Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

BioActive B12 Ingredients & Drug Interactions

by Pure TheraPro Rx

Liquid Category: Vitamin
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

BioActive B12 is a dietary supplement by Pure TheraPro Rx with 4 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of BioActive B12 by Pure TheraPro Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

BioActive B12 has 4 active ingredients, all forms of vitamin B12: standard vitamin B12, MecobalActive methylcobalamin, adenosylcobalamin, and hydroxocobalamin. These are different shapes of the same essential nutrient your body uses for nerve function, energy, and red blood cells.

The rest is inactive — water, vegetable glycerin, potassium sorbate as a preservative, and citric acid.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Energy and methylation support.
  • We looked for evidence on: Fatigue, Vitamin B12 deficiency, Peripheral neuropathy, Chemotherapy-induced peripheral neuropathy, Hyperhomocysteinemia, Age-related cognitive decline — and 4 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Age-related cognitive decline, Alzheimer disease.

Vitamin B12 is effective for treating B12 deficiency and for Imerslund-Grasbeck disease, a rare condition that prevents B12 absorption. It's also likely effective for cyanide poisoning — which is why it's kept in emergency rooms.

For canker sores and postherpetic neuralgia (nerve pain after shingles), the evidence is possibly effective, meaning it may help but the evidence isn't as solid.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B12 is generally very well tolerated by mouth. Your body gets rid of excess in the urine, so there's no established upper limit to worry about.

The most common side effect with injections is soreness at the shot site. Allergic reactions like rash, itching, or hives are rare but possible — they may be tied to the cobalt in the B12 molecule itself.

In rare cases, when B12 corrects a severe type of anemia, dangerously low potassium levels have occurred; your doctor can watch for this if you have that condition. B12 is needed in pregnancy and breastfeeding and is considered safe at normal recommended amounts — follow your provider's guidance.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take metformin for diabetes, let your pharmacist know — this product addresses a Minor interaction with that drug. We have no documented interactions for the other medications we checked, but run your full list through the tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This is a solid choice if you're deficient in B12 or your metformin is dragging your levels down. If you have an allergy to cobalt, talk to your pharmacist before starting.

Anyone taking other medications should check them below first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BioActive B12, straight from the product label.

Brand Pure TheraPro Rx
Barcode (UPC) X002BIBMEN
Net contents 0.5 fl. Oz.; 15 mL
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 268899
Product type Vitamin
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BioActive B12 by Pure TheraPro Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Drop(s)
Maximum serving Sizes:
4 Drop(s)
Servings per container
90
UPC/BARCODE
X002BIBMEN
IngredientAmount% DV
Vitamin B124000 mcg166667%
MecobalActive Methylcobalamin2000 mcg83333%
Adenosylcobalamin1200 mcg50000%
Hydroxocobalamin800 mcg33333%

Other ingredients: triple distilled Water, USP Kosher certified Vegetable Glycerin, Potassium Sorbate, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Full Spectrum Maximum Absorption for Energy & Methylation

Vegan + Vegetarian

Formulated to Exclude: Alcohol, fillers, wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and preservatives.

Formulated, tested & packaged in the USA

Concentrated Formula

3-in-1 Support Methylcobalamin Biologically Active Form Patented. Exceptional purity, no harmful solvents are used in production of this product. Adenosylcobalamin Mitochondrial Form Considered an active coenzyme form of B12-utilized directly in B12-dependeint enzyme reactions in the body. Hydroxocobalamin Protector Form Readily converts to methylcobalamin and has a unique role of supporting detoxification processes.

Seals/Symbols

Vegan

GMP Certified Good Manufacturing Practice

FDA Statement of Identity

Professional Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Shake gently before use take up to four (4) drops daily or as directed by a healthcare practitioner. Best taken sublingually or directly onto your tongue. Drops may also be placed into juice or water.

Precautions

Warning: Children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Warning: Children and pregnant or lactating women should consult their healthcare practitioner prior to use.

When taking high levels of Vitamin B12, track blood levels. Do not use if tamper seal is damaged.

Keep out of reach of children.

Storage

Storage: Keep tightly closed. Refrigerate for optimal freshness. May be kept in a cool, dry place away from direct sunlight.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent and disease.

Brand IP Statement(s)

Drops Methyl Adenosyl Hydroxo 1 500 300 200 2 1000 600 400 3 1500 900 600 4 2000 1200 800 # of Drops = Units in mcg

Copyright 2021 Pure Therapro RX MecobalActive The active form of B. MECOBALACTIVE is a trademark of HEALTHTECH BIO ACTIVES, S.L.U.

General Statements

Please recycle

Please retain box for reference

90 day supply

Formula

BioActive B12 is a high quality vegan vitamin B12 complex utilizing three bioavailable forms. These forms require no conversion in the liver in order to be available for use by your cells. As a sublingual supplement, BioActive B12 provides maximum absorption with a mild taste that is easy on the palate.

See for yourself

BioActive B12 by Pure TheraPro Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in BioActive B12 by Pure TheraPro Rx

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Drop(s) Dosage formLiquid Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
4000 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

MecobalActive Methylcobalamin

Interacts with
20 drugs
2000 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

MecobalActive Methylcobalamin monograph & interactions

Adenosylcobalamin

Interacts with
20 drugs
1200 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Adenosylcobalamin monograph & interactions

Hydroxocobalamin

Interacts with
20 drugs
800 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Hydroxocobalamin monograph & interactions

Other (inactive) ingredients: Triple distilled Water, USP Kosher certified Vegetable Glycerin, Potassium Sorbate, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

BioActive B12 by Pure TheraPro Rx Drug Interactions

Want to check YOUR meds against BioActive B12?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in BioActive B12 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
The maker

Brand information

Manufacturer and brand details for BioActive B12, from the product label.

Pure TheraPro Rx

See all Pure TheraPro Rx products
Name
Pure TheraPro RX
Street Address
9888 W. Belleview Ave. #2006
City
Denver
State
Colorado
ZipCode
80123
Phone Number
888-655-4648
Web Address
Purethera.com
Pharmacist Counseling Corner

BioActive B12 by Pure TheraPro Rx: Common Questions

Does BioActive B12 by Pure TheraPro Rx interact with any medications?
Yes. Based on its ingredients, BioActive B12 has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BioActive B12 contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
Yes. B12 is actually needed during pregnancy and breastfeeding, and it's considered safe at recommended amounts. That said, always follow your provider's advice on supplementation during pregnancy and while nursing.
Will this interact with my diabetes medication?
If you take metformin, there's a Minor interaction to know about. Metformin can lower your B12 levels by interfering with absorption, which is partly why people on it often take B12 — but tell your pharmacist so they can keep an eye on your levels.
What are the side effects?
B12 taken by mouth is generally well tolerated. Allergic reactions like rash or itching are rare but possible, and they may be related to the cobalt in B12 itself. In rare cases, when B12 corrects severe anemia, potassium can drop dangerously low — your doctor can monitor for this if needed.
Is it safe to take extra B12 if I already get enough?
Yes. B12 is very safe because your body removes excess in your urine — there's no upper limit. So you can't really overdose on it.
Does this actually work for B12 deficiency?
Yes. B12 is effective for treating B12 deficiency. It's also effective for a rare absorption disorder called Imerslund-Grasbeck disease and likely effective for cyanide poisoning.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BioActive B12 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BioActive B12 label
Sources

Sources & How We Checked

BioActive B12's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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