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Dietary supplement

Bio.Me S. boulardii Ingredients & Drug Interactions

by Invivo

Bio.Me S. boulardii label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bio.Me S. boulardii against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Bio.Me S. boulardii is a dietary supplement by Invivo with 1 active ingredient. Its ingredients are commonly taken for acute diarrhea, antibiotic-associated diarrhea, traveler's diarrhea.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are S. boulardii CNCM I-1079. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bio.Me S. boulardii by Invivo

Ask about any prescription or over-the-counter medication and we check it for interactions with Bio.Me S. boulardii by Invivo — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bio.Me S. boulardii by Invivo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Bio.Me S. boulardii contains one active ingredient: Saccharomyces boulardii CNCM I-1079, a live yeast strain. The capsule also contains an inactive ingredient, hydroxypropyl methylcellulose, which is a binder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: clinical grade Saccharomyces boulardii for gastrointestinal microbiome.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Crohn disease, HIV/AIDS-related diarrhea, Irritable bowel syndrome (IBS), Rotaviral diarrhea — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Saccharomyces Boulardii is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS-related diarrhea, Crohn disease, Ulcerative colitis.

The evidence we hold shows S. boulardii is possibly effective for several types of diarrhea: rotaviral diarrhea (the kind caused by rotavirus), travelers' diarrhea, and diarrhea that develops after taking antibiotics. It's also possibly effective for two serious intestinal conditions: necrotizing enterocolitis in infants (a form of gut inflammation) and Clostridioides difficile infection (a severe bacterial infection of the colon).

Additionally, it's possibly effective for Helicobacter pylori, a stomach bacterium linked to ulcers. In all these cases, the evidence supports its use but isn't conclusive.

The evidence, ingredient by ingredient Saccharomyces Boulardii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

S. boulardii is generally well tolerated in healthy adults. However, it should be avoided by people who are critically ill, immunocompromised (have a weakened immune system), or are in intensive care — especially those with central lines (catheters placed into a vein), on feeding tubes, or taking broad-spectrum antibiotics.

In rare cases, the live yeast has caused a bloodstream infection (fungemia) in these vulnerable patients. Rarely, people have reported mild digestive complaints like stomach cramps, gas, nausea, vomiting, or decreased appetite.

Safety data is limited, so speak with your doctor before use, particularly if you have any serious illness or immune system concerns.

Side effects, ingredient by ingredient Saccharomyces Boulardii

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saccharomyces Boulardii.
  • The most serious interaction on file is rated Minor.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use antifungal medications (drugs to treat fungal infections). Antifungals can reduce S. boulardii's effectiveness because they kill the live yeast.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

S. boulardii may be worth considering if you have one of the types of diarrhea the evidence supports and you're in good overall health. It's not for people who are critically ill, immunocompromised, or hospitalized in intensive care.

Don't take it at the same time as antifungal medications — they'll interfere with each other. Talk it over with your doctor or pharmacist first, especially if you have any serious health condition or immune system weakness.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio.Me S. boulardii, straight from the product label.

Brand Invivo
Barcode (UPC) 7105353660994
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 259872
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio.Me S. boulardii by Invivo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
7105353660994
IngredientAmount% DV
S. boulardii CNCM I-1079500 mg--

Other ingredients: Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Food Supplement

Formula

Clinical grade Saccharomyces boulardii for the gastrointestinal microbiome

Formulation

GMO-free

Vegetarian

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules daily. Do not exceed the recommended dose, unless advised by your healthcare professional.

Precautions

If you are pregnant, breastfeeding, taking medication or under medical supervision, please consult your healthcare professional before use.

Food supplements are not a substitute for a varied and balanced diet or lifestyle.

Keep out of reach of children.

Do not exceed the recommended dose, unless advised by your healthcare professional.

Storage

Store in the original packaging, at room temperature, in a dry place.

Seals/Symbols

Certified B Corporation

GMP Certified

Carbon Neutral

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bio.Me S. boulardii by Invivo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bio.Me S. boulardii label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bio.Me S. boulardii by Invivo

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

S. boulardii CNCM I-1079

Interacts with
40 drugs
500 mg per serving

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea,...

S. boulardii CNCM I-1079 monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio.Me S. boulardii by Invivo Drug Interactions

Want to check YOUR meds against Bio.Me S. boulardii?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Minor

Ingredients driving the most interactions

S. boulardii CNCM I-1079 40

Individual Drug Interactions

The ingredients in Bio.Me S. boulardii interact with 40 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bio.Me S. boulardii interact with drugs. Each result below shows which ingredient is responsible. S. boulardii CNCM I-1079

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio.Me S. boulardii with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

S. boulardii CNCM I-10791 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
S. boulardii CNCM I-1079 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bio.Me S. boulardii, from the product label.

Invivo

See all Invivo products
Name
Invivo Healthcare
State
UK
ZipCode
GL5 2TE
Web Address
invivohealthcare.com
Pharmacist Counseling Corner

Bio.Me S. boulardii by Invivo: Common Questions

Does Bio.Me S. boulardii by Invivo interact with any medications?
Yes. Based on its ingredients, Bio.Me S. boulardii has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio.Me S. boulardii contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Saccharomyces boulardii?
It's a live yeast — a beneficial microorganism that may help restore gut health. Unlike probiotic bacteria, this is a fungal strain that's been studied for its role in preventing and treating certain types of diarrhea.
Can I take this if I'm on an antifungal medication?
Not at the same time. Antifungals kill the yeast in this product, so they'll interfere with each other. Talk with your doctor or pharmacist about the best timing if you need both.
Is it safe if I'm in the hospital or critically ill?
No — this product should be avoided if you're critically ill or immunocompromised, especially if you're in intensive care, on a feeding tube, or have a central line. In rare cases, the live yeast has caused bloodstream infections in these vulnerable patients.
Does this work for all types of diarrhea?
The evidence supports it for specific types: rotaviral diarrhea, travelers' diarrhea, antibiotic-associated diarrhea, and two serious intestinal conditions. It's not established for other causes of diarrhea.
What side effects might I get?
Most people tolerate it well. Rarely, people report mild digestive complaints like stomach cramps, gas, nausea, or vomiting. Very rarely, the live yeast has caused a bloodstream infection, though that's mainly in hospitalized patients with weakened immunity.
Is there enough safety data for me to take this?
Safety information is limited, so it's not a 'set it and forget it' choice. Talk with your doctor before starting, especially if you have any serious health condition or concerns about your immune system.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bio.Me S. boulardii is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio.Me S. boulardii label
Go deeper

The Full Monographs Behind Bio.Me S. boulardii’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph →
Sources

Sources & How We Checked

Bio.Me S. boulardii's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saccharomyces Boulardii 26 references
  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
  7. Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.
  8. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.
  9. Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. PubMed
  10. Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. PubMed
  11. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed
  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.
  16. Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7. PubMed
  17. Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. PubMed
  18. Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8. PubMed
  19. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr 2017;35(3):361-4.
  20. Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380.
  21. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr. 2017 Jul-Sep;35(3):361-364. doi: 10.1590/1984-0462/;2017;35;3;00014.
  22. Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. PubMed
  23. Ventoulis I, Sarmourli T, Amoiridou P, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi (Basel). 2020;6(3):98. PubMed
  24. Wombwell E, Bransteitter B, Gillen LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic. Mycoses 2021;64(12):1521-1526.
  25. Rannikko J, Holmberg V, Karppelin M, et al. Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements. Emerg Infect Dis 2021;27(8):2090-6.
  26. Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. PubMed

See these in context on the Saccharomyces Boulardii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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