Major interaction on record — check this product against your medications before combining. Based on 4 of 9 ingredients. Check your meds →
Dietary supplement

Bone Broth Protein Vanilla Ingredients & Drug Interactions

by Ancient Nutrition

Bone Broth Protein Vanilla label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bone Broth Protein Vanilla against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Bone Broth Protein Vanilla is a dietary supplement by Ancient Nutrition with 9 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 390 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Glucosamine, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Bone Broth Protein Vanilla by Ancient Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Bone Broth Protein Vanilla by Ancient Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Bone Broth Protein Vanilla by Ancient Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 6 of its 8 active ingredients.
  • “Bone Broth Protein Blend” is a proprietary blend — the label gives one combined amount (22.30 Gram(s)) without saying how much of each component you get.

This powder contains 8 active ingredients. Sodium and potassium are electrolytes that help with fluid balance and nerve function.

Hyaluronic acid supports skin hydration and joint health. Glucosamine and chondroitin are compounds that support cartilage and joint structure.

The broth protein concentrates from chicken and beef bone broth, plus a collagen blend, provide amino acids and protein. The product also contains inactive ingredients — vanilla flavor, xanthan gum (a thickener), and stevia leaf extract (a sweetener).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: skin and joint health support.
  • We looked for evidence on: Aging skin, Joint pain, Knee pain, Osteoarthritis, Dry eye, Wound healing — and 3 related terms.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Possibly Effective" for Dry eye.
  • Also on file: Glucosamine is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Wound healing, Joint pain, Knee pain.

Sodium is likely effective for cystic fibrosis and possibly effective for amphotericin B kidney damage. Glucosamine is likely effective for osteoarthritis.

Hyaluronic acid is possibly effective for dry eyes and venous leg ulcers. For other uses listed — such as aging skin, hay fever, heart failure, and bipolar disorder — the evidence in our data is insufficient to rate these ingredients' effectiveness.

The evidence, ingredient by ingredient Sodium Potassium Hyaluronic Acid Glucosamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated at normal dietary amounts, but the safety notes advise caution: too much is linked to high blood pressure and heart strain. Avoid sodium supplements or very high intake without medical guidance.

Serious side effects from excess sodium are rare but can include worsened heart disease, high blood pressure, or kidney disease. Potassium is generally well tolerated by mouth, though high amounts can cause abdominal pain, nausea, vomiting, and diarrhea; rare serious effects include irregular heartbeat and low blood pressure.

Glucosamine is well tolerated orally for most people, though it can cause bloating, constipation, diarrhea, heartburn, and nausea. Rare allergic reactions have been reported, including anaphylaxis in a small number of cases.

Hyaluronic acid appears well tolerated when used orally, though long-term supplement safety hasn't been fully studied. Pregnancy and lactation: sodium is likely safe in pregnancy but possibly unsafe while breastfeeding; potassium is likely safe in both; glucosamine safety data isn't available, so the facts advise against it in pregnancy and breastfeeding; hyaluronic acid has insufficient data for pregnancy and lactation.

Side effects, ingredient by ingredient Sodium Potassium Hyaluronic Acid Glucosamine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Glucosamine, Potassium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 390 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against these drug types before using this product: blood thinners like warfarin (Major risk from glucosamine), blood pressure medications and diuretics (Moderate risk from sodium and potassium), heart and kidney medications including ACE inhibitors and ARBs (Moderate risk from potassium), lithium for bipolar disorder (Moderate risk from sodium), corticosteroids or steroid medications (Moderate risk from sodium), diabetes drugs (Minor risk from glucosamine), and chemotherapy drugs. No interactions are documented for Chondroitin, Collagen, Chicken Bone Broth Protein concentrate, or Beef Bone Broth Protein Concentrate in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medications, a blood thinner like warfarin, lithium, diabetes drugs, heart medications (ACE inhibitors or ARBs), or any other sodium-containing medication or supplement, check your specific medications with the tool on this page before starting. Sodium and potassium at food levels are fine, but this product adds extra amounts.

Talk to your pharmacist or doctor, especially if you have heart disease, kidney disease, or high blood pressure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bone Broth Protein Vanilla, straight from the product label.

Brand Ancient Nutrition
Barcode (UPC) 816401020017
Net contents 17.4 Ounce(s); 1.1 Pound(s); 492 Gram(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 305931
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bone Broth Protein Vanilla by Ancient Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
24.6 Gram(s)
Maximum serving Sizes:
24.6 Gram(s)
Servings per container
20
UPC/BARCODE
816401020017
IngredientAmount% DV
Calories100 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Sodium172 mg7%
Potassium193 mg4%
Protein20 Gram(s)18%
Hyaluronic Acid140 mg--
Glucosamine15 mg--
Chondroitin800 mg--
Collagen14500 mg--
Chicken Bone Broth Protein concentrate0 NP--
Beef Bone Broth Protein Concentrate0 NP--
Bone Broth Protein Blend22.3 Gram(s)--

Other ingredients: Vanilla Flavor, Natural, Xanthan Gum, Stevia Leaf Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Ancient Nutrition has one goal - to transform the health of every individual on the planet with history's most powerful superfoods.

Facebook Instagram @ancientnutrition Save the world with superfoods www.AncientNutrition.com

Packaged by weight, not volume. Settling may occur.

Formula

Bone Broth Protein is Paleo friendly, made without common allergens and the ideal protein source for those who are sensitive to dairy, grains, eggs, nuts, and legumes.

Each serving contains approximately: 14,500 mg Collagen 800 mg Chondroitin 140 mg Hyaluronic acid 15 mg Glucosamine

Protein 20 g per serving

Formulation

Bone Broth Protein is Paleo friendly, made without common allergens and the ideal protein source for those who are sensitive to dairy, grains, eggs, nuts, and legumes.

Skin Joints

Dairy free

Supports a healthy gut, joints and inflammation response

Color and odor may vary from lot to lot.

IGEN Non-GMO tested This product does not contain common GE genes or proteins. Visit igenprogram.com

We support the RANCH Project to heal the planet, feed the world and transform health. www.RanchProject.com

Suggested/Recommended/Usage/Directions

Bone broth made easy! Great in smoothies or added to your favorite sweet recipes.

Suggested use: Adults mix one scoop with 12 ounces of liquid.

Brand IP Statement(s)

Patented formula

Bone Broth Protein is protected by US patent # 9,974,326

FDA Statement of Identity

Whole Food Dietary Supplement

Precautions

Produced on equipment that also processes peanuts, tree nuts, milk, soybean, wheat, sesame, shellfish, fish, egg. Caution: If you are pregnant, nursing, allergic, have a medical condition, or taking any medications, consult a doctor before using this or any other dietary supplement.

Caution: If you are pregnant, nursing, allergic, have a medical condition, or taking any medications, consult a doctor before using this or any other dietary supplement.

Do not use if inner safety seal is broken or missing.

Keep out of reach of children.

Notice: Use this product as a food supplement only. Do not use for weight reduction.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

IGEN Non-GMO tested This product does not contain common GE genes or proteins. Visit igenprogram.com Certified Carbon Neutral Product CarbonNeutral.com

R.A.N.C.H. Project

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bone Broth Protein Vanilla by Ancient Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bone Broth Protein Vanilla label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bone Broth Protein Vanilla by Ancient Nutrition

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size24.6 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
172 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
193 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Protein

20 Gram(s) per serving

Hyaluronic Acid

No known
interactions
140 mg per serving

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Glucosamine

Interacts with
170 drugs
15 mg per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine monograph & interactions

Chondroitin

800 mg per serving

Collagen

14500 mg per serving

Bone Broth Protein Blend

22.3 Gram(s) per serving
  • › Chicken Bone Broth Protein concentrate
  • › Beef Bone Broth Protein Concentrate

Other (inactive) ingredients: Vanilla Flavor, Natural, Xanthan Gum, Stevia Leaf Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bone Broth Protein Vanilla by Ancient Nutrition Drug Interactions

Want to check YOUR meds against Bone Broth Protein Vanilla?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
390Drugs
2 Major 233 Moderate 155 Minor

Ingredients driving the most interactions

Sodium 205
Glucosamine 170
Potassium 62

Individual Drug Interactions

The ingredients in Bone Broth Protein Vanilla interact with 390 drugs. Click any drug to see the details.

3 of the 9 ingredients in Bone Broth Protein Vanilla interact with drugs. Each result below shows which ingredient is responsible. Sodium Glucosamine Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Bone Broth Protein Vanilla with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Glucosamine4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bone Broth Protein Vanilla, from the product label.

Ancient Nutrition

See all Ancient Nutrition products
Name
Ancient Nutrition, LLC
Street Address
3480 Summertown Hwy
City
Summertown
State
TN
ZipCode
38483
Web Address
www.AncientNutrition.com
Pharmacist Counseling Corner

Bone Broth Protein Vanilla by Ancient Nutrition: Common Questions

Does Bone Broth Protein Vanilla by Ancient Nutrition interact with any medications?
Yes. Based on its ingredients, Bone Broth Protein Vanilla has a known interaction with 390 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bone Broth Protein Vanilla contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have a lot of sodium in it?
The product facts show sodium is a listed ingredient, but the specific amount per serving isn't given here. Because sodium has interactions with blood pressure and heart medications, you should ask your pharmacist how much is in each serving and whether it fits your dietary sodium limit.
Can I take this if I'm on a blood thinner?
Glucosamine in this product has a Major interaction with warfarin — it may increase the blood-thinning effect and raise bleeding risk. If you take warfarin or another blood thinner, check with your pharmacist or doctor before starting this product.
Is glucosamine really effective for joint pain?
Glucosamine is likely effective for osteoarthritis. For other types of joint or back pain, the evidence in our data is insufficient to say whether it works.
Can I use this while pregnant or breastfeeding?
Sodium is likely safe in pregnancy but possibly unsafe while breastfeeding. Potassium is likely safe in both. Glucosamine safety data isn't available — the facts advise against it in pregnancy and breastfeeding. Hyaluronic acid has insufficient data. Talk with your doctor or pharmacist for personalized advice.
What are the common side effects of this product?
The main side effects from the active ingredients are bloating, constipation, diarrhea, heartburn, and nausea — mostly from glucosamine. High amounts of potassium can also cause abdominal pain and diarrhea. At normal dietary amounts, sodium and potassium side effects are uncommon.
Does it have any fillers or just the active ingredients?
It contains three inactive ingredients: vanilla flavor, xanthan gum (a thickener), and stevia leaf extract (a sweetener). These are excipients that help with taste and texture, not active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bone Broth Protein Vanilla label
Go deeper

The Full Monographs Behind Bone Broth Protein Vanilla’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph →
Sources

Sources & How We Checked

Bone Broth Protein Vanilla's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 112 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
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Glucosamine 58 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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