Benfotiamine Ingredients & Drug Interactions
by XYMOGEN
What is this page for?
First and foremost: checking Benfotiamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Benfotiamine is a dietary supplement by XYMOGEN with 1 active ingredient. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), supporting healthy nerve function, thiamine deficiency.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Benfotiamine by XYMOGEN
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: benfotiamine, a fat-soluble form of thiamine (vitamin B1) that your body absorbs more easily than regular thiamine. The capsule also includes inactive ingredients — microcrystalline cellulose, hypromellose, water, ascorbyl palmitate, silica, and medium chain triglyceride oil — that help deliver and protect the active ingredient.
Does it work?
Moderate evidence
Benfotiamine is possibly effective for diabetic nerve damage (diabetic neuropathy). For diabetic kidney disease (diabetic nephropathy), the evidence suggests it's possibly ineffective.
For Alzheimer disease, alcohol use disorder, and general nerve damage (peripheral neuropathy) without diabetes, we don't have enough reliable evidence to rate how well it works.
How safe is it?
Well-documented data
Benfotiamine is generally well tolerated in the studies we have, but long-term safety isn't fully established. In a clinical trial of 98 patients taking 300–600 mg daily for 6 weeks, a small number reported allergic skin reactions and mild stomach discomfort — rates that matched placebo, so the supplement wasn't singled out.
There isn't enough safety information to recommend it in pregnancy; talk with your doctor or pharmacist for personalized advice. Safety while breastfeeding hasn't been well studied, so caution is advised.
Meds to double-check
No known interactions
No interactions are documented in our data for benfotiamine with any medication types. Still, if you take blood sugar medications or anything new, run it by your pharmacist — absence of documented interactions isn't a guarantee none exist.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
If you have diabetic nerve pain and your doctor suggests it, benfotiamine is an option worth discussing. The evidence for other uses — like Alzheimer disease or general nerve damage — isn't clear yet.
Because long-term safety data is limited, check with your pharmacist before you start, especially if you're pregnant, breastfeeding, or on blood sugar medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Benfotiamine, straight from the product label.
| Brand | XYMOGEN |
|---|---|
| Barcode (UPC) | 871149003616 |
| Net contents | 120 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2025 |
| DSLD ID | 335430 |
| Product type | Vitamin |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Benfotiamine by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Benfotiamine | 300 mg | -- |
Other ingredients: Microcrystalline Cellulose, Hypromellose, Water, Ascorbyl Palmitate, Silica, Medium Chain Triglyceride Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Take 2 capsules twice daily, or use as directed by your healthcare professional.
Precautions
Consult your healthcare professional prior to use.
Individuals taking medication should discuss potential interactions with their healthcare professional.
Do not use if tamper seal is damaged.
Storage: Keep closed in a cool, dry place out of reach of children.
Formula
Benfotiame is a well-absorbed, bioactive derivative of thiamin. Once absorbed, benfotiamine readily converts to thiamine, an essential vitamin and cofactor in many metabolic reactions, including for transketolase enzyme activity, which is critical in managing advanced glycation end products (AGE), a biomarker associated with aging. This formula is an excellent choice for improving thiamine levels and is indicated for cardiovascular and neurologic support.
Lipid-Soluble, Highly Bioavailable Thiamin Derivative
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
Storage: Keep closed in a cool, dry place out of reach of children.
Formulation
Formulated to exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.
Vegetarian caps
Brand IP Statement(s)
Copyright 2025 XYMOGEN
Xymogen Professional Formulas
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
GMP compliant third-party verified
General Statements
Scan to learn
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Benfotiamine by XYMOGEN label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Benfotiamine by XYMOGEN
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Benfotiamine
No knowninteractions
Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...
Benfotiamine monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Water, Ascorbyl Palmitate, Silica, Medium Chain Triglyceride Oil. These complete the product’s ingredient list but are not active constituents.
Benfotiamine by XYMOGEN Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Benfotiamine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Benfotiamine, from the product label.
XYMOGEN
See all XYMOGEN products- Name
- XYMOGEN Professional Formulas
- Street Address
- 6900 Kingspointe Pkwy.
- City
- Orlando
- State
- FL
- ZipCode
- 32819
- Phone Number
- 800-647-6100
- Web Address
- xymogen.com
Benfotiamine by XYMOGEN: Common Questions
Does Benfotiamine by XYMOGEN interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will benfotiamine help my diabetic nerve pain?
What side effects might I get?
Is it safe to take while pregnant or breastfeeding?
Can I take this for Alzheimer disease or general nerve damage?
What is benfotiamine, and why is it different from regular B1?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Benfotiamine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Benfotiamine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Benfotiamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 1 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Benfotiamine 1 reference
- Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116(10):600-5. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC