Interactions on record — worth a quick check against your medications. Based on 2 of 9 ingredients. Check your meds →
Dietary supplement

Bio.Me Barrier Ingredients & Drug Interactions

by Invivo

Bio.Me Barrier label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bio.Me Barrier against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bio.Me Barrier is a dietary supplement by Invivo with 9 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium bifidum W23, Lactobacillus acidophilus W37. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bio.Me Barrier by Invivo

Ask about any prescription or over-the-counter medication and we check it for interactions with Bio.Me Barrier by Invivo — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bio.Me Barrier by Invivo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Ecologic Barrier Probiotics” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Bio.Me Barrier contains 9 active probiotic ingredients: the checked ones are Bifidobacterium bifidum and Lactobacillus acidophilus, plus several others (Bifidobacterium lactis W51, Bifidobacterium lactis W52, Lactobacillus brevis W63, Lactobacillus casei W56, Lactobacillus salivarius W24, Lactobacillus lactis W19, and Lactococcus lactis W58) for which we hold no interaction data. The powder also contains inactive ingredients like maize starch, maltodextrin, and inulin as carriers and prebiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: clinically researched probiotics for gut-brain microbiome.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence is mixed. Bifidobacterium bifidum and Lactobacillus acidophilus are both rated possibly effective for irritable bowel syndrome — meaning there's some promise, but the science isn't ironclad yet.

L. acidophilus is also possibly effective for Helicobacter pylori, antibiotic-associated diarrhea, and bacterial vaginosis. For other conditions like hay fever, anxiety, and Alzheimer's disease, we don't have enough reliable evidence to say either way.

The effectiveness of the other strains in this blend isn't established in the data we hold.

The evidence, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Bifidobacterium bifidum and Lactobacillus acidophilus are generally well tolerated in healthy people. Side effects like bloating, flatulence, and mild stomach discomfort can occur when you take probiotics, but they're uncommon with these species in particular.

If you have a weakened immune system, check with your doctor first — live probiotics carry a theoretical risk in that situation. Pregnancy and lactation data are limited; the available information suggests B. bifidum may be possibly safe in pregnancy, but there's not enough to be certain.

Talk to your doctor or pharmacist before taking this if you're pregnant or nursing.

Side effects, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, hold off on this supplement or space them out — the antibiotics can kill the live organisms in the probiotics. We couldn't check six of the nine strains in this product for interactions, so ask your pharmacist about your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bio.Me Barrier may help with IBS, certain infections, and diarrhea linked to antibiotics, though the evidence is preliminary. If you're on antibiotics, separate them from this supplement by a few hours.

Those with weakened immunity should check with their doctor first. For anyone else, it's generally well tolerated — run your medications through the checker on this page to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio.Me Barrier, straight from the product label.

Brand Invivo
Barcode (UPC) 0710535365931
Net contents 120 Gram(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 215248
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio.Me Barrier by Invivo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gram(s)
Maximum serving Sizes:
2 Gram(s)
UPC/BARCODE
0710535365931
IngredientAmount% DV
Ecologic Barrier Probiotics0 NP--
Bifidobacterium bifidum W230 NP--
Bifidobacterium lactis W510 NP--
Bifidobacterium lactis W520 NP--
Lactobacillus acidophilus W370 NP--
Lactobacillus brevis W630 NP--
Lactobacillus casei W560 NP--
Lactobacillus salivarius W240 NP--
Lactobacillus lactis W190 NP--
Lactococcus lactis W580 NP--

Other ingredients: Maize Starch, Maltodextrin, Inulin, Polydextrose, Vegetable Protein, Potassium Chloride, Magnesium Sulphate, Manganese Sulphate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Food Supplement

General Statements

e

Ecologic Barrier

Carbon Neutral

Formulation

Clinically researched probiotics for the gut-brain microbiome

GMO free

Suitable for vegetarians

Probioact Technology

Storage

No need to refrigerate

Store in the original packaging, at room temperature, in a dry place.

Formula

Suitable for vegetarians

Suggested/Recommended/Usage/Directions

Directions: Mix 2g (1 tsp) daily into 100ml of water. Leave for 1 minute. Stir and take on an empty stomach.

Precautions

Do not exceed the recommended dose, unless advised by your healthcare professional.

When taking antibiotics, wait 2-3 hours before taking Bio.Me Barrier.

Food supplements are not a substitute for a varied and balanced diet or lifestyle.

Keep out of reach of children.

Do not use if immunoccompromised or allergic to any of the ingredients.

Do not use if immunoccompromised or allergic to any of the ingredients.

Seals/Symbols

B Certified Corporation

GMP Certified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bio.Me Barrier by Invivo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bio.Me Barrier label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bio.Me Barrier by Invivo

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gram(s) Dosage formPowder Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Ecologic Barrier Probiotics

0 NP per serving

Other (inactive) ingredients: Maize Starch, Maltodextrin, Inulin, Polydextrose, Vegetable Protein, Potassium Chloride, Magnesium Sulphate, Manganese Sulphate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio.Me Barrier by Invivo Drug Interactions

Want to check YOUR meds against Bio.Me Barrier?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium bifidum W23 182
Lactobacillus acidophilus W37 182

Individual Drug Interactions

The ingredients in Bio.Me Barrier interact with 182 drugs. Click any drug to see the details.

2 of the 9 ingredients in Bio.Me Barrier interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium bifidum W23 Lactobacillus acidophilus W37

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio.Me Barrier with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium bifidum W231 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum W23 full monograph & interactions

Lactobacillus acidophilus W371 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus W37 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bio.Me Barrier, from the product label.

Invivo

See all Invivo products
Name
Invivo Clinical
State
Gloucestershire
ZipCode
GL5 1RN
Web Address
invivohealthcare.com
Pharmacist Counseling Corner

Bio.Me Barrier by Invivo: Common Questions

Does Bio.Me Barrier by Invivo interact with any medications?
Yes. Based on its ingredients, Bio.Me Barrier has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio.Me Barrier contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Bio.Me Barrier work for IBS?
Bifidobacterium bifidum and Lactobacillus acidophilus, two of the strains in this product, are rated possibly effective for irritable bowel syndrome. That means there's encouraging evidence, but it's not a guarantee — response varies from person to person.
Can I take this if I'm on antibiotics?
You can, but timing matters. Antibiotics kill the live bacteria in probiotics, making them less effective. Space them out by a few hours — take your antibiotic, then the probiotic later (or vice versa), and talk to your pharmacist about the best schedule for your specific antibiotic.
What side effects should I watch for?
Bloating, flatulence, and mild stomach discomfort can happen with probiotics in general, though these aren't commonly reported with Bifidobacterium bifidum or Lactobacillus acidophilus specifically. If you experience these, they often settle down as your body adjusts.
Is this safe if I have a weakened immune system?
The data are limited. Live probiotics carry a theoretical risk in immunocompromised patients, so check with your doctor before starting this product if that applies to you.
Can I take this while pregnant or breastfeeding?
There isn't enough data to know for certain. Bifidobacterium bifidum is rated possibly safe in pregnancy, but that's preliminary. Talk to your doctor or pharmacist before using it during pregnancy or lactation — they know your full health picture.
What do all these different Lactobacillus and Bifidobacterium strains do?
They're all live beneficial bacteria meant to support gut health. Bifidobacterium bifidum and Lactobacillus acidophilus have the most evidence; the others in this blend are included for their potential to promote a healthy microbiome, though we don't have robust effectiveness data for them individually.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bio.Me Barrier is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio.Me Barrier label
Go deeper

The Full Monographs Behind Bio.Me Barrier’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Bio.Me Barrier's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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