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Dietary supplement

Butterbur Extract Powder 150 mg Ingredients & Drug Interactions

by BulkSupplements.com

Butterbur Extract Powder 150 mg label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Butterbur Extract Powder 150 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Butterbur Extract Powder 150 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Butterbur Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Butterbur Extract Powder 150 mg by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Butterbur Extract Powder 150 mg by BulkSupplements.com — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Butterbur Extract Powder 150 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: butterbur root extract at 150 mg per serving. Butterbur has been studied for migraine headaches and hay fever (allergic rhinitis).

The extract is blended with maltodextrin, an inactive ingredient that helps with texture and handling.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Butterbur's overall clinical evidence instead.

Moderate

Some clinical evidence supports Butterbur for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Natural Medicines).
  • On file: Migraine headache — rated "Possibly Effective" (Natural Medicines).

Butterbur root extract is possibly effective for migraine headaches and possibly effective for hay fever (allergic rhinitis). The evidence supports its use for these conditions, though more research would strengthen that support.

Keep in mind: the safety note below is critical — you need a PA-free (pyrrolizidine alkaloid-free) product.

The evidence, ingredient by ingredient Butterbur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butterbur is generally well tolerated orally. The most common side effects are belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset.

Rarely, it can cause liver damage from pyrrolizidine alkaloids — a group of plant compounds that can be toxic. That's why this product must be PA-free; raw butterbur can harm your liver.

Avoid butterbur entirely during pregnancy and while breastfeeding — there isn't enough safety data, and liver and other risks are possible.

Side effects, ingredient by ingredient Butterbur

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butterbur.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check whether you take any CYP3A4 inducers — drugs that speed up a liver enzyme and might theoretically increase butterbur's toxicity. This includes certain seizure medications and some antibiotics.

Use the medication checker on this page with your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you're dealing with migraines or hay fever and you're not pregnant, breastfeeding, or taking CYP3A4 inducers, butterbur extract is worth a conversation with your pharmacist. Make sure this is labeled as PA-free.

Check your medications against the interaction list below before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Butterbur Extract Powder 150 mg, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X001CYXR13
Net contents 50 Gram(s); 1.76 Ounce(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 330482
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Butterbur Extract Powder 150 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
150 Milligram(s)
Maximum serving Sizes:
150 Milligram(s)
Servings per container
333
UPC/BARCODE
X001CYXR13
IngredientAmount% DV
Butterbur Root Extract150 mg--

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Butterbur Extract Powder 150 mg per serving

Brand IP Statement(s)

BulkSupplements.com Clean & pure bulk supplements

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 150 mg once daily with water or as directed by a physician.

Storage

Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

General Statements

Use an accurate milligram scale to measure. New

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Butterbur Extract Powder 150 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Butterbur Extract Powder 150 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Butterbur Extract Powder 150 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size150 Milligram(s) Dosage formPowder Servings per container333 Amounts shown are per serving.

Butterbur Root Extract

Interacts with
87 drugs
150 mg per serving Form: Petasites japonicus Root Extract

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Butterbur Root Extract monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Butterbur Extract Powder 150 mg by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Butterbur Extract Powder 150 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Butterbur Root Extract 87

Individual Drug Interactions

The ingredients in Butterbur Extract Powder 150 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Butterbur Extract Powder 150 mg interact with drugs. Each result below shows which ingredient is responsible. Butterbur Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Butterbur Extract Powder 150 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Butterbur Root Extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Butterbur Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Butterbur Extract Powder 150 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Butterbur Extract Powder 150 mg by BulkSupplements.com: Common Questions

Does Butterbur Extract Powder 150 mg by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Butterbur Extract Powder 150 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Butterbur Extract Powder 150 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my migraines or hay fever?
Butterbur root extract is possibly effective for both migraine headaches and hay fever, so there's reasonable evidence it may help. Results vary from person to person — talk to your pharmacist about whether it makes sense for your situation.
Can I take this while pregnant or breastfeeding?
No. Butterbur is rated likely unsafe in pregnancy and while breastfeeding. There isn't enough safety data, and there are possible risks to the liver and other organs. Skip it during these times.
What's PA-free, and why does it matter?
PA stands for pyrrolizidine alkaloids — plant compounds that can damage your liver. Raw butterbur contains them; this product should be PA-free standardized extract. Always check the label to confirm PA-free, because even some supplements labeled PA-free have rarely caused liver injury.
What side effects should I watch for?
Most people tolerate butterbur well. Common mild side effects are belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset. Rarely, it can cause liver damage — a serious concern that's why PA-free products exist.
Does this powder have fillers?
It has one inactive ingredient: maltodextrin, which helps the powder hold together and pour smoothly. It's a binder, not a filler meant to bulk up the product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Butterbur Extract Powder 150 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Butterbur Extract Powder 150 mg label
Go deeper

The Full Monographs Behind Butterbur Extract Powder 150 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Butterbur Extract Powder 150 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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