Major interaction on record — check this product against your medications before combining. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

ACG3 Supercharged+ Flex On The Beach Ingredients & Drug Interactions

by PMD

ACG3 Supercharged+ Flex On The Beach label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ACG3 Supercharged+ Flex On The Beach against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

ACG3 Supercharged+ Flex On The Beach is a dietary supplement by PMD with 6 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 1,906 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ACG3 Supercharged+ Flex On The Beach by PMD

Ask about any prescription or over-the-counter medication and we check it for interactions with ACG3 Supercharged+ Flex On The Beach by PMD — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ACG3 Supercharged+ Flex On The Beach by PMD

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 30 active ingredients.
  • “Neuro-Transmit Matrix” is a proprietary blend — the label gives one combined amount (825 mg) without saying how much of each component you get.
  • “G-Force Energy Blend” is a proprietary blend — the label gives one combined amount (425 mg) without saying how much of each component you get.
  • “Magna-3 Complex” is a proprietary blend — the label gives one combined amount (3,000 mg) without saying how much of each component you get.

ACG3 Supercharged+ Flex On The Beach is a 30-ingredient powder formula. The active ingredients include potassium, taurine, caffeine anhydrous, L-arginine (in two forms), calcium, magnesium (as magnesium creatine chelate), creatine citrate, licorice root extract, L-tyrosine, L-carnitine L-tartrate, guarana seed extract (which contains additional caffeine), glycerol powder, beta-alanine, L-histidine, and phosphatidyl serine.

The product also contains several proprietary blends: the Neuro-Transmit Matrix, G-Force Energy Blend, Magna-3 Complex, Beta-PUMP Blend, ACG3 Supercharged+ Blend, Burn Complex, and Pump Complex, whose individual component amounts are not disclosed. Inactive ingredients include natural and artificial flavors, malic acid, maltodextrin, sucralose, waxy maize, and food colorings.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: energy focus power endurance athletic performance.
  • We looked for evidence on: Athletic performance, muscle strength, exercise recovery, workout intensity.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glycerol is rated "Possibly Effective" for Athletic performance.
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance, Muscle strength.

The evidence for this product's ingredients is mixed. Caffeine is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance.

Calcium is effective for bone health (osteoporosis) and likely effective for that purpose. Creatine is possibly effective for muscle strength and athletic performance.

Taurine shows possibly effective evidence for congestive heart failure and hepatitis, though it's possibly ineffective for weight loss. L-carnitine is possibly effective for heart failure and cholesterol management.

Beta-alanine is possibly effective for athletic and physical performance. Phosphatidyl serine is possibly effective for age-related cognitive decline and Alzheimer disease.

L-tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory. Potassium, L-arginine, L-histidine, and several other ingredients have no established effectiveness ratings in our data.

Betaine anhydrous has mixed evidence—it's effective for homocystinuria but shows insufficient evidence for depression, GERD, and fatty liver disease.

The evidence, ingredient by ingredient Potassium Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 24 of the 27 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 26 of 27.
  • General safety write-ups exist for 27 of 27.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is safe, but potassium supplements can raise blood levels dangerously in people with kidney disease—use only under medical guidance. Caffeine is generally well tolerated in moderate amounts for healthy adults, though high doses can cause serious side effects; during pregnancy it's possibly unsafe and during breastfeeding it passes into milk.

Taurine is generally well tolerated short-term but long-term safety is less certain; use only under medical guidance during pregnancy and breastfeeding. L-arginine is often well tolerated short-term but can lower blood pressure and requires medical supervision; pregnancy safety data is incomplete.

Calcium is generally safe at recommended doses; its safety during pregnancy is rated possibly unsafe at high doses. Licorice root extract should be avoided in pregnancy (rated unsafe) and while breastfeeding; high doses or long-term use of its active compound glycyrrhizin can cause serious problems.

Creatine is generally well tolerated in healthy adults but those with kidney disease should be careful; it should be avoided in pregnancy and breastfeeding. Glucuronolactone is generally well tolerated in beverage amounts but should be avoided in pregnancy and breastfeeding due to lack of safety data.

L-carnitine is generally well tolerated at typical doses; pregnancy safety is unknown and breastfeeding use requires caution. Beta-alanine is generally well tolerated but commonly causes harmless skin tingling and should be avoided in pregnancy and breastfeeding.

Glycerol is generally well tolerated in normal amounts orally. Betaine anhydrous and phosphatidyl serine are generally well tolerated but have insufficient pregnancy/breastfeeding data.

Side effects, ingredient by ingredient Potassium Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 21 of the 27 matched ingredients can interact with medications — Quercetin, Ginkgo, Choline, Yohimbe, Calcium, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,907 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications against these drug types before taking this product. Major interaction: ephedrine.

Moderate interactions: potassium-sparing diuretics, ACE inhibitors, angiotensin receptor blockers (for potassium and L-arginine), HIV integrase inhibitors like dolutegravir and elvitegravir (calcium), ceftriaxone (calcium), skeletal muscle relaxants, levodopa/carbidopa, barbiturates, anticonvulsants, quinolone antibiotics, antipsychotics like clozapine, blood thinners (warfarin, acenocoumarol), digoxin, anticoagulants/antiplatelets, antidiabetes drugs, blood pressure medications, sildenafil (Viagra), levothyroxine (thyroid), and several others. Use the medication checker on this page to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a complex multi-ingredient sports and performance formula best suited for healthy adults without kidney disease, high blood pressure, or heart conditions—and only after checking every medication you take. Because it contains potassium, calcium, magnesium, and caffeine (from two sources), it carries real risks if you take blood pressure drugs, blood thinners, diabetes medications, thyroid medication, certain antibiotics, or muscle relaxants.

Talk to your pharmacist or doctor before starting, especially if you take any prescription medications or have kidney or heart issues.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 29 of 30 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ACG3 Supercharged+ Flex On The Beach, straight from the product label.

Brand PMD
Barcode (UPC) 811020911074
Net contents 13.2 Ounce(s); 375 Gram(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 278531
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ACG3 Supercharged+ Flex On The Beach by PMD, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6.25 Gram(s)
Maximum serving Sizes:
12.5 Gram(s)
Servings per container
30
UPC/BARCODE
811020911074
IngredientAmount% DV
Potassium65 mg1%
Taurine0 NP--
Caffeine Anhydrous325 mg--
Calories20 Calorie(s)--
L-Arginine Alpha Ketoglutarate0 NP--
Calcium95 mg7%
Glucuronolactone0 NP--
Betaine Anhydrous0 NP--
Licorice Root Extract0 NP--
Total Carbohydrates1 Gram(s)1%
L-Tyrosine0 NP--
L-Arginine0 NP--
Phosphatidyl Serine0 NP--
Creatine Citrate0 NP--
Neuro-Transmit Matrix825 mg--
G-Force Energy Blend425 mg--
Guarana (Paullinia cupana) seed extract0 NP--
Magna-3 Complex3000 mg--
Glycerol powder0 NP--
L-Carnitine L-Tartrate0 NP--
ACG3 Supercharged+ Blend9775 mg--
Magnesium Creatine Chelate0 NP--
Beta-PUMP Blend5525 mg--
Burn Complex0 NP--
Beta-Alanine0 NP--
L-Histidine0 NP--
Pump Complex0 NP--
AstraGin25 mg--
Choline Complex0 NP--
Ashwagandha root extract0 NP--
Theacrine0 NP--
Yohimbe bark extract0 NP--
Quercetin0 NP--
Amla (Phyllanthus emblica) extract0 NP--
Theobromine0 NP--
Green Tea leaf extract0 NP--
Beta Blend0 NP--
Ginkgo biloba0 NP--
Ribose0 NP--
Creatine Alpha-Ketoglutarate0 NP--

Other ingredients: Natural & Artificial flavors, Malic Acid, Calcium Silicate, Maltodextrin, Sucralose, Waxy Maize, Acesulfame Potassium, Salt, FD&C Red 40, FD&C Yellow #5

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Higher voltage concentrated pre-workout intensifier Support for: Amped up energy and focus, maximum power output, electrifying muscle pumps, enhanced endurance and supercharged performance. Feel the power!

Professional muscular development High voltage pre-workout

Free of: Gluten, lactose, preservative, aspartame or yeast.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, mix 1 scoop of PMD's ACG3 SuperCharged+ with 4-6 fl. oz. of cold water 30-45 minutes before workout. Follow this regimen for the first week of use. If necessary, on week two increase to 1 and a half scoops prior to workout. The optimal dose will vary by individual between 1-2 scoops. Do not exceed recommended dose. Do not exceed 2 scoops in any 24 hour period. Exceeding the recommended amounts or not following directions may lead to unwanted effects. Consume a minimum 125 fl. oz. of water per day while taking this product. To be used as part of a physical conditioning program.

General Statements

Contents may settle after shipping. Moisture and humidity can cause clumping and discoloration. Discard after expiration date.

Consumer Notice: FitLife Brands can only confirm product purity when our brands are purchased from authorized retailers, on gnc.com, or on pmdsports.com. For an approved list of retailers, go to pmdsports.com.

Share what this #ACG3 did for you @PMDSPORTS

Servings per container 30-60 servings

Storage

Store in a cool, dry place and avoid excessive heat.

Precautions

Warning: Keep out of reach of children.

For use by healthy individuals only.

Not for use by those under the age of 18.

Do not exceed recommended dose.

Do not use if you are pregnant or nursing.

Before consuming seek advice from a health care professional if you are unaware of your current health condition. Contains caffeine. Do not consume caffeine from other sources, including but not limited to, coffee, tea, soda and other dietary supplements or medications containing caffeine.

Consult with your physician prior to use if you are taking medication, including but not limited to MAOI inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants.

Consult your physician prior to use if you have a medical condition, including but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high or low blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Do not use if you are prone to dehydration or exposed to excessive heat. Do not use if you suffer from the rare genetic disorder, Hyper Beta-Alaninemia. This product contains beta-alanine which may cause a tingling skin sensation in some individuals. Discontinue use 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache or shortness of breath. Do not use if tamper resistant seal is broken.

California Residents Warning: Cancer and Reproductive Harm - www.P65Warnings.ca.gov/Food

Contains milk, soy.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Creatine MagnaPower CarnoSyn Carnosine Synthesizer TeaCrine AstraGin

Flex on the beach natural and artificial flavor

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Creatine MagnaPower is a registered trademark of Albion Laboratories, Inc. covered by U.S. Patent 6,114,379. Natural Alternatives International (NAI) is the owner of patents as listed on www.carnosyn.com and registered trademark CarnoSyn. AstraGin is a registered trademark of NuLiv Science USA Inc. VitaCholine is a registered trademark of Balchem Corporation. TeaCrine is a registered trademark and protected by Patents Pending, Serial No. 61/903,362; under exclusive global distribution by Compound Solutions, Inc. KSM-66 is a registered trademark of Ixoreal Biomed, Inc. QU995 is a trademark of Quercegen Pharmaceuticals.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ACG3 Supercharged+ Flex On The Beach by PMD label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ACG3 Supercharged+ Flex On The Beach label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ACG3 Supercharged+ Flex On The Beach by PMD

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size6.25 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Potassium

Interacts with
62 drugs
65 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Calcium

Interacts with
168 drugs
95 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

ACG3 Supercharged+ Blend

9775 mg per serving
  • › Neuro-Transmit Matrix
  • › G-Force Energy Blend
  • › Magna-3 Complex
  • › Beta-PUMP Blend

Other (inactive) ingredients: Natural & Artificial flavors, Malic Acid, Calcium Silicate, Maltodextrin, Sucralose, Waxy Maize, Acesulfame Potassium, Salt, FD&C Red 40, FD&C Yellow #5. These complete the product’s ingredient list but are not active constituents.

Interaction report

ACG3 Supercharged+ Flex On The Beach by PMD Drug Interactions

Want to check YOUR meds against ACG3 Supercharged+ Flex On The Beach?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,906Drugs
36 Major 1,851 Moderate 19 Minor

Ingredients driving the most interactions

Calcium 168
Potassium 62

Individual Drug Interactions

The ingredients in ACG3 Supercharged+ Flex On The Beach interact with 1,906 drugs. Click any drug to see the details.

2 of the 6 ingredients in ACG3 Supercharged+ Flex On The Beach interact with drugs. Each result below shows which ingredient is responsible. Calcium Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in ACG3 Supercharged+ Flex On The Beach with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ACG3 Supercharged+ Flex On The Beach, from the product label.

PMD

See all PMD products
Name
FitLife Brands, Inc.
Street Address
5214 S. 136th St.
City
Omaha
State
NE
ZipCode
68137
Web Address
PMDSports.com
Pharmacist Counseling Corner

ACG3 Supercharged+ Flex On The Beach by PMD: Common Questions

Does ACG3 Supercharged+ Flex On The Beach by PMD interact with any medications?
Yes. Based on its ingredients, ACG3 Supercharged+ Flex On The Beach has a known interaction with 1,906 medications, including 36 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ACG3 Supercharged+ Flex On The Beach contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this powder contain stimulants?
Yes—it contains caffeine anhydrous and guarana seed extract (which is also high in caffeine), making the total caffeine content significant. If you're sensitive to caffeine or take medications that interact with it, this is important to discuss with your pharmacist before using.
Is it safe to take if I have high blood pressure or take blood pressure medication?
No—not without talking to your doctor first. This product contains potassium, L-arginine, and caffeine, all of which can lower blood pressure or interact with blood pressure drugs. Depending on which medication you take, the risks may be serious.
Can I take this while pregnant or breastfeeding?
No, not safely. Caffeine is possibly unsafe in pregnancy, licorice root extract is unsafe in pregnancy, and creatine, beta-alanine, glucuronolactone, and phosphatidyl serine have insufficient safety data. Caffeine and taurine pass into breast milk. Talk to your doctor or midwife before using.
Will this help me with athletic performance?
Possibly. Caffeine, creatine, beta-alanine, and L-carnitine all show possibly effective evidence for athletic performance in the data we hold. Results vary between individuals, and the right dose matters.
What's the tingling feeling some people report?
Beta-alanine, one of the ingredients, commonly causes a harmless skin-tingling sensation (paresthesia) that usually starts on the scalp within 20 minutes and lasts about an hour. It's dose-dependent and fades with continued use in many people.
Can I take this if I have kidney disease?
No. This product contains potassium, which can accumulate to dangerous levels in people with kidney problems. Talk to your doctor or kidney specialist before considering any supplement with potassium.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ACG3 Supercharged+ Flex On The Beach label
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The Full Monographs Behind ACG3 Supercharged+ Flex On The Beach’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

ACG3 Supercharged+ Flex On The Beach's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1,450 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Taurine 21 references
  1. Ahmad S, Robertson HT, Golper TA, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 1990;38:912-8. PubMed
  2. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  3. Obermann M, Schorn CF, Mummel P, et al. Taurine induced toxic encephalopathy? Clin Neurol Neurosurg 2006;108:812-3. PubMed
  4. Bichler, A., Swenson, A., and Harris, M. A. A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 2006;31(4):471-476. PubMed
  5. Iyadurai, S. J. and Chung, S. S. New-onset seizures in adults: possible association with consumption of popular energy drinks. Epilepsy Behav 2007;10(3):504-508. PubMed
  6. Berger, A. J. and Alford, K. Cardiac arrest in a young man following excess consumption of caffeinated "energy drinks". Med J Aust. 1-5-2009;190(1):41-43. PubMed
  7. Worthley, M. I., Prabhu, A., De, Sciscio P., Schultz, C., Sanders, P., and Willoughby, S. R. Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med 2010;123(2):184-187. PubMed
  8. Morchon, Simon D. and Perez Castrillon, J. L. [Hypoglycemia by intake of taurine]. Rev.Clin Esp. 2010;210(1):49.
  9. Livshits, Z., Hoffman, R. S., Hymes, K. B., and Nelson, L. S. If vitamins could kill: massive hemolysis following naturopathic vitamin infusion. J Med Toxicol. 2011;7(3):224-226. PubMed
  10. Schoffl, I., Kothmann, J. F., Schoffl, V., Rupprecht, H. D., and Rupprecht, T. "Vodka energy": too much for the adolescent nephron? Pediatrics 2011;128(1):e227-e231. PubMed
  11. Calabro, R. S., Italiano, D., Gervasi, G., and Bramanti, P. Single tonic-clonic seizure after energy drink abuse. Epilepsy Behav 2012;23(3):384-385. PubMed
  12. Fujita, T., Ando, K., Noda, H., Ito, Y., and Sato, Y. Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 1987;75(3):525-532. PubMed
  13. Darling, P. B., Lepage, G., Leroy, C., Masson, P., and Roy, C. C. Effect of taurine supplements on fat absorption in cystic fibrosis. Pediatr Res 1985;19(6):578-582. PubMed
  14. Fukuyama, Y. and Ochiai, Y. Therapeutic trial by taurine for intractable childhood epilepsies. Brain Dev. 1982;4(1):63-69. PubMed
  15. Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G. Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am.J. DOI
  16. Stohs SJ, Miller M. A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides. Food Chem Toxicol. 2014 Jan;63:240-3. PubMed
  17. Sun Q, Wang B, Li Y, Sun F, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016 Mar;67(3):541-9. PubMed
  18. Jang ES, Hwang SH, Kim JW, Jeong SH. Effectiveness of 4-week oral taurine treatment for muscle cramps in patients with liver cirrhosis: a single-arm pilot study. Yonsei Med J 2021;62(1):21-8. PubMed
  19. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol 2020;885:173533. PubMed
  20. Higgins JP, Liras GN, Liras IN, et al. Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. Cardiology. 2021;146(2):258-262. PubMed
  21. Pallangyo P, Bhalia SV, Komba M, et al. Acute Myocardial Infarction Following the Consumption of Energy Drink in a 28-Year-Old Male: A Case Report. J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231168811. PubMed

See these in context on the Taurine monograph →

Caffeine 236 references
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  2. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  3. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
  4. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
  5. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
  6. Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
  7. Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. PubMed
  8. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  9. Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. PubMed
  10. Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. PubMed
  11. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. PubMed
  12. The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.
  13. Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med 1999;341:1639-44. PubMed
  14. Eskenazi B. Caffeine—filtering the facts. N Engl J Med 1999;341:1688-9. PubMed
  15. Fernandes O, Sabharwal M, Smiley T, et al. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Reprod Toxicol 1998;12:435-44. PubMed
  16. Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. PubMed
  17. Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. PubMed
  18. Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. PubMed
  19. FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).
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  21. Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. PubMed
  22. Tobias JD. Caffeine in the treatment of apnea associated with respiratory syncytial virus infection in neonates and infants. South Med J 2000;93:297-304. DOI
  23. Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. PubMed
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  36. Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70. PubMed
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  38. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
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Glucuronolactone 2 references
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See these in context on the Creatine monograph →

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Beta-alanine 13 references
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Ashwagandha 32 references
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See these in context on the Cocoa monograph →

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  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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