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Dietary supplement

Borage Oil 1000 mg Ingredients & Drug Interactions

by DC

Borage Oil 1000 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Borage Oil 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Borage Oil 1000 mg is a dietary supplement by DC with 1 active ingredient. Its ingredients are commonly taken for eczema and dry skin, rheumatoid arthritis, inflammation.Based on those ingredients, 226 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Borage Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Borage Oil 1000 mg by DC

Ask about any prescription or over-the-counter medication and we check it for interactions with Borage Oil 1000 mg by DC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Borage Oil 1000 mg by DC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: borage oil, which is rich in gamma-linolenic acid (a type of omega-6 fatty acid), and polyunsaturated fat. The inactive ingredients are gelatin and vegetable glycerin, which form the softgel capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Borage's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Gamma linolenic acid nutrient source.
  • We looked for evidence on: Atopic dermatitis (eczema), Neurodermatitis, Rheumatoid arthritis (RA), Stress, Skin health, Joint health — and 1 related terms.
  • The closest evidence on file: Borage is rated "Possibly Ineffective" for Atopic dermatitis (eczema) (Natural Medicines).
  • Also on file: Borage is rated "Insufficient Reliable Evidence To Rate" for Acute respiratory distress syndrome (ARDS), Rheumatoid arthritis (RA), Stress, Neurodermatitis.

The evidence for borage oil is mixed and limited. For atopic dermatitis (eczema), the data suggests it's possibly ineffective.

For other conditions like ADHD, acute respiratory distress syndrome, and alcoholism, there isn't enough reliable evidence in our data to rate whether it works.

The evidence, ingredient by ingredient Borage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Borage seed oil is generally well tolerated, with the most common side effects being mild digestive issues — belching, bloating, diarrhea, and soft stools. The bigger concern is pyrrolizidine alkaloids (PA), which are toxic compounds found in some borage plant parts like leaves and flowers.

Although borage seed oil contains little to no PAs, the safety data advises avoiding this product during pregnancy because of the theoretical risk from these alkaloids and effects on the uterus. It's also not recommended during breastfeeding due to insufficient safety data.

Look for products certified PA-free if you do use borage oil.

Side effects, ingredient by ingredient Borage

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Borage.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 227 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), antipsychotic medications (phenothiazines), or drugs that induce the liver enzyme CYP3A4. These have Moderate-severity interactions documented.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Borage oil might interest you if you're exploring omega-6 fatty acid supplements, but if you take blood thinners, antipsychotics, or certain liver enzyme-inducing medications, you need to talk with your pharmacist first. Pregnant or breastfeeding?

Skip this one — the safety data advises against it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Borage Oil 1000 mg, straight from the product label.

Brand DC
Barcode (UPC) 052301191901
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 266461
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Borage Oil 1000 mg by DC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
90
UPC/BARCODE
052301191901
IngredientAmount% DV
Calories10 Calorie(s)--
Calories from Fat10 Calorie(s)--
Polyunsaturated Fat0.5 Gram(s)--
Total Fat1 Gram(s)2%
Borage Oil1000 mg--

Other ingredients: Gelatin, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 to 3 softgels daily.

Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant, nursing, epileptic or schizophrenic do not take this product.

Formulation

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Contains no preservatives, sugar, starch, milk, lactose, wheat, yeast, fish, artificial color, flavor, sweetener, Non-GMO.

Made in USA

Gluten free

Supports skin, nerve and joint health

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

Formula

Dee Cee Borage Oil softgels supply pure Borage Oil, the richest source of Gamma Linolenic Acid (GLA)

Rich source of GLA

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Quali Pure

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Borage Oil 1000 mg by DC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Borage Oil 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Borage Oil 1000 mg by DC

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Borage Oil

Interacts with
226 drugs
1000 mg per serving

Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arth...

Borage Oil monograph & interactions

Other (inactive) ingredients: Gelatin, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Borage Oil 1000 mg by DC Drug Interactions

Want to check YOUR meds against Borage Oil 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
226Drugs
226 Moderate

Ingredients driving the most interactions

Borage Oil 226

Individual Drug Interactions

The ingredients in Borage Oil 1000 mg interact with 226 drugs. Click any drug to see the details.

1 of the 1 ingredient in Borage Oil 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Borage Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Borage Oil 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Borage Oil3 drug types · 226 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In healthy individuals, borage seed oil supplementation does not seem to affect platelet aggregation. However, gamma-linolenic acid, a constituent of borage seed oil, seems to decrease platelet aggregation by 45% and increase the risk of bleeding by 40% in animal and clinical research.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Although borage seed oil contains little to no PAs, some borage plant parts, such as the leaf, flower, and seed, can contain hepatotoxic PAs. Hepatotoxic PAs are substrates of CYP3A4, which converts these chemicals into toxic metabolites. Tell patients to avoid borage preparations that are not certified and labeled as hepatotoxic PA-free.

Likelihood Possible Evidence D
Phenothiazines

Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Borage seed oil contains gamma-linolenic acid (GLA). There is concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines. This is based on limited data from two reports published in the 1980s. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with evening primrose, another source of GLA. However, none experienced an actual seizure. In the other report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily was added. One of these patients had a prior history of seizures. It is unclear whether evening primrose had any additive epileptogenic effects with the phenothiazines, but there is no evidence that taking GLA-containing supplements alone can cause seizures.

Likelihood Possible Evidence D
Borage Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Borage Oil 1000 mg, from the product label.

DC

See all DC products
Name
Dee Cee Laboratories, Inc.
Street Address
304 Dee Cee Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Borage Oil 1000 mg by DC: Common Questions

Does Borage Oil 1000 mg by DC interact with any medications?
Yes. Based on its ingredients, Borage Oil 1000 mg has a known interaction with 226 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Borage Oil 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's borage oil actually for?
Borage oil is a supplement containing gamma-linolenic acid, an omega-6 fatty acid. The data we hold shows it's possibly ineffective for eczema, and there isn't enough evidence yet to know if it helps with ADHD, respiratory distress, or alcoholism.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against it during pregnancy because of liver-toxic alkaloids and a theoretical risk to the uterus, and there isn't enough safety data for breastfeeding either. Talk with your doctor or pharmacist about whether borage oil is right for you.
What are the side effects?
Most people tolerate borage seed oil well. The common mild side effects are belching, bloating, diarrhea, and soft stools. Rarely, if borage contains pyrrolizidine alkaloids, it can harm your liver — which is why PA-certified products are a safer choice.
Why do you mention pyrrolizidine alkaloids so much?
Borage leaves, flowers, and seeds can contain toxic compounds called pyrrolizidine alkaloids (PAs) that damage the liver. Borage seed oil itself has little to none, but if contamination occurs or if you use other borage plant parts, the risk exists — so look for a PA-free certification.
Do I need to worry about interactions if I'm not on blood thinners?
That depends on your full medication list. If you take antipsychotic medications or certain drugs that work through your liver, there are documented interactions — even Moderate severity ones — so run all your medications through the checker on this page before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Borage Oil 1000 mg label
Go deeper

The Full Monographs Behind Borage Oil 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Borage

Interacts with 226 drugs

Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arthritis with mixed results. The plant's le...

Read the full Borage monograph →
Sources

Sources & How We Checked

Borage Oil 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Borage 11 references
  1. Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr 1998;128:1411-4.
  4. Takwale A, Tan E, Agarwal S, et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. BMJ 2003;327:1385. PubMed
  5. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  6. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  7. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  8. Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
  9. Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed
  10. Bard, J. M., Luc, G., Jude, B., Bordet, J. C., Lacroix, B., Bonte, J. P., Parra, H. J., and Duriez, P. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. Fundam.Clin.Pharmacol. 1997;1
  11. Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. PubMed

See these in context on the Borage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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