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Dietary supplement

Best Energy Featuring Niagen Ingredients & Drug Interactions

by Doctor's Best

Best Energy Featuring Niagen label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Best Energy Featuring Niagen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Best Energy Featuring Niagen is a dietary supplement by Doctor's Best with 1 active ingredient. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Nicotinamide Riboside. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Best Energy Featuring Niagen by Doctor's Best

Ask about any prescription or over-the-counter medication and we check it for interactions with Best Energy Featuring Niagen by Doctor's Best — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Best Energy Featuring Niagen by Doctor's Best

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Best Energy Featuring Niagen contains one active ingredient: nicotinamide riboside (also called Niagen). Nicotinamide riboside is a form of vitamin B3 that your cells can convert into NAD+, a molecule involved in energy production and cellular repair.

The capsule also contains inactive ingredients — cellulose, modified cellulose, silicon dioxide, and magnesium stearate — which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: brain energy optimizer and cellular energy support.
  • We looked for evidence on: Alzheimer disease, Parkinson disease, Athletic performance, Physical performance, Cognitive function, Mitochondrial health — and 2 related terms.
  • The closest evidence on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Parkinson disease, Physical performance.

The evidence for nicotinamide riboside isn't established yet for the conditions studied so far. Our data shows insufficient reliable evidence to rate it for age-related macular degeneration (AMD), Alzheimer disease, athletic performance, nonalcoholic fatty liver disease, and heart failure.

That doesn't mean it doesn't work — it means the clinical trials so far haven't been large or rigorous enough to say either way. Talk with your pharmacist about whether this is right for what you're hoping to address.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears generally well tolerated in short-term studies, though long-term safety isn't fully known yet. The most common side effects reported in clinical trials are bloating, muscle pain, nausea, itching, sweating, and temporary changes in stool.

A few people have reported leg cramps or mild muscle soreness. Because there isn't enough safety data, the facts advise against using it during pregnancy or while breastfeeding — talk with your doctor or pharmacist about your personal situation.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Best Energy Featuring Niagen, check any blood pressure–lowering medications (antihypertensives) you take — nicotinamide riboside may theoretically add to their effect and lower your blood pressure further. Use the medication search tool on this page with your exact drug names to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Best Energy Featuring Niagen is a single-ingredient supplement of nicotinamide riboside, a form of vitamin B3. If you take blood pressure medication, check it with your pharmacist first — there's a small theoretical risk of additive effects.

Otherwise, it's generally well tolerated, though the evidence for specific health claims isn't established yet. Avoid it during pregnancy or breastfeeding without talking to your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Best Energy Featuring Niagen, straight from the product label.

Brand Doctor's Best
Barcode (UPC) 753950003613
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62969
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Best Energy Featuring Niagen by Doctor's Best, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
753950003613
IngredientAmount% DV
Nicotinamide Riboside150 mg--

Other ingredients: Cellulose, Modified Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

ORTHO1 Science-Based Nutrition

NIAGEN is a trademark of Chromadex

Best Energy Featuring NIAGEN supplies authentic nicotinamide riboside (NR), an ORTHO1 nutrient broadly involved in human energy production and metabolic regulation.

General Statements

NR occurs naturally in foods, and is a metabolic starter for NAD (nicotinamide adenine dinucleotide), which our cells absolutely require to make energy. NR also helps regulate cell energy utilization to support structural integrity in the brain, heart, muscles, liver and other organs. Enhances mitochondrial energy production* Facilitates glucose and fat utilization for energy* Promotes energy-dependent regulation of cell functions*

Scan for more info

BRAIN ENERGY OPTIMIZER*

CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS

1A nutrient naturally built into the body's chemistry

FDA Statement of Identity

Dietary Supplement

Formula

Authentic Nicotinamide Riboside

Formulation

Vegan

Non-GMO and Gluten Free

Seals/Symbols

Vegan

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 2 capsules daily, after meals, or more, as recommended by a nutritionally informed physician.

General

P 01/14

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Best Energy Featuring Niagen by Doctor's Best label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Best Energy Featuring Niagen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Best Energy Featuring Niagen by Doctor's Best

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Nicotinamide Riboside

Interacts with
172 drugs
150 mg per serving

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Nicotinamide Riboside monograph & interactions

Other (inactive) ingredients: Cellulose, Modified Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Best Energy Featuring Niagen by Doctor's Best Drug Interactions

Want to check YOUR meds against Best Energy Featuring Niagen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Nicotinamide Riboside 172

Individual Drug Interactions

The ingredients in Best Energy Featuring Niagen interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Best Energy Featuring Niagen interact with drugs. Each result below shows which ingredient is responsible. Nicotinamide Riboside

Each ingredient & the kinds of drugs it affects

For each ingredient in Best Energy Featuring Niagen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nicotinamide Riboside1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Nicotinamide Riboside full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Best Energy Featuring Niagen, from the product label.

Doctor's Best

See all Doctor's Best products
Name
Doctor's Best, Inc.
City
San Clemente
State
CA
ZipCode
92673
Phone Number
(800) 777-2474
Web Address
www.drbvitamins.com
Pharmacist Counseling Corner

Best Energy Featuring Niagen by Doctor's Best: Common Questions

Does Best Energy Featuring Niagen by Doctor's Best interact with any medications?
Yes. Based on its ingredients, Best Energy Featuring Niagen has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Best Energy Featuring Niagen contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is nicotinamide riboside and what does it do?
Nicotinamide riboside is a form of vitamin B3. Your cells convert it into NAD+, a molecule that plays a role in energy production and cellular repair. It's the active ingredient in this product.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data for nicotinamide riboside in pregnancy or breastfeeding, so the safety data advises against it. Talk with your doctor or pharmacist about your personal situation before deciding.
What side effects should I expect?
Most people tolerate it well. The most common side effects reported in trials are bloating, muscle pain, nausea, itching, sweating, and temporary changes in stool. A few people have reported leg cramps or mild muscle soreness.
Does this supplement actually work for anything?
Our data shows insufficient reliable evidence to rate nicotinamide riboside for the conditions studied so far — age-related macular degeneration, Alzheimer disease, athletic performance, fatty liver disease, and heart failure. The research isn't conclusive yet.
Is it safe to take long-term?
Short-term studies show it's generally well tolerated, but long-term safety hasn't been fully studied yet. If you're thinking about taking it for months or years, that's worth discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Best Energy Featuring Niagen is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Best Energy Featuring Niagen label
Go deeper

The Full Monographs Behind Best Energy Featuring Niagen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph →
Sources

Sources & How We Checked

Best Energy Featuring Niagen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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