Bitter Melon Extract Powder 750 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bitter Melon Extract Powder 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bitter Melon Extract Powder 750 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bitter Melon Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bitter Melon Extract Powder 750 mg by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Bitter Melon Extract Powder 750 mg by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bitter Melon Extract Powder 750 mg by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Bitter Melon Fruit Extract at 750 mg per serving. It's prepared as a powder with dextrin as an inactive ingredient (a binder that helps with texture and flow).
Does it work?
Couldn't assess
The evidence for bitter melon's effectiveness isn't well established in the data we hold. Studies rate its use for amenorrhea, athletic performance, liver disease, constipation, diabetes, and indigestion (dyspepsia) as having insufficient reliable evidence — meaning the science so far hasn't proven it works well enough for these conditions.
If you're considering this for blood sugar management or any other health concern, talk with your doctor about whether the research supports its use.
How safe is it?
Well-documented data
Bitter melon is generally well tolerated when taken by mouth. The most common side effects are gastrointestinal — heartburn, nausea, vomiting, diarrhea, constipation, gas, and stomach discomfort — occurring in about 3% to 16% of people in studies.
Dizziness, fatigue, and headache have also been reported. In rare cases, people have experienced dangerously low blood sugar (hypoglycemic coma) or seizures (especially in children), and one person developed kidney inflammation after taking high doses for several months.
During pregnancy, traditional use has avoided bitter melon because seeds and high doses may harm the uterus or cause other harmful effects. There isn't enough reliable safety information to know whether it's safe while breastfeeding, so it's best avoided then.
If you're pregnant or nursing, talk with your doctor before taking this product.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you take pazopanib (Votrient) for cancer — bitter melon may raise its levels and cause serious effects. Also double-check any antidiabetes medication (insulin, metformin, sulfonylureas, and others) because adding bitter melon could lower your blood sugar too much.
Finally, ask about any P-glycoprotein substrates you're on, as bitter melon may increase how much of these drugs your body absorbs.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Bitter melon extract might appeal to you if you're looking to support blood sugar levels, but the evidence for its effectiveness isn't solid in our data. The real concern is drug interactions — especially if you take diabetes medication or pazopanib.
Before you start, check your medications with the tool on this page or talk with your pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bitter Melon Extract Powder 750 mg, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X000ZOQ7GD |
| Net contents | 250 Gram(s); 8.8 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2025 |
| DSLD ID | 330420 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bitter Melon Extract Powder 750 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Bitter Melon Extract Powder 750 mg per serving
Brand IP Statement(s)
BulkSupplements.com Clean & Pure Bulk Supplements
Formulation
Color may vary
Free of: Added sugar, soy, dairy, yeast, gluten
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 750 mg (about 1/3 tsp) once daily with meal, or as directed by a physician.
Storage
Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place.
General Statements
Use an accurate milligram scale. New
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bitter Melon Extract Powder 750 mg by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bitter Melon Extract Powder 750 mg by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size750 Milligram(s) Dosage formPowder Servings per container333 Amounts shown are per serving.
Bitter Melon Fruit Extract
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
Bitter Melon Fruit Extract monograph & interactionsOther (inactive) ingredients: Dextrin. These complete the product’s ingredient list but are not active constituents.
Bitter Melon Extract Powder 750 mg by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Bitter Melon Extract Powder by BulkSupplements.com has documented interactions with medications, and the most serious concern is with pazopanib (Votrient), a cancer drug.
Bitter melon may increase pazopanib levels in your body, raising the risk of harmful effects — one patient taking pazopanib for kidney cancer developed acute inflammation of the pancreas (pancreatitis) four days after starting bitter melon juice. If you take pazopanib, do not start this supplement without talking to your oncologist first.
Read the full breakdown — every affected drug type, severity by severity
Bitter melon can lower blood sugar and may add to the effect of antidiabetes drugs (such as metformin, insulin, or sulfonylureas), which could raise your risk of low blood sugar (hypoglycemia). If you're on any diabetes medication, you'll need to watch your blood glucose closely and talk with your doctor or pharmacist before adding this.
Bitter melon may also increase levels of P-glycoprotein substrates — a group of medications your intestines normally filter — which could make those drugs work more intensely than intended. Altogether, these interactions span 275 individual medications.
Use the medication checker on this page to look up your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bitter Melon Extract Powder 750 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bitter Melon Extract Powder 750 mg interact with 282 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bitter Melon Extract Powder 750 mg interact with drugs. Each result below shows which ingredient is responsible. Bitter Melon Fruit Extract
AcalabrutinibCalquence
How Acalabrutinib interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Acetohexamide interactionAfatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Afatinib Dimaleate interactionAlbiglutideTanzeum
How Albiglutide interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Alogliptin, Pioglitazone interactionAlvimopanEntereg
How Alvimopan interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Ambrisentan interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Amphotericin, Tetracycline interactionAmprenavirAgenerase
How Amprenavir interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Amprenavir interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionApixabanEliquis
How Apixaban interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Apixaban interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Apomorphine Hydrochloride interactionArmodafinilNuvigil
How Armodafinil interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Armodafinil interactionAtogepantQulipta
How Atogepant interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Atogepant interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Atropine, Morphine Sulfate interactionAvatrombopag MaleateDoptelet
How Avatrombopag Maleate interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Avatrombopag Maleate interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Beclomethasone Dipropionate interactionBelinostatBeleodaq
How Belinostat interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Belinostat interactionBerotralstat HydrochlorideOrladeyo
How Berotralstat Hydrochloride interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Berotralstat Hydrochloride interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Bitter Melon Extract Powder 750 mg — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Betamethasone Valerate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bitter Melon Extract Powder 750 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bitter Melon Fruit Extract
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Bitter Melon Extract Powder 750 mg, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Bitter Melon Extract Powder 750 mg by BulkSupplements.com: Common Questions
Does Bitter Melon Extract Powder 750 mg by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What's in this powder, and is there anything else besides the extract?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I experience?
Does bitter melon actually work for blood sugar or other conditions?
I take diabetes medication — can I add this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bitter Melon Extract Powder 750 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bitter Melon Extract Powder 750 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bitter Melon Extract Powder 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC