Major interaction on record — check this product against your medications before combining. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

BX3 Ultra Unflavored Ingredients & Drug Interactions

by PMD

BX3 Ultra Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BX3 Ultra Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

BX3 Ultra Unflavored is a dietary supplement by PMD with 6 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 168 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against BX3 Ultra Unflavored by PMD

Ask about any prescription or over-the-counter medication and we check it for interactions with BX3 Ultra Unflavored by PMD — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of BX3 Ultra Unflavored by PMD

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “True Instantized 2:1:1 Aminos Blend” is a proprietary blend — the label gives one combined amount (4,000 mg) without saying how much of each component you get.
  • “Beta-Fix Endurance Agent” is listed as a grouped ingredient — the label gives one combined amount (3,200 mg) without saying how much of each component you get.
  • “Beta-Strong Muscle Compound” is listed as a grouped ingredient — the label gives one combined amount (1,500 mg) without saying how much of each component you get.

BX3 Ultra Unflavored is a powder with 6 active ingredients. The main ones are calcium, which supports bone and muscle function; three branched-chain amino acids (L-leucine, L-isoleucine, and L-valine) that work together to help with muscle recovery; beta-alanine, which may help athletic performance; and betaine anhydrous, which supports muscle function and metabolism.

Two of the ingredient groups—the 2:1:1 Aminos Blend and the Beta-Fix and Beta-Strong compounds—are proprietary blends, so their exact amounts aren't broken out separately. The inactive ingredients are calcium silicate and silicon dioxide, common fillers and anti-caking agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle performance strength and endurance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle breakdown, Exercise-induced muscle damage, Physical performance, Sarcopenia, Muscle strength — and 2 related terms.
  • The strongest evidence on file: Beta-alanine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beta-alanine is rated "Possibly Effective" for Physical performance.
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

Calcium in this product is effective for preventing kidney failure, heartburn (dyspepsia), low blood calcium (hypocalcemia), high potassium (hyperkalemia), and is likely effective for osteoporosis. Beta-alanine is possibly effective for athletic performance and physical performance, though evidence for its use in cognitive decline, COPD, cognitive function, or menopausal symptoms isn't established yet.

Betaine anhydrous is effective for homocystinuria (a rare inherited disorder) and possibly effective for high homocysteine levels in the blood; evidence for its use in liver disease, colorectal polyps, depression, or reflux isn't established in our data.

The evidence, ingredient by ingredient Calcium Beta-alanine Betaine Anhydrous

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high amounts can cause problems. The most common side effects when taken by mouth are belching, constipation or diarrhea, bloating, and stomach upset.

Rare concerns include kidney stones and calciphylaxis (a serious calcium deposit condition). Some research suggests very high calcium intake—over 1500–2000 mg daily—may be linked to increased prostate cancer risk and possibly heart disease, though the evidence has been debated.

Beta-alanine is generally well tolerated but commonly causes harmless tingling and flushing of the skin, especially on the scalp, starting within 20 minutes and lasting about an hour; severity depends on dose. Betaine anhydrous is generally well tolerated at studied doses but may cause body odor, nausea, vomiting, stomach upset, or diarrhea.

In pregnancy, calcium is likely safe at recommended amounts—adequate intake is important—though stay within your doctor's guidance. Beta-alanine and betaine anhydrous don't have enough safety data; the facts advise against beta-alanine in pregnancy and suggest caution with betaine unless your doctor advises otherwise.

During breastfeeding, calcium is likely safe at recommended amounts; safety data for beta-alanine is absent, so it's best to avoid it; and betaine's breastfeeding safety isn't well established. Talk with your doctor or pharmacist before using this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Calcium Beta-alanine Betaine Anhydrous

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Calcium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 168 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take dolutegravir or elvitegravir (HIV integrase inhibitors)—calcium significantly lowers their levels—or if you receive intravenous ceftriaxone (an antibiotic where IV calcium is dangerous). Also check if you're on levothyroxine (thyroid drug), raltegravir (HIV drug), sotalol (heart rhythm medication), calcipotriene (psoriasis cream), or diltiazem (blood pressure/heart drug), since calcium can interfere with how these work.

For the amino acids and beta-alanine in this powder, no interactions are documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

BX3 Ultra Unflavored is useful if you're looking to support bone health and muscle recovery, especially around workouts. But it's not for everyone: if you take HIV medications (dolutegravir, elvitegravir, raltegravir), thyroid replacement (levothyroxine), heart rhythm drugs (sotalol, diltiazem), or IV antibiotics like ceftriaxone, you need to check with your pharmacist first.

Pregnant and nursing customers should speak with their doctor before starting, and anyone with a history of kidney stones or prostate concerns should discuss calcium dosing with their healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BX3 Ultra Unflavored, straight from the product label.

Brand PMD
Barcode (UPC) 811020911463
Net contents 9.5 Ounce(s); 270 Gram(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 333851
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BX3 Ultra Unflavored by PMD, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
9 Gram(s)
Maximum serving Sizes:
9 Gram(s)
Servings per container
30
UPC/BARCODE
811020911463
IngredientAmount% DV
Calcium40 mg3%
L-Leucine2000 mg--
L-Isoleucine1000 mg--
L-Valine1000 mg--
Beta-Alanine3200 mg--
Betaine Anhydrous1500 mg--
True Instantized 2:1:1 Aminos Blend4000 mg--
Beta-Fix Endurance Agent3200 mg--
Beta-Strong Muscle Compound1500 mg--

Other ingredients: Calcium Silicate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

X002YHFD1T New

Instagram Facebook Twitter Share what #BX3ULTRA did for you @PMDSPORTS

For product questions: PMDSports.com

Formulation

Suggested use: Use this super powder to power up your results!

Stimulant free

Strength + endurance

Creatine free. Sugar free. Gluten free. Stim free.

Suggested/Recommended/Usage/Directions

Use with a pre-workout: Mix 1 scoop of BX3 Ultra with your favorite pre-workout (like an ACG3 SuperCharged+ or Pump Fuel) and drink 30-45 minutes prior to workout to maximize muscle performance, strength and endurance. Use as an intra-workout: Mix 1 scoop of BX3 Ultra with 8 fl. oz. of cold water, juice or your favorite sports drink and use during your workout for intra-performance and endurance. Use with a post-workout: Mix 1 scoop of BX3 Ultra with your favorite post-workout (like an Amplify XL protein) to enhance recovery.

To be used as part of a physical conditioning program.

Storage

Contents may settle after shipping. Moisture and humidity can cause clumping and discoloration. Discard after expiration date. Store in a cool, dry place and avoid excessive heat.

Precautions

Warning: Keep out of reach of children. Not for use by those under the age of 18.

For use by healthy individuals only. Do not exceed recommended dose. Before consuming seek advice from a health care professional if you are unaware of your current health condition. Do not use if you are prone to dehydration or exposed to excessive heat. Do not use if you suffer from the rare genetic disorder, Hyper Beta-Alaninemia. This product contains beta-alanine which may cause a tingling skin sensation in some individuals. Discontinue use and immediately consult your healthcare professional if you experience any adverse reaction to this product. Do not use if tamper resistant seal is broken. Consumer Notice: FitLife Brands can only confirm product purity when our brands are purchased from authorized retailers, GNC, or pmdsports.com. California residents warning: Cancer and reproductive harm - www.P65Warnings.ca.gov/Food

Do not use if you are pregnant or nursing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

PMD Professional Muscular Development

Formula

3.2 g Beta-Alanine 4 g 2:1:1 BCAAs 1.5 g Betaine

Power of 3 Beta-Alanine BCAAs Betaine 1 Beta-Alanine helps enhance muscular endurance and fights off muscle fatigue 2 Instantized BCAAs helps with lean muscle growth and enhances recovery 3 Betaine Anhydrous support for muscle strength and stronger pumps

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BX3 Ultra Unflavored by PMD label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BX3 Ultra Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BX3 Ultra Unflavored by PMD

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size9 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
40 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

True Instantized 2:1:1 Aminos Blend

4000 mg per serving
  • › L-Leucine
  • › L-Isoleucine
  • › L-Valine

Beta-Fix Endurance Agent

3200 mg per serving

Beta-Strong Muscle Compound

1500 mg per serving

Other (inactive) ingredients: Calcium Silicate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

BX3 Ultra Unflavored by PMD Drug Interactions

Want to check YOUR meds against BX3 Ultra Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
168Drugs
7 Major 143 Moderate 18 Minor

Ingredients driving the most interactions

Calcium 168

Individual Drug Interactions

The ingredients in BX3 Ultra Unflavored interact with 168 drugs. Click any drug to see the details.

1 of the 6 ingredients in BX3 Ultra Unflavored interact with drugs. Each result below shows which ingredient is responsible. Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in BX3 Ultra Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BX3 Ultra Unflavored, from the product label.

PMD

See all PMD products
Name
FitLife Brands
Street Address
5214 South 136th Street
City
Omaha
State
NE
ZipCode
68137
Web Address
PMDSports.com
Pharmacist Counseling Corner

BX3 Ultra Unflavored by PMD: Common Questions

Does BX3 Ultra Unflavored by PMD interact with any medications?
Yes. Based on its ingredients, BX3 Ultra Unflavored has a known interaction with 168 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BX3 Ultra Unflavored contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product cause tingling or flushing?
Beta-alanine, one of the active ingredients, commonly causes harmless tingling and skin flushing—especially on the scalp—starting within 20 minutes of taking it and lasting about an hour. How strong it is depends on the dose; at lower doses only about 1 in 4 people experience it. This is not dangerous, just uncomfortable for some.
Is beta-alanine safe for long-term use?
Beta-alanine is generally well tolerated in healthy adults, but it hasn't been studied for very high doses over a long period. If you're using it regularly, mention that to your doctor or pharmacist.
Can I take this if I'm pregnant?
Calcium at recommended amounts is likely safe and actually important in pregnancy, but beta-alanine and betaine anhydrous don't have enough safety data. It's best to talk with your doctor before using this product while pregnant.
What does betaine do in this powder?
Betaine anhydrous supports muscle function and metabolism. It's also effective for homocystinuria and possibly helpful for high homocysteine levels in your blood, though evidence for other uses isn't established yet.
What's the difference between the amino acids in here?
L-leucine, L-isoleucine, and L-valine are branched-chain amino acids that work together to help your muscles recover, especially after exercise. They're included in a 2:1:1 ratio blend in this product.
Does high calcium intake raise my disease risk?
Some research links very high calcium—over 1500–2000 mg daily—to increased prostate cancer risk and possibly heart disease, though scientists have debated these findings. If you have concerns about prostate or heart health, discuss your total daily calcium intake (food plus supplements) with your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BX3 Ultra Unflavored label
Go deeper

The Full Monographs Behind BX3 Ultra Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph →
Sources

Sources & How We Checked

BX3 Ultra Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 86 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  16. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  17. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  18. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  19. Decktor DL, Robinson M, Maton PN, et al. Effects of aluminum/magnesium hydroxide and calcium carbonate on esophageal and gastric pH in subjects with heartburn. Am J Ther 1995;2:546-52. PubMed
  20. Simoneau G. Absence of rebound effect with calcium carbonate. Eur J Drug Metab Pharmacokinet 1996;21:351-7. PubMed
  21. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
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See these in context on the Calcium monograph →

Beta-alanine 13 references
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See these in context on the Beta-alanine monograph →

Betaine Anhydrous 11 references
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See these in context on the Betaine Anhydrous monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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