Major interaction on record — check this product against your medications before combining. Based on 3 of 8 ingredients. Check your meds →
Dietary supplement

Methyl Andro Hardcore Ingredients & Drug Interactions

by PMD

Methyl Andro Hardcore label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Methyl Andro Hardcore against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Methyl Andro Hardcore is a dietary supplement by PMD with 8 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 1,627 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are FenuPRO, E-Fighter Agent, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Methyl Andro Hardcore by PMD

Ask about any prescription or over-the-counter medication and we check it for interactions with Methyl Andro Hardcore by PMD — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Methyl Andro Hardcore by PMD

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 6 of its 19 active ingredients.
  • “Muscle GROWTH Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Pro-Estro SUPPRESS Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Andro|Test Blend” is a proprietary blend — the label gives one combined amount (2,000 mg) without saying how much of each component you get.

Methyl Andro Hardcore contains 19 active and inactive ingredients, though six are proprietary blends (Muscle GROWTH Blend, Pro-Estro SUPPRESS Blend, Andro|Test Blend, LaxoTest Complex, 4-in-1 Test Support Matrix, Activate T Blend, and T Absorption Agent) whose individual amounts aren't disclosed. Among the named actives are Zinc, which supports immune function and wound healing; D-aspartic acid; Androstenolone (DHEA), a hormone precursor; botanical extracts including Yacon, Bladderwrack, Ashwagandha, white button mushroom, and Avena sativa (oats); Arginine Alpha-Ketoglutarate, an amino acid; Resveratrol, a polyphenol; Indole-3-carbinol and Diindolylmethane (DIM), plant compounds; Calcium Lactate Gluconate; Chrysin, a flavonoid; Sarsaparilla; Mucuna pruriens (cowhage), which contains levodopa; and Fenugreek.

The remaining ingredients are inactive fillers: bovine gelatin, magnesium stearate, silicon dioxide, cellulose, and titanium dioxide.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Athletic performance and muscle building support.
  • We looked for evidence on: Athletic performance, Strength, Muscle mass, Endurance.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Dhea is rated "Possibly Ineffective" for Muscle strength.
  • Also on file: Dhea is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The product contains several ingredients with established or possible effectiveness. Zinc is rated Effective for zinc deficiency and Likely Effective for Wilson disease, though possibly helpful for acne and a few other conditions.

Androstenolone (DHEA) is Likely Effective for vaginal atrophy and possibly effective for infertility, aging skin, and depression. Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder.

Oats (Avena sativa) are Likely Effective for dyslipidemia and coronary heart disease. Resveratrol and several other ingredients are possibly effective for obesity and allergic rhinitis, though some evidence suggests resveratrol may be ineffective for cardiovascular disease and high cholesterol.

Many ingredients—including BioPerine, Bladderwrack, Yacon, Indole-3-carbinol, Chrysin, white button mushroom, Sarsaparilla, Mucuna pruriens, and Fenugreek—have insufficient evidence to rate their effectiveness for the conditions cited on the label, meaning clinical data is limited or unclear.

The evidence, ingredient by ingredient Zinc Fenugreek Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 15 of the 16 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 16 of 16.
  • General safety write-ups exist for 16 of 16.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in this product are generally well tolerated at typical doses, but several carry cautions. Zinc is safe in recommended amounts (the upper limit is 40 mg daily for adults) but can cause nausea, diarrhea, metallic taste, and abdominal cramps; high doses risk copper deficiency.

Androstenolone (DHEA) acts as a hormone and may cause acne, mood changes, insomnia, and in women masculinization (voice deepening, unwanted hair growth, irregular periods); it should be avoided during pregnancy and breastfeeding. Black pepper at food levels is fine, but concentrated piperine supplements warrant caution.

Ashwagandha is well tolerated short-term but carries rare concerns of liver damage and is best avoided in pregnancy. Indole-3-carbinol can cause diarrhea, tremor, and unsteadiness, especially at higher doses, and should be avoided in pregnancy and breastfeeding.

Calcium is safe at recommended intakes but high doses may increase prostate cancer and cardiovascular risk; it is likely safe in pregnancy and breastfeeding. Several ingredients—Mucuna pruriens, Fenugreek, Resveratrol, Diindolylmethane, and others—lack sufficient pregnancy and breastfeeding safety data, and you should not use this product if you're pregnant or nursing without discussing it with your doctor or pharmacist first.

Side effects, ingredient by ingredient Zinc Fenugreek Diindolylmethane

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 16 of the 16 matched ingredients can interact with medications — Tribulus, Resveratrol, Dhea, Sarsaparilla, Fucus Vesiculosus, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,628 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Methyl Andro Hardcore, check with your pharmacist if you're on any of these: HIV integrase inhibitors (dolutegravir, elvitegravir), blood thinners or antiplatelet drugs, antidepressants (especially SSRIs), non-selective MAOIs, methyldopa or other blood pressure medicines, diabetes medications, thyroid hormones, levodopa, antipsychotics, or broad-spectrum antibiotics (quinolones, tetracyclines, cephalosporins). The product contains ingredients that can dangerously raise or lower your medication levels, prevent absorption, or trigger serious interactions like hypertensive crisis.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is complex and carries multiple serious drug interactions, particularly if you take blood pressure medicines, blood thinners, HIV medications, antidepressants, diabetes drugs, or anesthesia. Because it contains a hormone (DHEA) and levodopa (in cowhage), it requires careful consideration and professional guidance.

Talk to your pharmacist or doctor before starting, especially if you take any prescription medications, are pregnant, or are breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 16 of 19 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Methyl Andro Hardcore, straight from the product label.

Brand PMD
Barcode (UPC) 811020911432
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 321830
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Methyl Andro Hardcore by PMD, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
811020911432
IngredientAmount% DV
Zinc30 mg273%
D-Aspartic Acid1000 mg--
Androstenolone50 mg--
Yacon0 NP--
BioPerine0 NP--
Bladderwrack0 NP--
Ashwagandha Root Extract0 NP--
Indole-3-Carbinol0 NP--
Arginine Alpha-Ketoglutarate0 NP--
Resveratrol0 NP--
White Button Mushroom Fruit Extract0 NP--
Calcium Lactate Gluconate0 NP--
Chrysin0 NP--
Muscle GROWTH Blend0 NP--
Pro-Estro SUPPRESS Blend0 NP--
Andro|Test Blend2000 mg--
LaxoTest Complex0 NP--
4-in-1 Test Support Matrix315 mg--
Activate T Blend0 NP--
Avena sativa Whole Plant Extract0 NP--
T Absorption Agent0 NP--
Smilax officinalis, Powder250 mg--
Mucuna pruriens Seed Extract0 NP--
FenuPRO600 mg--
E-Fighter Agent100 mg--
TRIBPRO 900 NP--

Other ingredients: Bovine Gelatin, Magnesium Stearate, Silicon Dioxide, Cellulose, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: (By Training Level) Take 3 Methyl Andro capsules daily. One workout days take 3 capsules 30 minutes before your workout. On non-workout days take 1 capsule 30 minutes before each meal. For advanced results stack with Z-TEST for increase muscular performance. Methyl Andro is best used in cycles of 12 weeks on, 4 weeks off. To be used as part of a physical conditioning program.

Precautions

Warning: Keep out of reach of children. Not for use by those under the age of 18.

For use by healthy individuals only.

Do not use if you are pregnant, nursing, or have a serious medical condition.

Do not exceed recommended dose. Before consuming seek advice from a health care professional is you are unaware of your current health condition.

Consult your physician prior to use if you are taking OTC, prescription medication, or other dietary supplements.

Consult your physician prior to use if you have, or have a family history of, prostate cancer, prostate enlargement, heart, liver, kidney, or thyroid disease, difficulty urinating, diabetes, high or low blood pressure, or low "good" cholesterol (HDL). Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other symptoms. To report any adverse events call 1-800-332-1088. Discontinue use two weeks prior to surgery. Do not use if tamper resistant seal is broken.

Due to the unique restrictions of amateur and professional sports organizations (e.g., WADA, NCAA, NFL, MLB, NBA, UIL, etc.), it is recommended that you consult with the appropriate governing body before taking this or any other dietary supplement product.

California Residents Warning: Cancer and reproductive harm - www.P65Warnings.ca.gov/Food

Storage

Store in a cool, dry place and avoid excessive heat.

General Statements

Consumer notice: FitLife Brands can only confirm product purity when our brands are purchased from authorized retailers, GNC, or pmdsports.com.

Instagram Facebook Twitter Share what this did for you #METHYLANDRO @PMDSPORTS

For product questions: PMDSports.com

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Professional muscular development Anabolic testosterone

Gluten free.

Formula

50 mg DHEA LaxoTest Complex 600 mg FenuPRO

BioPerine

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

FenuPRO and LaxoTest are registered trademarks of FitLife Brands, Inc. BioPerine is a registered trademark and patented product of Sabinsa Corporation.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Methyl Andro Hardcore by PMD label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Methyl Andro Hardcore label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Methyl Andro Hardcore by PMD

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zinc

Interacts with
67 drugs
30 mg per serving Form: Zinc Oxide

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Andro|Test Blend

2000 mg per serving

4-in-1 Test Support Matrix

315 mg per serving
  • › Muscle GROWTH Blend
  • › Pro-Estro SUPPRESS Blend
  • › Activate T Blend
  • › T Absorption Agent

Other (inactive) ingredients: Bovine Gelatin, Magnesium Stearate, Silicon Dioxide, Cellulose, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Methyl Andro Hardcore by PMD Drug Interactions

Want to check YOUR meds against Methyl Andro Hardcore?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,627Drugs
24 Major 1,551 Moderate 52 Minor

Ingredients driving the most interactions

FenuPRO 389
E-Fighter Agent 269
Zinc 67

Individual Drug Interactions

The ingredients in Methyl Andro Hardcore interact with 1,627 drugs. Click any drug to see the details.

3 of the 8 ingredients in Methyl Andro Hardcore interact with drugs. Each result below shows which ingredient is responsible. FenuPRO E-Fighter Agent Zinc

Each ingredient & the kinds of drugs it affects

For each ingredient in Methyl Andro Hardcore with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

FenuPRO9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
FenuPRO full monograph & interactions

E-Fighter Agent3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
E-Fighter Agent full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Methyl Andro Hardcore, from the product label.

PMD

See all PMD products
Name
FitLife Brands, Inc.
Street Address
5214 South 136th Street
City
Omaha
State
NE
ZipCode
68137
Web Address
PMDSports.com
Pharmacist Counseling Corner

Methyl Andro Hardcore by PMD: Common Questions

Does Methyl Andro Hardcore by PMD interact with any medications?
Yes. Based on its ingredients, Methyl Andro Hardcore has a known interaction with 1,627 medications, including 24 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Methyl Andro Hardcore contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Androstenolone (DHEA) is unsafe in pregnancy, and Mucuna pruriens (cowhage) can reduce milk supply by lowering prolactin. Several other ingredients lack sufficient safety data. Do not use this product if you're pregnant or breastfeeding without explicit clearance from your doctor or pharmacist.
Will this cause side effects?
Possibly. Common side effects from the ingredients include nausea, diarrhea, headache, insomnia, and mood changes—especially from DHEA. Zinc can cause a metallic taste and abdominal cramps. Ashwagandha may cause drowsiness. Indole-3-carbinol can cause unsteadiness at higher doses.
What's DHEA, and why is it in here?
Androstenolone is a form of DHEA, a hormone your body naturally makes. It's included because DHEA is possibly effective for sexual dysfunction, infertility, and depression. However, as a hormone, it can cause side effects and interact with many drugs, so it needs medical oversight.
Does this contain any ingredients we couldn't check for interactions?
Yes. We have no interaction data on file for D-Aspartic Acid, Yacon, Bladderwrack, and Arginine Alpha-Ketoglutarate, so we cannot verify whether they interact with your medications. Discuss these with your pharmacist.
Why is cowhage a concern?
Cowhage (Mucuna pruriens) contains levodopa, an active drug. Combined with certain blood pressure medicines, MAOIs, or levodopa itself, it can cause dangerous blood pressure drops or hypertensive crises. It's a Major-severity interaction and not something to ignore.
Is this safe to take with my antidepressant?
It depends on which antidepressant and which other meds you're on. DHEA theoretically raises the risk of mania when combined with SSRIs, and Mucuna pruriens is dangerous with MAOIs. Check your exact medications with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Methyl Andro Hardcore label
Go deeper

The Full Monographs Behind Methyl Andro Hardcore’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

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Sources

Sources & How We Checked

Methyl Andro Hardcore's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 467 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zinc 88 references
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  7. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
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  19. Lagiou P, Wuu J, Trichopoulou A, et al. Diet and benign prostatic hyperplasia: a study in Greece. Urology 1999;54:284-90. PubMed
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  21. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  22. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Oph
  23. Greenberg JE, Lynn M, Kirsner RS, et al. Mucocutaneous pigmented macule as a result of zinc deposition. J Cutan Pathol 2002;29:613-5. PubMed
  24. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.
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  27. Mossad SB. Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. QJM 2003;96:35-43. DOI
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  29. Jafek BW, Linschoten M, Murrow BW. Zicam Induced Anosmia. American Rhinologic Society 49th Annual Fall Scientific Meeting abstract. Orlando, Florida. September 20, 2003. http://app.american-rhinologic.org/programs/2003ARSFallProgram071503.pdf (Accessed 24
  30. Uebayashi H, Hatanaka T, Kanemura F, Tonosaki K. Acute anosmia in the mouse: behavioral discrimination among the four basic taste substances. Physiol Behav 2001;72:291-6.. PubMed
  31. Barrett S. Zicam Marketers Sued. United States District Court Western District of Michigan Southern Division, Filed October 14, 2003, Case No. 4:03CV0146.
  32. Bilici M, Yildirim F, Kandil S, et al. Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:181-90.. PubMed
  33. Polk RE, Healy DP, Sahai J, et al. Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers. Antimicrob Agents Chemother 1989;33:1841-4. PubMed
  34. Mery C, Delrieu F, Ghozlan R, et al. Controlled trial of D-penicillamine in rheumatoid arthritis. Dose effect and the role of zinc. Scand J Rheumatol 1976;5:241-7. PubMed
  35. Penttila O, Hurme H, Neuvonen PJ. Effect of zinc sulfate on the absorption of tetracycline and doxycycline in man. Eur J Clin Pharmacol 1975;9:131-4.
  36. Kondo Y, Yamagata K, Satoh M, et al. Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein. J Urol 2003;170:2467-70. PubMed
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  38. Wester PO. Urinary zinc excretion during treatment with different diuretics. Acta Med Scand 1980;208:209-12. PubMed
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  40. Leary WP, Reyes AJ, Van der Byl K. Urinary magnesium and zinc excretion after two different single doses of amiloride in healthy adults. Curr Ther Res 1983;34:205-16.
  41. McBride K, Slotnick B, Margolis FL. Does intranasal application of zinc sulfate produce anosmia in the mouse? An olfactometric and anatomical study. Chem Senses 2003;28:659-70. PubMed
  42. Burd GD. Morphological study of the effects of intranasal zinc sulfate irrigation on the mouse olfactory epithelium and olfactory bulb. Microsc Res Tech 1993;24:195-213. PubMed
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  51. Health Canada / GlaxoSmithKline Consumer Healthcare. Association of long-term, excessive use of zinc-containing Poli-Grip products with myeloneuropathy and blood dyscrasias. February 18, 2010. Available at: http://hc-sc.gc.ca/dhp-mps/alt_formats/pdf/medef
  52. GlaxoSmithKline Consumer Advisory. GlaxoSmithKline (GSK) warns about a potential health risk associated with long-term, excessive use of GSK's zinc-containing denture adhesives Super Polygrip Original, Ultra Fresh and Extra Care. February 18, 2010. Availa
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  54. Castilla-Higuero, L., Romero-Gomez, M., Suarez, E., and Castro, M. Acute hepatitis after starting zinc therapy in a patient with presymptomatic Wilson's disease. Hepatology 2000;32(4 Pt 1):877. PubMed
  55. Sharquie, K. E., Najim, R. A., Farjou, I. B., and Al Timimi, D. J. Oral zinc sulphate in the treatment of acute cutaneous leishmaniasis. Clin.Exp.Dermatol. 2001;26(1):21-26. PubMed
  56. Dreno, B., Moyse, D., Alirezai, M., Amblard, P., Auffret, N., Beylot, C., Bodokh, I., Chivot, M., Daniel, F., Humbert, P., Meynadier, J., and Poli, F. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of
  57. Moore, R. Bleeding gastric erosion after oral zinc sulphate. Br.Med J 3-25-1978;1(6115):754. PubMed
  58. Jafek, B. W., Linschoten, M. R., and Murrow, B. W. Anosmia after intranasal zinc gluconate use. Am J Rhinol. 2004;18(3):137-141. DOI
  59. Simonart, T. and de, Maertelaer, V. Systemic treatments for cutaneous warts: a systematic review. J Dermatolog.Treat. 2012;23(1):72-77. PubMed
  60. Cochran, R. J., Tucker, S. B., and Flannigan, S. A. Topical zinc therapy for acne vulgaris. Int.J Dermatol. 1985;24(3):188-190. DOI
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  63. Lang, C. J., Rabas-Kolominsky, P., Engelhardt, A., Kobras, G., and Konig, H. J. Fatal deterioration of Wilson's disease after institution of oral zinc therapy. Arch Neurol. 1993;50(10):1007-1008. PubMed
  64. Fjellner, B. Drug-induced lupus erythematosus aggravated by oral zinc therapy. Acta Derm.Venereol. 1979;59(4):368-370. DOI
  65. Varas Lorenzo, M. J. Zinc acexamate and ranitidine in the short- and mid-term management of gastroduodenal ulcers. Curr Ther Res 21986;39:19-29.
  66. Bosch, F. and Jimenez, E. Post-marketing surveillance of zinc acexamate in peptic ulcer treatment. Clin Trials J 1990;27:301-312.
  67. DeCook, C. A. and Hirsch, A. R. Anosmia due to inhalational zinc: a case report (abstract). Chem Senses 2000;25:659.
  68. Crown LA, May JA. Zinc toxicity: denture adhesives, bone marrow failure and polyneuropathy. Tenn Med. 2012 Feb;105(2):39-40, 42.
  69. Dadamio J, Van Tournout M, Teughels W, Dekeyser C, Coucke W, Quirynen M. Efficacy of different mouthrinse formulations in reducing oral malodour: a randomized clinical trial. J Clin Periodontol. 2013 May;40(5):505-13. PubMed
  70. Moyle G, Else L, Jackson A, Back D, Yapa MH, Seymour N, Ringner-Nackter L, Karolia Z, Gazzard B, Boffito M. Coadministration of atazanavir-ritonavir and zinc sulfate: impact on hyperbilirubinemia and pharmacokinetics. Antimicrob Agents Chemother. 2013 Aug PubMed
  71. Zittel S, Ufer F, Gerloff C, Münchau A, Rosenkranz M. Severe myelopathy after denture cream use--is copper deficiency or excess zinc the cause? Clin Neurol Neurosurg. 2014 Jun;121:17-8. PubMed
  72. Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
  73. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents: Drug Interactions between Integrase Inhibitors and Other Drugs. AIDSinfo. July 14, 2016. Available at: https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescen
  74. Ding Y, Jia YY, Li F, et al. The effect of staggered administration of zinc sulfate on the pharmacokinetics of oral cephalexin. Br J Clin Pharmacol. 2012 Mar;73(3):422-7. PubMed
  75. Fallah R, Sabbaghzadegan S, Karbasi SA, Binesh F. Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial. Nutrition. 2015;31(11-12):1358-61. PubMed
  76. Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev. 2016;12:CD005436. PubMed
  77. Mahmoud AM, Al-Alem U, Dabbous F, et al. Zinc intake and risk of prostate cancer: Case-control study and meta-analysis. PLoS One. 2016;11(11):e0165956. PubMed
  78. Nagraj SK, George RP, Shetty N, Levenson D, Ferraiolo DM, Shrestha A. Interventions for managing taste disturbances. Cochrane Database Syst Rev. 2017 Dec 20;12(12):CD010470. PubMed
  79. Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020:e14252. PubMed
  80. Janyajirawong R, Vilaichone RK, Sethasine S. Efficacy of zinc supplement in minimal hepatic encephalopathy: A prospective, randomized controlled study (Zinc-MHE Trial). Asian Pac J Cancer Prev 2021;22(9):2879-2887. PubMed
  81. Nakano M, Nakamura Y, Miyazaki A, Takahashi J. Zinc pharmacotherapy for elderly osteoporotic patients with zinc deficiency in a clinical setting. Nutrients 2021;13(6):1814. PubMed
  82. Tolino E, Skroza N, Mambrin A, et al. An open-label study comparing oral zinc to lymecycline in the treatment of acne vulgaris. J Clin Aesthet Dermatol 2021;14(5):56-58.
  83. Hunter J, Arentz S, Goldenberg J, et al. Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials. BMJ Open. 2021;11(11):e047474. PubMed
  84. Yamazaki K, Kageyama H, Fujiyama T, Ito T, Urano S, Honda T. A case of systemic contact dermatitis due to zinc supplements. Int J Dermatol 2022. PubMed
  85. Magham K, Han J, Eilbert W, Bunney EB. Severe copper deficiency anemia caused by zinc supplement use. Am J Emerg Med 2023;72:222. PubMed
  86. Sivakumar RR, Chinnaiah Govindareddy D, Sahoo J, Bobby Z, Chinnakali P. Effect of daily zinc supplementation for 12 weeks on serum thyroid auto-antibody levels in children and adolescents with autoimmune thyroiditis - a randomized controlled trial. J Pedi PubMed
  87. AlDhasee O, AlMalki H, AlKharashi N, AlJeraisy N, Al Deeb M. Acute zinc sulfate overdose: clinical presentation and management. BMJ Case Rep 2025;18(1):e263899. PubMed
  88. US Food and Drug Administration (FDA). Biktarvy Prescribing Information. October 2024. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/210251Orig1s020lbl.pdf. Accessed July 16, 2025.

See these in context on the Zinc monograph →

Dhea 98 references
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Diindolylmethane 14 references
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