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Dietary supplement

Bitter Melon 1000 mg Ingredients & Drug Interactions

by NusaPure

Bitter Melon 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bitter Melon 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bitter Melon 1000 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bitter melon extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bitter Melon 1000 mg by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Bitter Melon 1000 mg by NusaPure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bitter Melon 1000 mg by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bitter melon extract at 1000 mg per capsule. Bitter melon is a tropical plant used traditionally to support various health goals.

The capsule itself is filled with inactive ingredients—cellulose, silica, magnesium stearate, and rice powder—that serve as binders, flow agents, and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Bitter Melon product and its label doesn't state a use — see Bitter Melon's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't have reliable evidence in our data to rate bitter melon for any of the uses it's promoted for—amenorrhea, athletic performance, liver disease, constipation, diabetes, or upset stomach. That doesn't mean it doesn't work; it means rigorous clinical trials haven't settled the question yet.

If you're thinking about using it for a specific health goal, that's a conversation to have with your pharmacist or doctor.

The evidence, ingredient by ingredient Bitter Melon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bitter melon taken orally is generally well tolerated, though gastrointestinal effects are common. In clinical studies, about 3% to 16% of people reported heartburn, nausea, vomiting, diarrhea, constipation, flatulence, or belly discomfort.

Rarely, it can cause dizziness, fatigue, or headache. One case report documented kidney inflammation after months of higher-dose bitter melon extract, which resolved after stopping it.

For pregnancy: the safety data advises against it—traditionally seeds and high doses have been avoided because they may trigger harmful effects. For breastfeeding: there isn't enough reliable safety information, so it's best to avoid it while nursing.

If you're pregnant or breastfeeding and interested in this product, talk with your pharmacist or doctor for personalized advice.

Side effects, ingredient by ingredient Bitter Melon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bitter Melon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 282 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check whether you're on diabetes medications (insulin, metformin, sulfonylureas, and others)—bitter melon may lower your blood sugar too far. Also double-check if you take pazopanib or any P-glycoprotein substrates, a wide drug class that includes certain heart and antiviral medications.

Use the search tool below with your specific medication names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bitter melon works best for people without diabetes, not on cancer drugs, and without a long list of medications sensitive to absorption changes. If you take diabetes drugs, a blood thinner, heart medication, or an antiviral, check your exact medications here before you start.

Pregnant and breastfeeding folks should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bitter Melon 1000 mg, straight from the product label.

Brand NusaPure
Barcode (UPC) X001WOAVYT
Net contents 180 Veg Cap(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 246150
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bitter Melon 1000 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
90
UPC/BARCODE
X001WOAVYT
IngredientAmount% DV
Bitter melon extract1000 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) capsules daily, preferably with a meal.

Precautions

Warning: This product is not intended for pregnant or nursing mothers or children under the age of 18.

Warning: This product is not intended for pregnant or nursing mothers or children under the age of 18. If you are pregnant, nursing, or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Allergen Information: Contains no artificial coloring, artificial flavors, corn starch, milk or milk derivatives, lactose, salt, sodium, soy, gluten, egg, wheat, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool dry place. Avoid excessive heat or moisture.

Formulation

Natural color variation may occur in this product.

GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility

1000 mg per serving Assembled in USA Natural Supports healthy blood pressure and blood glucose levels already within normal ranges Supports healthy weight management Supports a healthy immune system

Max Strength

Allergen Information: Contains no artificial coloring, artificial flavors, corn starch, milk or milk derivatives, lactose, salt, sodium, soy, gluten, egg, wheat, fish, shellfish or tree nut ingredients.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium Quality Assembled in USA GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility

Manufactured in a cGMP Inspected Facility

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bitter Melon 1000 mg by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bitter Melon 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bitter Melon 1000 mg by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Bitter melon extract

Interacts with
282 drugs
1000 mg per serving Form: Mormodicosides

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...

Bitter melon extract monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bitter Melon 1000 mg by NusaPure Drug Interactions

Want to check YOUR meds against Bitter Melon 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
282Drugs
282 Moderate

Ingredients driving the most interactions

Bitter melon extract 282

Individual Drug Interactions

The ingredients in Bitter Melon 1000 mg interact with 282 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bitter Melon 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Bitter melon extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bitter Melon 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bitter melon extract3 drug types · 282 drugs

Antidiabetes Drugs

Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Pazopanib (Votrient)

Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.

Likelihood Possible Evidence D
Bitter melon extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bitter Melon 1000 mg, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central LLC
Street Address
4700 Millenia Boulevard, Suite 175 PMB 92909
City
Orlando
State
FL
ZipCode
32839
Pharmacist Counseling Corner

Bitter Melon 1000 mg by NusaPure: Common Questions

Does Bitter Melon 1000 mg by NusaPure interact with any medications?
Yes. Based on its ingredients, Bitter Melon 1000 mg has a known interaction with 282 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bitter Melon 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes or take diabetes medication?
You should talk with your doctor or pharmacist first. Bitter melon itself lowers blood sugar, so combining it with diabetes drugs raises your risk of low blood sugar (hypoglycemia). If your doctor clears it, you'd need to monitor your glucose closely and may need a dose adjustment.
What side effects should I expect?
The most common ones are gastrointestinal: heartburn, nausea, vomiting, diarrhea, constipation, or belly discomfort. These happened in about 3% to 16% of people in studies. Dizziness, fatigue, or headache can occur too. Serious effects are rare but have been reported.
Is there evidence this supplement actually works?
We don't have reliable evidence in our data to rate bitter melon for any specific use—whether that's blood sugar, digestion, athletic performance, or anything else. That means the clinical picture isn't settled yet, not that it definitely doesn't work.
Is it safe to take while I'm pregnant or breastfeeding?
For pregnancy, the safety data advises against it because seeds and high doses traditionally have been avoided due to concerns about harmful effects. For breastfeeding, there isn't enough reliable safety information. Talk with your pharmacist or doctor before using it in either situation.
Can this interact with my other medications?
Yes—bitter melon can interact with diabetes drugs, some cancer medications, and potentially with a broad class of drugs that rely on intestinal absorption. The safest move is to search your exact medication names in the tool on this page before you start.
What is bitter melon extract?
It's a concentrated form of bitter melon, a tropical plant. This product delivers 1000 mg per capsule. It's been used traditionally for various health purposes, though the evidence for specific uses isn't established yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bitter Melon 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bitter Melon 1000 mg label
Go deeper

The Full Monographs Behind Bitter Melon 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bitter Melon

Interacts with 282 drugs

Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it may modestly lower blood sugar, the evid...

Read the full Bitter Melon monograph →
Sources

Sources & How We Checked

Bitter Melon 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bitter Melon 18 references
  1. Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
  2. Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
  3. Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
  4. Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
  5. Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
  6. Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
  7. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
  8. Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
  9. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
  10. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
  11. Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
  12. Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
  13. Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
  14. Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
  15. Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
  16. Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
  17. Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
  18. Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed

See these in context on the Bitter Melon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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