Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Children's Ingredients & Drug Interactions

by UP4

Children's label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Children's against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Children's is a dietary supplement by UP4 with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus DDS-1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Children's by UP4

Ask about any prescription or over-the-counter medication and we check it for interactions with Children's by UP4 — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Children's by UP4

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “A Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (22 mg) without saying how much of each component you get.

This powder contains 2 active probiotic ingredients: Lactobacillus acidophilus DDS-1 and a proprietary probiotic blend that includes Bifidobacterium lactis UABla-12. Probiotics are beneficial live bacteria meant to support digestive and immune health.

The product also contains inactive ingredients (potato maltodextrin, fructooligosaccharides, and silica) that serve as carriers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Lactobacillus Acidophilus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Lactobacillus Acidophilus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The evidence is not yet established for acute respiratory distress syndrome (ARDS), and it appears possibly ineffective for atopic disease.

The effectiveness data for the proprietary blend and Bifidobacterium lactis ingredient are not on file.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy children and adults. Since the product contains live organisms, there's a theoretical concern they could cause infection in certain patients, though this is rare and usually involves bacteria that have moved from their natural location in the body.

Gastrointestinal side effects like mild bloating, gas, abdominal discomfort, or diarrhea can occur but are uncommon. One trial reported rare cases of rash and itching, though it's unclear if these were caused by the probiotic or another factor.

Safety data for Bifidobacterium lactis are not on file. Check with your child's doctor before starting this product.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main medication type to double-check before your child takes this product. Antibiotics can reduce how well the probiotic works, so timing matters.

Use the medication search tool on this page to check any prescriptions or over-the-counter medicines your child is taking.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

UP4 Children's Powder may help with certain digestive and infection-related concerns in children, particularly IBS and antibiotic-associated diarrhea. The main thing to watch for is taking it with antibiotics — you'll need to space them out so the antibiotics don't kill off the live bacteria.

Talk to your pharmacist before giving this to your child if they're on any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Children's, straight from the product label.

Brand UP4
Net contents 60 Gram(s); 2.1 Oz(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 75099
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Kosher, Children (All), Halal, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Children's by UP4, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 tsp
Maximum serving Sizes:
0.25 tsp
Servings per container
60
IngredientAmount% DV
Lactobacillus acidophilus DDS-10 NP--
A Proprietary Probiotic Blend22 mg--
Bifidobacterium lactis UABla-120 NP--

Other ingredients: Potato Maltodextrin, Fructooligosaccharides, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Dosage: For Children Ages 3 And Under: Take one 1/4 teaspoon per day. For Ages 3 And Up: Take up to three 1/4 teaspoon servings per day. Directions: Mix with favorite drink or food and consume soon after mixing.

Storage

Refrigeration is recommended, but not required, after opening.

Refrigeration not required

Precautions

Caution: Do not take if seal is broken

Keep out of reach of children

As with any supplement, if you are pregnant, nursing, have a medical condition or are taking medication, consult a health practitioner before use

While there are no dairy-derived ingredients in the product, it is produced in a facility that also handles dairy ingredients.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

M Halal

OK D

Formula

OK D

Support for tots to tweens

UP4 Children's is formulated with 80% bifidobacteria plus lactobacilli to provide overall digestive balance for growing bodies.

Features over 80% bifidobacterium lactis UABla-12 plus the trademarked superstrain lactobacillus acidophilus DDS-1 to support digestive and immune health.

For ages 1+

General Statements

Made in USA

Naturally acid & bile resistant Shelf stable

A developing digestive system requires a balance of good bacteria. In growing infants and children, vital bifidobacteria species tend to be at less than ideal levels. This can lead to poor digestion, a weakened immune system, or issues with respiratory and skin health.

This formula is backed by clinical studies for digestive, immune, skin and respiratory health. Digestive and immune health

Respiratory health This proven formula is backed by a clinical study in the area of respiratory health in children ages 3-12. European journal of clinical nutrition (2015) 1-7 Skin health This proven formula is clinically studied to support skin health in infants and toddlers. American journal of clinical dermotology 2010;11 (5):351-61

Clinically proven

Probiotics Probiotic supplement in powder form

5 billion cfu

Easy mix powder

Respiratory + digestive + immune support

General

CC. 001

Brand IP Statement(s)

The DDS-1 difference The trademarked superstrain, Lactobacillus acidophilus DDS-1 is: Backed by over 35 years of clinical research in the areas of digestive and immune health. Clinically proven to be beneficial in people of all ages.

Simple Goodness UP4 contains the simple goodness and purity of probiotics to naturally support your digetive and immune health.

Learn more about UP4 visit us online at www.up4probiotics.com

A happier inside

DDS-1 trademarked superstrain

Formulation

Non-dairy Preservative free Non-gmo Soy free Gluten free

Non-dairy Non-GMO Gluten free

Vegan

FDA Statement of Identity

Probiotic Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Children's by UP4 label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Children's label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Children's by UP4

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.25 tsp Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

A Proprietary Probiotic Blend

22 mg per serving

Other (inactive) ingredients: Potato Maltodextrin, Fructooligosaccharides, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Children's by UP4 Drug Interactions

Want to check YOUR meds against Children's?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus DDS-1 182

Individual Drug Interactions

The ingredients in Children's interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Children's interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus DDS-1

Each ingredient & the kinds of drugs it affects

For each ingredient in Children's with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus DDS-11 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus DDS-1 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Children's, from the product label.

UP4

See all UP4 products
Name
i-Health, Inc.
Street Address
55 Sebethe Drive
City
Cromwell
State
CT
ZipCode
06416
Phone Number
1 (800) 722-3476
Pharmacist Counseling Corner

Children's by UP4: Common Questions

Does Children's by UP4 interact with any medications?
Yes. Based on its ingredients, Children's has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Children's contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my child if they're taking an antibiotic?
Yes, but timing is important. Antibiotics can kill the live bacteria in this probiotic, making it less effective. Your pharmacist or doctor can help you space out the doses so they don't interfere with each other.
Is this safe for children?
Lactobacillus acidophilus is generally well tolerated in healthy children. However, the product does contain live organisms, so it's wise to check with your child's doctor before starting — especially if your child has any serious health conditions.
What does this probiotic do?
The Lactobacillus acidophilus in this powder is possibly effective for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis. The specific roles of the other probiotic ingredients aren't detailed in our data.
Can my child take this while breastfeeding?
Safety data for this product during breastfeeding aren't on file. Talk with your pediatrician or pharmacist about whether it's right for your nursing child.
What side effects might happen?
Most children tolerate it well. Mild gastrointestinal side effects like bloating, gas, or loose stool can happen but are uncommon. In rare cases, a rash or itching has been reported, though it's unclear if the probiotic caused it.
Does this have fillers?
Yes. The inactive ingredients are potato maltodextrin, fructooligosaccharides, and silica. These help carry and bind the active probiotics.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Children's is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Children's label
Go deeper

The Full Monographs Behind Children's’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Children's's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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