Interactions on record — worth a quick check against your medications. Based on 3 of 9 ingredients. Check your meds →
Dietary supplement

Bio.Me Oral Ingredients & Drug Interactions

by Invivo

Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Bio.Me Oral is a dietary supplement by Invivo with 9 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium bifidum W23, Bifidobacterium breve W25. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Bio.Me Oral by Invivo

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Winclove Smile Probiotic” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Bio.Me Oral contains 9 active ingredients—all live probiotic bacteria (also called friendly bacteria or beneficial microorganisms). The ones we have data for are Bifidobacterium bifidum, Bifidobacterium breve, and Streptococcus thermophilus, along with several Lactobacillus and Bifidobacterium strains.

The product also contains three inactive ingredients: maize starch, maltodextrin, and hydrolyzed rice protein—these are fillers and binders that help hold the powder together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: clinically researched probiotics for oral microbiome.
  • We looked for evidence on: Dental plaque, Oral mucositis, Oropharyngeal candidiasis, Pharyngitis, Oral health, Oral microbiome balance — and 1 related terms.
  • The closest evidence on file: Streptococcus Thermophilus is rated "Insufficient Reliable Evidence To Rate" for Oral mucositis (Natural Medicines).
  • Also on file: Bifidobacterium Bifidum is rated "Insufficient Reliable Evidence To Rate" for Dental plaque, Oropharyngeal candidiasis, Pharyngitis.

The evidence for this product is mixed. Bifidobacterium bifidum is possibly effective for irritable bowel syndrome (IBS) and respiratory tract infections, but the evidence for other conditions—including hay fever, anxiety, and cognitive decline—is too limited to rate.

Bifidobacterium breve shows a possibly ineffective rating for age-related cognitive decline and sepsis. Streptococcus thermophilus has insufficient evidence for conditions like antibiotic-associated diarrhea, bacterial vaginosis, and constipation.

In short, the strongest evidence supports use for IBS and respiratory infections, but for most other uses the science isn't established enough yet.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotics are generally well tolerated in healthy people. That said, if you have a weakened immune system, you should be cautious—rare cases of Bifidobacterium infection (bacteremia) have occurred in critically ill patients, preterm infants, and those with central lines.

Bloating and flatulence are reported with probiotics in general, though not specifically tied to the individual strains here. One case of vomiting and fever was reported in a child taking two probiotics together, but it's unclear whether the probiotics caused it.

The safety data are limited, so talk with your doctor or pharmacist before starting, especially if you're very ill or immunocompromised.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Bifidobacterium Breve, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Separate doses of antibiotic drugs from Bio.Me Oral by several hours—antibiotics can kill the live bacteria in the supplement and reduce its effectiveness. The interaction is Moderate in severity.

If you're on any antibiotics, double-check the timing with the interaction tool on this page before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic powder may help with IBS or respiratory infections, but the evidence for other uses isn't clear yet. If you take antibiotics, you'll need to space them apart from this supplement to keep it effective.

Anyone with a weakened immune system should check with their doctor first. Talk to your pharmacist about timing and whether it's right for your specific health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bio.Me Oral, straight from the product label.

Brand Invivo
Barcode (UPC) 7105353660130>
Net contents 30 Gram(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217500
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bio.Me Oral by Invivo, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
UPC/BARCODE
7105353660130>
IngredientAmount% DV
Bifidobacterium bifidum W230 NP--
Bifidobacterium lactis W510 NP--
Lactobacillus salivarius W240 NP--
Lactobacillus plantarum W210 NP--
Winclove Smile Probiotic0 NP--
Bifidobacterium breve W250 NP--
Enterococcus faecium W540 NP--
Lactobacillus rhamnosus W710 NP--
Lactobacillus salivarius W570 NP--
Streptococcus thermophilus W690 NP--

Other ingredients: Maize Starch, Maltodextrin, hydrolyzed Rice Protein

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Food Supplement

Formula

Clinically research probiotics for the oral microbiome

Formulation

GMO free, no need to refrigerate, suitable for vegetarians

GMO free, no need to refrigerate, suitable for vegetarians

Probioact Technology

Storage

GMO free, no need to refrigerate, suitable for vegetarians

Store in the original packaging, at room temperature, in a dry place.

Suggested/Recommended/Usage/Directions

Directions: Mix 1g (0.5 tsp) twice daily into 50ml of water. Leave for 1 minute. Stir before swilling in your mouth for 20 seconds before swallowing.

Precautions

Do not exceed the recommended dose, unless advised by your healthcare professional.

When taking antibiotics, wait 2-3 hours before taking Bio.Me Oral.

Do not use if immunocompromised.

Food supplements are not a substitute for a varied and balanced diet or lifestyle.

Keep out of reach of children.

Seals/Symbols

Certified B Corporation

Carbon Neutral

GMP Certified

See for yourself

Bio.Me Oral by Invivo label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Bio.Me Oral by Invivo

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Winclove Smile Probiotic

0 NP per serving

Other (inactive) ingredients: Maize Starch, Maltodextrin, Hydrolyzed Rice Protein. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bio.Me Oral by Invivo Drug Interactions

Want to check YOUR meds against Bio.Me Oral?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Bio.Me Oral with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium bifidum W231 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D

Bifidobacterium breve W251 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Bio.Me Oral, from the product label.

Invivo

See all Invivo products
Name
Invivo Clinical
State
Gloucestershire
ZipCode
GL5 1RN
Web Address
invivohealthcare.com
Pharmacist Counseling Corner

Bio.Me Oral by Invivo: Common Questions

Does Bio.Me Oral by Invivo interact with any medications?
Yes. Based on its ingredients, Bio.Me Oral has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bio.Me Oral contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm taking an antibiotic?
Not as well as it should. Antibiotics kill bacteria, including the live organisms in this supplement. Space them out by several hours—for example, take your antibiotic in the morning and this powder in the evening—so they don't interfere with each other. Ask your pharmacist for the best timing for your specific antibiotic.
Is Bio.Me Oral safe if I have a weak immune system?
You should be cautious. While rare, infections from probiotic bacteria have been reported in critically ill patients and those with weakened immunity. Talk with your doctor before starting, especially if you're very ill or immunocompromised.
Can I take this while pregnant or breastfeeding?
Bifidobacterium bifidum is rated possibly safe in pregnancy, and Streptococcus thermophilus is also possibly safe in pregnancy. However, the safety data on these probiotic supplements during lactation aren't on file. Since the evidence is limited, it's best to check with your doctor or pharmacist for personalized advice if you're pregnant or nursing.
What side effects should I expect?
Bloating and flatulence are reported with probiotics in general, though these specific strains haven't been particularly linked to them. One case of vomiting and fever was reported in a child, but it's unclear whether the probiotics caused it. Most people tolerate them well.
Does this really help with IBS?
Bifidobacterium bifidum, one of the ingredients, is rated possibly effective for IBS based on available evidence. That means there's some support, but the science isn't definitive yet. It may help some people, but results vary.
What are all these bacterial strains for?
They're all probiotics—live beneficial bacteria meant to support gut health. Each strain has slightly different properties. The blend aims to provide a diverse mix, though the evidence for most specific conditions is still limited or hasn't been fully studied yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bio.Me Oral is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bio.Me Oral label
Sources

Sources & How We Checked

Bio.Me Oral's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Streptococcus Thermophilus 21 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Dolatkhah N, Hajifaraji M, Abbasalizadeh F, Aghamohammadzadeh N, Mehrabi Y, Abbasi MM. Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial. J Health Popul Nutr. 2015;33:25. PubMed
  12. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  13. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  14. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  15. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  16. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  17. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  18. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  19. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  20. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  21. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Streptococcus Thermophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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