Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Buck Build Unflavored Ingredients & Drug Interactions

by Bucked Up

Buck Build Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Buck Build Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Buck Build Unflavored is a dietary supplement by Bucked Up with 4 active ingredients. Its ingredients are commonly taken for preventing or treating magnesium deficiency, constipation, muscle cramps.Based on those ingredients, 343 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magnesium, Glutamine Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Buck Build Unflavored by Bucked Up

Ask about any prescription or over-the-counter medication and we check it for interactions with Buck Build Unflavored by Bucked Up — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Buck Build Unflavored by Bucked Up

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 11 of its 11 active ingredients.
  • “Glutamine Blend” is a proprietary blend — the label gives one combined amount (2.50 Gram(s)) without saying how much of each component you get.
  • “Creatine Blend” is a proprietary blend — the label gives one combined amount (2.50 Gram(s)) without saying how much of each component you get.

Buck Build Unflavored contains 11 active ingredients focused on muscle building and recovery. The product includes three forms of creatine (Citrate, AKG, and Pyruvate) plus Creatine MagnaPower, a creatine-magnesium compound, all chosen to support muscle strength and athletic performance.

L-Glutamine and its derivative L-Alanyl L-Glutamine support muscle recovery and are often used after intense training or illness. N-Acetyl-L-Glutamine and L-Glutamine Alpha-Ketoglutarate are additional glutamine-related compounds.

BetaPure (betaine anhydrous) supports muscle function and cardiovascular health. Magnesium rounds out the formula for muscle and recovery support.

Silicon Dioxide is included as an inactive ingredient (anti-caking agent).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle growth strength and recovery.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Cognitive function, Memory, Muscle endurance — and 3 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Magnesium is rated "Possibly Ineffective" for Athletic performance.

The evidence for effectiveness varies by ingredient and purpose. Creatine (found in three separate forms here) is possibly effective for muscle strength, athletic performance, and sarcopenia (age-related muscle loss), but possibly ineffective for Huntington disease and bone density.

L-Glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting and recovery after surgery or critical illness, though most trial participants experienced digestive side effects at high doses. Magnesium is effective for constipation and indigestion, and possibly effective for low magnesium levels.

BetaPure (betaine) is effective for homocystinuria and possibly effective for elevated homocysteine, but evidence for its other claimed uses—nonalcoholic fatty liver, colorectal health, mood, and reflux—is insufficient. We have no effectiveness data for the ingredients we could not check.

The evidence, ingredient by ingredient Magnesium Glutamine Betaine Anhydrous Creatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is generally well tolerated in healthy adults but requires medical supervision if you have kidney or liver disease. Most common side effects are digestive: belching, bloating, constipation, diarrhea, flatulence, gas, nausea, and vomiting.

Rare cases of dizziness and headache have been reported, and two people with bipolar disorder developed mania or hypomania at 4 grams daily—glutamine is converted to glutamate, which can affect the brain. Creatine (in its three forms here) is generally well tolerated but requires caution if you have kidney problems.

Common side effects include dehydration, diarrhea, gastrointestinal upset, muscle cramps, and water retention. Rare serious effects reported in case studies include kidney inflammation, muscle breakdown (rhabdomyolysis), and blood clots, though these are uncommon.

About 26% of ALS patients in one trial reported swelling at high doses. Magnesium is generally well tolerated but can cause diarrhea, nausea, vomiting, and gastrointestinal irritation.

Rare cases of a stomach bezoar (indigestible mass) have been reported with very high doses. BetaPure is generally well tolerated; common side effects include body odor, diarrhea, nausea, vomiting, and GI distress.

Cerebral edema (brain swelling) is a rare serious effect. For pregnancy: L-Glutamine is rated Likely Safe.

Creatine forms are best avoided in pregnancy because safety hasn't been established. BetaPure has no safety data in pregnancy, so your doctor should advise you.

For breastfeeding: avoid creatine, use L-Glutamine only if your doctor recommends it, and check with your doctor about BetaPure and the other ingredients we couldn't assess.

Side effects, ingredient by ingredient Magnesium Glutamine Betaine Anhydrous Creatine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Glutamine, Magnesium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 343 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take levodopa/carbidopa (Sinemet) for Parkinson's disease—magnesium reduces how much of this drug your body absorbs. Also check if you take seizure medications (anticonvulsants), since L-Glutamine may interfere with them.

Moderate caution applies if you take skeletal muscle relaxants, water pills (potassium-sparing diuretics), blood pressure medications (calcium channel blockers), stomach acid reducers, diabetes drugs (sulfonylureas), quinolone antibiotics, or bone medications (bisphosphonates)—magnesium can alter how these work. Use the medication checker below to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Buck Build Unflavored is designed for muscle building and post-workout recovery, with creatine and glutamine as its cornerstones. It's generally well tolerated by healthy adults, but if you take seizure medications, Parkinson's drugs, blood pressure medications, diabetes drugs, antibiotics, or bone medications, you need to check with us or your pharmacist first—several ingredient-drug interactions can change how your medicines work.

People with kidney disease should get medical clearance before use. Talk to your pharmacist before starting, especially if you're pregnant or nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Buck Build Unflavored, straight from the product label.

Brand Bucked Up
Barcode (UPC) 850048134188
Net contents 11.4 Ounce(s); 324 Gram(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 328389
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Buck Build Unflavored by Bucked Up, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5.4
Maximum serving Sizes:
5.4
Servings per container
60
UPC/BARCODE
850048134188
IngredientAmount% DV
L-Glutamine2150 mg--
Creatine Citrate900 mg--
N-Acetyl-L-Glutamine125 mg--
Creatine AKG150 mg--
Di-Creatine Malate400 mg--
Magnesium70 mg17%
Creatine Pyruvate150 mg--
Creatine MagnaPower900 mg--
Glutamine Blend2.5 Gram(s)--
L-Alanyl L-Glutamine100 mg--
BetaPure200 mg--
Creatine Blend2.5 Gram(s)--
L-Glutamine Alpha-Ketoglutarate125 mg--

Other ingredients: Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Accelerates muscle growth Strengthens immune system Promotes muscle cell recovery

Muscle Strength Recovery

Harness the benefits of 2 powerful recovery tools Buck Build can give you the power needed to push through the hardest of workouts.

Formula

Creatine Glutamine

With two of the most common performance enhancements in the world, Buck Build provides the powerful formula of our signature creatine blend with the natural essence of our L-glutamine. Buck Build contains 5 different types of creatine, each with different benefits and different rates of release to help you accelerate muscle growth, increase strength & power output. With an added amino acid boost, L-glutamine plays a crucial role in muscle recovery as well as strengthening the immune system. Creatine + Glutamine = Max Recovery

Creatine MagnaPower BetaPure

FDA Statement of Identity

Dietary Supplement

General Statements

#getbuckedup

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Manufactured in USA domestic & imported ingredients GMP Good Manufacturing Practice Consistent Quality

Brand IP Statement(s)

MagnaPower is a trademark of Balchem Inc. BetaPure is a trademark of Creative Compounds.

Suggested/Recommended/Usage/Directions

Recommended dosage & directions: Mix 1 well-rounded scoop of Buck Build into 6-8 oz of water 15-30 minutes prior to physical activity. Due to its potency, we recommend taking no more than 1 scoop.

Precautions

Do not exceed 2 scoops in a 24-hour period.

This product is intended for use by adults 18+ keep out of reach of children.

Manufacturer's disclaimer: Consult your physician before using this product if you are taking any prescription or over-the-counter medications or supplements. Do not use this product if you are pregnant or nursing.

Do not use this product if you are at risk of or being treated for any medical condition. Discontinue use and consult your healthcare professional if you experience any adverse reaction to this product. Discontinue use two weeks prior to surgery.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Buck Build Unflavored by Bucked Up label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Buck Build Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Buck Build Unflavored by Bucked Up

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size5.4 Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Magnesium

Interacts with
295 drugs
70 mg per serving Form: Magnesium Creatine Chelate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Glutamine Blend

Interacts with
50 drugs
2.5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

Glutamine Blend monograph & interactions
  • › L-Glutamine
  • › N-Acetyl-L-Glutamine
  • › L-Alanyl L-Glutamine
  • › L-Glutamine Alpha-Ketoglutarate

BetaPure

No known
interactions
200 mg per serving Form: Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

BetaPure monograph & interactions

Creatine Blend

No known
interactions
2.5 Gram(s) per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Blend monograph & interactions

Other (inactive) ingredients: Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Buck Build Unflavored by Bucked Up Drug Interactions

Want to check YOUR meds against Buck Build Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
343Drugs
6 Major 224 Moderate 113 Minor

Ingredients driving the most interactions

Magnesium 295
Glutamine Blend 50

Individual Drug Interactions

The ingredients in Buck Build Unflavored interact with 343 drugs. Click any drug to see the details.

2 of the 4 ingredients in Buck Build Unflavored interact with drugs. Each result below shows which ingredient is responsible. Magnesium Glutamine Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Buck Build Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium full monograph & interactions

Glutamine Blend1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Glutamine Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Buck Build Unflavored, from the product label.

Bucked Up

See all Bucked Up products
Name
DAS Labs
Street Address
781 Auto Mall Dr #102
City
American Fork
State
UT
ZipCode
84003
Phone Number
855.205.2825
Pharmacist Counseling Corner

Buck Build Unflavored by Bucked Up: Common Questions

Does Buck Build Unflavored by Bucked Up interact with any medications?
Yes. Based on its ingredients, Buck Build Unflavored has a known interaction with 343 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Buck Build Unflavored contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
L-Glutamine is rated likely safe in pregnancy. The creatine forms in this product should be avoided in pregnancy because safety hasn't been established. For BetaPure (betaine), we don't have enough data—talk with your doctor. If breastfeeding, avoid the creatine forms, use L-Glutamine only if your doctor recommends it, and check with your doctor about the other ingredients. Each has different safety information, so discuss this product with your doctor or pharmacist before use.
What are the most common side effects?
Digestive upset is the most frequent complaint: belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting—especially from L-Glutamine and BetaPure at higher doses. Creatine can cause dehydration, diarrhea, muscle cramps, and water retention. Body odor has been reported with BetaPure. Most of these are mild and dose-dependent.
Will this help me build muscle?
The creatine in this product is possibly effective for muscle strength and athletic performance. L-Glutamine is possibly effective for muscle recovery after surgery or critical illness. How well it works depends on your training and diet—the supplement supports your efforts but isn't a substitute for proper exercise and nutrition.
Can I take this if I have kidney disease?
Both the creatine forms and L-Glutamine should be used only under medical supervision if you have kidney or liver disease. Talk to your doctor before using this product if you have any kidney or liver concerns.
What is BetaPure and what does it do?
BetaPure is betaine anhydrous, an amino acid compound. It's effective for a rare genetic condition called homocystinuria and possibly effective for high homocysteine levels. Evidence for other uses like liver health, mood, and reflux isn't established yet.
Why are there three types of creatine in one product?
The three creatine forms (Citrate, AKG, and Pyruvate) and Creatine MagnaPower are included because they're claimed to be absorbed or used differently by your body. All three have the same effectiveness rating for muscle and athletic performance, so the difference comes down to how the manufacturer formulated the product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Buck Build Unflavored label
Go deeper

The Full Monographs Behind Buck Build Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph →
Sources

Sources & How We Checked

Buck Build Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 190 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Creatine 86 references
  1. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
  2. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  3. Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
  4. Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
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See these in context on the Creatine monograph →

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Betaine Anhydrous 11 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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