Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Boneset Vanilla Flavor Ingredients & Drug Interactions

by TerraVita

Boneset Vanilla Flavor label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Boneset Vanilla Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Boneset Vanilla Flavor is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for colds and flu, fever, body aches.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boneset Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Boneset Vanilla Flavor by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Boneset Vanilla Flavor by TerraVita — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Boneset Vanilla Flavor by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: boneset glycerite liquid extract. Boneset is a plant traditionally used as a herbal remedy, prepared here as a liquid extract in glycerin.

The inactive ingredients are glycerin itself (which is also the extraction base) and vanilla flavor.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Boneset's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support for cold and flu symptoms.
  • We looked for evidence on: Common Cold, fever, body aches, congestion.
  • The closest evidence on file: Boneset is rated "Insufficient Reliable Evidence To Rate" for Common Cold (Natural Medicines).

The evidence for boneset and the common cold is insufficient — we simply don't have reliable data showing whether it works for that purpose. If you're considering it for another reason, that information isn't available in our data either.

The evidence, ingredient by ingredient Boneset

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boneset has limited safety data, and here's what matters: it contains compounds that can be toxic to the liver, especially at higher doses or with longer use. Nausea, severe diarrhea, and vomiting have been reported.

The safety data advises against use during pregnancy and while breastfeeding because of the potential for toxicity and because these alkaloids may pass into breast milk and harm the infant. If you're pregnant, planning to become pregnant, or nursing, do not use this product.

Because of the liver-toxicity concern, this is a supplement to use cautiously and only short-term, if at all. If you do use it, keep your doses moderate and your duration brief.

Side effects, ingredient by ingredient Boneset

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boneset.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take seizure medications, mood stabilizers, or any other drugs that induce CYP3A4 enzymes, check with your doctor or pharmacist before adding boneset — these combinations may increase the risk of converting boneset's alkaloids into toxic forms. The interaction list is long, so run your full medication list through the checker on this page before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Boneset Vanilla Flavor is a traditional herbal remedy with limited evidence of benefit and real concerns about liver toxicity from its alkaloid content. It's not for pregnancy or breastfeeding, and it interacts with a significant number of medications, particularly those that affect how your liver processes drugs.

Before you take it, talk with your doctor or pharmacist about whether boneset makes sense for you and whether it's safe alongside your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Boneset Vanilla Flavor, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435132217
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 281704
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Boneset Vanilla Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435132217
IngredientAmount% DV
Boneset Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin, Vanilla flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2005 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5) Vanilla flavored

Formulation

Alcohol free

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Boneset Vanilla Flavor by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Boneset Vanilla Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Boneset Vanilla Flavor by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Boneset Glycerite Liquid Extract

Interacts with
87 drugs
0.13 mL per serving

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains comp...

Boneset Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Vanilla flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Boneset Vanilla Flavor by TerraVita Drug Interactions

Want to check YOUR meds against Boneset Vanilla Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Boneset Glycerite Liquid Extract 87

Individual Drug Interactions

The ingredients in Boneset Vanilla Flavor interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Boneset Vanilla Flavor interact with drugs. Each result below shows which ingredient is responsible. Boneset Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Boneset Vanilla Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Boneset Glycerite Liquid Extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs). Hepatotoxic PAs are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Boneset Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Boneset Vanilla Flavor, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Boneset Vanilla Flavor by TerraVita: Common Questions

Does Boneset Vanilla Flavor by TerraVita interact with any medications?
Yes. Based on its ingredients, Boneset Vanilla Flavor has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Boneset Vanilla Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
No. The safety data advises against boneset use in pregnancy because of potential toxicity and lack of safety data. If you're pregnant or planning to become pregnant, do not use this product. Talk with your doctor about safer options.
Is boneset safe while breastfeeding?
No. Safety has not been established while breastfeeding, and the harmful alkaloids in boneset may pass into breast milk and affect your infant. Avoid this product while nursing.
Does boneset actually work for colds?
The evidence is insufficient — we don't have reliable data showing boneset helps the common cold. It's a traditional remedy, but modern research hasn't confirmed its benefit.
What side effects might I experience?
Nausea, severe diarrhea, and vomiting have been reported with boneset. At higher doses, liver toxicity and liver damage are possible because of the alkaloids it contains.
How long should I take this?
Because of liver-toxicity concerns, boneset should be used short-term only, if at all, and at moderate doses. Do not use it long-term without talking to your doctor or pharmacist about the risks.
What is a glycerite extract?
A glycerite is an herbal extract made by soaking the plant material in glycerin instead of alcohol. In this product, glycerin is both the extraction base and an inactive ingredient, making it a liquid that's easy to take.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Boneset Vanilla Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Boneset Vanilla Flavor label
Go deeper

The Full Monographs Behind Boneset Vanilla Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boneset

Interacts with 87 drugs

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains compounds (pyrrolizidine alkaloids) that may...

Read the full Boneset monograph →
Sources

Sources & How We Checked

Boneset Vanilla Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boneset 5 references
  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  2. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  3. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  4. Gassinger, C. A., Wunstel, G., and Netter, P. [A controlled clinical trial for testing the efficacy of the homeopathic drug eupatorium perfoliatum D2 inthe treatment of common cold (author's transl)]. Arzneimittelforschung. 1981;31(4):732-736.
  5. Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018;29(6):613-626.

See these in context on the Boneset monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team