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Dietary supplement

Broccoli Seed Extract Ingredients & Drug Interactions

by Kirkman

Broccoli Seed Extract label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Broccoli Seed Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Broccoli Seed Extract is a dietary supplement by Kirkman with 2 active ingredients. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 723 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sulforaphane Glucosinolate, Broccoli Seed Raffinate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Broccoli Seed Extract by Kirkman

Ask about any prescription or over-the-counter medication and we check it for interactions with Broccoli Seed Extract by Kirkman — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Broccoli Seed Extract by Kirkman

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: Broccoli Seed Raffinate and Sulforaphane Glucosinolate, both derived from broccoli. Sulforaphane is a sulfur-containing compound found naturally in broccoli that's thought to be responsible for some of the plant's health-promoting properties.

The supplement also contains several inactive ingredients—calcium ascorbate, microcrystalline cellulose, gellan gum, and hydroxymethyl cellulose—which serve as preservatives, binders, and capsule materials to hold the product together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: antioxidant immune support and detoxification.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

For Broccoli Seed Raffinate, the evidence suggests it may be possibly effective for colorectal cancer prevention. For other cancers (bladder, breast, gastric) and for fibromyalgia, the evidence we hold is insufficient to rate whether it works.

Sulforaphane Glucosinolate is rated possibly effective for prostate cancer but possibly ineffective for Helicobacter pylori infection (a bacteria linked to ulcers). For allergic rhinitis (hay fever), asthma, and cancer in general, the evidence is insufficient to establish whether it helps.

The evidence, ingredient by ingredient Broccoli Sulforaphane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as food is safe for most people, but concentrated supplements like this one are less studied for long-term safety. The safety data advises caution with concentrated extracts unless your doctor approves.

Common side effects reported with broccoli seed and sprout extracts include loose stools, diarrhea, abdominal pain, and cramping, especially at higher doses. Allergic contact dermatitis from broccoli has been reported when applied to skin.

Sulforaphane in concentrated form is generally well tolerated, but reported side effects include bowel discomfort, heartburn, stomach upset, vomiting, headache, and in rare cases insomnia and irritability. A small number of patients with autism who took sulforaphane supplements experienced seizures; two cases occurred within 3 weeks of starting the supplement.

Weight gain (averaging 4 pounds over 18 weeks) was also noted in one clinical study of young males with autism. For pregnancy and lactation, both ingredients are rated Likely Safe, though concentrated supplement use during breastfeeding warrants caution due to limited data at higher doses.

Side effects, ingredient by ingredient Broccoli Sulforaphane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Sulforaphane, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 724 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your own doctor or pharmacist if you're on any medications metabolized by CYP2A6, CYP1A2, CYP3A4, or CYP2E1 enzymes—these cover a very broad range of drugs. This includes blood thinners, certain cancer and heart medications, antidepressants, and many others.

The two active ingredients work differently on these enzymes, so it's not a simple yes or no; your pharmacist can look up your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Broccoli Seed Extract may interest people looking for plant-based support for colorectal health, but the evidence for other conditions is thin. However, anyone taking prescription medications—especially those processed by your liver—should not start this supplement without clearing it with their own doctor or pharmacist first, since it can significantly speed up or slow down how your body handles many common drugs.

The side effects are usually mild (digestive discomfort), but seizures have been reported rarely in people with autism. Talk it over with your healthcare provider to make sure it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Broccoli Seed Extract, straight from the product label.

Brand Kirkman
Barcode (UPC) 812325024100
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 296955
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Broccoli Seed Extract by Kirkman, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
812325024100
IngredientAmount% DV
Broccoli Seed Raffinate228 mg--
Sulforaphane Glucosinolate11 mg--

Other ingredients: Calcium Ascorbate, Microcrystalline Cellulose, Gellan Gum, Hydroxymethyl Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Important: Store in a cool dry place and tightly capped.

Precautions

Keep out of the reach of children.

Formula

Enzyme activated broccoli seed converts to sulforaphane in the body.

Formulation

Sulforaphane is a powerful anti-oxidant, immune supporter, and detoxifier.

Free of: milk, eggs, fish, shellfish, tree nuts, peanuts, wheat or soy

Hypoallergenic

Gluten-free

Enzyme activated for immune system support

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Ultra tested cGMP Good Manufacturing Products Consistent Quality

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: One capsule daily or as directed by your physician.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Broccoli Seed Extract by Kirkman label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Broccoli Seed Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Broccoli Seed Extract by Kirkman

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Broccoli Seed Raffinate

Interacts with
187 drugs
228 mg per serving

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli Seed Raffinate monograph & interactions

Sulforaphane Glucosinolate

Interacts with
722 drugs
11 mg per serving

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effec...

Sulforaphane Glucosinolate monograph & interactions

Other (inactive) ingredients: Calcium Ascorbate, Microcrystalline Cellulose, Gellan Gum, Hydroxymethyl Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Broccoli Seed Extract by Kirkman Drug Interactions

Want to check YOUR meds against Broccoli Seed Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
723Drugs
723 Moderate

Ingredients driving the most interactions

Sulforaphane Glucosinolate 722
Broccoli Seed Raffinate 187

Individual Drug Interactions

The ingredients in Broccoli Seed Extract interact with 723 drugs. Click any drug to see the details.

2 of the 2 ingredients in Broccoli Seed Extract interact with drugs. Each result below shows which ingredient is responsible. Sulforaphane Glucosinolate Broccoli Seed Raffinate

Each ingredient & the kinds of drugs it affects

For each ingredient in Broccoli Seed Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sulforaphane Glucosinolate3 drug types · 722 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP1A2 enzyme activity. However, its precursor glucoraphanin also appears to increase the expression of the CYP1A2 enzyme, which could lead to increased metabolism of CYP1A2 substrates. These effects have not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP2E1 substrates.
In vitro evidence shows that sulforaphane inhibits CYP2E1 enzymes. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP3A4 enzyme activity and downregulates its expression. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Sulforaphane Glucosinolate full monograph & interactions

Broccoli Seed Raffinate2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Broccoli Seed Raffinate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Broccoli Seed Extract, from the product label.

Kirkman

See all Kirkman products
Name
Kirkman
City
Lake Oswego
State
OR
ZipCode
97035
Phone Number
(800) 245-8282
Web Address
www.kirkmangroup.com
Pharmacist Counseling Corner

Broccoli Seed Extract by Kirkman: Common Questions

Does Broccoli Seed Extract by Kirkman interact with any medications?
Yes. Based on its ingredients, Broccoli Seed Extract has a known interaction with 723 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Broccoli Seed Extract contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy and breastfeeding?
Both active ingredients are rated Likely Safe in pregnancy. For breastfeeding, there isn't enough information on concentrated supplement doses, so caution is advised—stick to dietary amounts of broccoli if you can. Talk with your doctor or pharmacist about your individual situation.
What are the side effects?
The most common are digestive: loose stools, diarrhea, abdominal pain, cramping, heartburn, and stomach upset, especially at higher doses. Less commonly, headache, insomnia, and irritability have been reported. Very rarely, sulforaphane has been associated with seizures in people with autism. Weight gain has also been noted in one study.
Does this actually prevent cancer?
Broccoli Seed Raffinate is rated possibly effective for colorectal cancer. Sulforaphane is rated possibly effective for prostate cancer. For other cancers, the evidence we hold is insufficient to say whether it helps.
Can I just eat broccoli instead?
Yes—eating fresh broccoli is safe for most people and avoids the uncertainty around concentrated extracts. If you're interested in a supplement, your doctor or pharmacist can help you decide whether a concentrated form makes sense for you.
What does sulforaphane do?
Sulforaphane is a sulfur-containing compound naturally found in broccoli. It's thought to have antioxidant and anti-inflammatory properties, which is why researchers have studied it for cancer prevention and immune support, though evidence remains limited for most uses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Broccoli Seed Extract label
Go deeper

The Full Monographs Behind Broccoli Seed Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Sulforaphane

Interacts with 722 drugs

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effects in lab studies, but strong human evid...

Read the full Sulforaphane monograph →
Sources

Sources & How We Checked

Broccoli Seed Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Sulforaphane 16 references
  1. Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55. PubMed
  2. Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20. PubMed
  3. Cipolla BG, Mandron E, Lefort JM, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prev Res (Phila). 2015;8(8):712-9. PubMed
  4. Fahey JW, Wade KL, Wehage SL, et al. Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. Mol Nutr Food Res. 2017 Apr;61(4). PubMed
  5. Alumkal JJ, Slottke R, Schwartzman J, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33(2):480-9. PubMed
  6. Heber D, Li Z, Garcia-Lloret M, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014;5(1):35-41. PubMed
  7. Singh K, Connors SL, Macklin EA, et al. Sulforaphane treatment of autism spectrum disorder (ASD). Proc Natl Acad Sci U S A. 2014;111(43):15550-5. PubMed
  8. Wise RA, Holbrook JT, Criner G, et al. Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial. PLoS One. 2016;11(11):e0163716. PubMed
  9. Bent S, Lawton B, Warren T, et al. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018;9:35. PubMed
  10. Momtazmanesh S, Amirimoghaddam-Yazdi Z, Moghaddam HS, Mohammadi MR, Akhondzadeh S. Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial. Psychiatr PubMed
  11. Fimognari C, Lenzi M, Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008;9(7):668-78. PubMed
  12. Chinnappan SM, George A, Evans M, Anthony J. Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled stud
  13. Mahéo K, Morel F, Langouët S, et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997;57(17):3649-52.
  14. Yoxall V, Kentish P, Coldham N, Kuhnert N, Sauer MJ, Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. Int J Cancer. 2005;117(3):356-62. PubMed
  15. Zimmerman AW, Singh K, Connors SL, et al. Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder. Mol Autism 2021;12(1):38.
  16. Yusin J, Wang V, Henning SM, et al. The effect of broccoli sprout extract on seasonal grass pollen-induced allergic rhinitis. Nutrients 2021;13(4):1337. PubMed

See these in context on the Sulforaphane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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