. Theoretically, abrupt caffeine withdrawal might increase serum lithium levels. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Guarana contains caffeine. Caffeine has been shown to inhibit MAO-A and -B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Guarana contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence D
Pentobarbital (Nembutal)

Theoretically, guarana might decrease the effects of pentobarbital.
Guarana contains caffeine. In vivo evidence suggests that caffeine can negate the hypnotic effects of pentobarbital in humans. However, animal research suggests that guarana does not alter the hypnotic effect of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, guarana might reduce the effects of phenobarbital and increase the risk for convulsions.
Guarana contains caffeine. Animal research shows that caffeine can decrease the anticonvulsant activity of phenobarbital. The exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Guarana contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, guarana might reduce the effects of phenytoin and increase the risk for convulsions.
Guarana contains caffeine. Animal research shows that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, guarana might increase the levels and clinical effects of pioglitazone.
Guarana contains caffeine. Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Guarana contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, concomitant use might increase stimulant adverse effects.
Guarana contains caffeine. Due to the central nervous system (CNS) stimulant effects of caffeine, concomitant use with stimulant drugs can increase the risk of adverse effects.

Likelihood Possible Evidence D
Guarana (seed) extract full monograph & all 41 interactions

Damiana (leaf) 4:1 concentrate1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that taking damiana lowers blood glucose level.

Likelihood Possible Evidence D
Damiana (leaf) 4:1 concentrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Belly Off, from the product label.

BioGenetic Laboratories

See all BioGenetic Laboratories products
Name
BioGenetic Laboratories a division of iSatori
Street Address
15000 W. 6th Ave., Ste. #202
City
Golden
State
CO
ZipCode
80401
Phone Number
1-888-752-6615
Web Address
www.BioGeneticLabs.com
Pharmacist Counseling Corner

Belly Off by BioGenetic Laboratories: Common Questions

Does Belly Off by BioGenetic Laboratories interact with any medications?
Yes. Based on its ingredients, Belly Off has a known interaction with 1,102 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Belly Off contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Belly Off if I'm pregnant or breastfeeding?
Guarana should be avoided during pregnancy and limited while breastfeeding. Yerba mate is advised against during both pregnancy and lactation. Damiana has insufficient safety data and should be avoided in both pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What side effects might I get from guarana or yerba mate?
Both are high in caffeine, so expect possible stomach burning, nausea, dizziness, insomnia, nervousness, restlessness, tremors, headache, and anxiety—especially with larger doses or long-term use. Caffeine allergy with anaphylaxis is rare but possible.
Does this product actually help with weight loss?
The evidence we hold doesn't establish that the ingredients work for weight loss. Each ingredient's effectiveness for its stated purpose is rated insufficient in our data.
What is damiana supposed to do in this product?
Damiana is a traditional herbal extract, but we don't have reliable evidence that it works for the conditions it's used for—sexual function, asthma, depression, or others. Its effectiveness rating is insufficient.
Is it safe to use Belly Off with my seizure medication?
No. Guarana and yerba mate—both high in caffeine—carry Moderate interactions with seizure medications like valproate, felbamate, and carbamazepine. Caffeine may reduce how well they work. Talk to your pharmacist before taking this product.
What's the YGD Weight-Loss Blend on the ingredient list?
That's a blend container for the other three active ingredients: guarana, yerba mate, and damiana. The individual components are listed separately.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Belly Off is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Belly Off label
Go deeper

The Full Monographs Behind Belly Off’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Guarana

Interacts with 655 drugs

Guarana is an Amazonian seed that is naturally high in caffeine, which explains most of its stimulant and energy effects. While it may give a short-term boost in alertness and reduce fatigue...

Read the full Guarana monograph → Herb & supplement monograph

Yerba Mate

Interacts with 1,086 drugs

Yerba mate is a caffeine-containing herbal beverage from South America that is widely enjoyed for its stimulating, coffee-like effects. While it is rich in antioxidants and is being studied...

Read the full Yerba Mate monograph → Herb & supplement monograph

Damiana

Interacts with 86 drugs

Damiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limited. It is generally well tolerated in the small am...

Read the full Damiana monograph →
Sources

Sources & How We Checked

Belly Off's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 239 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guarana 114 references
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See these in context on the Guarana monograph →

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See these in context on the Damiana monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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