Bitter Melon Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bitter Melon Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bitter Melon Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bitter Melon extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bitter Melon Extract by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Bitter Melon Extract by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Bitter Melon Extract by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains a single active ingredient: bitter melon extract. Bitter melon is a tropical fruit used traditionally in herbal medicine, and the extract concentrates its compounds into powder form.
There are no other inactive ingredients or fillers listed.
Does it work?
Couldn't assess
The evidence we hold for bitter melon extract is limited. It's rated as having insufficient reliable evidence for amenorrhea, athletic performance, liver disease, constipation, diabetes, and indigestion.
That doesn't mean it doesn't work — it means the research so far isn't strong enough for us to make a confident claim about whether it does. If you're considering it for one of these purposes, talk with your pharmacist about what the current evidence looks like and whether it makes sense for your situation.
How safe is it?
Well-documented data
Bitter melon is generally well tolerated when taken by mouth, but it can cause gastrointestinal side effects. The most common ones are heartburn, nausea, vomiting, diarrhea, constipation, bloating, and belly discomfort — these showed up in about 3% to 16% of people in studies.
You might also experience dizziness, fatigue, or headache. Rarely, it's been linked to dangerously low blood sugar (hypoglycemic coma) in children, and one case report documented kidney inflammation after long-term use of high doses.
Bitter melon is traditionally avoided in pregnancy because the seeds and high doses may cause uterine effects or other harm. For breastfeeding, there isn't enough reliable safety information, so it's best to avoid it.
If you're pregnant or nursing, talk with your doctor or pharmacist before using this product.
Meds to double-check
Moderate interaction found
If you take any blood sugar–lowering medication (diabetes drugs), you'll need to check your blood glucose closely and discuss this with us first — there's a real risk of going too low. Also double-check if you're on any cancer medications, especially pazopanib, or any other drug that uses the P-glycoprotein transporter in your gut.
If you're unsure, use the search tool on this page with your medication list.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Bitter melon extract may be worth considering if you're interested in traditional herbal approaches, but the evidence for its effectiveness is limited. The main concern is with anyone taking diabetes medications or cancer drugs — those interactions are real and need to be checked first.
If you're pregnant, breastfeeding, or have any stomach sensitivity, talk with your pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bitter Melon Extract, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X000ZOQ7ZJ |
| Net contents | 1 kg; 35.3 oz |
| Market status | On market |
| Date entered into DSLD | Jun 23, 2021 |
| DSLD ID | 252474 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bitter Melon Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Clean & pure bulk supplements
New - Bulksupplements Bitter Melon Extract Powder (1 Kilogram)
Formulation
Free of: Added sugar, soy, dairy, yeast, gluten.
Color may vary
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 750 mg (about 1/3 tsp) once daily with meal, or as directed by a physician.
Storage
Store in a dry, cool place.
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bitter Melon Extract by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bitter Melon Extract by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size750 mg Dosage formPowder Servings per container1333 Amounts shown are per serving.
Bitter Melon extract
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
Bitter Melon extract monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Bitter Melon Extract by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Bitter Melon Extract by BulkSupplements.com does interact with medications, and the interactions we've documented are Moderate in severity.
The main concern is with drugs that lower blood sugar (antidiabetes medications). Bitter melon itself lowers blood glucose, so taking it alongside diabetes medications could push your blood sugar too low (hypoglycemia).
If you're on any diabetes drug, you'll want to monitor your blood glucose closely and talk with us before starting this.
Read the full breakdown — every affected drug type, severity by severity
Bitter melon may also increase levels of certain cancer drugs and other medications that rely on a specific intestinal transporter called P-glycoprotein. There's also a case report of a patient on pazopanib (a cancer medication) who developed acute pancreatitis after taking bitter melon juice.
Altogether, these interactions span 275 individual medications.
To check whether your exact medications are affected, use the search tool below. If you take any blood sugar–lowering drug, a cancer medication, or anything you're unsure about, we should review it together before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bitter Melon Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bitter Melon Extract interact with 282 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bitter Melon Extract interact with drugs. Each result below shows which ingredient is responsible. Bitter Melon extract
AcalabrutinibCalquence
How Acalabrutinib interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Acetohexamide interactionAfatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Afatinib Dimaleate interactionAlbiglutideTanzeum
How Albiglutide interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Extract + Alogliptin, Pioglitazone interactionAlvimopanEntereg
How Alvimopan interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Ambrisentan interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Amphotericin, Tetracycline interactionAmprenavirAgenerase
How Amprenavir interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Amprenavir interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionApixabanEliquis
How Apixaban interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Apixaban interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Apomorphine Hydrochloride interactionArmodafinilNuvigil
How Armodafinil interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Armodafinil interactionAtogepantQulipta
How Atogepant interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Atogepant interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Atropine, Morphine Sulfate interactionAvatrombopag MaleateDoptelet
How Avatrombopag Maleate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Avatrombopag Maleate interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Beclomethasone Dipropionate interactionBelinostatBeleodaq
How Belinostat interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Belinostat interactionBerotralstat HydrochlorideOrladeyo
How Berotralstat Hydrochloride interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Berotralstat Hydrochloride interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Bitter Melon Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Extract + Betamethasone Valerate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bitter Melon Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bitter Melon extract
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Bitter Melon Extract, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Bitter Melon Extract by BulkSupplements.com: Common Questions
Does Bitter Melon Extract by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is it safe while breastfeeding?
What side effects might I experience?
Does bitter melon actually work for diabetes?
What's the difference between bitter melon used as food versus this supplement?
Do I need to worry about interactions with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bitter Melon Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bitter Melon Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bitter Melon Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC