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Dietary supplement

Cardiokinase Ingredients & Drug Interactions

by Iagen Professional

Cardiokinase label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cardiokinase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cardiokinase is a dietary supplement by Iagen Professional with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cardiokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cardiokinase by Iagen Professional

Ask about any prescription or over-the-counter medication and we check it for interactions with Cardiokinase by Iagen Professional — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cardiokinase by Iagen Professional

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Cardiokinase contains a single active ingredient: nattokinase, an enzyme derived from fermented soybeans. It's designed to support cardiovascular health by promoting healthy blood flow.

The softgel capsule also contains several inactive ingredients—soybean oil, glycerin fatty ester, beeswax, gelatin, and glycerin—which serve as the capsule and delivery system.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cardiovascular health and blood clot support.
  • We looked for evidence on: Atherosclerosis, Cardiovascular disease (CVD), Hypertension, Hyperlipidemia, Peripheral arterial disease (PAD), Venous insufficiency — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Peripheral arterial disease (PAD), and more.

The evidence for nattokinase in this product is not established. We hold no reliable data showing it works for angina, atherosclerosis, cancer, cardiovascular disease, or chronic fatigue syndrome.

If you're considering it for a specific heart or circulation concern, talk it over with your doctor to explore what the research actually supports for your situation.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated in the short term, but its blood-thinning effects mean you should be cautious if you have any bleeding risk—including bleeding disorders or recent surgery. The safety data advises against nattokinase in pregnancy and while breastfeeding.

Additionally, nattokinase can trigger allergic reactions in people sensitive to natto or its components; symptoms may include throat or airway swelling and can occur within 2 hours of taking it. Rare reports of bleeding, including serious brain bleeding, have been documented when nattokinase is combined with blood thinners.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking Cardiokinase if you're on blood thinners or antiplatelet drugs (like warfarin, apixaban, dabigatran, rivaroxaban, aspirin, or clopidogrel)—nattokinase raises the risk of bleeding. Also double-check any blood pressure medications you take, since nattokinase may lower blood pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Cardiokinase is an option if you're interested in nattokinase for circulation support, but it's not something to start without checking your medications first—especially if you take blood thinners or blood pressure drugs. It's not for pregnancy or breastfeeding.

Talk with your doctor or pharmacist before adding it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cardiokinase, straight from the product label.

Brand Iagen Professional
Barcode (UPC) 852980001160
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 304441
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cardiokinase by Iagen Professional, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
852980001160
IngredientAmount% DV
Cardiokinase25 IU--

Other ingredients: Soybean Oil, Glycerin Fatty Ester, Beeswax, Gelatin, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cardiokinase features "Strain N" nattokinase, an enzyme that is extracted from the traditional Japanese soy food called "natto."

Formulation

Nattokinase was first discovered by Dr. Hiroyuki Sumi, Ph. D. Natto has been used traditionally to help support cardiovascular health. Modern research has revealed that nattokinase works by breaking down fibrin, a protein involved in clotting of the blood.

No gluten, milk derivatives, or artificial colors or flavors.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

www.cardiokinase.com

by Iagen Naturals, Inc.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: take one or two softgels daily, with food, or as directed by a healthcare professional. For best results take an additional softgel at night before bed.

Precautions

Read first: If you are pregnant or breastfeeding, or taking prescription medications, consult with your health care professional before using this product.

Allergen statement: This product contains soy.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cardiokinase by Iagen Professional label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cardiokinase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cardiokinase by Iagen Professional

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Cardiokinase

Interacts with
289 drugs
25 IU per serving Form: Nattokinase-N

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Cardiokinase monograph & interactions

Other (inactive) ingredients: Soybean Oil, Glycerin Fatty Ester, Beeswax, Gelatin, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cardiokinase by Iagen Professional Drug Interactions

Want to check YOUR meds against Cardiokinase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Cardiokinase 289

Individual Drug Interactions

The ingredients in Cardiokinase interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cardiokinase interact with drugs. Each result below shows which ingredient is responsible. Cardiokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Cardiokinase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cardiokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Cardiokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cardiokinase, from the product label.

Iagen Professional

See all Iagen Professional products
Name
Iagen Naturals, Inc.
Web Address
www.iagen.com
Pharmacist Counseling Corner

Cardiokinase by Iagen Professional: Common Questions

Does Cardiokinase by Iagen Professional interact with any medications?
Yes. Based on its ingredients, Cardiokinase has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cardiokinase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Cardiokinase if I'm on aspirin?
Not without checking with your doctor first. There's a documented case of serious brain bleeding in someone who combined nattokinase with aspirin. Since both thin the blood, the risk of bleeding goes up when you add them together.
Is Cardiokinase safe during pregnancy or while breastfeeding?
No. The safety data advises against nattokinase in pregnancy and while breastfeeding. Talk with your doctor about what you can safely take during these times.
What is nattokinase, and what does it do?
Nattokinase is an enzyme from fermented soybeans designed to support blood flow and cardiovascular health. It has blood-thinning effects, which is why it can interact with medications that affect clotting.
Can Cardiokinase cause allergic reactions?
Yes, in people sensitive to natto or its components. Symptoms can include throat or airway swelling and may show up within 2 hours of taking it. If you have a natto allergy, avoid this product.
Does nattokinase actually work for heart health?
The evidence isn't established in our data. We have no reliable studies showing it works for angina, heart disease, atherosclerosis, or other cardiovascular conditions. Talk with your doctor about what's proven for your specific concern.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cardiokinase is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cardiokinase label
Go deeper

The Full Monographs Behind Cardiokinase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Cardiokinase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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