Interactions on record — worth a quick check against your medications. Based on 4 of 8 ingredients. Check your meds →
Dietary supplement

Best BCAA Rainbow Ice Ingredients & Drug Interactions

by BPI Sports

Best BCAA Rainbow Ice label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Best BCAA Rainbow Ice against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Best BCAA Rainbow Ice is a dietary supplement by BPI Sports with 8 active ingredients. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine, Safflower Oil powder, Coconut Oil powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Best BCAA Rainbow Ice by BPI Sports

Ask about any prescription or over-the-counter medication and we check it for interactions with Best BCAA Rainbow Ice by BPI Sports — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Best BCAA Rainbow Ice by BPI Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 8 active ingredients.
  • “CLA Matrix (Proprietary Blend)” is a proprietary blend — the label gives one combined amount (1 Gram(s)) without saying how much of each component you get.

Best BCAA Rainbow Ice is a powder containing 8 ingredients, including branched-chain amino acids (BCAAs) in the form of three dipeptide-based compounds — Glycyl-Alanyl-Lysine-L-Leucine, Glycyl-Alanyl-Lysine-L-Isoleucine, and Glycyl-Alanyl-Lysine-L-Valine — which support muscle function and recovery. The formula also includes agmatine (a byproduct of the amino acid arginine), a proprietary CLA matrix (conjugated linoleic acid blend), and three oil powders: safflower, avocado, and coconut.

Inactive ingredients include maltodextrin, natural and artificial flavors, citric acid, malic acid, sucralose, acesulfame-K, silica, FD&C Blue No. 1, and an oligopeptide-enzymatic technology.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: lean muscle recovery and muscle protein synthesis.
  • We looked for evidence on: Athletic performance, Muscle strength, muscle recovery, exercise performance, post-workout recovery.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The data we hold does not establish effectiveness ratings for the BCAA compounds in this formula. For the other active ingredients — agmatine, safflower oil, avocado oil, and coconut oil — the evidence in our files shows ratings of Insufficient Reliable Evidence or no established effectiveness for athletic performance, weight management, or metabolic conditions.

That doesn't mean they don't work; it means the research we have on file is too limited or unclear to make a solid claim.

The evidence, ingredient by ingredient Agmatine Safflower Avocado Coconut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Agmatine appears generally well tolerated in short-term use, though long-term safety in humans hasn't been well studied. The most common side effects reported are diarrhea, indigestion (dyspepsia), and nausea, which appeared within 2–3 days in a small number of trial participants and resolved when they stopped taking it.

Safflower oil in food amounts is generally well tolerated, but concentrated extracts and high-dose supplements carry less safety data; rare case reports link very high doses to liver failure, though the exact dose threshold is unclear. Avocado is widely eaten and considered safe as a food, though concentrated supplements haven't been studied much in pregnancy.

Coconut is generally well tolerated at normal food doses, but high-dose concentrated supplements lack safety data. Allergic reactions to coconut — ranging from hives to anaphylaxis — are rare but possible, especially with oral exposure.

Side effects, ingredient by ingredient Agmatine Safflower Avocado Coconut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Safflower, Avocado, Coconut, Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take blood thinners or warfarin — safflower oil and avocado oil can interfere with their effect or increase bleeding risk (Moderate severity). If you take blood pressure medications, agmatine may theoretically lower your blood pressure further (Moderate).

If you take diabetes medications, both agmatine and coconut oil may theoretically increase the risk of low blood sugar — agmatine at Moderate severity and coconut oil at Minor severity (Minor). If you take any of these medication types, run your exact prescriptions through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for people looking to support muscle recovery and performance with branched-chain amino acids and specialized compounds. If you take blood pressure medications, diabetes medications, or blood thinners (especially warfarin), talk to your pharmacist before starting — the interactions documented here could affect how your drugs work.

Agmatine, safflower oil, and avocado oil all need a quick check against your current prescriptions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Best BCAA Rainbow Ice, straight from the product label.

Brand BPI Sports
Barcode (UPC) 811213026530
Net contents 10.58 Ounce(s); 300 Gram(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 259462
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Best BCAA Rainbow Ice by BPI Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Gram(s)
Maximum serving Sizes:
10 Gram(s)
Servings per container
30
UPC/BARCODE
811213026530
IngredientAmount% DV
Conjugated Linoleic Acid0 NP--
Glycyl-Alanyl-Lysine-L-Leucine2.5 Gram(s)--
Glycyl-Alanyl-Lysine-L-Isoleucine1.25 Gram(s)--
Glycyl-Alanyl-Lysine-L-Valine1.25 Gram(s)--
Agmatine250 mg--
CLA Matrix (Proprietary Blend)1 Gram(s)--
Safflower Oil powder0 NP--
Avocado Oil powder0 NP--
Coconut Oil powder0 NP--

Other ingredients: Oligopeptide-Enzymatic Technology, Maltodextrin, Natural & Artificial Flavors, Citric Acid, Fiber Blend, Malic Acid, Sucralose, Acesulfame-K, Silica, FD&C Blue No. 1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Limited edition New flavor!

When combined with a proper exercise and nutrition regimen. Statements based on early-stage independent 3rd party in vivo and/or in vitro model scientific research data findings for individual ingredients. Weight is based on total of Oligopeptides. Not based on single ingredient weight of Leucine, Isoleucine, or Valine. Facebook www.facebook.com/BPIonline

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

To report an adverse event or for more information call: 954.926.0900 (tel)

Warnings: Not intended for use by persons under age 18.

Do not exceed recommended dose.

The daily recommended intake for agmatine should not exceed 1000 mg/day.

Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, you are pregnant, nursing or thinking about becoming pregnant.

Discontinue use two weeks prior to surgery.

Keep this product and all supplements out of the reach of children.

Contain(s): Tree nuts (coconut).

Formulation

Lean muscle Recovery

Muscle recovery Muscle protein synthesis Lean muscle

Brand IP Statement(s)

Be better. Be stronger. BPI.

Formula

Rainbow ice Natural and artificial flavors Delicious flavor Peptide linked branched chain aminos

+ CLA Matrix + Agmatine

CLA Matrix 5g BCAA Oligopeptides Agmatine sulfate

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Take 1 scoop blended into 8oz water Pre/intra/post workout

Please read entire label before use. Suggested Use: Take one (1) serving (1 scoop) blended into 8oz of ice cold water, either before, during, or after workout, or as directed by a qualified healthcare practitioner. On non-training days, take one (1) serving (1 scoop) first thing in the morning, on an empty stomach, or as directed by a qualified healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Best BCAA Rainbow Ice by BPI Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Best BCAA Rainbow Ice label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Best BCAA Rainbow Ice by BPI Sports

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glycyl-Alanyl-Lysine-L-Leucine

2.5 Gram(s) per serving Form: Oligopeptide-Enzymatic Technology Glycyl-Alanyl-Lysine-L-Leucine

Glycyl-Alanyl-Lysine-L-Isoleucine

1.25 Gram(s) per serving Form: Oligopeptide-Enzymatic Technology Glycyl-Alanyl-Lysine-L-Isoleucine

Glycyl-Alanyl-Lysine-L-Valine

1.25 Gram(s) per serving Form: Oligopeptide-Enzymatic Technology Glycyl-Alanyl-Lysine-L-Valine

Agmatine

Interacts with
258 drugs
250 mg per serving Form: Oligopeptide-Enzymatic Technology Agmatine Sulfate

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine monograph & interactions

CLA Matrix (Proprietary Blend)

1 Gram(s) per serving

Other (inactive) ingredients: Oligopeptide-Enzymatic Technology, Maltodextrin, Natural & Artificial Flavors, Citric Acid, Fiber Blend, Malic Acid, Sucralose, Acesulfame-K, Silica, FD&C Blue No. 1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Best BCAA Rainbow Ice by BPI Sports Drug Interactions

Want to check YOUR meds against Best BCAA Rainbow Ice?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Agmatine 258
Safflower Oil powder 208
Coconut Oil powder 86
Avocado Oil powder 2

Individual Drug Interactions

The ingredients in Best BCAA Rainbow Ice interact with 375 drugs. Click any drug to see the details.

4 of the 8 ingredients in Best BCAA Rainbow Ice interact with drugs. Each result below shows which ingredient is responsible. Agmatine Safflower Oil powder Coconut Oil powder Avocado Oil powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Best BCAA Rainbow Ice with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine full monograph & interactions

Safflower Oil powder3 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Small clinical studies show that taking safflower oil, approximately 55 grams daily for 2-3 weeks, decreases platelet aggregation. However, taking lower doses of safflower oil, such as 5 grams daily for 4 weeks, does not seem to affect platelet function. In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, safflower oil might alter the effects of antidiabetes drugs.
Some clinical research shows that taking safflower oil 10 grams daily for 3 weeks can increase fasting blood glucose in patients with type 2 diabetes. However, clinical research in patients with metabolic syndrome with or without impaired glucose tolerance shows that taking safflower oil 8 grams daily for 12 weeks reduces fasting glucose levels by around 8 mg/dL. Some clinical research also shows that taking safflower oil 8 grams daily for 16 weeks does not affect fasting glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence B
Warfarin

Theoretically, safflower oil might increase the risk of bleeding when taken with warfarin.
In one case report, a 74-year-old male stabilized on warfarin developed urinary tract bleeding and an elevated INR after taking a safflower extract 20 grams daily for 14 days.

Likelihood Possible Evidence D
Safflower Oil powder full monograph & interactions

Coconut Oil powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that coconut milk might increase insulin levels and/or decrease blood glucose levels.

Likelihood Unlikely Evidence D
Coconut Oil powder full monograph & interactions

Avocado Oil powder1 drug type · 2 drugs

Warfarin (Coumadin)

Avocado may antagonize the anticoagulant effects of warfarin.
Avocado may antagonize the anticoagulant effects of warfarin; however, there has been only one case report of this interaction.

Likelihood Unlikely Evidence D
Avocado Oil powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Best BCAA Rainbow Ice, from the product label.

BPI Sports

See all BPI Sports products
Name
BPI Sports
Street Address
3149 SW 42nd St. Suite 200
City
Hollywood
State
FL
ZipCode
33312
Phone Number
954.926.0900
Web Address
www.bpisports.com
Pharmacist Counseling Corner

Best BCAA Rainbow Ice by BPI Sports: Common Questions

Does Best BCAA Rainbow Ice by BPI Sports interact with any medications?
Yes. Based on its ingredients, Best BCAA Rainbow Ice has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Best BCAA Rainbow Ice contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are BCAAs and what do they do?
BCAAs — branched-chain amino acids — are three essential amino acids (leucine, isoleucine, and valine) that your muscles use for recovery and repair. This product delivers them in a specialized peptide form, though the research we hold does not establish effectiveness for athletic performance at this time.
Can I take this if I'm pregnant or breastfeeding?
We don't have enough safety data on agmatine, safflower oil, avocado oil powder, or the BCAA compounds in pregnancy or while breastfeeding. Safflower flower has traditionally been used to bring on menstruation and should be avoided in medicinal amounts during pregnancy. Talk to your doctor or pharmacist before starting — they can weigh the risks and benefits for your situation.
What side effects might I experience?
Agmatine may cause diarrhea, indigestion, or nausea, which typically appear within a few days and go away if you stop taking it. Allergic reactions to coconut (ranging from hives to anaphylaxis) are rare but possible. We don't have specific side-effect data on the other ingredients at the doses in this product.
Is this safe to use long-term?
Agmatine appears well tolerated in short-term use, but long-term safety in humans hasn't been well studied. Safflower oil at very high doses has been linked to rare cases of liver failure, though the threshold isn't clear. Talk to your pharmacist about your personal use plan.
Does this product have any fillers?
The product contains inactive ingredients including maltodextrin, silica, sucralose, acesulfame-K, citric acid, malic acid, flavoring, food coloring, and a fiber blend — these are typical for a powder supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Best BCAA Rainbow Ice is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Best BCAA Rainbow Ice label
Go deeper

The Full Monographs Behind Best BCAA Rainbow Ice’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph → Herb & supplement monograph

Safflower

Interacts with 208 drugs

Safflower is a thistle-like plant used mainly for its seed oil (a common cooking oil) and its colorful flowers. Safflower oil is a reasonable source of unsaturated fats, but strong proof tha...

Read the full Safflower monograph → Herb & supplement monograph

Avocado

Interacts with 2 drugs

Avocado is a nutritious fruit rich in healthy monounsaturated fats, fiber, and potassium, and eating it as part of a balanced diet may support heart health. A specific extract called avocado...

Read the full Avocado monograph → Herb & supplement monograph

Coconut

Interacts with 86 drugs

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) h...

Read the full Coconut monograph →
Sources

Sources & How We Checked

Best BCAA Rainbow Ice's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Safflower 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Borkman M, Chisholm DJ, Furler SM, et al. Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 1989;38:1314-9.. PubMed
  5. Amato, P. and Quercia, R. A. A historical perspective and review of the safety of lipid emulsion in pregnancy. Nutr Clin Pract. 1991;6(5):189-192. PubMed
  6. Demke, D. M., Peters, G. R., Linet, O. I., Metzler, C. M., and Klott, K. A. Effects of a fish oil concentrate in patients with hypercholesterolemia. Atherosclerosis 1988;70(1-2):73-80. PubMed
  7. Kaji, K., Yoshida, S., Nagata, N., Yamashita, T., Mizukoshi, E., Honda, M., Kojima, Y., and Kaneko, S. An open-label study of administration of EH0202, a health-food additive, to patients with chronic hepatitis C. J Gastroenterol. 2004;39(9):873-878. PubMed
  8. Kwon, J. S., Snook, J. T., Wardlaw, G. M., and Hwang, D. H. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. Am.J.Clin.Nutr. PubMed
  9. Lloyd-Still, J. D., Simon, S. H., Wessel, H. U., and Gibson, L. E. Negative effects of oral fatty acid supplementation on sweat chloride in cystic fibrosis. Pediatrics 1979;64(1):50-52. DOI
  10. Challen, A. D., Branch, W. J., and Cummings, J. H. The effect of aspirin and linoleic acid on platelet aggregation, platelet fatty acid composition and haemostasis in man. Hum Nutr Clin Nutr 1983;37(3):197-208.
  11. Asp ML, Collene AL, Norris LE, Cole RM, Stout MB, Tang SY, Hsu JC, Belury MA. Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, cro
  12. Liu Y, Liu S, Shi Y, et al. Effects of safflower injection on the pharmacodynamics and pharmacokinetics of warfarin in rats. Xenobiotica. 2017 Oct 25:1-6. [Epub ahead of print] PubMed
  13. de Ataide EC, Reges Perales S, de Oliveira Peres MA, et al. Acute liver failure induced by Carthamus tinctorius oil: Case reports and literature review. Transplant Proc. 2018;50(2):476-477. PubMed
  14. Ruyvaran M, Zamani A, Mohamadian A, et al. Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial. PubMed

See these in context on the Safflower monograph →

Avocado 10 references
  1. Blickstein D, Shaklai M, Inbal A. Warfarin antagonism by avocado. Lancet 1991;337:914-5. PubMed
  2. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  3. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  4. Stucker M, Memmel U, Hoffmann M, et al. Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis. Dermatology 2001;203:141-7.
  5. Ahlroth, M., Alenius, H., Turjanmaa, K., Makinen-Kiljunen, S., Reunala, T., and Palosuo, T. Cross-reacting allergens in natural rubber latex and avocado. J.Allergy Clin.Immunol. 1995;96(2):167-173. PubMed
  6. de Groot, A. C., van der Meeren, H. L., and Weyland, J. W. Contact allergy to avocado oil in a sunscreen. Contact Dermatitis 1987;16(2):108-109. PubMed
  7. Blanco, C., Carrillo, T., Castillo, R., Quiralte, J., and Cuevas, M. Avocado hypersensitivity. Allergy 1994;49(6):454-459. PubMed
  8. Crisi, G. and Belsito, D. V. Contact urticaria from latex in a patient with immediate hypersensitivity to banana, avocado and peach. Contact Dermatitis 1993;28(4):247-248.
  9. Cherian S, Neupert K, Varshney P. Avocado as an emerging trigger for food protein-induced enterocolitis syndrome. Ann Allergy Asthma Immunol. 2018;121(3):369-71. PubMed
  10. Lichtenstein AH, Kris-Etherton PM, Petersen KS, et al. Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial. J Am Heart Assoc 2022;11(14):e025657.

See these in context on the Avocado monograph →

Coconut 10 references
  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
  3. Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. Int Arch Allergy Immunol 1994;103(2):194-201. PubMed
  4. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
  5. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
  6. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
  8. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

See these in context on the Coconut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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