BioActive B12 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking BioActive B12 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
BioActive B12 is a dietary supplement by Pure TheraPro Rx with 4 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against BioActive B12 by Pure TheraPro Rx
Ask about any prescription or over-the-counter medication and we check it for interactions with BioActive B12 by Pure TheraPro Rx — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of BioActive B12 by Pure TheraPro Rx
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
BioActive B12 has 4 active ingredients, all forms of vitamin B12: standard vitamin B12, MecobalActive methylcobalamin, adenosylcobalamin, and hydroxocobalamin. These are different shapes of the same essential nutrient your body uses for nerve function, energy, and red blood cells.
The rest is inactive — water, vegetable glycerin, potassium sorbate as a preservative, and citric acid.
Does it work?
Strong evidence
Vitamin B12 is effective for treating B12 deficiency and for Imerslund-Grasbeck disease, a rare condition that prevents B12 absorption. It's also likely effective for cyanide poisoning — which is why it's kept in emergency rooms.
For canker sores and postherpetic neuralgia (nerve pain after shingles), the evidence is possibly effective, meaning it may help but the evidence isn't as solid.
How safe is it?
Well-documented data
B12 is generally very well tolerated by mouth. Your body gets rid of excess in the urine, so there's no established upper limit to worry about.
The most common side effect with injections is soreness at the shot site. Allergic reactions like rash, itching, or hives are rare but possible — they may be tied to the cobalt in the B12 molecule itself.
In rare cases, when B12 corrects a severe type of anemia, dangerously low potassium levels have occurred; your doctor can watch for this if you have that condition. B12 is needed in pregnancy and breastfeeding and is considered safe at normal recommended amounts — follow your provider's guidance.
Meds to double-check
Minor interactions only
If you take metformin for diabetes, let your pharmacist know — this product addresses a Minor interaction with that drug. We have no documented interactions for the other medications we checked, but run your full list through the tool on this page to be sure.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
This is a solid choice if you're deficient in B12 or your metformin is dragging your levels down. If you have an allergy to cobalt, talk to your pharmacist before starting.
Anyone taking other medications should check them below first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about BioActive B12, straight from the product label.
| Brand | Pure TheraPro Rx |
|---|---|
| Barcode (UPC) | X002BIBMEN |
| Net contents | 0.5 fl. Oz.; 15 mL |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 268899 |
| Product type | Vitamin |
| Supplement form | Liquid |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for BioActive B12 by Pure TheraPro Rx, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin B12 | 4000 mcg | 166667% |
| MecobalActive Methylcobalamin | 2000 mcg | 83333% |
| Adenosylcobalamin | 1200 mcg | 50000% |
| Hydroxocobalamin | 800 mcg | 33333% |
Other ingredients: triple distilled Water, USP Kosher certified Vegetable Glycerin, Potassium Sorbate, Citric Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Full Spectrum Maximum Absorption for Energy & Methylation
Vegan + Vegetarian
Formulated to Exclude: Alcohol, fillers, wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and preservatives.
Formulated, tested & packaged in the USA
Concentrated Formula
3-in-1 Support Methylcobalamin Biologically Active Form Patented. Exceptional purity, no harmful solvents are used in production of this product. Adenosylcobalamin Mitochondrial Form Considered an active coenzyme form of B12-utilized directly in B12-dependeint enzyme reactions in the body. Hydroxocobalamin Protector Form Readily converts to methylcobalamin and has a unique role of supporting detoxification processes.
Seals/Symbols
Vegan
GMP Certified Good Manufacturing Practice
FDA Statement of Identity
Professional Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Shake gently before use take up to four (4) drops daily or as directed by a healthcare practitioner. Best taken sublingually or directly onto your tongue. Drops may also be placed into juice or water.
Precautions
Warning: Children and pregnant or lactating women should consult their healthcare practitioner prior to use.
Warning: Children and pregnant or lactating women should consult their healthcare practitioner prior to use.
When taking high levels of Vitamin B12, track blood levels. Do not use if tamper seal is damaged.
Keep out of reach of children.
Storage
Storage: Keep tightly closed. Refrigerate for optimal freshness. May be kept in a cool, dry place away from direct sunlight.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent and disease.
Brand IP Statement(s)
Drops Methyl Adenosyl Hydroxo 1 500 300 200 2 1000 600 400 3 1500 900 600 4 2000 1200 800 # of Drops = Units in mcg
Copyright 2021 Pure Therapro RX MecobalActive The active form of B. MECOBALACTIVE is a trademark of HEALTHTECH BIO ACTIVES, S.L.U.
General Statements
Please recycle
Please retain box for reference
90 day supply
Formula
BioActive B12 is a high quality vegan vitamin B12 complex utilizing three bioavailable forms. These forms require no conversion in the liver in order to be available for use by your cells. As a sublingual supplement, BioActive B12 provides maximum absorption with a mild taste that is easy on the palate.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
BioActive B12 by Pure TheraPro Rx label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in BioActive B12 by Pure TheraPro Rx
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Drop(s) Dosage formLiquid Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin B12
Interacts with20 drugs
Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...
Vitamin B12 monograph & interactionsMecobalActive Methylcobalamin
Interacts with20 drugs
Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...
MecobalActive Methylcobalamin monograph & interactionsAdenosylcobalamin
Interacts with20 drugs
Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...
Adenosylcobalamin monograph & interactionsHydroxocobalamin
Interacts with20 drugs
Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...
Hydroxocobalamin monograph & interactionsOther (inactive) ingredients: Triple distilled Water, USP Kosher certified Vegetable Glycerin, Potassium Sorbate, Citric Acid. These complete the product’s ingredient list but are not active constituents.
BioActive B12 by Pure TheraPro Rx Drug Interactions
HelloPharmacist Interaction Report
BioActive B12 by Pure TheraPro Rx contains four forms of vitamin B12, and they share one documented interaction with medications.
If you take metformin (Glucophage) for type 2 diabetes, this product may interact with it. Metformin can lower your B12 levels by interfering with how your body absorbs it in the digestive tract — this supplement aims to offset that, but the interaction is Minor in severity and worth flagging.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 19 individual medications.
Beyond metformin, no other drug types are documented in our data for these B12 forms. That doesn't mean interactions don't exist — it means we haven't found them yet.
Before you start, run your exact medications through the checker below to be sure.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against BioActive B12?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in BioActive B12 interact with 20 drugs. Click any drug to see the details.
1 of the 4 ingredients in BioActive B12 interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12
Alogliptin, MetforminKazano
How Alogliptin, Metformin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Alogliptin, Metformin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Canagliflozin, Metformin Hydrochloride interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Dapagliflozin Propanediol, Metformin interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Empagliflozin, Metformin Hydrochloride interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Ertugliflozin, Metformin Hydrochloride interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Glipizide, Metformin interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Glyburide, Metformin interactionLinagliptin, Metformin HydrochlorideJentadueto XR
How Linagliptin, Metformin Hydrochloride interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Linagliptin, Metformin Hydrochloride interactionMetforminGlucophage, Metformin
How Metformin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Metformin interactionMetformin HydrochlorideRiomet ER
How Metformin Hydrochloride interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Metformin Hydrochloride interactionMetformin, LinagliptinJentadueto
How Metformin, Linagliptin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
How Metformin, Rosiglitazone interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
How Metformin, Sitagliptin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Metformin, Sitagliptin interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Saxagliptin, Metformin Xr interactionSitagliptin, MetforminZituvimet
How Sitagliptin, Metformin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Sitagliptin, Metformin interactionPioglitazone, MetforminActoPlus Met
How Pioglitazone, Metformin interacts with BioActive B12 — through 1 ingredient. Tap an ingredient for the detail:
HydroxocobalaminMetformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Hydroxocobalamin + Pioglitazone, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in BioActive B12 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin B12
Metformin (Glucophage)
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.
Brand information
Manufacturer and brand details for BioActive B12, from the product label.
Pure TheraPro Rx
See all Pure TheraPro Rx products- Name
- Pure TheraPro RX
- Street Address
- 9888 W. Belleview Ave. #2006
- City
- Denver
- State
- Colorado
- ZipCode
- 80123
- Phone Number
- 888-655-4648
- Web Address
- Purethera.com
BioActive B12 by Pure TheraPro Rx: Common Questions
Does BioActive B12 by Pure TheraPro Rx interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while I'm pregnant or breastfeeding?
Will this interact with my diabetes medication?
What are the side effects?
Is it safe to take extra B12 if I already get enough?
Does this actually work for B12 deficiency?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if BioActive B12 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind BioActive B12’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
BioActive B12's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin B12 30 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
- Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
- Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
- Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
- Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
- Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
- Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
- Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
- Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
- Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
- Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
- Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
- Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
- Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
- Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
- Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
- Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
- Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
- Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
- Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
- Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
- Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
- Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
- Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
- Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
- Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
- Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
- Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC