Chewable Original Papaya Enzyme Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Chewable Original Papaya Enzyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chewable Original Papaya Enzyme is a dietary supplement by American Health with 5 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya fruit powder, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chewable Original Papaya Enzyme by American Health
Ask about any prescription or over-the-counter medication and we check it for interactions with Chewable Original Papaya Enzyme by American Health — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Chewable Original Papaya Enzyme by American Health
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 4 active ingredients: papain, papaya fruit powder, amylase, and protease. Papain and papaya fruit powder are enzymes derived from papaya that help digest proteins and other compounds.
Amylase and protease are additional digestive enzymes designed to break down carbohydrates and proteins respectively. The product also contains inactive ingredients—sucrose, calcium carbonate, stearic acid, corn starch, vegetable magnesium stearate, and papaya flavor—that serve as binders, fillers, and flavorings.
Does it work?
Not established
The evidence we hold doesn't establish that papain works for any of the conditions listed in the data—cancer, dental cavities, radiation skin damage, exercise muscle soreness, shingles, or intestinal parasites all carry ratings of insufficient reliable evidence. The same applies to papaya fruit powder for aging skin, hair loss, gallbladder cancer, colorectal cancer, and diabetes.
In short, we don't have data supporting use of these ingredients for their commonly claimed purposes.
How safe is it?
Well-documented data
Papain and papaya fruit powder are generally well tolerated at typical food amounts, but supplements may irritate your digestive tract and trigger allergic reactions in sensitive people—symptoms can include itchy watery eyes, runny nose, sneezing, abdominal cramps, sweating, and diarrhea. High oral doses carry rare but serious risks like esophageal perforation and severe gastritis.
Protease is also generally well tolerated but may cause digestive upset or allergic reactions. If you're pregnant, concentrated papain and unripe papaya are best avoided due to safety concerns; papaya fruit itself is likely safe.
Breastfeeding safety data is limited for papain supplements and protease, so medical advice is recommended before use. Occupational exposure to airborne papain dust can cause respiratory allergies including wheezing and asthma.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your pharmacist if you take warfarin (a blood thinner)—papain may increase its effects and bleeding risk. Also check if you take antidiabetes drugs, amiodarone (heart rhythm medication), or levothyroxine (thyroid hormone), as papaya fruit powder may interfere with these.
Altogether, these interactions span 92 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This enzyme supplement interacts with blood thinners, heart and diabetes medications, and thyroid drugs—check your medications with the tool on this page before starting. Evidence supporting its effectiveness for claimed uses isn't established in our data.
If you take warfarin, antidiabetic drugs, amiodarone, or levothyroxine, talk to your pharmacist first. For others, it's generally tolerated but can cause digestive upset or allergies in sensitive people.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2015.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chewable Original Papaya Enzyme, straight from the product label.
| Brand | American Health |
|---|---|
| Barcode (UPC) | 076630501507 |
| Net contents | 12 Chewable Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Apr 24, 2015 |
| DSLD ID | 44839 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chewable Original Papaya Enzyme by American Health, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 {Calories} | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Sugar | 1 Gram(s) | -- |
| Papain | 43 mg | -- |
| Papaya fruit powder | 3 mg | -- |
| Amylase | 5.75 mg | -- |
| Protease | 5.75 mg | -- |
Other ingredients: Sucrose, Calcium Carbonate, Stearic Acid, Corn Starch, Vegetable Magnesium Stearate, Papaya flavor
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General
PROD. NO. 50150 B50151 18F
Brand IP Statement(s)
the "after meal" supplement(R)
(C)2014 American Health, Inc.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, chew one (1) tablet following a meal.
Formulation
No Gluten, Yeast, Wheat, Milk or Milk Derivatives, Lactose, Soy, Egg, Grapefruit, Preservatives, Artificial Color, Sodium.
Vegetarian Formula
Precautions
WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use.
Stop use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Do not use if package is torn or open.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chewable Original Papaya Enzyme by American Health label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chewable Original Papaya Enzyme by American Health
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Papain
Interacts with2 drugs
Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...
Papain monograph & interactionsPapaya fruit powder
Interacts with92 drugs
Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...
Papaya fruit powder monograph & interactionsAmylase
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsOther (inactive) ingredients: Sucrose, Calcium Carbonate, Stearic Acid, Corn Starch, Vegetable Magnesium Stearate, Papaya flavor. These complete the product’s ingredient list but are not active constituents.
Chewable Original Papaya Enzyme by American Health Drug Interactions
HelloPharmacist Interaction Report
American Health Chewable Original Papaya Enzyme contains two ingredients with documented drug interactions.
The most serious concern is papain and papaya fruit powder's potential effect on warfarin (Coumadin), a blood thinner. In one case report, a patient stable on warfarin developed an elevated INR of 7.4 after taking a papain-containing supplement, suggesting papain may increase warfarin's effects and bleeding risk.
Read the full breakdown — every affected drug type, severity by severity
Papaya fruit powder also interacts with antidiabetes drugs, amiodarone (a heart rhythm medication), and levothyroxine (a thyroid hormone). With antidiabetes drugs, fermented papaya may have additive blood-sugar-lowering effects, though it's unclear if other papaya forms do the same.
Amiodarone levels may be delayed and increased by papaya extract. Large amounts of papaya fruit may reduce levothyroxine's effectiveness, as documented in a case where daily papaya consumption caused a previously stable patient to develop low thyroid hormone levels again.
We could not check amylase for interactions; no data is on file for it. Please use the medication checker below to verify your exact drugs against this product before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chewable Original Papaya Enzyme?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chewable Original Papaya Enzyme interact with 92 drugs. Click any drug to see the details.
2 of the 5 ingredients in Chewable Original Papaya Enzyme interact with drugs. Each result below shows which ingredient is responsible. Papaya fruit powder Papain
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Alogliptin, Pioglitazone interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Read the full Papaya Fruit Powder + Amiodarone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Chewable Original Papaya Enzyme — through 1 ingredient. Tap an ingredient for the detail:
Papaya Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Fruit Powder + Glipizide, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chewable Original Papaya Enzyme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Papaya fruit powder
Amiodarone (Cordarone)
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.
Antidiabetes Drugs
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.
Levothyroxine (Synthroid, Others)
Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.
Warfarin (Coumadin)
Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Papain
Warfarin (Coumadin)
Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Chewable Original Papaya Enzyme, from the product label.
American Health
See all American Health products- Name
- American Health, Inc.
- City
- Ronkonkoma
- State
- NY
- ZipCode
- 11779
- Phone Number
- 800-445-7137
- Web Address
- www.AmericanHealthUS.com
Chewable Original Papaya Enzyme by American Health: Common Questions
Does Chewable Original Papaya Enzyme by American Health interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this product safe during pregnancy?
What are the most common side effects?
Can this help with digestion or muscle soreness?
Is this safe while breastfeeding?
What's the difference between papain and papaya fruit powder?
Does this product have any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Chewable Original Papaya Enzyme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chewable Original Papaya Enzyme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Papain
Interacts with 2 drugsPapain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...
Read the full Papain monograph → Herb & supplement monographPapaya
Interacts with 92 drugsPapaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...
Read the full Papaya monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph →Sources & How We Checked
Chewable Original Papaya Enzyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Papain 11 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed
Papaya 14 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
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Proteolytic Enzymes (proteases) 3 references
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See these in context on the Proteolytic Enzymes (proteases) monograph →
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