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Dietary supplement

Boneset Ingredients & Drug Interactions

by Hawaii Pharm

Boneset label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Boneset against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Boneset is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for colds and flu, fever, body aches.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boneset Aerial Parts Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Boneset by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Boneset by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Boneset by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: boneset aerial parts extract in a dry form, supplied as a liquid (using alcohol, water, and glycerin as inactive carriers). Boneset is a traditional herbal remedy whose aerial parts — the stems and leaves above ground — have been used historically to support wellness, though modern evidence for its effectiveness is limited.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Boneset's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support for colds and fever symptoms.
  • We looked for evidence on: Common Cold, Influenza, Fever, Body aches.
  • The closest evidence on file: Boneset is rated "Insufficient Reliable Evidence To Rate" for Common Cold (Natural Medicines).

The evidence we hold does not establish that boneset relieves the common cold or other conditions. Our data rates its effectiveness for the common cold as insufficient reliable evidence to rate, meaning trials either haven't been done, are too small, or don't show a clear benefit.

If you're considering boneset for a specific health concern, talk with your doctor or pharmacist about whether it's the right choice.

The evidence, ingredient by ingredient Boneset

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boneset is generally well tolerated at the doses studied, but it does carry important cautions. It's reported to cause nausea, diarrhea, and vomiting in some people.

More concerning, boneset and related plants in its genus contain compounds called pyrrolizidine alkaloids, which can damage the liver — especially at high doses or with long-term use. We don't yet know exactly how toxic boneset's alkaloids are, so caution and short-term use only are advised.

You should avoid boneset during pregnancy and while breastfeeding; the safety data advises against it, and harmful alkaloids may reach a nursing infant.

Side effects, ingredient by ingredient Boneset

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boneset.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any medications that induce CYP3A4 — the enzyme responsible for breaking down boneset's potentially harmful compounds. These include seizure medications like carbamazepine (Tegretol), and other drugs that speed up liver metabolism.

Giving your doctor or pharmacist a full list of your medications is the best way to know if boneset is safe for you to use alongside them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Boneset may appeal to those interested in traditional herbal remedies, but the evidence for it working is not established, and the risk of liver damage — especially with CYP3A4-inducing medications — makes it a product to approach with care. If you take any prescription medications, especially seizure drugs or any that speed up liver metabolism, check with your doctor or pharmacist before you start.

Do not use it if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Boneset, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253608536
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 301299
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Boneset by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253608536
IngredientAmount% DV
Boneset Aerial Parts Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Eupatorium perfoliatum

Organic Alcohol Based

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Boneset by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Boneset label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Boneset by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Boneset Aerial Parts Extract, Dry

Interacts with
87 drugs
983 mg per serving Form: Eupatorium perfoliatum Aerial Parts Extract, Dry

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains comp...

Boneset Aerial Parts Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Boneset by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Boneset?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Boneset Aerial Parts Extract, Dry 87

Individual Drug Interactions

The ingredients in Boneset interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Boneset interact with drugs. Each result below shows which ingredient is responsible. Boneset Aerial Parts Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Boneset with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Boneset Aerial Parts Extract, Dry1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs). Hepatotoxic PAs are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Boneset Aerial Parts Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Boneset, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Boneset by Hawaii Pharm: Common Questions

Does Boneset by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Boneset has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Boneset contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Boneset if I'm pregnant or breastfeeding?
No. The safety data advises against boneset during pregnancy due to potential toxicity and lack of safety data. You should also avoid it while breastfeeding because the harmful alkaloids in it may pass to your infant. Talk with your doctor or pharmacist about safer options.
What side effects has boneset been reported to cause?
Boneset is reported to cause nausea, severe diarrhea, and vomiting in some people. At higher doses, there's also a risk of liver toxicity and liver damage, because boneset contains compounds that can harm the liver. Limited safety data and its unknown alkaloid profile mean short-term use only is advisable, if you use it at all.
Does boneset actually help with colds?
The evidence we hold is insufficient to say whether boneset relieves the common cold. Trials haven't clearly shown a benefit. If you're looking to support your health during a cold, discuss other options with your doctor or pharmacist.
Why should I be careful about boneset if I take seizure medication?
Boneset contains compounds that your liver breaks down via an enzyme called CYP3A4. Seizure medications like carbamazepine (Tegretol) speed up this enzyme. When that happens, boneset's compounds may be converted into toxic forms more quickly, raising the risk of liver damage. Always check with your doctor or pharmacist before combining them.
What exactly is in this liquid?
The active ingredient is boneset aerial parts extract (the stems and leaves). The liquid carrier is made from alcohol, water, and glycerin — these are inactive ingredients that help deliver the extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Boneset is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Boneset label
Go deeper

The Full Monographs Behind Boneset’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boneset

Interacts with 87 drugs

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains compounds (pyrrolizidine alkaloids) that may...

Read the full Boneset monograph →
Sources

Sources & How We Checked

Boneset's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boneset 5 references
  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  2. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  3. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  4. Gassinger, C. A., Wunstel, G., and Netter, P. [A controlled clinical trial for testing the efficacy of the homeopathic drug eupatorium perfoliatum D2 inthe treatment of common cold (author's transl)]. Arzneimittelforschung. 1981;31(4):732-736.
  5. Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018;29(6):613-626.

See these in context on the Boneset monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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