Major interaction on record — check this product against your medications before combining. Based on 3 of 8 ingredients. Check your meds →
Dietary supplement

Hardcore Testosterone Amplifier Ingredients & Drug Interactions

by PMD

Hardcore Testosterone Amplifier label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hardcore Testosterone Amplifier against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Hardcore Testosterone Amplifier is a dietary supplement by PMD with 8 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 1,627 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are FenuPRO, E-Fighter Agent, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hardcore Testosterone Amplifier by PMD

Ask about any prescription or over-the-counter medication and we check it for interactions with Hardcore Testosterone Amplifier by PMD — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Hardcore Testosterone Amplifier by PMD

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 6 of its 19 active ingredients.
  • “Muscle GROWTH Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Pro-Estro SUPPRESS Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “4-in-1 Test Support Matrix” is a proprietary blend — the label gives one combined amount (315 mg) without saying how much of each component you get.

Hardcore Testosterone Amplifier contains 19 active ingredients designed to support testosterone and muscle, including minerals, herbal extracts, and specialized blends. The key actives are zinc (for immune and hormonal function), BioPerine black pepper extract (for absorption), DHEA (a hormone precursor), ashwagandha root extract (an adaptogen), resveratrol (a plant compound), indole-3-carbinol (from cruciferous vegetables), cowhage seed extract (which contains levodopa), chrysin (a plant flavonoid), white button mushroom extract, calcium, sarsaparilla, oat extract, bladderwrack (a seaweed high in iodine), diindolylmethane, tribulus, and fenugreek.

Several are grouped as proprietary blends—Muscle GROWTH, Pro-Estro SUPPRESS, 4-in-1 Test Support Matrix, Activate T, T Absorption Agent, E-Fighter Agent, AndroTEST, and LaxoTest Complex—whose exact amounts aren't disclosed. The product also contains inactive ingredients: bovine gelatin, magnesium stearate, silicon dioxide, cellulose, and titanium dioxide.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Professional muscular development and testosterone support.
  • We looked for evidence on: Athletic performance, Muscle mass, Strength and endurance, Testosterone levels.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Aspartic Acid is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.
  • Also on file: Dhea is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence varies widely by ingredient. Zinc is effective for zinc deficiency and likely effective for Wilson disease; it's possibly effective for acne, diabetes, and age-related macular degeneration.

Oat extract is likely effective for high cholesterol and heart health. DHEA is likely effective for vaginal atrophy and possibly effective for depression and aging skin.

Ashwagandha is possibly effective for anxiety, stress, and insomnia. Fenugreek is possibly effective for sexual function and diabetes.

Resveratrol, tribulus, and sarsaparilla are possibly effective for sexual dysfunction; however, tribulus was possibly ineffective for athletic performance, and resveratrol was possibly ineffective for cardiovascular disease and high cholesterol. For several ingredients—BioPerine (black pepper), chrysin, cowhage, bladderwrack, indole-3-carbinol, diindolylmethane, and white button mushroom—the evidence we hold is insufficient to rate their effectiveness.

The evidence, ingredient by ingredient Zinc Diindolylmethane Fenugreek

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 15 of the 17 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 17 of 17.
  • General safety write-ups exist for 17 of 17.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated in recommended amounts. Zinc is generally well tolerated below 40 mg daily but can cause abdominal cramps, diarrhea, metallic taste, nausea, and vomiting at higher doses; high long-term use raises concern for copper deficiency.

Ashwagandha, oats, and fenugreek are generally well tolerated short-term, though fenugreek can cause bloating, diarrhea, and flatulence. However, several ingredients carry cautions: DHEA is a hormone with the potential for long-term cancer risk and can cause acne, mood changes, and masculinization in women; cowhage contains levodopa (an active drug) and should be used under guidance; bladderwrack is high in iodine and can disrupt thyroid function; resveratrol may cause digestive upset at high doses.

Calcium is generally safe in recommended amounts. Pregnancy and lactation safety varies: zinc, BioPerine, oats, resveratrol, diindolylmethane, and calcium are likely safe; DHEA, ashwagandha, indole-3-carbinol, cowhage, bladderwrack, chrysin, and tribulus are not recommended due to insufficient data or hormone effects.

Fenugreek is not advised in pregnancy but is possibly safe while breastfeeding.

Side effects, ingredient by ingredient Zinc Diindolylmethane Fenugreek

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 16 of the 17 matched ingredients can interact with medications — Tribulus, Resveratrol, Dhea, Sarsaparilla, Fucus Vesiculosus, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,628 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take HIV integrase inhibitors (dolutegravir, elvitegravir, bictegravir/emtricitabine/tenofovir alafenamide, or raltegravir) — calcium in this product may reduce their effectiveness significantly. Also double-check if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), antidiabetes or insulin, blood pressure drugs, antiseizure medications (phenytoin, mephenytoin), antidepressants, benzodiazepines, thyroid hormones, or theophylline.

No interactions are documented for arginine alpha-ketoglutarate and yacon, but we hold no data for these ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This is a high-interaction supplement aimed at testosterone support that requires careful medication screening before use. If you take any prescription medications—especially HIV drugs, blood thinners, diabetes drugs, blood pressure drugs, thyroid hormones, antiseizure drugs, antidepressants, or sedatives—talk with your pharmacist before starting.

The product contains a hormone (DHEA) and drug-like compounds (levodopa in cowhage, high iodine in bladderwrack) that need professional guidance, particularly if you're pregnant, breastfeeding, or managing a chronic condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 17 of 19 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hardcore Testosterone Amplifier, straight from the product label.

Brand PMD
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 339061
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hardcore Testosterone Amplifier by PMD, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
IngredientAmount% DV
Zinc30 mg273%
BioPerine0 NP--
Androstenolone50 mg--
Ashwagandha Root Extract 0 NP--
Resveratrol0 NP--
Indole-3-Carbinol0 NP--
Arginine Alpha-Ketoglutarate0 NP--
Yacon0 NP--
White Button Mushroom Fruit Extract0 NP--
Calcium Lactate Gluconate0 NP--
Chrysin0 NP--
Muscle GROWTH Blend0 NP--
Pro-Estro SUPPRESS Blend0 NP--
4-in-1 Test Support Matrix315 mg--
Activate T Blend0 NP--
Smilax officinalis, Powder250 mg--
Avena sativa Whole Plant Extract0 NP--
T Absorption Agent0 NP--
Bladderwrack0 NP--
Mucuna pruriens Seed Extract0 NP--
E-Fighter Agent100 mg--
TRIBPRO 900 NP--
AndroTEST Blend2000 mg--
FenuPRO600 mg--
LaxoTest Complex0 NP--
D-Aspartic Acid1000 mg--

Other ingredients: Bovine Gelatin, Magnesium Stearate, Silicon Dioxide, Cellulose, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Professional muscular development 24-Hour Hardcore Anabolic Activator

Gluten free.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

FenuPRO and LaxoTest are Registered Trademarks of FitLife Brands, Inc. BioPerine is a Registered Trademark and Patented Product of Sabinsa Corporation.

Formula

BioPerine

Precautions

Due to the unique restrictions of amateur and professional sports organizations (e.g., WADA, NCAA, NFL, MLB, NBA, UIL, etc.), it is recommended that you consult with the appropriate governing body before taking this or any other dietary supplement product.

General Statements

Awesome results " I love this product! I gained 15 pounds in 8 weeks. I got way stronger and even leaned out in my abs. I noticed more energy throughout my day as well." -Customer Review

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hardcore Testosterone Amplifier by PMD label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hardcore Testosterone Amplifier label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hardcore Testosterone Amplifier by PMD

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zinc

Interacts with
67 drugs
30 mg per serving Form: Zinc Oxide

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

4-in-1 Test Support Matrix

315 mg per serving
  • › Muscle GROWTH Blend
  • › Pro-Estro SUPPRESS Blend
  • › Activate T Blend
  • › T Absorption Agent

AndroTEST Blend

2000 mg per serving

Other (inactive) ingredients: Bovine Gelatin, Magnesium Stearate, Silicon Dioxide, Cellulose, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hardcore Testosterone Amplifier by PMD Drug Interactions

Want to check YOUR meds against Hardcore Testosterone Amplifier?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,627Drugs
24 Major 1,551 Moderate 52 Minor

Ingredients driving the most interactions

FenuPRO 389
E-Fighter Agent 269
Zinc 67

Individual Drug Interactions

The ingredients in Hardcore Testosterone Amplifier interact with 1,627 drugs. Click any drug to see the details.

3 of the 8 ingredients in Hardcore Testosterone Amplifier interact with drugs. Each result below shows which ingredient is responsible. FenuPRO E-Fighter Agent Zinc

Each ingredient & the kinds of drugs it affects

For each ingredient in Hardcore Testosterone Amplifier with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

FenuPRO9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
FenuPRO full monograph & interactions

E-Fighter Agent3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
E-Fighter Agent full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hardcore Testosterone Amplifier, from the product label.

PMD

See all PMD products
Name
PMD
Pharmacist Counseling Corner

Hardcore Testosterone Amplifier by PMD: Common Questions

Does Hardcore Testosterone Amplifier by PMD interact with any medications?
Yes. Based on its ingredients, Hardcore Testosterone Amplifier has a known interaction with 1,627 medications, including 24 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hardcore Testosterone Amplifier contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Not without checking first. Ashwagandha, tribulus, and fenugreek can theoretically lower blood pressure, which could add to your medication's effect and cause your pressure to drop too far. Talk to your pharmacist about whether it's safe to combine them.
Does this product contain hormones?
Yes. It contains DHEA, which is a hormone precursor that can shift your hormone levels and carry risks with long-term use, including a theoretical link to cancer. It also contains cowhage, which provides levodopa, an active drug-like compound. Both need professional oversight.
Is this safe to take while pregnant or breastfeeding?
No. Several ingredients—DHEA, ashwagandha, cowhage, bladderwrack, and tribulus—are not recommended in pregnancy or while breastfeeding due to insufficient safety data or hormone effects. Fenugreek is possibly unsafe in pregnancy but may be safe while breastfeeding if approved by your doctor. Talk with your provider first.
What are the most common side effects?
Zinc can cause nausea, diarrhea, and a metallic taste. Ashwagandha, fenugreek, resveratrol, and oats may cause digestive upset—bloating, gas, or diarrhea. DHEA can cause acne, insomnia, and mood changes, especially in women. Start with a lower dose and see how you feel.
Will this interact with my HIV medication?
Possibly, and it could be serious. Calcium in this product can reduce blood levels of HIV integrase inhibitors like dolutegravir and elvitegravir by up to 40%. Zinc may also affect ritonavir. You must check with your pharmacist or HIV doctor before starting.
Is the iodine content in bladderwrack a problem?
Bladderwrack is high in iodine, which can disrupt thyroid function—causing either high or low thyroid activity depending on your history. If you have or are at risk for thyroid disease, or take thyroid medications or antithyroid drugs, talk to your doctor before using this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hardcore Testosterone Amplifier label
Go deeper

The Full Monographs Behind Hardcore Testosterone Amplifier’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph →
Sources

Sources & How We Checked

Hardcore Testosterone Amplifier's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 468 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zinc 88 references
  1. Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
  2. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
  3. Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
  4. Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
  5. Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
  6. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
  7. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
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Agaricus Mushroom 5 references
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Diindolylmethane 14 references
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Tribulus 10 references
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Fenugreek 30 references
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Aspartic Acid 1 reference
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