Major interaction on record — check this product against your medications before combining. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

CarboFix Ingredients & Drug Interactions

by Gold Vida

CarboFix label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CarboFix against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

CarboFix is a dietary supplement by Gold Vida with 6 active ingredients. Its ingredients are commonly taken for diabetic nerve pain (neuropathy), blood sugar support in diabetes, antioxidant support.Based on those ingredients, 1,224 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Berberine HCl, Alpha Lipoic Acid, Cinnamon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CarboFix by Gold Vida

Ask about any prescription or over-the-counter medication and we check it for interactions with CarboFix by Gold Vida — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CarboFix by Gold Vida

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

CarboFix contains six active ingredients. Alpha-lipoic acid is an antioxidant thought to support nerve health and blood sugar control.

Benfotiamine is a fat-soluble form of thiamine (vitamin B1) used primarily for nerve-related complications of diabetes. Chromium picolinate is a mineral supplement that may help regulate blood sugar.

Cinnamon is included for its potential effects on blood sugar and blood pressure. Berberine is a plant alkaloid studied for effects on cholesterol, blood sugar, and blood pressure.

The product also contains inactive ingredients—gelatin and brown rice flour—which serve as a capsule material and filler.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: blood sugar and carbohydrate metabolism support.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Chromium deficiency, Diabetic neuropathy, Diabetic nephropathy, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Chromium is rated "Likely Effective" for Chromium deficiency (Natural Medicines).
  • Also on file: Alpha-lipoic Acid is rated "Possibly Effective" for Diabetic neuropathy, Hyperlipidemia.
  • Also on file: Chromium is rated "Possibly Effective" for Diabetes.

Alpha-lipoic acid is rated possibly effective for diabetic nerve damage (neuropathy) and for high cholesterol and obesity. Benfotiamine is possibly effective for diabetic nerve damage but is rated possibly ineffective for diabetic kidney disease; evidence for Alzheimer's disease, alcohol use disorder, and general nerve damage is insufficient.

Chromium picolinate is rated likely effective for chromium deficiency and possibly effective for diabetes, but possibly ineffective for prediabetes and schizophrenia. Cinnamon is rated possibly ineffective for obesity and diabetes; evidence for hay fever, COPD, and common cold is insufficient.

Berberine is rated possibly effective for high cholesterol, PCOS (polycystic ovary syndrome), H. pylori infection, high blood pressure, and diabetes. We could not find effectiveness data for naringin in our records.

The evidence, ingredient by ingredient Alpha-lipoic Acid Benfotiamine Chromium Ceylon Cinnamon Berberine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-lipoic acid is generally well tolerated but can lower blood sugar and should be used under medical guidance. The most common side effects are headache, heartburn, nausea, and vomiting.

Rare serious concerns include reports of an unusual insulin-related immune condition. It is not recommended during pregnancy or breastfeeding due to insufficient safety data.

Benfotiamine is generally well tolerated in studies; long-term safety is not fully established. Skin allergic reactions and mild stomach discomfort have been reported in small numbers of people.

Pregnancy and breastfeeding safety data are limited. Chromium picolinate is usually well tolerated at typical supplement doses, though long-term or high doses may carry risks.

Gastrointestinal irritation, headaches, insomnia, and mood changes are reported; rare cases of kidney and liver damage have been documented. Avoid extra supplement doses during pregnancy and breastfeeding unless your doctor advises otherwise.

Cinnamon (Ceylon type) is generally safe at food-spice doses; supplement-strength doses are less studied. Bloating, indigestion, and nausea can occur.

Food amounts are likely fine during pregnancy and breastfeeding, but supplement doses should be avoided without medical advice. Berberine is generally tolerated short-term but commonly causes digestive upset—abdominal pain, constipation, diarrhea, gas, nausea, and vomiting.

It can cause dizziness, drowsiness, fatigue, and headache. Berberine should be avoided during pregnancy (it may cross the placenta and harm the fetus) and while breastfeeding (it passes into breast milk).

Side effects, ingredient by ingredient Alpha-lipoic Acid Benfotiamine Chromium Ceylon Cinnamon Berberine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Ceylon Cinnamon, Alpha-lipoic Acid, Chromium, Berberine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 1,225 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking CarboFix, double-check with your pharmacist if you take cyclosporine (an immunosuppressant)—berberine can significantly raise its blood levels. Also check if you take any medications metabolized by your liver (CYP3A4, CYP2D6, or CYP2C9 substrates), blood thinners or antiplatelet drugs, diabetes medications or insulin, blood-pressure medications, thyroid hormone (levothyroxine), sedating drugs, or chemotherapy drugs.

Several ingredients in this product can interact with these drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

CarboFix may be worth considering if you're interested in blood sugar support and have no drug interactions, but the product carries significant medication interactions—especially if you take blood thinners, thyroid hormone, diabetes medications, blood-pressure drugs, sedating medications, or cyclosporine. Talk with your pharmacist or doctor before starting, particularly if you take any prescription medications.

Berberine should be avoided entirely during pregnancy and breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CarboFix, straight from the product label.

Brand Gold Vida
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 248089
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CarboFix by Gold Vida, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Alpha Lipoic Acid50 mg--
Benfotiamine80 mg--
Chromium Picolinate200 mcg571%
Cinnamon100 mg--
Berberine HCl400 mg--
Naringin50 mg--

Other ingredients: Gelatin, Brown Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one (1) capsule with your two (2) largest carbohydrate-containing meals of the day. If you're following the keto diet, simply take one (1) capsule with your two (2) largest meals of the day for the best results.

Precautions

Caution: Do not exceed the recommended dose.

Do not use if you are under 18 yeas old, pregnant, nursing or have any medical conditions.

Do not use if you are under 18 yeas old, pregnant, nursing or have any medical conditions.

Always consult a physician before using this product.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in an FDA Registered Facility Made in USA Quality Guaranteed GMP Good Manufacturing Practice Consistent Quality

Formulation

Maximum strength Carbohydrate management formula

Supports healthy blood glucose levels Helps improve glucose utilization Supports ketogenic lifestyle

General Statements

Eat carbs guilt free

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CarboFix by Gold Vida label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CarboFix label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CarboFix by Gold Vida

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha Lipoic Acid

Interacts with
263 drugs
50 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha Lipoic Acid monograph & interactions

Benfotiamine

No known
interactions
80 mg per serving

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied...

Benfotiamine monograph & interactions

Chromium Picolinate

Interacts with
178 drugs
200 mcg per serving

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium Picolinate monograph & interactions

Cinnamon

Interacts with
258 drugs
100 mg per serving

Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evid...

Cinnamon monograph & interactions

Berberine HCl

Interacts with
1,160 drugs
400 mg per serving Form: Berberine, Berberis aristata

Berberine is a yellow plant compound that has shown promise for lowering blood sugar and cholesterol in some studies, but the quality of research vari...

Berberine HCl monograph & interactions

Naringin

50 mg per serving Form: Grapefruit

Other (inactive) ingredients: Gelatin, Brown Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

CarboFix by Gold Vida Drug Interactions

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1,224Drugs
1 Major 1,204 Moderate 19 Minor

Ingredients driving the most interactions

Berberine HCl 1,160
Alpha Lipoic Acid 263
Cinnamon 258
Chromium Picolinate 178

Individual Drug Interactions

The ingredients in CarboFix interact with 1,224 drugs. Click any drug to see the details.

4 of the 6 ingredients in CarboFix interact with drugs. Each result below shows which ingredient is responsible. Berberine HCl Alpha Lipoic Acid Cinnamon Chromium Picolinate

Each ingredient & the kinds of drugs it affects

For each ingredient in CarboFix with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Berberine HCl15 drug types · 1,160 drugs

Cyclosporine (Neoral, Sandimmune)

Berberine can increase serum levels of cyclosporine.
Berberine can reduce metabolism and increase serum levels of cyclosporine. Berberine might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine.

Likelihood Probable Evidence A
Anticoagulant/Antiplatelet Drugs

Theoretically, berberine might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro and in vivo research suggest that berberine can inhibit platelet aggregation. Theoretically, berberine might have additive effects when used with anticoagulant and antiplatelet drugs and increase the risk of bleeding.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, berberine may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that berberine may lower blood glucose levels. Theoretically, berberine might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, berberine might have additive effects with antihypertensive drugs.
Animal research suggests that berberine can have hypotensive effects. Also, a clinical study suggests that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, berberine might increase the sedative effects of CNS depressants.
Animal research suggests that berberine may have sedative effects. Theoretically, use of berberine along with CNS depressants might produce additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.
Preliminary clinical research shows that berberine can inhibit CYP2C9. Theoretically, taking berberine with drugs metabolized by CYP2C9 might increase drug levels and increase the risk of adverse effects.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, berberine might increase serum levels of drugs metabolized by CYP2D6.
In vitro research and preliminary clinical evidence show that berberine can inhibit CYP2D6. Theoretically, use of berberine with drugs metabolized by CYP2D6 might increase drug levels and increase the risk of adverse effects.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.
In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4. Theoretically, use of berberine with drugs metabolized by CYP3A4 might increase drug levels and increase the risk of adverse effects.

Likelihood Possible Evidence A
Dextromethorphan (Robitussin Dm, Others)

Theoretically, berberine may increase serum levels of dextromethorphan.
Preliminary clinical research shows that berberine can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan. This may increase the effects and side effects of dextromethorphan.

Likelihood Possible Evidence B
Losartan (Cozaar)

Berberine might reduce the therapeutic effects of losartan by decreasing its conversion to its active form.
Preliminary clinical research suggests that berberine can inhibit cytochrome P450 2C9 (CYP2C9) activity and reduce metabolism of losartan.

Likelihood Possible Evidence B
Metformin (Glucophage)

Theoretically, berberine might increase the therapeutic and adverse effects of metformin.
In vitro and animal studies show that berberine can increase the systemic exposure and half-life of metformin, potentially increasing metformin's effects and side effects. This interaction seems to be most apparent when berberine is administered 2 hours prior to metformin. Taking berberine and metformin at the same time does not appear to increase systemic exposure to metformin.

Likelihood Possible Evidence D
Midazolam (Versed)

Berberine can reduce metabolism of midazolam, which might increase the risk of severe adverse effects.
Preliminary clinical research shows that berberine can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Berberine might increase the sedative effect of pentobarbital.
Evidence from animal research shows that berberine can prolong pentobarbital-induced sleeping time. Theoretically, combining berberine and pentobarbital might increase the sedative effects of pentobarbital.

Likelihood Possible Evidence D
Tacrolimus (Prograf)

Berberine has been associated with increased blood levels of tacrolimus.
In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with tacrolimus 6.5 mg twice daily, intake of berberine 200 mg three times daily increased the blood concentration of tacrolimus from 8 to 22 ng/mL. Following a reduction of the tacrolimus dose to 3 mg daily, blood levels of tacrolimus decreased to 12 ng/mL.

Likelihood Possible Evidence D
Acetazolamide

Laboratory studies and initial clinical findings suggest that berberine has the potential to increase acetazolamide concentrations in the body. More research is needed to confirm this interaction.

Likelihood Possible Evidence C
Berberine HCl full monograph & interactions

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

Cinnamon2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Ceylon cinnamon may lower blood glucose levels. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Animal research shows that Ceylon cinnamon extract has vasorelaxant properties and reduces blood pressure in rat models of hypertension, possibly via inhibition of calcium influx through L-type voltage-sensitive channels.

Likelihood Possible Evidence D
Cinnamon full monograph & interactions

Chromium Picolinate5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium Picolinate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CarboFix, from the product label.

Gold Vida

See all Gold Vida products
Name
Gold Vida
Street Address
2283 Yellowbirch Way
City
London
State
ON
ZipCode
N6G0N3
Pharmacist Counseling Corner

CarboFix by Gold Vida: Common Questions

Does CarboFix by Gold Vida interact with any medications?
Yes. Based on its ingredients, CarboFix has a known interaction with 1,224 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CarboFix contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take CarboFix if I'm pregnant?
No. Berberine, one of the active ingredients, should be avoided during pregnancy because it may cross the placenta and harm the fetus. Alpha-lipoic acid also lacks sufficient safety data in pregnancy. Talk with your doctor about alternatives if you're pregnant or planning to become pregnant.
Can I take CarboFix while breastfeeding?
No. Berberine passes into breast milk and should be avoided while breastfeeding. Alpha-lipoic acid also lacks sufficient safety information for breastfeeding. The safety of other ingredients while nursing is not fully studied. Discuss other options with your doctor.
Will CarboFix lower my blood sugar?
Several ingredients—alpha-lipoic acid, chromium, cinnamon, and berberine—may theoretically lower blood sugar. If you take diabetes medications or insulin, this product could increase your risk of low blood sugar (hypoglycemia), which is why you must check with your pharmacist first.
What are the most common side effects?
Berberine most commonly causes digestive upset: abdominal pain, constipation, diarrhea, gas, nausea, and vomiting. Alpha-lipoic acid may cause headache, heartburn, nausea, and vomiting. Chromium can cause headaches, insomnia, and irritability. These side effects tend to be mild in most people.
Does cinnamon in this product really work for blood sugar?
Cinnamon is rated possibly ineffective for diabetes and obesity based on the evidence we have on file, so the research doesn't show it's reliable for blood sugar control.
What is berberine, and why is it in this product?
Berberine is a plant compound studied for effects on cholesterol, blood sugar, blood pressure, and other metabolic markers. It's included in CarboFix for its possibly effective rating for diabetes, high cholesterol, and hypertension, but it carries the most significant drug interactions in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CarboFix is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CarboFix label
Go deeper

The Full Monographs Behind CarboFix’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Benfotiamine

Benfotiamine is a man-made, fat-soluble form of vitamin B1 (thiamine) that the body may absorb more easily than regular thiamine. It is mostly studied for diabetic nerve problems, but the ev...

Read the full Benfotiamine monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Ceylon Cinnamon

Interacts with 258 drugs

Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evidence for most health benefits is limited...

Read the full Ceylon Cinnamon monograph → Herb & supplement monograph

Berberine

Interacts with 1,160 drugs

Berberine is a yellow plant compound that has shown promise for lowering blood sugar and cholesterol in some studies, but the quality of research varies and it is not a replacement for presc...

Read the full Berberine monograph →
Sources

Sources & How We Checked

CarboFix's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 165 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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