Karelahills Ingredients & Drug Interactions
by Herbal Hills
What is this page for?
First and foremost: checking Karelahills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Karelahills is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are {Bitter Gourd} Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Karelahills by Herbal Hills
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Karelahills by Herbal Hills
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Karelahills contains 2 active ingredients, both forms of bitter gourd (bitter melon): the fruit extract and the fruit powder. Bitter melon is a tropical plant traditionally used in Ayurvedic and herbal medicine; the whole fruit, seeds, and leaves have been studied for various health purposes.
The product also contains three inactive ingredients — magnesium stearate, silica, and a gelatin capsule — that serve as binders, flow agents, and the capsule shell.
Does it work?
Not established
The evidence we hold doesn't establish that bitter melon works for any of the conditions it's traditionally used for — including amenorrhea, athletic performance, liver disease, constipation, diabetes, or indigestion (dyspepsia). For all of these, the data shows insufficient reliable evidence to rate effectiveness.
That doesn't mean it doesn't work; it means the studies we have aren't strong enough to say. If you're considering this product for a specific health goal, talk it over with your doctor or pharmacist about whether the evidence supports its use for your situation.
How safe is it?
Well-documented data
Bitter melon is generally well tolerated when eaten as food, but supplement doses may lower your blood sugar and cause stomach upset. The most common side effects in studies were gastrointestinal — heartburn, loss of appetite, nausea, vomiting, diarrhea, constipation, gas, and belly discomfort — occurring in about 3% to 16% of people.
Rare serious effects include hypoglycemic coma (very low blood sugar) and seizures in children. One case report documented kidney inflammation (acute interstitial nephritis) after months of high-dose bitter melon; kidney function returned to normal after stopping the supplement.
During pregnancy, the safety data advises against this product because the seeds and high doses may cause harm to the uterus or the pregnancy itself. There isn't enough reliable safety information to use it while breastfeeding.
If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this.
Meds to double-check
Moderate interaction found
Before taking Karelahills, check with your doctor or pharmacist if you take any antidiabetes medications (insulin, metformin, sulfonylureas, or others) — bitter melon may lower blood sugar further and increase hypoglycemia risk. Also confirm with them if you take any medications that depend on a cellular intestinal pump (P-glycoprotein substrates; many cancer drugs, heart drugs, and immunosuppressants fall here) or if you take pazopanib (Votrient) for cancer.
No other interactions are documented for the inactive ingredients.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Karelahills is a two-ingredient bitter melon supplement. The evidence we hold doesn't establish it works for its traditional uses — amenorrhea, diabetes, digestion, and others — so effectiveness remains unproven.
More importantly, if you take blood sugar–lowering drugs, drugs absorbed via a cellular pump, or pazopanib for cancer, this product poses a Moderate interaction risk and requires your doctor's or pharmacist's approval. Even without those medications, expect possible stomach upset, and don't use it in pregnancy or while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Karelahills, straight from the product label.
| Brand | Herbal Hills |
|---|---|
| Barcode (UPC) | 8906008264760 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 25, 2013 |
| DSLD ID | 16398 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Karelahills by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bitter Gourd fruit extract | 0 NP | -- |
| {Bitter Gourd} Blend | 450 mg | -- |
| Bitter Gourd fruit powder | 0 NP | -- |
Other ingredients: Magnesium Stearate, Silica, Gelatin Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Direction for use : As a dietary supplement take 1 each of Diabohills tablet, Jambuhills Capsule & Karelahills Capsule twice daily preferably before meals or as recommended by the Healthcare Practitioner. It should ideally be taken on empty stomach. For better results it should be taken with warm water.
Brand IP Statement(s)
Karelahills(R)
HERBAL HILLS(R) Back to Nature
General Statements
Healthy Blood Sugar
Herbal Formulation with Herbal Dietary Supplement for Speedy, Effective & Complete Result
Kit Content
Not intended for sale of individual units. Multipiece package
Seals/Symbols
EXTRACT STANDARDIZED EXTRACT
GMP Good Manufacturing Practice
ISO 22000:2005 CERTIFIED COMPANY
HERBALHILLS
Formula
2% Bitter
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution : Pregnant or lactating women are advised to consume herbal products under the advice of the Healthcare Practitioner.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Karelahills by Herbal Hills label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Karelahills by Herbal Hills
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
{Bitter Gourd} Blend
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
{Bitter Gourd} Blend monograph & interactionsOther (inactive) ingredients: Magnesium Stearate, Silica, Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.
Karelahills by Herbal Hills Drug Interactions
HelloPharmacist Interaction Report
Karelahills by Herbal Hills interacts with medications through its bitter gourd fruit extract and powder.
Both forms contain the same active ingredient — bitter melon — which carries Moderate-severity interactions with three drug types. The most serious concern is with blood sugar–lowering drugs (antidiabetes medications); bitter melon can lower blood glucose on its own, and combined use raises the risk of low blood sugar (hypoglycemia).
You'll need to monitor your blood sugar closely if you take insulin, metformin, sulfonylureas, or other diabetes drugs alongside this product.
Read the full breakdown — every affected drug type, severity by severity
Bitter melon also interacts with a large class of medications called P-glycoprotein substrates — drugs that depend on a intestinal pump to be absorbed and moved through your body. Bitter melon may block that pump, potentially raising drug levels in your bloodstream and increasing the risk of side effects.
Additionally, there's a documented case of a patient taking pazopanib (Votrient), a cancer drug, who developed acute pancreatitis after starting bitter melon juice; theoretically, bitter melon might raise pazopanib levels and toxicity risk.
Although the product contains 2 active ingredients, we could only check bitter melon's interaction data. The inactive ingredients (magnesium stearate, silica, and gelatin capsule) carry no known drug interactions.
Altogether, these interactions span 282 individual medications. Use the interaction checker below to see if any of your exact medications are affected before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Karelahills?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Karelahills interact with 282 drugs. Click any drug to see the details.
1 of the 1 ingredient in Karelahills interact with drugs. Each result below shows which ingredient is responsible. {Bitter Gourd} Blend
AcalabrutinibCalquence
How Acalabrutinib interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Acetohexamide interactionAfatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Afatinib Dimaleate interactionAlbiglutideTanzeum
How Albiglutide interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Alogliptin, Pioglitazone interactionAlvimopanEntereg
How Alvimopan interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Ambrisentan interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Amphotericin, Tetracycline interactionAmprenavirAgenerase
How Amprenavir interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Amprenavir interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionApixabanEliquis
How Apixaban interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Apixaban interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Apomorphine Hydrochloride interactionArmodafinilNuvigil
How Armodafinil interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Armodafinil interactionAtogepantQulipta
How Atogepant interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Atogepant interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Atropine, Morphine Sulfate interactionAvatrombopag MaleateDoptelet
How Avatrombopag Maleate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Avatrombopag Maleate interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Beclomethasone Dipropionate interactionBelinostatBeleodaq
How Belinostat interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Belinostat interactionBerotralstat HydrochlorideOrladeyo
How Berotralstat Hydrochloride interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Berotralstat Hydrochloride interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Betamethasone Valerate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Karelahills with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
{Bitter Gourd} Blend
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Karelahills, from the product label.
Herbal Hills
See all Herbal Hills products- Name
- Isha Agro Developers Pvt. Ltd.
- Street Address
- 55-A/B, Lonavala Indl. Co-op. Est. Ltd.
- City
- Nangargaon
- State
- Lonavala
- Phone Number
- 0091 22 2868 6868
- Web Address
- www.herbalhills.in
Karelahills by Herbal Hills: Common Questions
Does Karelahills by Herbal Hills interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is bitter melon, and what's it supposed to do?
Can I take this if I'm pregnant or breastfeeding?
What side effects should I expect?
Will this help my blood sugar if I have diabetes?
Does it matter that this has two forms of bitter melon in it?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Karelahills is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Karelahills’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Karelahills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC