Interaction check not available yet — this product's ingredients haven't been matched to our database.
Dietary supplement

Biofilm Defense Ingredients & Drug Interactions

by Kirkman

Biofilm Defense label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Biofilm Defense against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Biofilm Defense is a dietary supplement by Kirkman with 3 active ingredients.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Biofilm Defense by Kirkman

Ask about any prescription or over-the-counter medication and we check it for interactions with Biofilm Defense by Kirkman — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
🔥 Most-checked with this product
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Biofilm Defense by Kirkman

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 15 active ingredients.
  • “Biofilm Enzyme Proprietary Blend” is a proprietary blend — the label gives one combined amount (432.50 mg) without saying how much of each component you get.
  • “Protein Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Fat Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Biofilm Defense contains 15 active ingredients, most of them digestive enzymes designed to break down different components of food and biofilm structures. The main players are proteases (including protease and protease AM) that digest proteins, lipase for fat digestion, and carbohydrate-digesting enzymes like amylase, cellulase, and glucoamylase.

You'll also find nattokinase and serrapeptase, which are specialized enzymes with effects beyond digestion — nattokinase is a fibrin-dissolving enzyme, and serrapeptase is known for its anti-inflammatory properties. The product is rounded out with inactive ingredients like hypromellose (a capsule component), rice extract, gum arabic, and maltodextrose.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for how well these ingredients work isn't established in the data we hold. Nattokinase, lipase, and serrapeptase all show insufficient reliable evidence for the conditions they're commonly taken for — whether that's cardiovascular health, digestive support, or inflammation.

Most of the other enzymes in this blend also lack clear effectiveness ratings. If you're considering this product for a specific health concern, it's worth talking with your pharmacist or doctor about what the research actually shows.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The digestive enzymes in this product — protease and protease AM — are generally well tolerated but may occasionally cause digestive upset or allergic reactions. Nattokinase and serrapeptase are generally tolerated short-term, though long-term safety data for serrapeptase is limited.

Because nattokinase has blood-thinning effects, it does carry a caution for people with bleeding risk. Protease enzymes have been known to trigger allergic reactions in some people, especially with airborne exposure.

For pregnancy and breastfeeding, the safety data is thin across the board. Protease is best avoided during pregnancy unless prescribed.

Nattokinase and serrapeptase should be avoided in pregnancy — there isn't enough data to know if they're safe. While breastfeeding, there's little safety information for protease, lipase, nattokinase, and serrapeptase; your doctor should weigh in before you use this product.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Nattokinase, Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners (anticoagulants) or antiplatelet drugs like warfarin, aspirin, apixaban, or clopidogrel, check with your pharmacist before using this product. Nattokinase and serrapeptase both carry a Moderate interaction risk for increased bleeding.

Also double-check if you're on blood pressure medications — nattokinase may lower your pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is an enzyme-based supplement aimed at digestion and biofilm support, but the evidence for its effectiveness isn't well established. If you take blood thinners or blood pressure medications, you need to check with your pharmacist first — nattokinase and serrapeptase could increase bleeding risk or lower your pressure further.

Pregnant or breastfeeding? Talk to your doctor before starting, since safety data is limited for most ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Biofilm Defense, straight from the product label.

Brand Kirkman
Barcode (UPC) 812325024957
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 333034
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Biofilm Defense by Kirkman, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
812325024957
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Peptidase0 NP--
Pectinase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Xylanase0 NP--
Beta-Glucanase0 NP--
Hemicellulase0 NP--
Nattokinase0 NP--
Alpha-Galactosidase0 NP--
Biofilm Enzyme Proprietary Blend432.5 mg--
Protein Digestion0 NP--
Serrapeptase0 NP--
Protease AM0 NP--
Fat Digestion0 NP--
Carbohydrate Digestion0 NP--

Other ingredients: Hypromellose, Water, Rice extract, Rice Husk, Gum Arabic, Sunflower Oil, Maltodextrin, Dextrose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Important: Store in a cool dry place and tightly capped.

Precautions

Keep out of the reach of children.

Caution: Consult your physician if using in the presence of peptic ulcer. If stomach or abdominal pain occurs, discontinue use.

If you are taking blood thinning drugs or supplements, consult your doctor before use.

Allergen warning: Contains sulphites. Enzymes grown on fermentation media containing wheat and soy (may contain undetectable trace amounts).

Formulation

Free of: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat or

Gluten-free

Supports digestion of intestinal biofilm

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Registered Trademark is Reg. US. Pat. & Tm. off.

Seals/Symbols

Ultra Tested cGMP Good Manufacturing Products Consistent Quality

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: One capsule daily or as directed by your physician.

General Statements

503.694.1600

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Biofilm Defense by Kirkman label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Biofilm Defense label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Biofilm Defense by Kirkman

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biofilm Enzyme Proprietary Blend

432.5 mg per serving
  • › Protein Digestion
  • › Fat Digestion
  • › Carbohydrate Digestion

Other (inactive) ingredients: Hypromellose, Water, Rice extract, Rice Husk, Gum Arabic, Sunflower Oil, Maltodextrin, Dextrose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Biofilm Defense by Kirkman Drug Interactions

Want to check YOUR meds against Biofilm Defense?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Biofilm Defense interact with 289 drugs. Click any drug to see the details.

0 of the 3 ingredients in Biofilm Defense interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Biofilm Defense with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Biofilm Defense, from the product label.

Kirkman

See all Kirkman products
Name
Kirkman
City
Lake Oswego
State
OR
ZipCode
97035
Phone Number
1-800-245-8282
Web Address
KirkmanGroup.com
Pharmacist Counseling Corner

Biofilm Defense by Kirkman: Common Questions

Does Biofilm Defense by Kirkman interact with any medications?
Yes. Based on its ingredients, Biofilm Defense has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Biofilm Defense contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin or warfarin?
Not without talking to your pharmacist first. Nattokinase and serrapeptase in this product both have blood-thinning effects, and there's even a case report of brain bleeding when someone combined nattokinase with aspirin. Your pharmacist can help you decide if it's safe for your specific situation.
Is this safe during pregnancy?
The safety data isn't there. Protease is best avoided during pregnancy unless prescribed by your doctor, and nattokinase and serrapeptase should be avoided because there isn't enough information. Talk with your doctor before using this product if you're pregnant or planning to be.
Will this cause digestive upset?
Most people tolerate it well, but some report nausea, stomach pain, or general digestive discomfort — especially with serrapeptase. These side effects appear uncommon and happen at roughly the same rate as placebo in studies, but they're possible.
What's nattokinase and why is it in here?
Nattokinase is an enzyme from fermented soybeans that breaks down fibrin — a protein involved in blood clots and biofilm formation. It's included in biofilm-defense products because of that fibrin-dissolving activity, though the evidence for how well it works for biofilm specifically isn't established in our data.
Can I take this while breastfeeding?
Safety information is limited or absent for most ingredients in this product while breastfeeding. Protease, lipase, nattokinase, and serrapeptase all lack reliable safety data in this situation, so check with your doctor or pharmacist first.
What does serrapeptase do?
Serrapeptase is a protein-digesting enzyme known for anti-inflammatory properties. It's included here for its potential to help break down biofilm and reduce inflammation, though the evidence for specific conditions isn't well established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Biofilm Defense is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Biofilm Defense label
Sources

Sources & How We Checked

Biofilm Defense's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team