Chew C Berry Ingredients & Drug Interactions
by B.E.S.T. Process Alka-Line Supplements
What is this page for?
First and foremost: checking Chew C Berry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chew C Berry is a dietary supplement by B.E.S.T. Process Alka-Line Supplements with 3 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 376 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rose Hips, Vitamin C, Rutin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chew C Berry by B.E.S.T. Process Alka-Line Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with Chew C Berry by B.E.S.T. Process Alka-Line Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Chew C Berry by B.E.S.T. Process Alka-Line Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Chew C Berry contains 3 active ingredients. Vitamin C is the main player here—it's an antioxidant your body needs to make collagen, heal wounds, and fight cell damage.
Rose hips add more vitamin C plus other compounds; they're traditionally used for joint pain and inflammation. Rutin is a plant flavonoid (a type of antioxidant) that may help with blood vessel health and inflammation.
The product also contains inactive ingredients like cane sugar, maltodextrin, and strawberry flavor to make it taste better and hold it together.
Does it work?
Not established
Vitamin C is effective for preventing and treating vitamin C deficiency, and possibly effective for anemia of chronic disease, atrial fibrillation, cataracts, and infections triggered by heavy exercise. Rose hips show possibly effective evidence for postoperative pain and osteoarthritis, though the data aren't strong.
For rutin, the evidence we hold shows insufficient data to rate it for any condition—aging skin, autism, inflammatory bowel disease, diabetes, exercise infections, and hemorrhoids all lack established proof in our data. If you're taking this for a specific reason, talk with your pharmacist about whether the evidence matches your goal.
How safe is it?
Well-documented data
Vitamin C is generally well tolerated at normal supplement doses, but very high doses can cause abdominal cramps, heartburn, osmotic diarrhea, nausea, vomiting, and kidney stones in people prone to them—especially doses above 2 grams daily. Rose hips are well tolerated; the most common side effects are flatulence and loose stools.
Rutin may cause headache, flushing, or rashes in some people. Long-term safety data for rutin are limited.
Regarding pregnancy: vitamin C at normal dietary and supplement doses is likely safe, but the facts also note possibly unsafe ratings—talk with your doctor before using high-dose vitamin C in pregnancy. Rose hips safety data in pregnancy are incomplete.
Rutin is rated likely safe in pregnancy but safety during breastfeeding is unknown, so avoid supplement doses while nursing unless your doctor approves.
Meds to double-check
Moderate interaction found
Check moderate-severity interactions first: estrogen-containing birth control and hormone therapy, blood thinners like warfarin (especially at high doses), chemotherapy drugs that work through free radicals, levothyroxine for thyroid disease, HIV protease inhibitors, and antidiabetes drugs. Also flag anticoagulants and antiplatelet drugs, lithium, the antipsychotic fluphenazine, aspirin, and aluminum-containing products like some antacids.
Use the medication checker on this page to search your exact drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Chew C Berry works well if you need vitamin C or have evidence-based reasons to try rose hips for joint pain. If you take birth control, hormone replacement therapy, blood thinners, thyroid medication, chemotherapy, HIV drugs, diabetes medication, or lithium, check your medications with the tool on this page before starting.
Talk to your pharmacist, especially if you're pregnant, nursing, or take multiple prescriptions.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chew C Berry, straight from the product label.
| Brand | B.E.S.T. Process Alka-Line Supplements |
|---|---|
| Net contents | 200 Chewable Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2021 |
| DSLD ID | 242201 |
| Product type | Botanical With Nutrients |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chew C Berry by B.E.S.T. Process Alka-Line Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin C | 125 mg | 208% |
| Rose Hips | 2 mg | -- |
| Rutin | 2 mg | -- |
Other ingredients: Cane Sugar, Evaporated, Maltodextrin, Magnesium Stearate, natural Strawberry flavor, Hydroxypropyl Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, chew one tablet daily or as directed by your healthcare practitioner.
For alkaline reserve testing, eat or drink nothing for 1 hour before testing. Test pH of saliva before placing tablet in mouth. Place one tablet on tongue and wet saliva. Do not chew the tablet. Leave tablet on tongue for 15 seconds, then remove tablet. Retest pH in 20 seconds after swallowing 4 times. Individual testing procedures may vary as recommended by your physician.
Formulation
Contains no wheat, soy, yeast, dairy, artificial preservatives, colorings or animal products.
Contains no yeast
Not heat treated
Formula
Naturally sweetened with whole cane sugar.
Chewable Vitamin C
Storage
Keep in a cool, dry place out of reach of children.
Precautions
Keep in a cool, dry place out of reach of children.
Warning: Consult a healthcare professional before taking this product if you are pregnant or nursing.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chew C Berry by B.E.S.T. Process Alka-Line Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chew C Berry by B.E.S.T. Process Alka-Line Supplements
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin C
Interacts with207 drugs
Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...
Vitamin C monograph & interactionsRose Hips
Interacts with213 drugs
Rose hip is the vitamin C–rich fruit of the wild rose, used traditionally for colds and joint pain. A standardized rose hip powder has some research s...
Rose Hips monograph & interactionsRutin
Interacts with86 drugs
Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...
Rutin monograph & interactionsOther (inactive) ingredients: Cane Sugar, Evaporated, Maltodextrin, Magnesium Stearate, Natural Strawberry flavor, Hydroxypropyl Cellulose. These complete the product’s ingredient list but are not active constituents.
Chew C Berry by B.E.S.T. Process Alka-Line Supplements Drug Interactions
HelloPharmacist Interaction Report
Chew C Berry by B.E.S.T.
Process Alka-Line Supplements does interact with medications. The most serious interaction involves vitamin C and estrogen-containing drugs—birth control pills and hormone replacement therapy.
Vitamin C can raise estrogen levels in your blood by up to 55%, which may change how well your hormones work or alter their side effects.
Read the full breakdown — every affected drug type, severity by severity
Vitamin C also has moderate interactions with blood thinners like warfarin (at high doses), chemotherapy drugs (alkylating agents and antitumor antibiotics), levothyroxine for thyroid disease, HIV protease inhibitors like indinavir, and the antipsychotic fluphenazine. Rose hips, which contain vitamin C, add theoretical moderate interactions with anticoagulants and antiplatelet drugs, lithium, aspirin, and warfarin—though the vitamin C in rose hips is likely too low to cause clinical problems with aspirin or warfarin.
Rutin in this product has a theoretical moderate interaction with antidiabetes drugs, raising the risk of low blood sugar (hypoglycemia).
Aluminum compounds (like antacids) are affected by both vitamin C and rose hips, which can increase aluminum absorption. Altogether, these interactions span 376 individual medications.
Use the medication checker on this page to look up your exact prescriptions before you start Chew C Berry.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chew C Berry?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chew C Berry interact with 376 drugs. Click any drug to see the details.
3 of the 3 ingredients in Chew C Berry interact with drugs. Each result below shows which ingredient is responsible. Rose Hips Vitamin C Rutin
DacarbazineDTIC-Dome
How Dacarbazine interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Vitamin CAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Vitamin C + Dacarbazine interactionRose HipsAlkylating Agents Moderate
Interaction Summary
Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative damage caused by certain alkylating agents.
Read the full Rose Hips + Dacarbazine interactionDactinomycinCosmegan, Cosmegen
How Dactinomycin interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Rose HipsAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of antitumor antibiotics.
Read the full Rose Hips + Dactinomycin interactionVitamin CAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
Read the full Vitamin C + Dactinomycin interactionDalteparinFragmin
How Dalteparin interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Dalteparin interactionDanaparoidOrgaran
How Danaparoid interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Danaparoid interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
RutinAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
RutinAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
RutinAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
RutinAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
RutinAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin + Dasiglucagon Hydrochloride interactionDaunorubicin CitrateDaunoXome
How Daunorubicin Citrate interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Vitamin CAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
Read the full Vitamin C + Daunorubicin Citrate interactionRose HipsAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of antitumor antibiotics.
Read the full Rose Hips + Daunorubicin Citrate interactionDaunorubicin HydrochlorideCerubidine
How Daunorubicin Hydrochloride interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Rose HipsAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of antitumor antibiotics.
Read the full Rose Hips + Daunorubicin Hydrochloride interactionVitamin CAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
Read the full Vitamin C + Daunorubicin Hydrochloride interactionDaunorubicin, CytarabineVyxeos
How Daunorubicin, Cytarabine interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Vitamin CAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
Read the full Vitamin C + Daunorubicin, Cytarabine interactionRose HipsAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of antitumor antibiotics.
Read the full Rose Hips + Daunorubicin, Cytarabine interactionDefibrotide SodiumDefitelio
How Defibrotide Sodium interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Defibrotide Sodium interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Rose HipsEstrogens Moderate
Interaction Summary
Theoretically, rose hip might increase blood levels of estrogens.
Read the full Rose Hips + Desogestrel, Ethinyl Estradiol interactionVitamin CEstrogens Moderate
Interaction Summary
Vitamin C might increase blood levels of estrogens.
Read the full Vitamin C + Desogestrel, Ethinyl Estradiol interactionDiclofenacZorvolex
How Diclofenac interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Diclofenac interactionDiclofenac PotassiumCambia, Cataflam, Cataflam IR, Voltaren Rapide, Voltarol Rapid
How Diclofenac Potassium interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Diclofenac Potassium interactionDiclofenac SodiumAcoflam, Acoflam 75 SR, Acoflam Retard, Defenac, Defenac Retard, Defenac SR +40 more
How Diclofenac Sodium interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Diclofenac Sodium interactionDiclofenac Sodium, MisoprostolArthrotec 50, Arthrotec 75
How Diclofenac Sodium, Misoprostol interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Diclofenac Sodium, Misoprostol interactionDiclofenac EpolamineFlector, Licart
How Diclofenac Epolamine interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Diclofenac Epolamine interactionDicumarolDicumarol
How Dicumarol interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Dicumarol interactionDihydroxyaluminum Sodium CarbonateRolaids
How Dihydroxyaluminum Sodium Carbonate interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Rose HipsAluminum Moderate
Interaction Summary
Theoretically, rose hip might increase the amount of aluminum absorbed from aluminum compounds.
Read the full Rose Hips + Dihydroxyaluminum Sodium Carbonate interactionVitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Dihydroxyaluminum Sodium Carbonate interactionDiphenhydramine Hydrochloride, Naproxen SodiumAleve PM
How Diphenhydramine Hydrochloride, Naproxen Sodium interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Diphenhydramine Hydrochloride, Naproxen Sodium interactionDipyridamoleDipyridamole, Persantin, Persantin Injection, Persantin Retard, Persantine
How Dipyridamole interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Dipyridamole interactionDoripenemDoribax
How Doripenem interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Vitamin CAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
Read the full Vitamin C + Doripenem interactionRose HipsAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of antitumor antibiotics.
Read the full Rose Hips + Doripenem interactionDoxorubicinAdriamycin, Caelyx, Doxil, Myocet, Rubex
How Doxorubicin interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Rose HipsAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of antitumor antibiotics.
Read the full Rose Hips + Doxorubicin interactionVitamin CAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
Read the full Vitamin C + Doxorubicin interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Rose HipsEstrogens Moderate
Interaction Summary
Theoretically, rose hip might increase blood levels of estrogens.
Read the full Rose Hips + Drospirenone, Estetrol interactionVitamin CEstrogens Moderate
Interaction Summary
Vitamin C might increase blood levels of estrogens.
Read the full Vitamin C + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with Chew C Berry — through 2 ingredients. Tap an ingredient for the detail:
Vitamin CEstrogens Moderate
Interaction Summary
Vitamin C might increase blood levels of estrogens.
Read the full Vitamin C + Drospirenone, Ethinyl Estradiol interactionRose HipsEstrogens Moderate
Interaction Summary
Theoretically, rose hip might increase blood levels of estrogens.
Read the full Rose Hips + Drospirenone, Ethinyl Estradiol interactionDulaglutideTrulicity
How Dulaglutide interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
RutinAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rutin + Dulaglutide interactionEdoxabanSavaysa
How Edoxaban interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Edoxaban interactionEffientPrasugrel
How Effient interacts with Chew C Berry — through 1 ingredient. Tap an ingredient for the detail:
Rose HipsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
Read the full Rose Hips + Effient interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chew C Berry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Rose Hips
Alkylating Agents
Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative damage caused by certain alkylating agents.
Rose hip contains vitamin C. The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. Further, some animal research suggests that the antioxidant effects of rose hip might attenuate cyclophosphamide-induced testicular toxicity. More evidence is needed to determine what effect, if any, antioxidants found in rose hip, such as vitamin C, have on the effectiveness and adverse effects of chemotherapy.
Aluminum
Theoretically, rose hip might increase the amount of aluminum absorbed from aluminum compounds.
Rose hip contains vitamin C. Theoretically, vitamin C increases the absorption of aluminum. Concomitant use might increase aluminum absorption, but the clinical significance of this is unknown. Administer rose hip two hours before or four hours after antacids.
Anticoagulant/Antiplatelet Drugs
Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that a constituent of rose hip, rugosin E, can induce platelet aggregation. This has not been shown in humans. Theoretically, concomitant use of rose hip might reduce the effectiveness of antiplatelet or anticoagulant drugs.
Antitumor Antibiotics
Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of antitumor antibiotics.
Rose hip contains the antioxidant vitamin C. There is concern that antioxidants might reduce the activity of chemotherapy drugs that generate free radicals, such as antitumor antibiotics. In contrast, other researchers theorize that antioxidants might make antitumor antibiotic chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on antitumor antibiotic chemotherapy.
Estrogens
Theoretically, rose hip might increase blood levels of estrogens.
Rose hip contains vitamin C. Increases in plasma estrogen levels of up to 55% have occured under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. However, increases in plasma estrogen levels may occur when women who are deficient in vitamin C take supplements.
Lithium
Theoretically, rose hip might increase blood levels of lithium.
Rose hip is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, rose hip might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Aspirin
Theoretically, rose hip might reduce the clearance of aspirin; however, its vitamin C content is likely too low to produce clinically significant effects.
Rose hip contains vitamin C. It has been suggested that acidification of the urine by vitamin C can decrease the urinary excretion of salicylates, increasing plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion. The vitamin C content of rose hip is typically about 500 mg per 100 grams. Thus, a clinically significant interaction between rose hip and aspirin is unlikely.
Warfarin (Coumadin)
Theoretically, rose hip might reduce the effectiveness of warfarin; however, its vitamin C content is likely too low to produce clinically significant effects.
Rose hip contains vitamin C. High doses of vitamin C may reduce the response to warfarin, possibly by causing diarrhea and reducing warfarin absorption. This occurred in two people who took up to 16 grams daily of vitamin C, and resulted in decreased prothrombin time. Lower doses of 5-10 grams daily of vitamin C can also reduce warfarin absorption, but this does not seem to be clinically significant. The vitamin C content of rose hip is typically about 500 mg per 100 grams. Thus, a clinically significant interaction between rose hip and warfarin is unlikely.
Vitamin C
Alkylating Agents
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.
Aluminum
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.
Antitumor Antibiotics
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.
Estrogens
Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.
Fluphenazine (Prolixin)
Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.
Indinavir (Crixivan)
Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.
Levothyroxine (Synthroid, Others)
Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.
Warfarin (Coumadin)
High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.
Acetaminophen (Tylenol, Others)
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.
Aspirin
Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.
Choline Magnesium Trisalicylate (Trilisate)
Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Niacin
Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.
Salsalate (Disalcid)
Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Rutin
Antidiabetes Drugs
Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.
Brand information
Manufacturer and brand details for Chew C Berry, from the product label.
B.E.S.T. Process Alka-Line Supplements
See all B.E.S.T. Process Alka-Line Supplements products- Name
- B.E.S.T. Process
- Phone Number
- 1-800-874-1478
- Web Address
- www.morter.com
Chew C Berry by B.E.S.T. Process Alka-Line Supplements: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Chew C Berry’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin C
Interacts with 207 drugsVitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...
Read the full Vitamin C monograph → Herb & supplement monographRose Hip
Interacts with 213 drugsRose hip is the vitamin C–rich fruit of the wild rose, used traditionally for colds and joint pain. A standardized rose hip powder has some research support for easing osteoarthritis symptom...
Read the full Rose Hip monograph → Herb & supplement monographRutin
Interacts with 86 drugsRutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...
Read the full Rutin monograph →Sources & How We Checked
Chew C Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 77 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin C 51 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
- Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
- Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
- Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
- Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Houston JB, Levy G. Drug biotransformation interactions in man VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218-21. PubMed
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
- Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
- Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
- Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. PubMed
- Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467.
- Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
- Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. PubMed
- Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
- Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
- Dysken MW, Cumming RJ, Channon RA, Davis JM. Drug interaction between ascorbic acid and fluphenazine. JAMA 1979;241:2008. DOI
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
- Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed
- Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 1974;28:53-6. PubMed
- Lee DH, Folsom AR, Harnack L, et al. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? Am J Clin Nutr 2004;80:1194-200. PubMed
- Taylor EN, Stampfer MJ, Curhan GC. Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J Am Soc Nephrol 2004;15:3225-32. PubMed
- Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
- Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
- Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
- Fairweather-Tait S, Hickson K, McGaw B, et al. Orange juice enhances aluminium absorption from antacid preparation. Eur J Clin Nutr. 1994;48(1):71-3.
- Gruenwald, J., Graubaum, H. J., Busch, R., and Bentley, C. Safety and tolerance of ester-C compared with regular ascorbic acid. Adv.Ther. 2006;23(1):171-178.
- Rahimi, R., Nikfar, S., Rezaie, A., and Abdollahi, M. A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women. Hypertens.Pregnancy. 2009;28(4):417-434. PubMed
- Einerson, B., Nathorn, C., Kitiyakara, C., Sirada, M., and Thamlikitkul, V. The efficacy of ascorbic acid in suboptimal responsive anemic hemodialysis patients receiving erythropoietin: a meta-analysis. J Med.Assoc.Thai. 2011;94 Suppl 1:S134-S146.
- Li, G., Li, L., Yu, C., and Chen, L. Effect of vitamins C and E supplementation on Helicobacter pylori eradication: a meta-analysis. Br.J Nutr 2011;106(11):1632-1637.
- Chen X, Shen L, Gu X, et al. High-dose supplementation with vitamin C--induced pediatric urolithiasis: the first case report in a child and literature review. Urology. 2014;84(4):922-4. PubMed
- Sattar A, Willman JE, Kolluri R. Possible warfarin resistance due to interaction with ascorbic acid: case report and literature review. Am J Health Syst Pharm. 2013;70(9):782-6. PubMed
- Yaich S, Chaabouni Y, Charfeddine K, et al. Secondary oxalosis due to excess vitamin C intake: a cause of graft loss in a renal transplant recipient. Saudi J Kidney Dis Transpl. 2014;25(1):113-6. PubMed
- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
- Rumbold A, Ota E, Nagata C, Shahrook S, Crowther CA. Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev. 2015;(9):CD004072. PubMed
- Seo MS, Kim JK, Shim JY. High-dose vitamin C promotes regression of multiple pulmonary metastases originating from hepatocellular carcinoma. Yonsei Med J. 2015;56(5):1449-52. PubMed
- Skelin M, Lucijanic T, Amidzic Klaric D, et al. Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review. Clin Ther. 2017 Feb;39(2):378-403. PubMed
- Jiang K, Tang K, Liu H, Xu H, Ye Z, Chen Z. Ascorbic acid supplements and kidney stones incidence among men and women: a systematic review and meta-analysis. Urol J. 2019;16(2):115-120.
- Thomas S, Patel D, Bittel B, et al. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open. 2 PubMed
- Giffen MA, McLemore JL. Hyperoxalosis Secondary to Intravenous Vitamin C Administration as a Non-Allopathic Treatment for Cancer. Acad Forensic Pathol 2019;9(1-2):118-126. PubMed
- Maike A, Sturgill D, Gallan A. Oxalate Nephropathy in a Renal Transplant Recipient After Receiving High Dose Ascorbic Acid. Am J Med Sci 2021. PubMed
- Shen ZY, Chen YR, Wang MC, Chang SS. High-dose vitamin C-induced acute oxalate nephropathy in a renal transplant recipient: a case report and literature review. Asian J Surg 2022. PubMed
- Yanase F, Spano S, Maeda A, et al. Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial. Crit Care 2023;27(1):371. PubMed
- Sharma Y, Sumanadasa S, Shahi R, et al. Efficacy and safety of vitamin C supplementation in the treatment of community-acquired pneumonia: a systematic review and meta-analysis with trial sequential analysis. Sci Rep 2024;14(1):11846. PubMed
- Pejcic AV, Petrovic NZ, Djordjic MD, Milosavljevic MN. Vitamin C Levels in Pregnant Women and the Efficacy of Vitamin C Supplements in Preventing Premature Rupture of Membranes: A Systematic Review and Meta-Analysis. Balkan Med J 2024;41(4):248-260. PubMed
Rose Hip 24 references
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
- Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
- Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. DOI
- Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. DOI
- Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. DOI
- Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. DOI
- Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. PubMed
- Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. PubMed
- Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. PubMed
- Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 1974;28:53-6. PubMed
- Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
- Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
- Andersson U, Berger K, Hogberg A, et al. Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr 2012;66:585-90. PubMed
- Rein, E., Kharazmi, A., and Winther, K. A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis--a double-blind, placebo-controlled, randomised trial. PubMed
- Winther, K., Apel, K., and Thamsborg, G. A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol. 2005;34
- Teng, C. M., Kang, Y. F., Chang, Y. L., Ko, F. N., Yang, S. C., and Hsu, F. L. ADP-mimicking platelet aggregation caused by rugosin E, an ellagitannin isolated from Rosa rugosa Thunb. Thromb.Haemost. 1997;77(3):555-561. DOI
- Seifi M, Abbasalizadeh S, Mohammad-Alizadeh-Charandabi S, Khodaie L, Mirghafourvand M. The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium: a randomized placebo-controlled trial. Phytother Res 2018;32(1):76-83
- Parandin R, Ghowsi M, Dadbod A. Protective effects of hydroalcoholic extract of Rosa canina L. fruit on cyclophosphamide-induced testicular toxicity in mice. Avicenna J Phytomed 2023;13(1):7-17.
Rutin 2 references
- Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
- Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC