Interactions on record — worth a quick check against your medications. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Chewable Super Papaya Enzyme Plus Ingredients & Drug Interactions

by American Health

Chewable Super Papaya Enzyme Plus label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chewable Super Papaya Enzyme Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chewable Super Papaya Enzyme Plus is a dietary supplement by American Health with 8 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 431 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium Copper Chlorophyllin, Bromelain, Papaya. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Chewable Super Papaya Enzyme Plus by American Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Chewable Super Papaya Enzyme Plus by American Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Chewable Super Papaya Enzyme Plus by American Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 8 active ingredients: papain and bromelain (both protein-digesting enzymes from papaya and pineapple), protease and lipase (additional digestive enzymes), alpha amylase and cellulase enzyme (to help break down starches and plant fiber), papaya fruit extract, and sodium copper chlorophyllin (a derivative of the green pigment in plants). The remaining ingredients are inactive fillers and binders — sorbitol, mannitol, calcium carbonate, maltodextrin, stearic acid, magnesium stearate, silica, dicalcium phosphate, and peppermint oil — that help form the tablet and add flavor.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive aid after meals.
  • We looked for evidence on: Dyspepsia, Inflammatory bowel disease (IBD), Cystic fibrosis, Intestinal parasite infection, Indigestion, Bloating — and 2 related terms.
  • The strongest evidence on file: Sodium is rated "Likely Effective" for Cystic fibrosis (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Dyspepsia.

The evidence for most uses of these enzymes is not well established in the data we hold. Papain's effectiveness for cancer, dental caries, radiation skin damage, muscle soreness after exercise, shingles, and intestinal parasites all carries insufficient reliable evidence to rate.

Bromelain similarly shows insufficient evidence for hay fever, burns, cancer, nerve damage from chemotherapy, poor circulation in the legs, and diabetes. Lipase effectiveness for inflammatory bowel disease and indigestion also lacks sufficient reliable evidence.

Sodium copper chlorophyllin is rated likely effective for cystic fibrosis and possibly effective for kidney damage from the antibiotic amphotericin B, but its use for bipolar disorder and heart failure is insufficiently studied.

The evidence, ingredient by ingredient Papain Bromelain Proteolytic Enzymes (proteases) Lipase Papaya Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as a food but supplements may irritate your digestive tract or cause allergic reactions in sensitive people — symptoms can include itchy watery eyes, runny nose, sneezing, belly cramps, sweating, and diarrhea. Very high doses are unsafe and may rarely cause severe stomach inflammation or even esophageal perforation.

Bromelain is generally well tolerated short-term, but the evidence on long-term use is limited; the most common side effects are diarrhea, gas, stomach upset, and headache. Protease and lipase are generally tolerated but may cause digestive upset or allergic reactions, and occupational exposure to airborne protease has caused asthma and nasal congestion in rare cases.

The sodium in this product contributes to your daily sodium intake — too much is linked to high blood pressure and may strain your heart and kidneys. Pregnancy and breastfeeding data are limited: papain, bromelain, protease, and papaya should be avoided in pregnancy; papain and bromelain should be avoided while breastfeeding.

Lipase and sodium have insufficient safety data for pregnancy and breastfeeding — talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Papain Bromelain Proteolytic Enzymes (proteases) Lipase Papaya Sodium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Papain, Papaya, Bromelain, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 431 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you use blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, apixaban, and others) — papain and bromelain may increase bleeding risk. Tell your pharmacist if you take the heart drug amiodarone, thyroid medication levothyroxine, blood-pressure drugs, corticosteroids, lithium, didanosine, or any sodium-containing medication, as this product contains sodium and interacts with those classes.

Tetracycline antibiotics may theoretically have increased levels, though evidence is mixed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This enzyme and papaya supplement is an option if you're looking for digestive support and have no blood-thinning medications or heart rhythm drugs. If you take warfarin, blood thinners, antiplatelet drugs, levothyroxine, amiodarone, blood-pressure medications, corticosteroids, lithium, or any sodium-sensitive medication, you should check with your pharmacist first.

Avoid it if you're pregnant or breastfeeding unless your doctor advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chewable Super Papaya Enzyme Plus, straight from the product label.

Brand American Health
Barcode (UPC) 076630502054
Net contents 360 Tablet(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 317668
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chewable Super Papaya Enzyme Plus by American Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
120
UPC/BARCODE
076630502054
IngredientAmount% DV
Papain45 mg--
Bromelain3 mg--
Protease3 mg--
Lipase1.5 mg--
Alpha Amylase3 mg--
Cellulase Enzyme94.5 mg--
Papaya15 mg--
Sodium Copper Chlorophyllin1.5 mg--

Other ingredients: Sorbitol, Mannitol, Calcium Carbonate, Maltodextrin, Stearic Acid, Magnesium Stearate, Silica, Dicalcium Phosphate, Oil of Peppermint

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

An advanced, great-tasting digestive aid, our award-winning "after meal" supplement contains plant and fermentation-based enzymes and may be especially helpful when looking for a higher level of support. Each serving has 15 mg of freshly ripened Papaya. In addition, the formula contains enzymes including papain, protease, amylase, lipase, and bromelain, which aid in the digestion of proteins, carbohydrates and fats. Peppermint is added to help with the bad taste and to sweeten breath.

Plant and fermentation-based enzymes

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, including a known sensitivity to latex, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Contains wheat ingredients.

Storage

Store at room temperature.

Seals/Symbols

Igen Non-GMO Tested

Formulation

Igen Non-GMO Tested This product does not contain common GE genes or proteins. Visit igenprogram.com

The "after meal" Supplement Promotes the breakdown of food Advanced formula Digestive aids

No yeast, no milk or milk derivatives, no lactose, no soy, no egg, no grapefruit, no sugar, no starch, no artificial color, no artificial flavor.

General Statements

Visit www.AmericanHealthUS.com for our complete line of products.

Brand IP Statement(s)

Copyright 2022 American Health, Inc.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, chew three (3) tablets with a meal, up to three times daily, as needed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chewable Super Papaya Enzyme Plus by American Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chewable Super Papaya Enzyme Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chewable Super Papaya Enzyme Plus by American Health

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
45 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Bromelain

Interacts with
141 drugs
3 mg per serving

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Protease

No known
interactions
3 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Lipase

No known
interactions
1.5 mg per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Alpha Amylase

3 mg per serving

Cellulase Enzyme

94.5 mg per serving

Papaya

Interacts with
92 drugs
15 mg per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Papaya monograph & interactions

Sodium Copper Chlorophyllin

Interacts with
205 drugs
1.5 mg per serving Form: Chlorophyll

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium Copper Chlorophyllin monograph & interactions

Other (inactive) ingredients: Sorbitol, Mannitol, Calcium Carbonate, Maltodextrin, Stearic Acid, Magnesium Stearate, Silica, Dicalcium Phosphate, Oil of Peppermint. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chewable Super Papaya Enzyme Plus by American Health Drug Interactions

Want to check YOUR meds against Chewable Super Papaya Enzyme Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
431Drugs
412 Moderate 19 Minor

Ingredients driving the most interactions

Sodium Copper Chlorophyllin 205
Bromelain 141
Papaya 92
Papain 2

Individual Drug Interactions

The ingredients in Chewable Super Papaya Enzyme Plus interact with 431 drugs. Click any drug to see the details.

4 of the 8 ingredients in Chewable Super Papaya Enzyme Plus interact with drugs. Each result below shows which ingredient is responsible. Sodium Copper Chlorophyllin Bromelain Papaya Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Chewable Super Papaya Enzyme Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium Copper Chlorophyllin7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium Copper Chlorophyllin full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papaya4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chewable Super Papaya Enzyme Plus, from the product label.

American Health

See all American Health products
Name
American Health, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
800-445-7137
Web Address
www.AmericanHealthUS.com
Pharmacist Counseling Corner

Chewable Super Papaya Enzyme Plus by American Health: Common Questions

Does Chewable Super Papaya Enzyme Plus by American Health interact with any medications?
Yes. Based on its ingredients, Chewable Super Papaya Enzyme Plus has a known interaction with 431 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chewable Super Papaya Enzyme Plus contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
No, not without talking to your pharmacist first. Papain and papaya extract in this product can increase how strong your blood thinner works, raising your risk of bleeding. A real patient had a dangerous blood-thinning spike from papain. Your pharmacist needs to check your specific medications and may advise against this product or adjust your dosing.
What are the most common side effects?
The enzymes may cause diarrhea, gas, stomach upset, or headache. Some people have allergic reactions — itchy watery eyes, sneezing, runny nose, belly cramps, or diarrhea. Allergic reactions are more common in people sensitive to papain or if you've had reactions to papaya or pineapple in the past.
Is this safe if I'm pregnant or breastfeeding?
The safety data advises against papain, bromelain, protease, and papaya during pregnancy. While breastfeeding, papain and bromelain should be avoided because there isn't enough safety information. Lipase and sodium don't have enough data either way — talk with your doctor or midwife for personalized advice.
Can I take this with tetracycline antibiotics?
There's a theoretical concern that bromelain might increase tetracycline levels, but one study in healthy adults found no actual difference in antibiotic levels. Still, mention this product to your pharmacist or doctor when you fill a tetracycline prescription to be sure.
Does this product have any fillers or artificial ingredients?
It contains several inactive ingredients: sorbitol, mannitol, calcium carbonate, maltodextrin, stearic acid, magnesium stearate, silica, dicalcium phosphate, and peppermint oil. These help form and flavor the tablet but are not the active enzymes.
Is there sodium in this product?
Yes, it contains sodium copper chlorophyllin, which adds sodium to each dose. If you're watching your sodium intake, take blood-pressure medications, corticosteroids, lithium, or have heart or kidney disease, ask your pharmacist whether the sodium level in this product is safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chewable Super Papaya Enzyme Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chewable Super Papaya Enzyme Plus label
Go deeper

The Full Monographs Behind Chewable Super Papaya Enzyme Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Chewable Super Papaya Enzyme Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 86 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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