Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Supreme Hawaiian Astaxanthin 6 mg Ingredients & Drug Interactions

by BioAstin

Supreme Hawaiian Astaxanthin 6 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Supreme Hawaiian Astaxanthin 6 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Supreme Hawaiian Astaxanthin 6 mg is a dietary supplement by BioAstin with 3 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 791 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Astaxanthin, Natural. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Supreme Hawaiian Astaxanthin 6 mg by BioAstin

Ask about any prescription or over-the-counter medication and we check it for interactions with Supreme Hawaiian Astaxanthin 6 mg by BioAstin — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Supreme Hawaiian Astaxanthin 6 mg by BioAstin

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Supreme Hawaiian Astaxanthin 6 mg contains 3 active ingredients: vitamin E (a fat-soluble antioxidant), astaxanthin (a naturally derived carotenoid pigment), and extra virgin olive oil. Vitamin E supports cell health, astaxanthin is sourced from marine microalgae, and olive oil serves as a carrier and source of its own polyphenols.

The softgel capsule also contains several inactive ingredients — corn starch, carrageenan, glycerin, sorbitol, purified water, high-oleic safflower oil, sunflower oil, and natural tocopherols — which function as binders, thickeners, and preservatives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Immune, eye, skin, cardiovascular, and joint health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Aging skin, Atherosclerosis, Athletic performance, Atopic dermatitis (eczema), Cardiovascular disease (CVD) — and 4 related terms.
  • The strongest evidence on file: Vitamin E is rated "Possibly Effective" for Exercise-induced muscle damage (Natural Medicines).
  • Also on file: Vitamin E is rated "Possibly Ineffective" for Age-related macular degeneration (AMD), Atherosclerosis, Cataracts, Congestive heart failure (CHF), and more.
  • Also on file: Vitamin E is rated "Likely Ineffective" for Cardiovascular disease (CVD).

Vitamin E is effective for vitamin E deficiency and ataxia with vitamin E deficiency (a rare genetic disorder affecting nerve function). For other uses — Alzheimer disease, beta-thalassemia, and glucose-6-phosphate dehydrogenase deficiency — the evidence is possibly effective, meaning research suggests some benefit but isn't conclusive.

Astaxanthin and extra virgin olive oil have been studied for various health conditions, but the evidence in our data is insufficient to establish their effectiveness for any of the uses listed — including age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome.

The evidence, ingredient by ingredient Vitamin E Olive Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E from typical dietary amounts is generally well tolerated, but high-dose long-term supplements carry caution: there's concern they may increase bleeding risk and other harms. In rare cases, very high doses have caused bleeding and hemorrhagic stroke, particularly in male smokers.

Astaxanthin at the 6 mg dose in this product is generally well tolerated in studies, though long-term safety data are limited; minor side effects reported in trials include abdominal discomfort, diarrhea, and red-colored stool. Extra virgin olive oil is very safe as food, though concentrated supplements are less well studied.

For pregnancy and breastfeeding, the safety data for astaxanthin advises against its use. Vitamin E amounts from food and prenatal vitamins are appropriate in pregnancy, but avoid high-dose supplements unless your doctor directs it; similarly, normal dietary amounts are fine while breastfeeding, but check with your doctor before taking high-dose supplements.

There is no pregnancy or breastfeeding data on file for extra virgin olive oil.

Side effects, ingredient by ingredient Vitamin E Olive Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin E, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 792 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use blood thinners or antiplatelet drugs (such as warfarin, aspirin, or clopidogrel) — vitamin E in this product may increase bleeding risk. Also double-check if you take cancer chemotherapy drugs, cyclosporine, selumetinib, niacin, or any medications metabolized by the CYP3A4 or CYP2B6 enzyme systems.

Use the medication search tool below to verify your prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in antioxidant support and have no relevant drug interactions, but you'll need to check your exact medications first — especially if you take blood thinners, cancer therapies, or immunosuppressants. If you're pregnant, breastfeeding, or taking high-dose vitamin supplements, talk with your pharmacist or doctor before starting.

Always run your complete medication list through the checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Supreme Hawaiian Astaxanthin 6 mg, straight from the product label.

Brand BioAstin
Barcode (UPC) 732894035126
Net contents 60 Vegan Softgel(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 320600
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Supreme Hawaiian Astaxanthin 6 mg by BioAstin, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegan Softgel(s)
Maximum serving Sizes:
2 Vegan Softgel(s)
Servings per container
30
UPC/BARCODE
732894035126
IngredientAmount% DV
Calories10 Calorie(s)--
Vitamin E30 IU100%
Calories from Fat10 Calorie(s)--
Total Fat1 Gram(s)1%
Extra Virgin Olive Oil800 mg--
Astaxanthin, Natural12 mg--

Other ingredients: Corn Starch, Modified, Carrageenan, Glycerin, Sorbitol, Water, Purified, Safflower Oil, High Oleic, Sunflower Oil, Tocopherols, Natural

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Nature's Powerful Antioxidant Human clinical studies have demonstrated Astaxanthin's support for: Immune health Eye health Skin health during UV/Sun exposure Cardiovascular health Joint health and recovery from exercise

IGEN Non-GMO Tested This product does not contain common GE genes or proteins. Visit igenprogram.com Free of soy, gluten, lactose, yeast, wheat, and artificial colors. Free of herbicides and pesticides.

Glyphosate Residue Free detoxfreeproject.org Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Certified Vegan Vegan.org Vegan

Naturally grown Astaxanthin on our farm at Keahole Point in Hawaii.

General Statements

Setting the standard for microalgae since 1984

To learn more about Supreme, scan the QR code. Made with Aloha.

Farm Grown For your wellbeing Since 1984

Results are usually seen within 2 to 6 weeks of daily use.

Precautions

Consult your healthcare practitioner before use if you are pregnant or nursing.

Do not use if outer seal is broken.

Seals/Symbols

IGEN Non-GMO Tested

Glyphosate Residue Free detoxfreeproject.org Certified Gluten Free GFCO.org (Gluten-Free Certification Organization) Certified Vegan Vegan.org

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Copyright 2023 Nutrex Hawaii

Formula

Extra virgin olive oil & vitamin E

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

2 Per Day

Suggested Use: One to two soft gels daily with food, BioAstin is best absorbed when taken with food or meal that contains fat.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Supreme Hawaiian Astaxanthin 6 mg by BioAstin label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Supreme Hawaiian Astaxanthin 6 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Supreme Hawaiian Astaxanthin 6 mg by BioAstin

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegan Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
30 IU per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Extra Virgin Olive Oil

No known
interactions
800 mg per serving

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Extra Virgin Olive Oil monograph & interactions

Astaxanthin, Natural

Interacts with
671 drugs
12 mg per serving Form: Haematococcus pluvialis

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin, Natural monograph & interactions

Other (inactive) ingredients: Corn Starch, Modified, Carrageenan, Glycerin, Sorbitol, Water, Purified, Safflower Oil, High Oleic, Sunflower Oil, Tocopherols, Natural. These complete the product’s ingredient list but are not active constituents.

Interaction report

Supreme Hawaiian Astaxanthin 6 mg by BioAstin Drug Interactions

Want to check YOUR meds against Supreme Hawaiian Astaxanthin 6 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
791Drugs
790 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 764
Astaxanthin, Natural 671

Individual Drug Interactions

The ingredients in Supreme Hawaiian Astaxanthin 6 mg interact with 791 drugs. Click any drug to see the details.

2 of the 3 ingredients in Supreme Hawaiian Astaxanthin 6 mg interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Astaxanthin, Natural

Each ingredient & the kinds of drugs it affects

For each ingredient in Supreme Hawaiian Astaxanthin 6 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Astaxanthin, Natural2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin, Natural full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Supreme Hawaiian Astaxanthin 6 mg, from the product label.

BioAstin

See all BioAstin products
Name
Nutrex Hawaii Inc.
City
Kailua-Kona
State
HI
ZipCode
96740
Phone Number
800-453-1187
Web Address
nutrex-hawaii.com
Pharmacist Counseling Corner

Supreme Hawaiian Astaxanthin 6 mg by BioAstin: Common Questions

Does Supreme Hawaiian Astaxanthin 6 mg by BioAstin interact with any medications?
Yes. Based on its ingredients, Supreme Hawaiian Astaxanthin 6 mg has a known interaction with 791 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Supreme Hawaiian Astaxanthin 6 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Astaxanthin in this product is best avoided during pregnancy and breastfeeding due to insufficient safety data. Vitamin E in normal dietary amounts is fine during pregnancy and breastfeeding, but avoid high-dose supplements unless your doctor approves. Talk with your doctor or pharmacist about what's right for your situation.
What does astaxanthin actually do?
Astaxanthin is a natural antioxidant pigment. In our data, the evidence for its effectiveness on specific conditions — including age-related cognitive decline, macular degeneration, skin aging, and athletic performance — is insufficient to establish that it works. If you're considering it for a particular health goal, ask your pharmacist what the current research shows.
What's the difference between the vitamin E in this product and a regular vitamin E supplement?
We don't have the specific form of vitamin E in this product listed. The interactions and safety cautions for vitamin E apply here — particularly the dose-dependent bleeding risk with blood thinners and the concern about high-dose long-term use. The presence of astaxanthin and olive oil may affect how your body absorbs or processes the vitamin E, but we don't have specific data on that.
Can I take this with my blood pressure or cholesterol medication?
It depends on which specific medication you take. Vitamin E in this product can interact with several drug categories. Run your exact medication through the checker on this page — don't assume it's safe — and if you have questions, ask your pharmacist.
What are the common side effects of this product?
At the 6 mg dose of astaxanthin in this product, the most commonly reported effects in trials are abdominal discomfort, diarrhea, and red-colored stool. Vitamin E and olive oil are generally well tolerated at typical doses, though high-dose vitamin E raises concerns about bleeding. Most people tolerate this product without problems, but if you notice unusual bleeding, bruising, or stomach upset, stop and talk to your pharmacist.
Is this product safe to use long-term?
Astaxanthin's long-term safety data are limited. Vitamin E at high doses long-term raises safety concerns, particularly around bleeding and hemorrhagic stroke. We don't have clear guidance on how long this specific product is safe to take, so it's a good question for your pharmacist or doctor — they can assess your individual risk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Supreme Hawaiian Astaxanthin 6 mg label
Go deeper

The Full Monographs Behind Supreme Hawaiian Astaxanthin 6 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Supreme Hawaiian Astaxanthin 6 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 69 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
  21. Stein JH, Carlsson CM, Papcke-Benson K, et al. The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia. J Am Coll Cardiol 2001;38:1806-13.. PubMed
  22. Carlsson CM, Papcke-Benson K, Carnes M, et al. Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adults. Drugs Aging 2002;19:793-805. . PubMed
  23. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
  24. Schrogie JJ. Coagulopathy and fat-soluble vitamins (letter). JAMA 1975;232:19. DOI
  25. Celestini A, Pulcinelli FM, Pignatelli P, et al. Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets. Haematologica 2002;87:420-6.
  26. Stampfer MJ, Jakubowski JA, Faigel D, et al. Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels. Am J Clin Nutr 1988;47:700-6. PubMed
  27. Jandak J, Steiner M, Richardson PD. Alpha-tocopherol, an effective inhibitor of platelet adhesion. Blood 1989;73:141-9. DOI
  28. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 1996;94:2434-40. PubMed
  29. Steiner M. Vitamin E, a modifier of platelet function: rationale and use in cardiovascular and cerebrovascular disease. Nutr Rev 1999;57:306-9. PubMed
  30. Brodkin RH, Bleiberg J. Sensitivity to topically applied vitamin E. Arch Dermatol 1965;92:76-7. DOI
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See these in context on the Vitamin E monograph →

Olive 2 references
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See these in context on the Olive monograph →

Astaxanthin 3 references
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See these in context on the Astaxanthin monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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